KR830007678A - β-락탐계 항생물질 용액의 농축방법 - Google Patents
β-락탐계 항생물질 용액의 농축방법 Download PDFInfo
- Publication number
- KR830007678A KR830007678A KR1019810005106A KR810005106A KR830007678A KR 830007678 A KR830007678 A KR 830007678A KR 1019810005106 A KR1019810005106 A KR 1019810005106A KR 810005106 A KR810005106 A KR 810005106A KR 830007678 A KR830007678 A KR 830007678A
- Authority
- KR
- South Korea
- Prior art keywords
- lactam antibiotic
- poly
- ether
- aqueous solution
- lower alcohol
- Prior art date
Links
- 239000003782 beta lactam antibiotic agent Substances 0.000 title claims 5
- 239000002132 β-lactam antibiotic Substances 0.000 title claims 5
- 229940124586 β-lactam antibiotics Drugs 0.000 title claims 5
- 239000000243 solution Substances 0.000 title claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 3
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 1
- FDQSRULYDNDXQB-UHFFFAOYSA-N benzene-1,3-dicarbonyl chloride Chemical compound ClC(=O)C1=CC=CC(C(Cl)=O)=C1 FDQSRULYDNDXQB-UHFFFAOYSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000003951 lactams Chemical class 0.000 claims 1
- 229920002492 poly(sulfone) Polymers 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/06—Cephalosporin C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (7)
- 2내지 20%(V/V)의 저급 알코올을 함유하는 β-락탐계 항생물질의 희박 수용액액을 폴리(에테르/아미드) 또는 폴리벤 트이미다졸론으로 만들어진 투과막을 사용하여 농축시킴을 특징으로 하는 β-락탐계 항생물질 용액을 농축방법.
- 제1항에 있어서, 저급알코올이 메탄올, 에탄올, 프로판올 및 부탄올 중에서 선택됨을 특징으로하는 방법.
- 제1항에 있어서, 저급알코올이 메탄올임을 특징으로 하는 방법.
- 제1 내지 3항에 있어서, β-락탐계 항생물질의 희박수용액이 0.01내지 5%(W/V)의 β-락탐계 항생물질을 함유함을 특징으로 하는 방법.
- 제4항에 있어서, -락탐계 항생물질이 세팔로스포린 C, 디아세틸세파로스포린 C, 디아세톡시세팔로스포린 C 및 그의 7-위 탈아세틸화 화합물 중에서 선택됨을 특징으로하는 방법.
- 제1항에 있어서, 투과막이 폴리(에테르/아미드)로 만들어짐을 특징으로하는 방법.
- 제1항에 있어서, 에피클로로히드린-에틸렌디아민 축합물 수용액의 박층을 폴리술폰지지막의 미세다공 표면상에 침착시킨 다음 폴리(에테르/아민)층을 이소프탈일디클로라이드의 수불혼화성 용액과 접촉시킴으로써 투과막을 제조됨을 특징으로하는 방법.※ 참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP184597 | 1980-12-24 | ||
| JP55184597A JPS57106683A (en) | 1980-12-24 | 1980-12-24 | Method for concentrating beta-lactam antibiotic substance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830007678A true KR830007678A (ko) | 1983-11-04 |
| KR880000872B1 KR880000872B1 (ko) | 1988-05-28 |
Family
ID=16155988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810005106A KR880000872B1 (ko) | 1980-12-24 | 1981-12-23 | β-락탐계 항생물질 용액의 농축방법 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4455306A (ko) |
| EP (1) | EP0055137B1 (ko) |
| JP (1) | JPS57106683A (ko) |
| KR (1) | KR880000872B1 (ko) |
| CA (1) | CA1177067A (ko) |
| DE (1) | DE3170658D1 (ko) |
| DK (1) | DK162287C (ko) |
| ES (1) | ES508300A0 (ko) |
| GB (1) | GB2089802B (ko) |
| PH (1) | PH16710A (ko) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5970689A (ja) * | 1982-10-14 | 1984-04-21 | Fujisawa Pharmaceut Co Ltd | β−ラクタム系抗生物質水溶液の濃縮方法 |
| JPS61148180A (ja) * | 1984-12-21 | 1986-07-05 | Shionogi & Co Ltd | β−ラクタム化合物溶液の精製法 |
| GB8608798D0 (en) * | 1986-04-11 | 1986-05-14 | Lepetit Spa | Recovery of glycopeptide antibiotics from aqueous solutions |
| DE4127648C1 (ko) * | 1991-08-21 | 1993-01-14 | Hoechst Ag, 6230 Frankfurt, De | |
| JPH0714944B2 (ja) * | 1992-09-22 | 1995-02-22 | 塩野義製薬株式会社 | β−ラクタム化合物溶液の濃縮法 |
| ES2105988B1 (es) * | 1996-03-15 | 1998-07-01 | Antibioticos Sa | Procedimiento para purificar 7-sustituido-amino-desacetoxi-cefalosporinas mediante el empleo de membranas de filtracion. |
| ES2105989B1 (es) * | 1996-03-15 | 1998-07-01 | Antibioticos Sa | Procedimiento alternativo para la obtencion del acido 6-amino penicilanico (6-apa). |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH541579A (de) * | 1969-05-13 | 1973-09-15 | Ciba Geigy Ag | Verfahren zur Abtrennung von Cephalosporin C aus Rohlösungen |
-
1980
- 1980-12-24 JP JP55184597A patent/JPS57106683A/ja active Granted
-
1981
- 1981-12-21 US US06/333,182 patent/US4455306A/en not_active Expired - Fee Related
- 1981-12-23 KR KR1019810005106A patent/KR880000872B1/ko active
- 1981-12-23 DK DK575281A patent/DK162287C/da active
- 1981-12-23 GB GB8138721A patent/GB2089802B/en not_active Expired
- 1981-12-23 DE DE8181306094T patent/DE3170658D1/de not_active Expired
- 1981-12-23 EP EP81306094A patent/EP0055137B1/en not_active Expired
- 1981-12-23 ES ES508300A patent/ES508300A0/es active Granted
- 1981-12-23 CA CA000393108A patent/CA1177067A/en not_active Expired
- 1981-12-23 PH PH26673A patent/PH16710A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0055137A3 (en) | 1983-07-20 |
| EP0055137B1 (en) | 1985-05-22 |
| GB2089802A (en) | 1982-06-30 |
| ES8306021A1 (es) | 1983-05-01 |
| EP0055137A2 (en) | 1982-06-30 |
| JPH0246198B2 (ko) | 1990-10-15 |
| DK162287B (da) | 1991-10-07 |
| DK575281A (da) | 1982-06-25 |
| ES508300A0 (es) | 1983-05-01 |
| DE3170658D1 (en) | 1985-06-27 |
| CA1177067A (en) | 1984-10-30 |
| JPS57106683A (en) | 1982-07-02 |
| KR880000872B1 (ko) | 1988-05-28 |
| PH16710A (en) | 1984-01-20 |
| DK162287C (da) | 1992-03-02 |
| US4455306A (en) | 1984-06-19 |
| GB2089802B (en) | 1984-08-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69306569D1 (de) | Dünnfilmverbundmembran | |
| JPS5727102A (en) | Composite semipermeable membrane and its production | |
| KR910004214A (ko) | 분리막 및 분리방법 | |
| KR840007438A (ko) | 안트라시클리논 글루코시드의 정제방법 | |
| ES2077280T3 (es) | Metodo de pervaporacion con una membrana que comprende almidon y un polimero termoplastico sintetico. | |
| IT7904834A0 (it) | Procedimento per la desalinizzazione di soluzioni con applicazione della osmosi invertita. | |
| KR830007678A (ko) | β-락탐계 항생물질 용액의 농축방법 | |
| KR880009038A (ko) | 트립토판의 정제방법 | |
| KR890007773A (ko) | 물 흡수 조절된 탈수장치 | |
| FI824214A0 (fi) | Mikro-organismer av slaektet pseudomonas och foerfarande foer nedbrytning av metylgrupphaltiga foereningar i vattenhaltiga loesningar | |
| DK0653950T3 (da) | Materiale til ekstrahering af hydrofobe bestanddele opløst i vand | |
| DK317782A (da) | Referenceelektrode | |
| KR830006324A (ko) | 루틴 데카 또는 노나(수소-황산염)나트륨염의 제조방법 | |
| BR8906983A (pt) | Um processo para secagem de membranas de policarbonato umidas com agua | |
| NL170374C (nl) | Werkwijze voor het afscheiden van water uit mengsels van water en formaldehyd. | |
| KR930702907A (ko) | 감미-유도 물질인 미라쿨린의 제조방법 | |
| KR880003653A (ko) | 아미노산 수용액의 농축방법 | |
| KR900004815A (ko) | 소수성 다공질계 폴리올레핀 분리막의 친수화 처리방법 | |
| GB1179523A (en) | Enzyme Purification Process | |
| KR830003580A (ko) | 발효에 의한 세팔로스포린 제법 | |
| KR840004948A (ko) | 전해조용 다공성 막 | |
| KR960028960A (ko) | 물/유기 용매 분리용 비대칭 중공사막의 제조방법 | |
| KR890002173A (ko) | 소디움 아목시실린의 제조방법 | |
| KR870003720A (ko) | 5'-이노신산 2 칼륨염(imp 2k)의 제조방법 | |
| KR880002999A (ko) | 균사 증식 담체를 이용한 페니실린의 제조방법 |