KR840009295A - α-L-아스파르틸-L-페닐아라딘 메틸에스테르 및 그의 염산염의 제조방법 - Google Patents
α-L-아스파르틸-L-페닐아라딘 메틸에스테르 및 그의 염산염의 제조방법 Download PDFInfo
- Publication number
- KR840009295A KR840009295A KR1019840002906A KR840002906A KR840009295A KR 840009295 A KR840009295 A KR 840009295A KR 1019840002906 A KR1019840002906 A KR 1019840002906A KR 840002906 A KR840002906 A KR 840002906A KR 840009295 A KR840009295 A KR 840009295A
- Authority
- KR
- South Korea
- Prior art keywords
- aspartyl
- methyl ester
- hydrochloric acid
- hydrochloride
- phenylaradine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 0내지 10용량%의 메탄올, 8내지 55용광%의 진한 염산 및 물(평형)을 함유하는 메탄올/염산 혼합용매(여기에서 염산은 진한 염산 및 물로서 표현된다)중에-L-아스파르틸-L-페닐아라닌 디메틸에스테르를 용해시켜 상기 에스 테르의 농도가 0.01mol/dl 내지 0.3mol/dl인 용액을 생성시키고, 상기 용액을 0내지 60°C로 유지시켜 그의 염산염으로서 형성된-L-아스파르틸-L-페닐아라닌 메틸에스테르를 결정으로 석출하고, 상기 염산염을 분리하고, 필요에 따라서는 알카리로 중화함으로써 유리 에스테르를 수득함을 특징으로 하는-L-아스파르틸-L-페닐아라닌 메틸에스테르 및 그의 염산염의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58094477A JPS59219258A (ja) | 1983-05-28 | 1983-05-28 | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
| JP94477 | 1983-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR840009295A true KR840009295A (ko) | 1984-12-26 |
| KR900008012B1 KR900008012B1 (ko) | 1990-10-29 |
Family
ID=14111354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019840002906A KR900008012B1 (ko) | 1983-05-28 | 1984-05-26 | α-L-아스파르틸-L-페닐알라닌 메틸 에스테르 및 그의 염산염의 제조방법 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4606854A (ko) |
| EP (1) | EP0127411B1 (ko) |
| JP (1) | JPS59219258A (ko) |
| KR (1) | KR900008012B1 (ko) |
| CA (1) | CA1258749A (ko) |
| DE (1) | DE3473266D1 (ko) |
| IE (1) | IE57517B1 (ko) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59219258A (ja) * | 1983-05-28 | 1984-12-10 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
| US4618695A (en) * | 1983-06-02 | 1986-10-21 | Ajinomoto Co., Inc. | Method of preparing methyl ester and its hydrochloride |
| JPS60174799A (ja) * | 1984-02-21 | 1985-09-09 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法 |
| JPH07636B2 (ja) * | 1984-12-17 | 1995-01-11 | 三井東圧化学株式会社 | Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法 |
| ES8703487A1 (es) * | 1984-12-27 | 1987-03-01 | Mitsui Toatsu Chemicals | Procedimiento para la preparacion de a-l-aspartil-l-fenila- lanina metil ester |
| AU561384B2 (en) * | 1985-03-26 | 1987-05-07 | Mitsui Toatsu Chemicals Inc. | Preparation of -l-aspartyl-l-phenylalanine methyl ester or hydrochloride thereof |
| AU586669B2 (en) * | 1985-03-29 | 1989-07-20 | Mitsui Toatsu Chemicals Inc. | Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof |
| US4677220A (en) * | 1985-10-31 | 1987-06-30 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
| JPS6383098A (ja) * | 1986-09-27 | 1988-04-13 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニン又はその誘導体の製造方法 |
| EP0270345B1 (en) * | 1986-12-05 | 1992-07-22 | MITSUI TOATSU CHEMICALS, Inc. | Preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester or hydrohalide thereof |
| JPH0832719B2 (ja) * | 1986-12-19 | 1996-03-29 | 三井東圧化学株式会社 | 吸湿性の小さいα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法 |
| JP2927070B2 (ja) * | 1991-05-23 | 1999-07-28 | 味の素株式会社 | α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステルの製造方法 |
| US6657073B1 (en) | 1999-08-18 | 2003-12-02 | Daesang Corporation | Crystallization of α-L-aspartyl-L-phenylalanine methyl ester |
| EP3310476B1 (en) | 2015-06-19 | 2019-09-18 | Saudi Arabian Oil Company | Antifouling oligomerization catalyst systems |
| US11104621B2 (en) | 2016-01-07 | 2021-08-31 | Saudi Arabian Oil Company | Antifouling oligomerization catalyst systems |
| US10280125B2 (en) | 2016-12-07 | 2019-05-07 | Sumitomo Chemical Company, Limited | Process for selective ethylene oligomerization with antifouling components |
| KR102659762B1 (ko) | 2017-09-22 | 2024-04-24 | 사우디 아라비안 오일 컴퍼니 | 에틸렌 올리고머화를 위한 방오제 공촉매의 인라인 제조 방법 |
| US11440980B2 (en) | 2020-07-22 | 2022-09-13 | Saudi Arabian Oil Company | Methods for forming ultra high molecular weight polyethylenes and methods for reducing contaminant content in such |
| WO2022115749A1 (en) | 2020-11-30 | 2022-06-02 | Saudi Arabian Oil Company | Catalyst systems |
| WO2022115751A1 (en) | 2020-11-30 | 2022-06-02 | Saudi Arabian Oil Company | Catalyst systems |
| US11612883B2 (en) | 2020-11-30 | 2023-03-28 | Saudi Arabian Oil Company | Catalyst systems |
| US11458463B2 (en) | 2020-11-30 | 2022-10-04 | Saudi Arabian Oil Company | Catalyst systems |
| WO2022115750A1 (en) | 2020-11-30 | 2022-06-02 | Saudi Arabian Oil Company | Catalyst systems |
| CN116917040A (zh) | 2021-03-12 | 2023-10-20 | 沙特***石油公司 | 催化剂体系 |
| WO2023027749A1 (en) | 2021-08-26 | 2023-03-02 | Saudi Arabian Oil Company | Catalyst systems |
| US11639321B1 (en) | 2022-08-31 | 2023-05-02 | Saudi Arabian Oil Company | Catalyst systems that include meta-alkoxy substituted n-aryl bis-diphosphinoamine ligands |
| US11623901B1 (en) | 2022-08-31 | 2023-04-11 | Saudi Arabian Oil Company | Catalyst systems that include silyl ether moieties |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4941425B1 (ko) * | 1970-10-26 | 1974-11-08 | ||
| US3933781A (en) * | 1973-11-05 | 1976-01-20 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters |
| US4173562A (en) * | 1976-12-27 | 1979-11-06 | Monsanto Company | Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester |
| MX4704E (es) * | 1976-12-27 | 1982-08-04 | Monsanto Co | Procedimiento mejorado para la preparacion de ester metilico de alfa-l-aspartil-l-fenilalanina |
| US4111925A (en) * | 1977-10-14 | 1978-09-05 | Monsanto Company | Hydrolysis of esters of α-L-aspartyl-L-phenylalanine |
| JPS59219258A (ja) * | 1983-05-28 | 1984-12-10 | Ajinomoto Co Inc | α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル又はその塩酸塩の製法 |
-
1983
- 1983-05-28 JP JP58094477A patent/JPS59219258A/ja active Granted
-
1984
- 1984-05-17 US US06/611,531 patent/US4606854A/en not_active Expired - Lifetime
- 1984-05-21 IE IE1257/84A patent/IE57517B1/en not_active IP Right Cessation
- 1984-05-21 EP EP84303419A patent/EP0127411B1/en not_active Expired
- 1984-05-21 DE DE8484303419T patent/DE3473266D1/de not_active Expired
- 1984-05-25 CA CA000455146A patent/CA1258749A/en not_active Expired
- 1984-05-26 KR KR1019840002906A patent/KR900008012B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1258749A (en) | 1989-08-22 |
| JPH0363556B2 (ko) | 1991-10-01 |
| IE841257L (en) | 1984-11-28 |
| KR900008012B1 (ko) | 1990-10-29 |
| US4606854A (en) | 1986-08-19 |
| DE3473266D1 (en) | 1988-09-15 |
| EP0127411B1 (en) | 1988-08-10 |
| EP0127411A3 (en) | 1985-09-18 |
| IE57517B1 (en) | 1992-10-07 |
| EP0127411A2 (en) | 1984-12-05 |
| JPS59219258A (ja) | 1984-12-10 |
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Payment date: 20031023 Year of fee payment: 14 |
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