KR830009015A - 메르캅토 아실 카르니틴 에스테르류의 제조방법 - Google Patents
메르캅토 아실 카르니틴 에스테르류의 제조방법Info
- Publication number
- KR830009015A KR830009015A KR1019820001367A KR820001367A KR830009015A KR 830009015 A KR830009015 A KR 830009015A KR 1019820001367 A KR1019820001367 A KR 1019820001367A KR 820001367 A KR820001367 A KR 820001367A KR 830009015 A KR830009015 A KR 830009015A
- Authority
- KR
- South Korea
- Prior art keywords
- ester
- mercapto
- acid
- carnitine
- carbon atoms
- Prior art date
Links
- -1 mercapto acyl carnitine esters Chemical class 0.000 title claims 7
- 238000000034 method Methods 0.000 title claims 2
- 239000002253 acid Substances 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- JXXCENBLGFBQJM-FYZOBXCZSA-N [(2r)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O JXXCENBLGFBQJM-FYZOBXCZSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 claims 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 claims 1
- 229910052977 alkali metal sulfide Inorganic materials 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
- F15B—SYSTEMS ACTING BY MEANS OF FLUIDS IN GENERAL; FLUID-PRESSURE ACTUATORS, e.g. SERVOMOTORS; DETAILS OF FLUID-PRESSURE SYSTEMS, NOT OTHERWISE PROVIDED FOR
- F15B11/00—Servomotor systems without provision for follow-up action; Circuits therefor
- F15B11/08—Servomotor systems without provision for follow-up action; Circuits therefor with only one servomotor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/13—Burn treatment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (2)
- 카르니틴 하이드로클로라이드의 에스테르를 불활성 유기용매 존재하에 30-60℃에서 할로겐 아실클로라이드와 반응시켜 상응하는 할로겐 아실 카르니틴의 에스테르를 제조하고 이 화합물을 염산이나 황산 같은 부가신을 가하여 반응혼합물의 pH를 거의 중성으로 유지시키며 알칼리금속 설파이드와 산 설파이드로 부터 선택된 화합물과 실온에서 반응시켜 다음 일반식(I)인 메르캅토 아실 카르니틴 에스테르류를 제조하는 방법.상기 식에서, X-는 제약상 허용될 수 있는 할로게나이드의 온이고, R은 2-10개의 탄소수를 가진 포화된 메르캅토 산의 메르캅토 아실기이고, R1은 1-5개의 탄소수를 가진 직쇄 또는 측쇄의 알킬기이다.
- SH기는 트리틸 및 P로 치환된 벤질에서 선택된 보호기로 보호되어지는데 메르캅토 아실 클로라이드를 가진 카르니틴 하이드로클로라이드의 에스테르를 반응시켜 상응하는 S로 보호된 메르캅토 아실 카르니틴 에스테르를 제조하고, 이 S로 보호된 메르캅토 아실 카르니틴 에스테르의 보호기를 공지의 방법으로 제거시켜 다음 일반식(I)인 메르캅토 아실 카르니틴 에스테르류를 제조하는 방법.상기 식에서, X-는 제약상 허용 가능한 할로게나이드 이온이고, R은 2-10개의 탄소수를 가진 포화 메르캅토산의 메르캅토 아실기이고, R1은 1-5개의 탄소수를 가진 직쇄 또는 측쇄의 알킬기이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48166A | 1981-03-31 | ||
| IT48166/81A IT1170861B (it) | 1981-03-31 | 1981-03-31 | Ester di mercaptoacil-carnitine procedimento per la loro preparazione e loro uso terapeutico |
| IT81-48166A | 1981-03-31 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830009015A true KR830009015A (ko) | 1983-12-17 |
| KR860001902B1 KR860001902B1 (ko) | 1986-10-24 |
Family
ID=11264950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR8201367A KR860001902B1 (ko) | 1981-03-31 | 1982-03-30 | 메르캅토 아실 카르니틴 에스테르류의 제조방법 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4567200A (ko) |
| JP (1) | JPS57176949A (ko) |
| KR (1) | KR860001902B1 (ko) |
| AT (1) | AT384213B (ko) |
| BE (1) | BE892602A (ko) |
| CA (1) | CA1167864A (ko) |
| CH (1) | CH656873A5 (ko) |
| DE (1) | DE3209330A1 (ko) |
| DK (1) | DK165685C (ko) |
| ES (1) | ES8307736A1 (ko) |
| FR (1) | FR2503149B1 (ko) |
| GB (1) | GB2096136B (ko) |
| GR (1) | GR75921B (ko) |
| IE (1) | IE52314B1 (ko) |
| IL (1) | IL65396A0 (ko) |
| IT (1) | IT1170861B (ko) |
| LU (1) | LU84062A1 (ko) |
| NL (1) | NL8201320A (ko) |
| SE (1) | SE448539B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1209564B (it) * | 1984-06-29 | 1989-08-30 | Magis Farmaceutici | Derivati della l-carnitina o di l-acil carnitina. |
| IT1254135B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica. |
| IT1254136B (it) * | 1992-01-16 | 1995-09-08 | Sigma Tau Ind Farmaceuti | Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica. |
| US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
| US6138683A (en) * | 1997-09-19 | 2000-10-31 | Thione International, Inc. | Smokeless tobacco products containing antioxidants |
| US5922346A (en) * | 1997-12-01 | 1999-07-13 | Thione International, Inc. | Antioxidant preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3624887A (en) * | 1970-03-02 | 1971-12-07 | Bunker Ramo | Pin and socket removal tool |
| IT1111384B (it) * | 1978-12-21 | 1986-01-13 | Sigma Tau Ind Farmaceuti | Guaiacil esteri di derivati dello acido mercaptopropionico procedimento per la loro preparazione e loro uso terapeutico |
| IT1116037B (it) * | 1979-04-23 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico |
-
1981
- 1981-03-31 IT IT48166/81A patent/IT1170861B/it active
-
1982
- 1982-03-15 IE IE594/82A patent/IE52314B1/en not_active IP Right Cessation
- 1982-03-15 GB GB8207449A patent/GB2096136B/en not_active Expired
- 1982-03-15 US US06/358,502 patent/US4567200A/en not_active Expired - Fee Related
- 1982-03-15 DE DE19823209330 patent/DE3209330A1/de active Granted
- 1982-03-22 CA CA000398990A patent/CA1167864A/en not_active Expired
- 1982-03-23 BE BE0/207643A patent/BE892602A/fr not_active IP Right Cessation
- 1982-03-24 CH CH1819/82A patent/CH656873A5/it not_active IP Right Cessation
- 1982-03-26 SE SE8201954A patent/SE448539B/sv not_active IP Right Cessation
- 1982-03-29 GR GR67736A patent/GR75921B/el unknown
- 1982-03-30 NL NL8201320A patent/NL8201320A/nl not_active Application Discontinuation
- 1982-03-30 ES ES510927A patent/ES8307736A1/es not_active Expired
- 1982-03-30 KR KR8201367A patent/KR860001902B1/ko active
- 1982-03-30 AT AT0124882A patent/AT384213B/de not_active IP Right Cessation
- 1982-03-30 DK DK144982A patent/DK165685C/da not_active IP Right Cessation
- 1982-03-31 FR FR828205580A patent/FR2503149B1/fr not_active Expired
- 1982-03-31 JP JP57054752A patent/JPS57176949A/ja active Granted
- 1982-03-31 IL IL65396A patent/IL65396A0/xx not_active IP Right Cessation
- 1982-03-31 LU LU84062A patent/LU84062A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATA124882A (de) | 1987-03-15 |
| DK165685C (da) | 1993-06-01 |
| IL65396A0 (en) | 1982-05-31 |
| LU84062A1 (fr) | 1982-07-08 |
| FR2503149B1 (fr) | 1985-07-26 |
| AT384213B (de) | 1987-10-12 |
| SE8201954L (sv) | 1982-10-01 |
| IT8148166A0 (it) | 1981-03-31 |
| ES510927A0 (es) | 1983-08-01 |
| FR2503149A1 (fr) | 1982-10-08 |
| NL8201320A (nl) | 1982-10-18 |
| DE3209330A1 (de) | 1982-10-21 |
| JPS57176949A (en) | 1982-10-30 |
| DE3209330C2 (ko) | 1990-05-23 |
| IT1170861B (it) | 1987-06-03 |
| GB2096136B (en) | 1985-04-03 |
| DK144982A (da) | 1982-10-01 |
| JPH0251903B2 (ko) | 1990-11-08 |
| CA1167864A (en) | 1984-05-22 |
| BE892602A (fr) | 1982-07-16 |
| KR860001902B1 (ko) | 1986-10-24 |
| IE52314B1 (en) | 1987-09-02 |
| CH656873A5 (it) | 1986-07-31 |
| GB2096136A (en) | 1982-10-13 |
| GR75921B (ko) | 1984-08-02 |
| IE820594L (en) | 1982-09-30 |
| US4567200A (en) | 1986-01-28 |
| DK165685B (da) | 1993-01-04 |
| SE448539B (sv) | 1987-03-02 |
| ES8307736A1 (es) | 1983-08-01 |
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