KR20050052354A - NT―proBNP 측정용 분석 샌드위치 테스트 - Google Patents
NT―proBNP 측정용 분석 샌드위치 테스트 Download PDFInfo
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- KR20050052354A KR20050052354A KR1020040096674A KR20040096674A KR20050052354A KR 20050052354 A KR20050052354 A KR 20050052354A KR 1020040096674 A KR1020040096674 A KR 1020040096674A KR 20040096674 A KR20040096674 A KR 20040096674A KR 20050052354 A KR20050052354 A KR 20050052354A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/80—Antihypertensive peptides
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- Life Sciences & Earth Sciences (AREA)
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- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
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- Biotechnology (AREA)
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- Food Science & Technology (AREA)
- Endocrinology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims (10)
- 하기를 특징으로하는, NT-proBNP 측정용 면역 샌드위치 테스트:하나 이상의 항체는 MAB인, NT-proBNP에 대한 2개 이상의 항체를 사용하고,이들 항체 중 하나는 최소한, 아미노산 38-50을 함유하는 NT-proBNP의 에피토프 일부에 대한 것이며, 그리고,이들 항체 중 하나는 최소한, 아미노산 1-37 또는 43-76을 함유하는 NT-proBNP의 에피토프 일부에 대한 것으로, 항체에 의해 인식되는 에피토프는 약간 중복 가능함.
- 제 1 항에 있어서, 하기의 항체 조합 중 하나를 사용함을 특징으로하는 면역 테스트:AB (1-21) 또는 AB (13-16) 또는 AB (22-38) 또는 AB (27-31) 또는 AB (51-76) 또는 AB (64-67)와, AB (39-50); 또는AB (1-21) 또는 AB (22-37) 또는 AB (43-76)와, AB (38-42); 또는AB (1-21) 또는 AB (22-43) 또는 AB (51-76)와, AB (44-50).
- 제 1 항 또는 제 2 항에 있어서, 하기의 PAB/MAB 조합 중 하나를 사용함을 특징으로하는 면역 테스트:MAB (1-21) 또는 MAB (13-16) 또는 MAB (22-38) 또는 MAB (27-31) 또는 MAB (51-76) 또는 MAB (64-67)와, PAB (39-50); 또는MAB (1-21) 또는 MAB (22-37) 또는 MAB (43-76)와, PAB (38-42); 또는MAB (1-21) 또는 MAB (22-43) 또는 MAB (51-76)와, PAB (44-50).
- 제 1 항에 있어서, 하기의 항체 조합을 사용함을 특징으로하는 면역 테스트:PAB (39-50) 또는 PAB (38-42) 또는 PAB (44-50)와, MAB 18.4.34 (27-31), 또는,PAB (39-50) 또는 PAB (38-42) 또는 PAB (44-50)와, MAB 17.3.1 (13-16).
- 제 1 항에 있어서, 하기의 항체 조합을 사용함을 특징으로하는 면역 테스트:MAB (38-42)와 MAB 18.4.34 (27-31) 또는,MAB (38-42)와 MAB 18.9.8 (27-31).
- 제 5 항에 있어서, MAB (38-42)가 MAB 16.1.39 (38-42)임을 특징으로하는 면역 테스트.
- 제 1 항 또는 제 2 항에 있어서, 면역 신속 테스트임을 특징으로하는 면역 테스트.
- 제 7 항에 있어서, 항체 중 하나가 항체-금 컨쥬게이트로 존재함을 특징으로하는 면역 신속 테스트.
- 제 7 항에 있어서, 항체 중 하나가 비오틴화 항체로 존재함을 특징으로하는 면역 신속 테스트.
- 제 1 항 또는 제 2 항의 면역 테스트를 사용함을 특징으로하는, NT-proBNP 측정 방법.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10355731A DE10355731A1 (de) | 2003-11-28 | 2003-11-28 | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
DE10355731.8 | 2003-11-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20050052354A true KR20050052354A (ko) | 2005-06-02 |
KR100620297B1 KR100620297B1 (ko) | 2006-09-12 |
Family
ID=34442338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020040096674A KR100620297B1 (ko) | 2003-11-28 | 2004-11-24 | NT―proBNP 측정용 분석 샌드위치 테스트 |
Country Status (14)
Country | Link |
---|---|
US (2) | US7507550B2 (ko) |
EP (1) | EP1536232B1 (ko) |
JP (1) | JP4236629B2 (ko) |
KR (1) | KR100620297B1 (ko) |
CN (1) | CN1316248C (ko) |
AT (1) | ATE487946T1 (ko) |
AU (1) | AU2004231236B2 (ko) |
BR (1) | BRPI0405215B8 (ko) |
CA (1) | CA2488483C (ko) |
DE (2) | DE10355731A1 (ko) |
ES (1) | ES2355556T3 (ko) |
HK (1) | HK1078647A1 (ko) |
MX (1) | MXPA04011672A (ko) |
SG (1) | SG112059A1 (ko) |
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DE10355731A1 (de) * | 2003-11-28 | 2005-06-30 | Roche Diagnostics Gmbh | Analytischer Sandwichtest zur Bestimmung von NT-proBNP |
CN101000343B (zh) * | 2006-01-14 | 2012-11-14 | 霍夫曼-拉罗奇有限公司 | 具有改进的对照区的免疫检测件 |
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CN101230101B (zh) * | 2008-01-25 | 2012-03-28 | 中国人民解放军第三军医大学 | 一种用作NT-proBNP免疫诊断试剂标准品的重组蛋白及制备方法与应用 |
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EP2594940A1 (en) * | 2011-11-16 | 2013-05-22 | Koninklijke Philips Electronics N.V. | Particle repulsion to enhance surface contact in magnetic particle immunoassays |
CN102692512A (zh) * | 2012-06-26 | 2012-09-26 | 南京基蛋生物科技有限公司 | NT-proBNP双抗夹心快速检测试剂盒 |
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CA2904593A1 (en) * | 2013-03-14 | 2014-10-02 | Instrumentation Laboratory Company | Plasma separation from blood using a filtration device and methods thereof |
CN105092832B (zh) * | 2015-08-28 | 2016-11-30 | 宁波瑞源生物科技有限公司 | 一种NT-proBNP荧光免疫试剂及其制备方法 |
US10436773B2 (en) | 2016-01-18 | 2019-10-08 | Jana Care, Inc. | Mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening |
CN105699458A (zh) * | 2016-02-03 | 2016-06-22 | 洪国粦 | 用于NT-proBNP检测的新型免疫传感器及其制备方法 |
CN106771168A (zh) * | 2016-12-30 | 2017-05-31 | 武汉纽康度生物科技股份有限公司 | 荧光免疫层析检测卡及其制备方法和应用 |
CN107478848B (zh) * | 2017-08-23 | 2019-04-16 | 广州瑞博奥生物科技有限公司 | 定量检测人NT-proBNP的试剂盒及其制备方法 |
JP2021509709A (ja) * | 2017-12-15 | 2021-04-01 | ジャナ ケア インコーポレイテッドJana Care,Inc. | 病状をモニターするためにペプチド濃度を測定する生体医療用測定装置、システム、及び方法 |
US11446009B2 (en) | 2018-12-11 | 2022-09-20 | Eko.Ai Pte. Ltd. | Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images |
US11931207B2 (en) | 2018-12-11 | 2024-03-19 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device |
US12001939B2 (en) | 2018-12-11 | 2024-06-04 | Eko.Ai Pte. Ltd. | Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views |
CN112707964B (zh) * | 2019-10-25 | 2022-11-08 | 东莞市朋志生物科技有限公司 | 一种抗n末端脑钠肽前体的重组抗体 |
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CN111781385B (zh) * | 2020-08-19 | 2023-07-18 | 武汉生之源生物科技股份有限公司 | 一种NT-proBNP检测试剂盒及其制备方法 |
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-
2003
- 2003-11-28 DE DE10355731A patent/DE10355731A1/de not_active Withdrawn
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2004
- 2004-11-22 US US10/994,851 patent/US7507550B2/en active Active
- 2004-11-22 AU AU2004231236A patent/AU2004231236B2/en active Active
- 2004-11-24 SG SG200406770A patent/SG112059A1/en unknown
- 2004-11-24 ES ES04027831T patent/ES2355556T3/es active Active
- 2004-11-24 AT AT04027831T patent/ATE487946T1/de active
- 2004-11-24 DE DE502004011867T patent/DE502004011867D1/de active Active
- 2004-11-24 KR KR1020040096674A patent/KR100620297B1/ko active IP Right Grant
- 2004-11-24 EP EP04027831A patent/EP1536232B1/de active Active
- 2004-11-24 MX MXPA04011672A patent/MXPA04011672A/es active IP Right Grant
- 2004-11-25 CA CA2488483A patent/CA2488483C/en active Active
- 2004-11-25 JP JP2004339760A patent/JP4236629B2/ja active Active
- 2004-11-25 BR BRPI0405215A patent/BRPI0405215B8/pt not_active IP Right Cessation
- 2004-11-26 CN CNB2004100958784A patent/CN1316248C/zh active Active
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2005
- 2005-11-22 HK HK05110557A patent/HK1078647A1/xx unknown
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2009
- 2009-01-15 US US12/354,410 patent/US9140709B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BRPI0405215A (pt) | 2005-07-19 |
DE10355731A1 (de) | 2005-06-30 |
CN1641352A (zh) | 2005-07-20 |
CA2488483A1 (en) | 2005-05-28 |
EP1536232B1 (de) | 2010-11-10 |
US9140709B2 (en) | 2015-09-22 |
SG112059A1 (en) | 2005-06-29 |
CN1316248C (zh) | 2007-05-16 |
HK1078647A1 (en) | 2006-03-17 |
AU2004231236B2 (en) | 2006-10-19 |
US7507550B2 (en) | 2009-03-24 |
EP1536232A2 (de) | 2005-06-01 |
AU2004231236A1 (en) | 2005-06-16 |
DE502004011867D1 (de) | 2010-12-23 |
JP2005181304A (ja) | 2005-07-07 |
JP4236629B2 (ja) | 2009-03-11 |
US20050118662A1 (en) | 2005-06-02 |
BRPI0405215B1 (pt) | 2016-08-02 |
BRPI0405215B8 (pt) | 2021-07-27 |
CA2488483C (en) | 2011-09-06 |
KR100620297B1 (ko) | 2006-09-12 |
ES2355556T3 (es) | 2011-03-28 |
ATE487946T1 (de) | 2010-11-15 |
US20090123947A1 (en) | 2009-05-14 |
MXPA04011672A (es) | 2005-06-01 |
EP1536232A3 (de) | 2006-08-09 |
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