KR830006304A - 디옥사이드 화합물의 제조방법 - Google Patents
디옥사이드 화합물의 제조방법 Download PDFInfo
- Publication number
- KR830006304A KR830006304A KR1019810001790A KR810001790A KR830006304A KR 830006304 A KR830006304 A KR 830006304A KR 1019810001790 A KR1019810001790 A KR 1019810001790A KR 810001790 A KR810001790 A KR 810001790A KR 830006304 A KR830006304 A KR 830006304A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- compound
- salt
- formula
- resulting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims 8
- 150000003839 salts Chemical class 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Pregnancy & Childbirth (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- a) 다음 구조식(Ⅱa)의 화합물의(-위치를 산화시키거나여기서 R1및 R2는 하기 구조식(Ⅰ)에서와 같은며n은 0 또는 1이고b) 다음 구조식(Ⅱb)의 화합물에 R1-CH2그룹을 주입시키거나여기서 R2는 보호된 카복심그룹이고,c) 다음 구조식(Ⅱc)의 화합물의 Y그룹을 수소로 전환시키고여기서 R1및 R2는 하기 구조식(Ⅰ)에서와 같고 Y는 수소로 전환시킬 수 있는 그룹이며필요한 경우, 생성화합물의 R1그룹을 다른 R1그룹으로 전환시키고/또는 R2그룹을 다른 R2그룹으로 전화시키고/또는 생성된 염을 유리화합물이나 다른 염으로 전환시키고/또는 생성된 염 형성그룹을 가지는 유리화합물을 염으로 전환시키고/또는 생성된 이성체혼합물을 각 이성체혼 분리시켜 다음 구조식(Ⅰ)2,2-디메틸펜암-3-카복실산 1,1-디옥사이드화합물 및 염 형성그룹을 가지는 이들의 염을 제조하는 방법.상기 구조식에서R1은 하이드록시 또는 에테르화 또는 에스테르화 하이드록시이며R2는 카복실 또는 보호된 카복실을 나타낸다.※참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH4017/80-9 | 1980-05-22 | ||
CH401780 | 1980-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR830006304A true KR830006304A (ko) | 1983-09-20 |
Family
ID=4268255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810001790A KR830006304A (ko) | 1980-05-22 | 1981-05-22 | 디옥사이드 화합물의 제조방법 |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0041047A3 (ko) |
JP (1) | JPS5718685A (ko) |
KR (1) | KR830006304A (ko) |
AU (1) | AU7091181A (ko) |
DD (1) | DD159074A5 (ko) |
DK (1) | DK224281A (ko) |
FI (1) | FI811532L (ko) |
GB (1) | GB2076812A (ko) |
GR (1) | GR75639B (ko) |
IL (1) | IL62912A0 (ko) |
NO (1) | NO811740L (ko) |
PT (1) | PT73067B (ko) |
ZA (1) | ZA8103408D (ko) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
GR77151B (ko) * | 1982-01-11 | 1984-09-07 | Prizer | |
US4503040A (en) * | 1984-02-27 | 1985-03-05 | Pfizer Inc. | 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
EP0170192B1 (en) * | 1984-07-30 | 1992-05-13 | Merck & Co. Inc. | Penicillin derivatives as anti-inflammatory and antidegenerative agents |
US4591459A (en) * | 1984-12-03 | 1986-05-27 | Pfizer Inc. | Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides |
GB2206579B (en) * | 1987-07-10 | 1991-05-29 | Erba Farmitalia | 6a and 6b-(substituted methyl)-penicillanic acid derivatives |
EP0966471B1 (en) | 1997-12-29 | 2002-06-12 | Research Corporation Technologies, Inc | 2-beta-substituted-6-alkylidene penicillanic acid derivatives as beta-lactamase inhibitors |
EP1144418A1 (en) * | 1999-01-26 | 2001-10-17 | American Cyanamid Company | 3,6-disubstituted penam sulfone derivatives as antibacterials |
US6395726B1 (en) | 1999-01-26 | 2002-05-28 | American Cyanamid Company | 3,6-disubstituted penam sulfone derivatives |
US6407091B1 (en) | 1999-04-15 | 2002-06-18 | Research Corporation Technologies, Inc. | β-lactamase inhibiting compounds |
AU2002353768A1 (en) | 2001-07-24 | 2003-03-18 | Alamx, L.L.C. | 7-alkylidene-3-substituted-3-cephem-4-carboxylates as beta-lactamase inhibitors. |
JP2005525399A (ja) * | 2002-04-04 | 2005-08-25 | アラムクス エルエルシー | セリンおよびメタロ−β−ラクタマーゼの阻害剤 |
PA8579701A1 (es) * | 2002-08-23 | 2005-05-24 | Pfizer Prod Inc | Profarmaco inhibidor de beta-lactamasa |
EP1636240A1 (en) * | 2003-06-05 | 2006-03-22 | Pfizer Products Inc. | Beta-lactamase inhibitor prodrug |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1102308A (en) * | 1975-09-26 | 1981-06-02 | John C. Sheehan | Carbon and oxygen analogs of cephalosporins |
US4207323A (en) * | 1975-11-21 | 1980-06-10 | Merck & Co., Inc. | 6-Substituted methyl penicillins, derivatives and analogues thereof |
US4272439A (en) * | 1978-06-02 | 1981-06-09 | Schering Corporation | 6-(Substituted-hydroxymethylene penams) |
DE2927004A1 (de) * | 1979-07-04 | 1981-05-27 | Bayer Ag, 5090 Leverkusen | Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel |
US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
-
1981
- 1981-05-15 GB GB8114997A patent/GB2076812A/en not_active Withdrawn
- 1981-05-18 FI FI811532A patent/FI811532L/fi not_active Application Discontinuation
- 1981-05-18 EP EP81810188A patent/EP0041047A3/de not_active Withdrawn
- 1981-05-20 IL IL62912A patent/IL62912A0/xx unknown
- 1981-05-20 GR GR65008A patent/GR75639B/el unknown
- 1981-05-21 NO NO811740A patent/NO811740L/no unknown
- 1981-05-21 DD DD81230153A patent/DD159074A5/de unknown
- 1981-05-21 PT PT73067A patent/PT73067B/pt unknown
- 1981-05-21 AU AU70911/81A patent/AU7091181A/en not_active Abandoned
- 1981-05-21 ZA ZA19813408D patent/ZA8103408D/xx unknown
- 1981-05-21 DK DK224281A patent/DK224281A/da not_active Application Discontinuation
- 1981-05-22 KR KR1019810001790A patent/KR830006304A/ko unknown
- 1981-05-22 JP JP7681581A patent/JPS5718685A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NO811740L (no) | 1981-11-23 |
JPS5718685A (en) | 1982-01-30 |
ZA8103408D (en) | 1982-06-30 |
DD159074A5 (de) | 1983-02-16 |
EP0041047A3 (de) | 1982-04-07 |
GR75639B (ko) | 1984-03-02 |
AU7091181A (en) | 1981-11-26 |
DK224281A (da) | 1981-11-23 |
GB2076812A (en) | 1981-12-09 |
IL62912A0 (en) | 1981-07-31 |
EP0041047A2 (de) | 1981-12-02 |
PT73067A (en) | 1981-06-01 |
PT73067B (en) | 1983-02-08 |
FI811532L (fi) | 1981-11-23 |
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