KR830007662A - 5,6,7,7a-테트라하이드로-4H-티에노 [3,2-c]-피리딘-2-온 유도체의 제조방법 - Google Patents

5,6,7,7a-테트라하이드로-4H-티에노 [3,2-c]-피리딘-2-온 유도체의 제조방법 Download PDF

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Publication number
KR830007662A
KR830007662A KR1019810004596A KR810004596A KR830007662A KR 830007662 A KR830007662 A KR 830007662A KR 1019810004596 A KR1019810004596 A KR 1019810004596A KR 810004596 A KR810004596 A KR 810004596A KR 830007662 A KR830007662 A KR 830007662A
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group
alkyl group
general formula
hydrogen atom
represented
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KR1019810004596A
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KR870000824B1 (ko
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로버트 보이게그레인
진-피에르 마프랜드
노리오 스스키
키우이치 마츠바야시
시니치로 아시다
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진 루이스 델라루에
사노피
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

5,6,7,7a-테트라하이드로-4H-티에노 [3,2-c]-피리딘-2-온 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. a) 다음 일반식(V)으로 표시되는 붕소산 유돛를산화하고,
    b) 다음 일반식(VI)으로 표시되는 얻은 붕산 유도체의 가수분해하여 제조함을 특징으로 하는 다음 일반식(I)으로 표시되는 5,6,7,7a-테트라하이드로-4H-티에노[3,2-c] 피리딘-2-은 유도체와 이의 약학적으로 수용할 수 있는 무기산과 유기산과의 부가염의 제조방법.
    (상기 식들에서 R은 수소원자 또는 페닐기이고, 페닐기는 최소한 하나의 할로겐원자 또는 저급알킬기, 저급알콕시기, 니트로기, 카르복실기, 알콕시카르보닐기, 또는 시아노기로 임의로 치환될 수 있고; R'는 수소원자 또는 저급알킬기이고, n는 0,1,2,3 또는 4이고; R"는 수소원자 또는 저급알킬기이다)
  2. 산화를 반응혼합물의 온도 상승을 방해하지 않는 조건하에 불활성 용매에서 과산화수소로 행함을 특징으로 하는 청구범위 1에 따른 방법.
  3. 가수분해를 반응혼합물과 물을 접촉시켜서 행함을 특징으로 하는 청구범위 1 또는 2에 따른 방법.
  4. 실제적으로 전술한 바와 같이 하고 실시예와 같이 함을 특징으로 하는 일반식(I)으로 표시되는 화합물의 제조방법.
  5. R이 페닐기이고, 페닐기가 할로겐원자, C1-C4알킬기, 니트로기 또는 시아노기로 임의로 치환될 수 있고, R'가 수소원자 또는 C1-C4알킬기이고 n가 1임을 특징으로 하는 청구범위 1에 따른 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810004596A 1980-11-28 1981-11-27 5,6,7,7a-테트라하이드로-4H-티에노 [3,2-c]-피리딘-2-온 유도체의 제조방법 KR870000824B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR80-25274 1980-11-28
FR8025274A FR2495156A1 (fr) 1980-11-28 1980-11-28 Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
KR830007662A true KR830007662A (ko) 1983-11-04
KR870000824B1 KR870000824B1 (ko) 1987-04-23

Family

ID=9248448

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Application Number Title Priority Date Filing Date
KR1019810004596A KR870000824B1 (ko) 1980-11-28 1981-11-27 5,6,7,7a-테트라하이드로-4H-티에노 [3,2-c]-피리딘-2-온 유도체의 제조방법

Country Status (36)

Country Link
US (1) US4515951A (ko)
EP (1) EP0054442B1 (ko)
JP (1) JPS57120590A (ko)
KR (1) KR870000824B1 (ko)
AR (1) AR230285A1 (ko)
AT (1) ATE9160T1 (ko)
AU (1) AU559923B2 (ko)
BG (1) BG36348A3 (ko)
CA (1) CA1182458A (ko)
CS (1) CS224634B2 (ko)
CY (1) CY1281A (ko)
DD (1) DD201903A5 (ko)
DE (1) DE3165788D1 (ko)
DK (1) DK152132C (ko)
ES (1) ES8207180A1 (ko)
FI (1) FI72520C (ko)
FR (1) FR2495156A1 (ko)
GR (1) GR78021B (ko)
HK (1) HK61685A (ko)
HU (1) HU183711B (ko)
IE (1) IE51709B1 (ko)
IL (1) IL64146A (ko)
IN (1) IN155340B (ko)
MA (1) MA19331A1 (ko)
MY (1) MY8600008A (ko)
NO (1) NO155665C (ko)
NZ (1) NZ199021A (ko)
OA (1) OA06951A (ko)
PH (1) PH23776A (ko)
PL (1) PL129598B1 (ko)
PT (1) PT73988B (ko)
RO (1) RO83129B (ko)
SU (1) SU1110385A3 (ko)
YU (1) YU42448B (ko)
ZA (1) ZA817874B (ko)
ZW (1) ZW27481A1 (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2528848A1 (fr) * 1982-06-16 1983-12-23 Sanofi Sa Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
FR2576901B1 (fr) * 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FR2596392B1 (fr) * 1986-03-27 1988-08-05 Sanofi Sa Derives de l'acide a-(hydroxy-3 oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenylacetique, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
EP0284892B1 (de) * 1987-04-03 1990-10-31 Cl Pharma Aktiengesellschaft Neue 2-Thienyloxyessigsäurederivate, ein Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
FR2652579B1 (fr) * 1989-10-02 1992-01-24 Sanofi Sa Derives d'hydroxy-2 thiophene et furanne condenses avec un cycle azote, sur procede de preparation et leur application en therapeutique.
JP2730319B2 (ja) * 1991-04-26 1998-03-25 日本ビクター株式会社 磁気ディスク装置
US5874581A (en) * 1994-10-07 1999-02-23 Ube Industries, Ltd. 2-silyloxy-tetrahydrothienopyridine, salt thereof and process for preparing the same
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
RU2262933C2 (ru) * 2000-12-25 2005-10-27 Санкио Компани, Лимитед Медицинские композиции, содержащие аспирин
US7557101B2 (en) * 2006-12-08 2009-07-07 Hoffman-La Roche Inc. 4,5,6,7-tetrahydro-thieno[3,2-c] pyridine derivatives
WO2009066326A2 (en) * 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN102241690B (zh) * 2010-05-13 2015-08-12 天津药物研究院 一类含腈基的噻吩并吡啶酯类衍生物、其制备方法和用途
CN101948479B (zh) * 2010-09-29 2013-01-30 横店集团家园化工有限公司 普拉格雷中间体及其制备方法
MX337179B (es) 2010-10-18 2016-02-15 Cerenis Therapeutics Holding Sa Compuestos, composiciones y metodos utiles para la movilizacion de colesterol.
CN108069981A (zh) * 2016-11-14 2018-05-25 天津药物研究院有限公司 5-取代-4,5,6,7-四氢噻吩并[3,2-c]吡啶-2(4H)-酮的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215948B1 (ko) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma
FR2345150A2 (fr) * 1975-08-06 1977-10-21 Centre Etd Ind Pharma Nouveaux derives de la thienopyridine, et leur application
FR2495157A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2
FR2508459A1 (fr) * 1981-06-30 1982-12-31 Sanofi Sa Procede de preparation de derives de la tetrahydro-5,6,7,7a 4h thieno (3,2-c) pyridinone-2

Also Published As

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JPH0239517B2 (ko) 1990-09-05
CA1182458A (en) 1985-02-12
DE3165788D1 (en) 1984-10-04
ES507705A0 (es) 1982-09-01
EP0054442A1 (fr) 1982-06-23
IL64146A0 (en) 1982-01-31
PT73988B (fr) 1983-04-14
CS224634B2 (en) 1984-01-16
CY1281A (en) 1985-07-05
FR2495156B1 (ko) 1983-08-05
MY8600008A (en) 1986-12-31
RO83129B (ro) 1984-02-28
NO155665B (no) 1987-01-26
IE51709B1 (en) 1987-02-18
ZA817874B (en) 1982-10-27
NO814055L (no) 1982-06-01
FI813730L (fi) 1982-05-29
DK152132B (da) 1988-02-01
PT73988A (fr) 1981-12-01
RO83129A (ro) 1984-02-21
DK520781A (da) 1982-05-29
YU279081A (en) 1983-06-30
FI72520B (fi) 1987-02-27
ES8207180A1 (es) 1982-09-01
DK152132C (da) 1988-06-20
DD201903A5 (de) 1983-08-17
IN155340B (ko) 1985-01-19
NZ199021A (en) 1984-03-30
PL233979A1 (ko) 1982-08-02
GR78021B (ko) 1984-09-26
SU1110385A3 (ru) 1984-08-23
PL129598B1 (en) 1984-05-31
ATE9160T1 (de) 1984-09-15
ZW27481A1 (en) 1982-02-17
AR230285A1 (es) 1984-03-01
HK61685A (en) 1985-08-23
PH23776A (en) 1989-11-03
BG36348A3 (en) 1984-10-15
AU7742981A (en) 1982-06-03
KR870000824B1 (ko) 1987-04-23
FR2495156A1 (fr) 1982-06-04
OA06951A (fr) 1983-07-31
NO155665C (no) 1987-05-06
HU183711B (en) 1984-05-28
YU42448B (en) 1988-08-31
US4515951A (en) 1985-05-07
MA19331A1 (fr) 1982-07-01
EP0054442B1 (fr) 1984-08-29
IE812683L (en) 1982-05-28
IL64146A (en) 1984-12-31
AU559923B2 (en) 1987-03-26
JPS57120590A (en) 1982-07-27
FI72520C (fi) 1987-06-08

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