KR20210069080A - 모노아실글리세롤 리파아제 조절제 - Google Patents
모노아실글리세롤 리파아제 조절제 Download PDFInfo
- Publication number
- KR20210069080A KR20210069080A KR1020217012874A KR20217012874A KR20210069080A KR 20210069080 A KR20210069080 A KR 20210069080A KR 1020217012874 A KR1020217012874 A KR 1020217012874A KR 20217012874 A KR20217012874 A KR 20217012874A KR 20210069080 A KR20210069080 A KR 20210069080A
- Authority
- KR
- South Korea
- Prior art keywords
- pyrazolo
- pyridin
- methanone
- dimethyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862738600P | 2018-09-28 | 2018-09-28 | |
| US62/738,600 | 2018-09-28 | ||
| PCT/IB2019/058240 WO2020065613A1 (en) | 2018-09-28 | 2019-09-27 | Monoacylglycerol lipase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20210069080A true KR20210069080A (ko) | 2021-06-10 |
Family
ID=68109428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217012874A KR20210069080A (ko) | 2018-09-28 | 2019-09-27 | 모노아실글리세롤 리파아제 조절제 |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US20200102303A1 (es) |
| EP (1) | EP3856178A1 (es) |
| JP (1) | JP2022502424A (es) |
| KR (1) | KR20210069080A (es) |
| CN (1) | CN113164459A (es) |
| AU (1) | AU2019350624A1 (es) |
| BR (1) | BR112021005896A2 (es) |
| CA (1) | CA3111380A1 (es) |
| CL (1) | CL2021000757A1 (es) |
| CO (1) | CO2021003944A2 (es) |
| CR (1) | CR20210153A (es) |
| EA (1) | EA202190886A1 (es) |
| EC (1) | ECSP21021381A (es) |
| IL (1) | IL281812A (es) |
| JO (1) | JOP20210058A1 (es) |
| MA (1) | MA53721A (es) |
| MX (1) | MX2021003737A (es) |
| NI (1) | NI202100023A (es) |
| PE (1) | PE20211773A1 (es) |
| PH (1) | PH12021550659A1 (es) |
| SG (1) | SG11202102281VA (es) |
| TW (1) | TW202028198A (es) |
| WO (1) | WO2020065613A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3773B1 (ar) | 2013-03-14 | 2021-01-31 | Janssen Pharmaceutica Nv | معدلات p2x7 |
| EP3856178A1 (en) | 2018-09-28 | 2021-08-04 | Janssen Pharmaceutica NV | Monoacylglycerol lipase modulators |
| US20200102311A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Monoacylglycerol Lipase Modulators |
| EP4038070A1 (en) * | 2019-09-30 | 2022-08-10 | Janssen Pharmaceutica NV | Radiolabelled mgl pet ligands |
| KR20220157999A (ko) | 2020-03-26 | 2022-11-29 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 조절제 |
| WO2022150962A1 (en) | 2021-01-12 | 2022-07-21 | Westlake Pharmaceutical (Hangzhou) Co., Ltd. | Protease inhibitors, preparation, and uses thereof |
| WO2023110958A1 (en) | 2021-12-16 | 2023-06-22 | F. Hoffmann-La Roche Ag | Bicyclic heterocyclic compounds useful as monoacylglycerol lipase inhibitors |
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| US4812462A (en) | 1986-04-01 | 1989-03-14 | Warner-Lambert Company | 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity |
| US4816463A (en) | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
| JP3208139B2 (ja) | 1990-10-02 | 2001-09-10 | ワーナー−ランバート・コンパニー | アンギオテンシン▲ｉｉ▼アンタゴニスト |
| BR0312913A (pt) | 2002-07-25 | 2005-07-12 | Pharmacia Italia Spa | Ativo de biciclo-pirazóis como inibidores de cinase, processo para sua preparação e composições farmacêuticas compreendendo o mesmo |
| US20060100233A1 (en) | 2002-07-25 | 2006-05-11 | Manuela Villa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| AR045037A1 (es) | 2003-07-10 | 2005-10-12 | Aventis Pharma Sa | Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion. |
| FR2857363B1 (fr) | 2003-07-10 | 2007-09-07 | Aventis Pharma Sa | 4,5,6,7-tetrahydro-1h-pyrazolo[3,4-c] pyridines substituees compositions les contenant et utilisation |
| AU2005277283A1 (en) | 2004-08-23 | 2006-03-02 | Merck Sharp & Dohme Corp. | Fused triazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes |
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| JP6592510B2 (ja) | 2014-09-12 | 2019-10-16 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｐ２ｘ７調節因子 |
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| US20200102311A1 (en) | 2018-09-28 | 2020-04-02 | Janssen Pharmaceutica Nv | Monoacylglycerol Lipase Modulators |
| EP3856178A1 (en) | 2018-09-28 | 2021-08-04 | Janssen Pharmaceutica NV | Monoacylglycerol lipase modulators |
| CN112272670B (zh) | 2019-04-16 | 2023-12-12 | 上海翰森生物医药科技有限公司 | 含二并环类衍生物抑制剂、其制备方法和应用 |
| EP4038070A1 (en) | 2019-09-30 | 2022-08-10 | Janssen Pharmaceutica NV | Radiolabelled mgl pet ligands |
| KR20220157999A (ko) | 2020-03-26 | 2022-11-29 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 조절제 |
-
2019
- 2019-09-27 EP EP19780427.1A patent/EP3856178A1/en active Pending
- 2019-09-27 MX MX2021003737A patent/MX2021003737A/es unknown
- 2019-09-27 JO JOP/2021/0058A patent/JOP20210058A1/ar unknown
- 2019-09-27 JP JP2021517202A patent/JP2022502424A/ja active Pending
- 2019-09-27 EA EA202190886A patent/EA202190886A1/ru unknown
- 2019-09-27 CA CA3111380A patent/CA3111380A1/en active Pending
- 2019-09-27 SG SG11202102281VA patent/SG11202102281VA/en unknown
- 2019-09-27 TW TW108135035A patent/TW202028198A/zh unknown
- 2019-09-27 US US16/586,088 patent/US20200102303A1/en not_active Abandoned
- 2019-09-27 CN CN201980078969.1A patent/CN113164459A/zh active Pending
- 2019-09-27 BR BR112021005896-6A patent/BR112021005896A2/pt unknown
- 2019-09-27 PE PE2021000405A patent/PE20211773A1/es unknown
- 2019-09-27 CR CR20210153A patent/CR20210153A/es unknown
- 2019-09-27 WO PCT/IB2019/058240 patent/WO2020065613A1/en active Application Filing
- 2019-09-27 KR KR1020217012874A patent/KR20210069080A/ko unknown
- 2019-09-27 AU AU2019350624A patent/AU2019350624A1/en active Pending
- 2019-09-27 MA MA053721A patent/MA53721A/fr unknown
-
2020
- 2020-12-23 US US17/132,313 patent/US11820766B2/en active Active
-
2021
- 2021-03-22 PH PH12021550659A patent/PH12021550659A1/en unknown
- 2021-03-25 CL CL2021000757A patent/CL2021000757A1/es unknown
- 2021-03-25 IL IL281812A patent/IL281812A/en unknown
- 2021-03-26 NI NI202100023A patent/NI202100023A/es unknown
- 2021-03-26 EC ECSENADI202121381A patent/ECSP21021381A/es unknown
- 2021-03-29 CO CONC2021/0003944A patent/CO2021003944A2/es unknown
-
2022
- 2022-12-06 US US18/062,484 patent/US20230145249A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CO2021003944A2 (es) | 2021-04-19 |
| US20220332713A1 (en) | 2022-10-20 |
| AU2019350624A1 (en) | 2021-03-18 |
| CL2021000757A1 (es) | 2021-08-27 |
| CR20210153A (es) | 2021-05-11 |
| PE20211773A1 (es) | 2021-09-08 |
| CA3111380A1 (en) | 2020-04-02 |
| US20200102303A1 (en) | 2020-04-02 |
| CN113164459A (zh) | 2021-07-23 |
| US11820766B2 (en) | 2023-11-21 |
| SG11202102281VA (en) | 2021-04-29 |
| BR112021005896A2 (pt) | 2021-07-27 |
| MX2021003737A (es) | 2021-05-14 |
| JP2022502424A (ja) | 2022-01-11 |
| MA53721A (fr) | 2021-09-15 |
| WO2020065613A1 (en) | 2020-04-02 |
| ECSP21021381A (es) | 2021-04-29 |
| US20230145249A1 (en) | 2023-05-11 |
| EA202190886A1 (ru) | 2021-09-07 |
| NI202100023A (es) | 2021-09-07 |
| IL281812A (en) | 2021-05-31 |
| PH12021550659A1 (en) | 2022-02-21 |
| EP3856178A1 (en) | 2021-08-04 |
| JOP20210058A1 (ar) | 2021-03-24 |
| TW202028198A (zh) | 2020-08-01 |
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