KR102505677B1 - 2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법 - Google Patents

2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법 Download PDF

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KR102505677B1
KR102505677B1 KR1020167023497A KR20167023497A KR102505677B1 KR 102505677 B1 KR102505677 B1 KR 102505677B1 KR 1020167023497 A KR1020167023497 A KR 1020167023497A KR 20167023497 A KR20167023497 A KR 20167023497A KR 102505677 B1 KR102505677 B1 KR 102505677B1
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compound
formula
solvent
solid
certain embodiments
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KR1020167023497A
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KR20160113269A (ko
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안토니오 크리스티앙 페르티
혼-와 만
잘리 머슬히디노글루
진 쉬
켈빈 힌-영 용
마리아 조르주 보샹
모히트 아툴 코타르
난페이 추
나단 앤드류 뵈르젠
이이잉 리
로버트 힐그라프
마크 에이 나지
다오종 추
리안펭 황
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시그날 파마소티칼 엘엘씨
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07—ORGANIC CHEMISTRY
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020167023497A 2014-01-30 2015-01-29 2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법 KR102505677B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227013115A KR20220051440A (ko) 2014-01-30 2015-01-29 2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461933636P 2014-01-30 2014-01-30
US61/933,636 2014-01-30
US201462025161P 2014-07-16 2014-07-16
US62/025,161 2014-07-16
PCT/US2015/013412 WO2015116755A2 (en) 2014-01-30 2015-01-29 Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use

Related Child Applications (1)

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KR1020227013115A Division KR20220051440A (ko) 2014-01-30 2015-01-29 2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법

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KR20160113269A KR20160113269A (ko) 2016-09-28
KR102505677B1 true KR102505677B1 (ko) 2023-03-03

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KR1020227013115A KR20220051440A (ko) 2014-01-30 2015-01-29 2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법
KR1020167023497A KR102505677B1 (ko) 2014-01-30 2015-01-29 2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법

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KR1020227013115A KR20220051440A (ko) 2014-01-30 2015-01-29 2-(3급-부틸아미노)-4-((1ｒ,3ｒ,4ｒ)-3-하이드록시-4-메틸사이클로헥실아미노)-피리미딘-5-카복스아미드의 고체형, 이의 조성물 및 이의 사용방법

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US (6) US9365524B2 (el)
EP (2) EP3738954A1 (el)
JP (3) JP2017504632A (el)
KR (2) KR20220051440A (el)
CN (3) CN113717110A (el)
AU (2) AU2015211036B2 (el)
BR (2) BR122020003206B1 (el)
CA (1) CA2938187C (el)
CL (1) CL2016001927A1 (el)
CR (1) CR20160346A (el)
CY (1) CY1123267T1 (el)
DK (1) DK3099302T3 (el)
EA (2) EA036964B1 (el)
ES (1) ES2811834T3 (el)
HR (1) HRP20201244T1 (el)
HU (1) HUE051266T2 (el)
IL (2) IL246931B (el)
LT (1) LT3099302T (el)
MX (3) MX2016009989A (el)
MY (1) MY180020A (el)
NZ (3) NZ715903A (el)
PE (1) PE20161437A1 (el)
PH (1) PH12016501472B1 (el)
PL (1) PL3099302T3 (el)
PT (1) PT3099302T (el)
RS (1) RS60715B1 (el)
SA (1) SA516371578B1 (el)
SG (1) SG11201606054SA (el)
SI (1) SI3099302T1 (el)
TW (1) TWI631108B (el)
WO (1) WO2015116755A2 (el)

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