KR830006896A - 페닐피리딘의 제조방법과 살초제의 식물독 - Google Patents

페닐피리딘의 제조방법과 살초제의 식물독 Download PDF

Info

Publication number
KR830006896A
KR830006896A KR1019810005105A KR810005105A KR830006896A KR 830006896 A KR830006896 A KR 830006896A KR 1019810005105 A KR1019810005105 A KR 1019810005105A KR 810005105 A KR810005105 A KR 810005105A KR 830006896 A KR830006896 A KR 830006896A
Authority
KR
South Korea
Prior art keywords
halogen
alkyl
formula
hydrogen
phenyl
Prior art date
Application number
KR1019810005105A
Other languages
English (en)
Other versions
KR890001062B1 (ko
Inventor
부르데스카 쿠루트
카바스 구글리엘모
브루너 한스-죠오지
푀리 베르너
Original Assignee
아놀드 사일러
시바-가이기 에이 지
에른스트 알테르
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아놀드 사일러, 시바-가이기 에이 지, 에른스트 알테르 filed Critical 아놀드 사일러
Publication of KR830006896A publication Critical patent/KR830006896A/ko
Application granted granted Critical
Publication of KR890001062B1 publication Critical patent/KR890001062B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catching Or Destruction (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

내용 없음

Description

페닐피리딘의 제조방법과 살초제의 식물독
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 구조식(Ⅱ)의 페닐아미딘을 염기존재하의 알콜 용액에서 하기 구조식(Ⅲ)의 디에틸 말로네이트로 축합한 다음, 필요하다면, 형성된 하기 구조식(Ⅳ)의 2-페닐-4,6-디하이드록시피리미딘의 히드록실기를 할로겐원자(할로겐화제 이용)로 치환한 다음, 필요하다면, 이들 할로겐원자를 다시 자디몰 R1및 R3로 치환하는 것을 특징으로 하여 상기 구조식(Ⅰ)의 페닐피리미딘의 제조방법 :
    상기 식에서
    n은 1-5이고,
    R은 수소, 할로겐, 니트로, 시아노, -XR5, -NR6R7, -CO-A, -CS-NR6R7, -SO2-NR6R7,-PO(OR402, -SO3H, -N=CR8R9, C1-C6알킬, 할로겐, -XR5, -NR6R7, PO(OR4)2, -CO-A 또는 시아노, 또는 C2-C6알케닐로 치환된거나 치환된지 않은 C3-C6알킬 또는 C3-C6시클로알킬기, 할로겐 또는 -XR5로 치환되거나 치환되지 않은 C3-C6시클로알케닐 또는 C2-C6알키닐기이며,
    R1및 R3는 서로 다르며, 수소, 할로겐, C1-C6알킬, 시아노, -CO-A, -NR6R7, -XR5페닐 또는 할로겐, C1-C4알킬, 니트로 또는 -XR5로 치환된 페닐이며,
    R2는 수소, 할로겐, 페닐 또는 할로겐, C1-C4알킬, 트르플루오로메틸, 니트로 또는 -XR5- 로 치환된 페닐, 또는 할로겐 또는 -XR5로 치환되거나 치환되지 않은 C1-C6알킬, C3-C6시클로알킬, C2-C6알케닐 또는 C2-C6알키닐이고,
    R4는 수소 또는 할로겐, -CO-A, 히드록시, C1-C6알콕시 또는 -NR6R7으로 치환되거나 치환되지 않은 C1-C6알킬, C3-C6알케닐 또는 C3-C6알키닐기이며
    R5는 R4에서와 같고, 부가적으로 C1-C3알킬카르보닐, C3-C6알케닐카르보닐 또는 C3-C6알키닐카르보닐이며,
    R6및 R7은 각각 서로 다르며, 수소, C3-C6알케닐, C3-C6알키닐, C3-C6시클로 알킬 : 또는 -CO-A 로 치환되거나 치환되지 않은 C1-C6알킬이며 : R6및 R7중 하나는 -CO-A 또는 -OR4기 이거나, 또는 R4및 R7이 모두 산소, 황, 아미노 또는 C1-C4알킬이미노기로 차단될 수 있는 4- 내지 6- 멤버의 알킬렌 쇄이며,
    B는 직쇄 또는 측쇄의 C1-C6알킬렌이고,
    X는 산소, 황, -SO- 도는 -SO2-이며,
    A는 R5에서와 같거나, -OR5또는 NR6R7이며,
    R8은 C1-C6알콕시로 치환되거나 치환되지 않은 C1-C6알킬이며,
    R9는 수소 또는 R8에서와 같고,
    R8과 R9는 함께 4- 내지 5-멤버의 알킬렌 쇄이다.
  2. 상기 청구범위 1에 따른 구조식 I의 페닐피리미딘 0.1-0.5%, 고체 또는 액체 보조제 1-99%와 계면활성제 0.1-25%로 구성된 것을 특징으로 하는 살초제의 식물독성으로부터 작물을 보호하기 위한 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019810005105A 1980-12-23 1981-12-23 페닐피리딘의 제조방법 및 제초제의 식물독성으로부터 작물을 보호하기 위한 조성물 KR890001062B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CH952280 1980-12-23
CH9522 1980-12-23
CH9522/80-3 1980-12-23
CH2363 1981-04-08
CH2363/81-3 1981-04-08
CH236381 1981-04-08

Publications (2)

Publication Number Publication Date
KR830006896A true KR830006896A (ko) 1983-10-12
KR890001062B1 KR890001062B1 (ko) 1989-04-22

Family

ID=25690262

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810005105A KR890001062B1 (ko) 1980-12-23 1981-12-23 페닐피리딘의 제조방법 및 제초제의 식물독성으로부터 작물을 보호하기 위한 조성물

Country Status (30)

Country Link
US (2) US4493726A (ko)
EP (1) EP0055693B1 (ko)
KR (1) KR890001062B1 (ko)
AT (1) ATE32065T1 (ko)
AU (1) AU558710B2 (ko)
BG (1) BG37221A3 (ko)
BR (1) BR8108383A (ko)
CA (1) CA1220953A (ko)
CS (1) CS243465B2 (ko)
DD (1) DD202798A5 (ko)
DE (1) DE3176621D1 (ko)
DK (1) DK156687C (ko)
DO (1) DOP1981004033A (ko)
ES (1) ES8300322A1 (ko)
GR (1) GR76379B (ko)
HU (1) HU191339B (ko)
IL (1) IL64612A (ko)
IN (1) IN159209B (ko)
MA (1) MA19355A1 (ko)
MX (1) MX6720E (ko)
MY (1) MY101392A (ko)
NZ (1) NZ199360A (ko)
OA (1) OA06972A (ko)
PH (1) PH19369A (ko)
PL (1) PL130575B1 (ko)
PT (1) PT74181B (ko)
RO (1) RO83451B (ko)
SU (1) SU1482505A3 (ko)
YU (1) YU43250B (ko)
ZW (1) ZW30681A1 (ko)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3379544D1 (en) * 1982-06-08 1989-05-11 Ciba Geigy Ag 2-phenyl-2-naphthyl and 2-heterocyclic pyrimidines as antidotes for protecting cultured plants before phytotoxic damages caused by herbicides
US4648896A (en) * 1982-11-15 1987-03-10 Ciba-Geigy Corporation 2-aryl-4,6-dihalopyrimidines as antidote for protecting cultivated plants from phytotoxic damage caused by herbicides
DE3315295A1 (de) * 1983-04-27 1984-10-31 Merck Patent Gmbh, 6100 Darmstadt Fluorhaltige pyrimidinderivate
EP0136976A3 (de) * 1983-08-23 1985-05-15 Ciba-Geigy Ag Verwendung von Phenylpyrimidinen als Pflanzenregulatoren
CH659815A5 (de) * 1984-03-15 1987-02-27 Ciba Geigy Ag 2-(4'-hydroxymethylphenyl)-pyrimidine.
US4900813A (en) * 1987-07-02 1990-02-13 Ciba-Geigy Corporation Fiber-reactive azo dyes having a 4,6-diaminopyridine coupling component
US4927826A (en) * 1987-07-10 1990-05-22 Hoffman-La Roche Inc. Cycloproylpropenamides useful as platelet activing factor (PAF) antagonists
US4963676A (en) * 1988-02-09 1990-10-16 Georgia State University Foundation, Inc. Di-substituted phthalazines
US4929726A (en) * 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
MX16687A (es) * 1988-07-07 1994-01-31 Ciba Geigy Ag Compuestos de biarilo y procedimiento para su preparacion.
US5201933A (en) * 1988-08-01 1993-04-13 Monsanto Company Safening herbicidal benzoic acid derivatives
GB8909560D0 (en) * 1989-04-26 1989-06-14 Smith Kline French Lab Chemical compounds
WO1992004333A1 (en) * 1990-08-31 1992-03-19 Nippon Shinyaku Co., Ltd. Pyrimidine derivative and medicine
US5395816A (en) * 1990-12-12 1995-03-07 Imperial Chemical Industries Plc Antidoting herbicidal 3-ixoxazolidinone compounds
US5527762A (en) * 1990-12-12 1996-06-18 Zeneca Limited Antidoting herbicidal 3-isoxazolidinone compounds
EP0495749A1 (de) * 1991-01-14 1992-07-22 Ciba-Geigy Ag Bipyridyle
BR9200508A (pt) * 1991-02-15 1992-10-20 Kumiai Chemical Industry Co Composicao herbicida na forma de solucao estavel ou concentrado emulsificavel de propanil
US5541148A (en) * 1992-07-08 1996-07-30 Ciba-Geigy Corporation Selective safened herbicidal composition comprising 2-ethoxycarbonyl-3-(4,6-dimethoxypyrimidine-2-yl) oxy-pyridine and an acylsulfamoylphenyl-urea safener
AU683620B2 (en) * 1992-09-28 1997-11-20 Pfizer Inc. Substituted pyrimidines for control of diabetic complications
EP0723960B1 (en) * 1995-01-26 2003-04-02 Basf Aktiengesellschaft Herbicidal 2,6-disubstituted pyridines and 2,4-disubstituted pyrimidines
US5849758A (en) * 1995-05-30 1998-12-15 American Cyanamid Company Herbicidal 2, 6-disubstituted pyridines and 2, 4-disubstituted pyrimidines
CZ290330B6 (cs) * 1995-01-26 2002-07-17 American Cyanamid Company 2,6-Disubstituované pyridinové a 2,4-disubstituované pyrimidinové deriváty, způsob a meziprodukty pro jejich výrobu, jejich pouľití a herbicidní prostředky na jejich bázi a způsob potlačování růstu neľádoucích rostlin
US6008161A (en) * 1995-05-30 1999-12-28 American Cyanamid Company Herbicidal 2-(hetero)aryloxy-6-arylpyridines and 2-aryl-4-(hetero) aryloxypyrimidines
DE19836697A1 (de) * 1998-08-13 2000-02-17 Hoechst Marion Roussel De Gmbh Substituierte 4-Amino-2-aryl-pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
IL146531A0 (en) * 2000-03-16 2002-07-25 Neurogen Corp 5-substituted arylpyrimidines
EP1313369B1 (en) 2000-08-25 2005-06-29 Basf Aktiengesellschaft Herbicidal mixtures
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
CN1926132B (zh) * 2000-09-15 2010-12-29 沃泰克斯药物股份有限公司 可用作蛋白激酶抑制剂的吡唑化合物
SI1318997T1 (sl) * 2000-09-15 2006-12-31 Vertex Pharma Pirazolne spojine, uporabne kot inhibitorji protein-kinaze
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
DE60120193T2 (de) 2000-09-15 2007-03-29 Vertex Pharmaceuticals Inc., Cambridge Pyrazolverbindungen als protein-kinasehemmer
ATE528303T1 (de) * 2000-12-21 2011-10-15 Vertex Pharma Pyrazoleverbindungen als proteinkinasehemmer
SG159380A1 (en) * 2002-02-06 2010-03-30 Vertex Pharma Heteroaryl compounds useful as inhibitors of gsk-3
DE60332604D1 (de) * 2002-03-15 2010-07-01 Vertex Pharma Azolylaminoazine als proteinkinasehemmer
MY141867A (en) * 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
JP4733388B2 (ja) 2002-08-02 2011-07-27 バーテックス ファーマシューティカルズ インコーポレイテッド Ｇｓｋ−３のインヒビターとして有用なピラゾール組成物
ES2295816T3 (es) 2003-01-14 2008-04-16 Arena Pharmaceuticals, Inc. Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia.
WO2004072029A2 (en) * 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
AR045047A1 (es) 2003-07-11 2005-10-12 Arena Pharm Inc Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos
WO2005047268A2 (en) * 2003-11-10 2005-05-26 X-Ceptor Therapeutics, Inc. Substituted pyrimidine compositions and methods of use
AU2004297235A1 (en) * 2003-12-04 2005-06-23 Vertex Pharmaceuticals Incorporated Quinoxalines useful as inhibitors of protein kinases
TWI355894B (en) * 2003-12-19 2012-01-11 Du Pont Herbicidal pyrimidines
UA92150C2 (ru) * 2004-06-04 2010-10-11 Арена Фармасьютикалз, Инк. Замещенные производные арила и гетероарила как модуляторы метаболизма и для профилактики и лечения связанных с ним расстройств
MY148521A (en) * 2005-01-10 2013-04-30 Arena Pharm Inc Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto
DOP2006000010A (es) 2005-01-10 2006-07-31 Arena Pharm Inc Procedimiento para preparar eteres aromáticos
US7737151B2 (en) * 2005-08-18 2010-06-15 Vertex Pharmaceuticals Incorporated Pyrazine kinase inhibitors
CA2619093A1 (en) * 2005-09-16 2007-03-29 Arena Pharmaceuticals, Inc. Modulators of metabolism and the treatment of disorders related thereto
CA2627830A1 (en) * 2005-11-03 2007-05-18 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
AU2007229552C1 (en) * 2006-03-29 2013-06-13 F. Hoffmann-La Roche Ag Pyridine and pyrimidine derivatives as mGluR2 antagonists
TW200811147A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
TW200811140A (en) * 2006-07-06 2008-03-01 Arena Pharm Inc Modulators of metabolism and the treatment of disorders related thereto
JP2010509231A (ja) * 2006-11-02 2010-03-25 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼの阻害剤として有用なアミノピリジンおよびアミノピリミジン
AU2007333650A1 (en) * 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
ES2435997T3 (es) * 2007-03-09 2013-12-26 Vertex Pharmaceuticals, Inc. Aminopirimidinas útiles como inhibidores de las proteínas cinasas
AU2008226461A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
EP2137183B1 (en) * 2007-03-09 2011-09-28 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
JP2010523700A (ja) 2007-04-13 2010-07-15 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼインヒビターとして有用なアミノピリミジン
EP2155730A2 (en) * 2007-05-02 2010-02-24 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as kinase inhibitors
CA2685876A1 (en) * 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
CN101801959A (zh) * 2007-05-02 2010-08-11 沃泰克斯药物股份有限公司 可用作激酶抑制剂的氨基嘧啶类化合物
WO2008147626A2 (en) * 2007-05-24 2008-12-04 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
CN101790532B (zh) * 2007-07-31 2013-11-20 沃泰克斯药物股份有限公司 5-氟-1H-吡唑并[3，4-b]吡啶-3-胺及其衍生物的制备方法
MX2011002312A (es) * 2008-09-03 2011-04-26 Vertex Pharma Co-cristales y formulaciones farmaceuticas que comprenden los mismos.
CN103221391B (zh) 2010-01-27 2018-07-06 艾尼纳制药公司 (R)-2-(7-(4-环戊基-3-(三氟甲基)苄基氧基)-1,2,3,4-四氢环戊二烯并[b]吲哚-3-基)乙酸及其盐的制备方法
AU2011223888B2 (en) * 2010-03-04 2015-07-02 Merck Sharp & Dohme Llc Inhibitors of catechol O-methyl transferase and their use in the treatment of psychotic disorders
CN103539791B (zh) 2010-09-22 2017-01-11 艾尼纳制药公司 Gpr119 受体调节剂和对与其相关的障碍的治疗
US10533000B2 (en) 2011-05-26 2020-01-14 Sunovion Pharmaceuticals, Inc. Metabotrophic glutamate receptor 5 modulators and methods of use thereof
CN107405332A (zh) 2015-01-06 2017-11-28 艾尼纳制药公司 治疗与s1p1受体有关的病症的方法
US10301262B2 (en) 2015-06-22 2019-05-28 Arena Pharmaceuticals, Inc. Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders
US11178871B2 (en) * 2016-07-26 2021-11-23 Basf Se Herbicidal pyrimidine compounds
EP3582772A1 (en) 2017-02-16 2019-12-25 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
US11467605B2 (en) 2019-04-10 2022-10-11 Deere & Company Zonal machine control
US11653588B2 (en) 2018-10-26 2023-05-23 Deere & Company Yield map generation and control system
US11957072B2 (en) 2020-02-06 2024-04-16 Deere & Company Pre-emergence weed detection and mitigation system
US11178818B2 (en) 2018-10-26 2021-11-23 Deere & Company Harvesting machine control system with fill level processing based on yield data
US11079725B2 (en) 2019-04-10 2021-08-03 Deere & Company Machine control using real-time model
US11589509B2 (en) 2018-10-26 2023-02-28 Deere & Company Predictive machine characteristic map generation and control system
US11641800B2 (en) 2020-02-06 2023-05-09 Deere & Company Agricultural harvesting machine with pre-emergence weed detection and mitigation system
US11672203B2 (en) 2018-10-26 2023-06-13 Deere & Company Predictive map generation and control
US11240961B2 (en) 2018-10-26 2022-02-08 Deere & Company Controlling a harvesting machine based on a geo-spatial representation indicating where the harvesting machine is likely to reach capacity
US11234366B2 (en) 2019-04-10 2022-02-01 Deere & Company Image selection for machine control
US11778945B2 (en) 2019-04-10 2023-10-10 Deere & Company Machine control using real-time model
CN109897005B (zh) * 2019-04-12 2022-07-22 湖南省农业生物技术研究所 含取代苯氧基的苯基嘧啶类似物及其制备方法和应用
US11477940B2 (en) 2020-03-26 2022-10-25 Deere & Company Mobile work machine control based on zone parameter modification
US11983009B2 (en) 2020-10-09 2024-05-14 Deere & Company Map generation and control system
US11675354B2 (en) 2020-10-09 2023-06-13 Deere & Company Machine control using a predictive map
US11711995B2 (en) 2020-10-09 2023-08-01 Deere & Company Machine control using a predictive map
US11889788B2 (en) 2020-10-09 2024-02-06 Deere & Company Predictive biomass map generation and control
US11871697B2 (en) 2020-10-09 2024-01-16 Deere & Company Crop moisture map generation and control system
US11845449B2 (en) 2020-10-09 2023-12-19 Deere & Company Map generation and control system
US11592822B2 (en) 2020-10-09 2023-02-28 Deere & Company Machine control using a predictive map
US11474523B2 (en) 2020-10-09 2022-10-18 Deere & Company Machine control using a predictive speed map
US11727680B2 (en) 2020-10-09 2023-08-15 Deere & Company Predictive map generation based on seeding characteristics and control
US11849671B2 (en) 2020-10-09 2023-12-26 Deere & Company Crop state map generation and control system
US11849672B2 (en) 2020-10-09 2023-12-26 Deere & Company Machine control using a predictive map
US11844311B2 (en) 2020-10-09 2023-12-19 Deere & Company Machine control using a predictive map
US11635765B2 (en) 2020-10-09 2023-04-25 Deere & Company Crop state map generation and control system
US11946747B2 (en) 2020-10-09 2024-04-02 Deere & Company Crop constituent map generation and control system
US11874669B2 (en) 2020-10-09 2024-01-16 Deere & Company Map generation and control system
US11650587B2 (en) 2020-10-09 2023-05-16 Deere & Company Predictive power map generation and control system
US11895948B2 (en) 2020-10-09 2024-02-13 Deere & Company Predictive map generation and control based on soil properties
US11825768B2 (en) 2020-10-09 2023-11-28 Deere & Company Machine control using a predictive map
US11927459B2 (en) 2020-10-09 2024-03-12 Deere & Company Machine control using a predictive map
US11889787B2 (en) 2020-10-09 2024-02-06 Deere & Company Predictive speed map generation and control system

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR672216A (fr) * 1928-04-03 1929-12-24 Ig Farbenindustrie Ag Procédé pour la préparation de 2-aryl-4.6-dioxypyrimidines
DE520854C (de) * 1928-04-04 1931-03-20 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von 2-Aryl-4,6-dioxypyrimidinen
CH448083A (de) * 1963-05-04 1967-12-15 Ciba Geigy Verwendung von neuen Hydroxyaryl-pyrimidinen bei Verfahren zum Schützen von nicht-textilen organischen Materialien
FR1469787A (fr) * 1965-02-24 1967-02-17 Basf Ag Procédé de préparation d'acides carboxyliques aromatiques renfermant des atomes de chlore réactifs
DE1265752B (de) * 1965-02-24 1968-04-11 Basf Ag Verfahren zur Herstellung von aromatischen Carbonsaeuren
DE1670069A1 (de) * 1966-04-20 1970-01-02 Basf Ag Verfahren zur Herstellung von in 5-Stellung durch Halogen substituierten Pyrimidinen
DE1670070A1 (de) * 1966-04-20 1970-01-02 Basf Ag Verfahren zur Herstellung von 4,5-Dihalogenpyrimidinen
US3503976A (en) * 1966-04-20 1970-03-31 Basf Ag Production of pyrimidines bearing halogen as substituent in the 5-position
DE1670072A1 (de) * 1966-04-20 1970-01-02 Basf Ag Verfahren zur Herstellung von 5-Halogen-4-hydroxypyrimidinen
US3498984A (en) * 1966-10-28 1970-03-03 American Home Prod 4-amino-2-phenyl-6-thiopyrimidines
US3564768A (en) * 1968-10-25 1971-02-23 Gulf Research Development Co Coated corn seed
US3940395A (en) * 1969-08-29 1976-02-24 American Home Products Corporation 4-Amino-2-phenyl-6-thiopryimidines
US3719466A (en) * 1970-04-16 1973-03-06 Gulf Research Development Co Protection of wheat and grain sorghum from herbicidal injury
US4033756A (en) * 1971-09-17 1977-07-05 Gulf Research & Development Company Dichloroacetamide treated rice seeds
DE2202820B2 (de) * 1972-01-21 1976-07-01 Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen Pyrimidin-dispersionsazofarbstoffe, verfahren zu ihrer herstellung und ihre verwendung
DE2219841A1 (de) * 1972-04-22 1973-10-25 Basf Ag Verfahren zur herstellung von 2-(oalkylthiophenyl)-1,3-diazacycloalkenhydrohalogeniden
IN142539B (ko) * 1974-05-10 1977-07-23 Ciba Geigy India Ltd
US4297234A (en) * 1979-05-17 1981-10-27 Ciba-Geigy Corporation Benzoxazolyl-stilbenes

Also Published As

Publication number Publication date
NZ199360A (en) 1986-04-11
US4493726A (en) 1985-01-15
CA1220953A (en) 1987-04-28
CS243465B2 (en) 1986-06-12
US4674229A (en) 1987-06-23
OA06972A (fr) 1983-07-31
AU7884081A (en) 1982-07-01
MY101392A (en) 1991-10-23
CS967281A2 (en) 1985-08-15
AU558710B2 (en) 1987-02-05
PL130575B1 (en) 1984-08-31
DD202798A5 (de) 1983-10-05
DK156687C (da) 1990-03-12
DK571281A (da) 1982-06-24
PH19369A (en) 1986-04-02
DE3176621D1 (en) 1988-02-25
MX6720E (es) 1985-11-07
PT74181A (pt) 1982-01-02
RO83451A (ro) 1984-02-21
HU191339B (en) 1987-02-27
IL64612A0 (en) 1982-03-31
ES508254A0 (es) 1982-11-01
ATE32065T1 (de) 1988-02-15
YU305881A (en) 1984-04-30
BR8108383A (pt) 1982-10-13
IL64612A (en) 1988-09-30
ZW30681A1 (en) 1982-07-14
DK156687B (da) 1989-09-25
ES8300322A1 (es) 1982-11-01
EP0055693A1 (de) 1982-07-07
EP0055693B1 (de) 1988-01-20
DOP1981004033A (es) 1990-12-29
KR890001062B1 (ko) 1989-04-22
SU1482505A3 (ru) 1989-05-23
BG37221A3 (en) 1985-04-15
RO83451B (ro) 1984-02-28
GR76379B (ko) 1984-08-06
MA19355A1 (fr) 1982-07-01
IN159209B (ko) 1987-04-11
YU43250B (en) 1989-06-30
PT74181B (pt) 1985-01-04
PL234418A1 (ko) 1982-08-02

Similar Documents

Publication Publication Date Title
KR830006896A (ko) 페닐피리딘의 제조방법과 살초제의 식물독
SU582740A3 (ru) Гербицидна композици
DE59010806D1 (de) Pyrazoline zum schutz von kulturpflanzen gegenüber herbiziden
MY108103A (en) Aqueous agricultural compositions exhibiting reduced irritation and corrosion.
DE69125957T2 (de) N,n-disubstituierte amidsäuren, ihre ammoniumsalze sowie verwendung als emulgator
KR880011184A (ko) 페녹시카르복실산 및 이것을 유효성분으로 함유하는 제초제
KR830003204A (ko) 계면 활성제
ES2145287T3 (es) Composicion de los pesticidas que contienen aminas etoxiladas grasas para aumentar la efectividad del endothall y de sus sales.
DK546188D0 (da) 1,5-diphenyl-1,2,4-triazol-3-carboxylsyrederivater til beskyttelse af kulturplanter mod herbiciders fytotoksiske virkning
TNSN86160A1 (fr) Compositions nematicides et insecticides a base de composes heterocycle
JPS5446749A (en) Cyclohexane derivative, its preparation, and herbicides
GB1466278A (en) Thiolcarbamates
JPS57209203A (en) Herbicide composition
JPS54145613A (en) Preparation of novel cationic surfactant
JPS55160708A (en) Herbicide

Legal Events

Date Code Title Description
A201 Request for examination
N231 Notification of change of applicant
E902 Notification of reason for refusal
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20010316

Year of fee payment: 13

EXPY Expiration of term