KR20220084147A - 가상 기준 - Google Patents

가상 기준 Download PDF

Info

Publication number
KR20220084147A
KR20220084147A KR1020227016636A KR20227016636A KR20220084147A KR 20220084147 A KR20220084147 A KR 20220084147A KR 1020227016636 A KR1020227016636 A KR 1020227016636A KR 20227016636 A KR20227016636 A KR 20227016636A KR 20220084147 A KR20220084147 A KR 20220084147A
Authority
KR
South Korea
Prior art keywords
detector
lens
fluorescent label
fluid channel
image
Prior art date
Application number
KR1020227016636A
Other languages
English (en)
Korean (ko)
Inventor
디핑 처
제임스 처
Original Assignee
세큘라이트 제노믹스 유에스, 아이앤씨.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/658,052 external-priority patent/US10895727B1/en
Application filed by 세큘라이트 제노믹스 유에스, 아이앤씨. filed Critical 세큘라이트 제노믹스 유에스, 아이앤씨.
Publication of KR20220084147A publication Critical patent/KR20220084147A/ko

Links

Images

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/24—Base structure
    • G02B21/241—Devices for focusing
    • G02B21/245—Devices for focusing using auxiliary sources, detectors
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/006—Optical details of the image generation focusing arrangements; selection of the plane to be imaged
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/32—Fiducial marks and measuring scales within the optical system
    • G02B27/34—Fiducial marks and measuring scales within the optical system illuminated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
KR1020227016636A 2019-10-19 2020-10-19 가상 기준 KR20220084147A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16/658,052 2019-10-19
US16/658,052 US10895727B1 (en) 2019-10-19 2019-10-19 Microscope for locating structures on the inner surface of a fluidic channel
US202016824632A 2020-03-19 2020-03-19
US16/824,632 2020-03-19
PCT/US2020/056302 WO2021077075A1 (en) 2019-10-19 2020-10-19 Virtual fiducials

Publications (1)

Publication Number Publication Date
KR20220084147A true KR20220084147A (ko) 2022-06-21

Family

ID=75538690

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227016636A KR20220084147A (ko) 2019-10-19 2020-10-19 가상 기준

Country Status (7)

Country Link
EP (1) EP4031922A4 (zh)
JP (1) JP2022552743A (zh)
KR (1) KR20220084147A (zh)
CN (1) CN114585958B (zh)
AU (1) AU2020366521B2 (zh)
CA (1) CA3158318A1 (zh)
WO (1) WO2021077075A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114280806A (zh) * 2022-02-10 2022-04-05 中国人民解放军陆军装甲兵学院 一种基于相息图的光线准直方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3265668B2 (ja) * 1993-01-13 2002-03-11 株式会社ニコン ベストフォーカス位置の算出方法
JP3619571B2 (ja) * 1995-06-06 2005-02-09 オリンパス株式会社 光学顕微鏡における焦点検出装置及びその設計方法
JPH09133856A (ja) * 1995-11-07 1997-05-20 Nikon Corp 顕微鏡用自動焦点検出装置
US6025905A (en) * 1996-12-31 2000-02-15 Cognex Corporation System for obtaining a uniform illumination reflectance image during periodic structured illumination
US6181474B1 (en) * 1999-03-22 2001-01-30 Kovex Corporation Scanning confocal microscope with objective lens position tracking
US6974938B1 (en) * 2000-03-08 2005-12-13 Tibotec Bvba Microscope having a stable autofocusing apparatus
JP2002277736A (ja) * 2001-03-21 2002-09-25 Olympus Optical Co Ltd 撮像装置
JP3867143B2 (ja) * 2003-06-25 2007-01-10 独立行政法人産業技術総合研究所 三次元顕微鏡システムおよび画像表示方法
JP2005134834A (ja) * 2003-10-31 2005-05-26 Olympus Corp 撮像装置および電子的撮像機器
US7057826B2 (en) * 2004-03-22 2006-06-06 Angstrom Inc. Small and fast zoom system
US7295303B1 (en) * 2004-03-25 2007-11-13 Kla-Tencor Technologies Corporation Methods and apparatus for inspecting a sample
JP2006047922A (ja) * 2004-08-09 2006-02-16 Nikon Corp 結像装置
JP2006084794A (ja) * 2004-09-16 2006-03-30 Olympus Corp 焦点位置制御機構付き観察装置
US7518726B2 (en) * 2005-04-12 2009-04-14 Caliper Lifesciences, Inc. Compact optical detection system for a microfluidic device
JP5058483B2 (ja) * 2005-09-14 2012-10-24 オリンパス株式会社 生体試料の長期間ないし連続的検出方法
JP2009116271A (ja) * 2007-11-09 2009-05-28 Nikon Corp 焦点調節装置及び顕微鏡装置
US7723657B2 (en) * 2007-11-16 2010-05-25 Mitutoyo Corporation Focus detection apparatus having extended detection range
US9213176B2 (en) * 2008-12-02 2015-12-15 The Regents Of The University Of California Imaging arrangement and microscope
ES2617664T3 (es) * 2009-03-11 2017-06-19 Sakura Finetek U.S.A., Inc. Procedimiento de enfoque automático y dispositivo de enfoque automático
TWI456254B (zh) * 2010-05-19 2014-10-11 Ind Tech Res Inst 螢光顯微影像系統
EP2749941B1 (en) * 2011-08-24 2018-10-10 Olympus Corporation Image capture device and image capture device system
DE102011082756A1 (de) * 2011-09-15 2013-03-21 Leica Microsystems (Schweiz) Ag Autofokussierverfahren und -einrichtung für ein Mikroskop
DE102012009836A1 (de) * 2012-05-16 2013-11-21 Carl Zeiss Microscopy Gmbh Lichtmikroskop und Verfahren zur Bildaufnahme mit einem Lichtmikroskop
CA2878957A1 (en) * 2012-07-25 2014-01-30 Theranos, Inc. Image analysis and measurement of biological samples
CA2905999A1 (en) * 2013-03-15 2014-09-25 The Regents Of The University Of California High-throughput cargo delivery into live cells using photothermal platforms
JP6286183B2 (ja) * 2013-11-07 2018-02-28 株式会社日立ハイテクノロジーズ 分析装置
JP6197880B2 (ja) * 2013-12-12 2017-09-20 株式会社ニコン 構造化照明顕微鏡、構造化照明方法、及びプログラム
US9897791B2 (en) * 2014-10-16 2018-02-20 Illumina, Inc. Optical scanning systems for in situ genetic analysis
US10429628B2 (en) * 2015-04-23 2019-10-01 The University Of British Columbia Multifocal method and apparatus for stabilization of optical systems
DE102015209402A1 (de) * 2015-05-22 2016-11-24 Sirona Dental Systems Gmbh Vorrichtung zur optischen 3D-Vermessung eines Objekts
US10558029B2 (en) * 2016-10-27 2020-02-11 Scopio Labs Ltd. System for image reconstruction using a known pattern
WO2018140661A1 (en) * 2017-01-26 2018-08-02 Azure Biosystems, Inc. Devices and methods for imaging biomolecules
JP2019078866A (ja) * 2017-10-24 2019-05-23 オリンパス株式会社 顕微鏡システム、観察方法、及び観察プログラム
US10895727B1 (en) * 2019-10-19 2021-01-19 SequLITE Genomics US, Inc. Microscope for locating structures on the inner surface of a fluidic channel

Also Published As

Publication number Publication date
JP2022552743A (ja) 2022-12-19
CN114585958B (zh) 2024-05-28
EP4031922A4 (en) 2022-12-07
EP4031922A1 (en) 2022-07-27
AU2020366521B2 (en) 2024-03-07
CN114585958A (zh) 2022-06-03
CA3158318A1 (en) 2021-04-20
AU2020366521A1 (en) 2022-05-19
WO2021077075A1 (en) 2021-04-22

Similar Documents

Publication Publication Date Title
US10078206B2 (en) High-resolution microscope and image splitter arrangment
US6130745A (en) Optical autofocus for use with microtiter plates
US7170597B1 (en) Microplate reader
DK2594981T3 (en) Methods and apparatus for confocal imaging
EP1912740B1 (en) Optical assay system
JP7055098B2 (ja) フォトルミネセンス撮像のための徹照ベースの自動フォーカシングを備えた顕微鏡システム
JP7134251B2 (ja) 少なくとも１つの細胞および／または少なくとも１つの粒子を含有する液体を分配するためのディスペンサーを含む分配装置
WO2005069841A2 (en) Optical analysis systems
US20210010920A1 (en) Spectroscopic analysis device, spectroscopic analysis method, program, recording medium, and microscope
WO2005069842A2 (en) Optical analysis systems
CN108780216B (zh) 利用散射以降低源自发荧光并改善均匀性的成像***和方法
WO2011096835A1 (ru) Устройство для анализа люминесцирующих биологических микрочипов
KR20220084147A (ko) 가상 기준
CN112684600B (zh) 用于定位在流体通道的内表面上的结构的显微镜
CN111788473A (zh) 用于检测结合亲和力的装置
WO2005069843A2 (en) Optical analysis systems
CN102818796B (zh) 生物荧光显微检测仪器
JP7248833B2 (ja) フォトルミネセンス撮像のための徹照ベースの自動フォーカシングを備えた顕微鏡システム
Nie et al. Optical aspects of a miniature fluorescence microscope for super-sensitive biomedical detection
RU2679605C2 (ru) Флуориметрический анализатор биологических микрочипов
KR20230048931A (ko) 1차원 광센서를 이용한 2차원 형광 데이터 측정 장치

Legal Events

Date Code Title Description
A201 Request for examination