KR102159018B1 - Composition of natural-borne antifungals and moisturizers - Google Patents

Composition of natural-borne antifungals and moisturizers Download PDF

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KR102159018B1
KR102159018B1 KR1020180073507A KR20180073507A KR102159018B1 KR 102159018 B1 KR102159018 B1 KR 102159018B1 KR 1020180073507 A KR1020180073507 A KR 1020180073507A KR 20180073507 A KR20180073507 A KR 20180073507A KR 102159018 B1 KR102159018 B1 KR 102159018B1
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KR20200001047A (en
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배정은
이민석
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고려대학교 산학협력단
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
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    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

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Abstract

본 발명은 피부 보호를 위해 최대량의 보습제와 최소량의 항균제를 최적으로 조합하여 구강, 비뇨생식계, 피부에 존재할 수 있는 칸디다균을 단시간 안에 효과적으로 제어할 수 있는 인체 세정용 조성물에 관한 것이다. The present invention relates to a composition for cleaning the human body that can effectively control Candida bacteria that may exist in the oral cavity, urogenital system, and skin in a short time by optimally combining a maximum amount of a moisturizing agent and a minimum amount of an antimicrobial agent for skin protection.

Description

천연 유래 인체 세정용 조성물{Composition of natural-borne antifungals and moisturizers}Composition of natural-borne antifungals and moisturizers}

본 발명은 피부 보호를 위해 최대량의 보습제와 최소량의 항균제를 최적으로 조합하여 구강, 비뇨생식계, 피부에 존재할 수 있는 칸디다균을 단시간 안에 효과적으로 제어할 수 있는 인체 세정용 조성물에 관한 것이다. The present invention relates to a composition for cleaning the human body that can effectively control Candida bacteria that may exist in the oral cavity, urogenital system, and skin in a short time by optimally combining a maximum amount of a moisturizing agent and a minimum amount of an antimicrobial agent for skin protection.

칸디다증은 진균(곰팡이) 일종인 Candida spp. 에 의한 피부질환 일종으로 점막과 습도가 높은 피부 주위에 주로 감염된다. 주요 원인 균은 칸디다 Candida albicans 이다. 영향을 받는 부위(구강 내막, 얼굴, 손가락과 발가락 사이 공간, 외음부 등)에 따라 여드름, 구강염, 질염 등으로 구분될 수 있다. 칸디다증을 예방 또는 치료하기 위해 주로 항생제가 사용되나 항생제 성분은 인체에 정상적으로 서식하는 균을 없앨 수 있고 항생제 내성균이 생길 수 있는 단점을 지녀 오히려 그 질환의 심각성을 더욱 악화시킬 수 있다. 또한 피부에 직접적으로 적용되는 인체 세정제(구강청결제, 여성청결제, 안에 있는 화학물질(요오드, 알코올 등) 및 합성 진균제는 피부를 자극하거나 건조하게 하는 부작용을 지니고 있다. Candidiasis is a type of fungus (fungus) called Candida spp. It is a kind of skin disease caused by the mucous membrane and is mainly infected around the skin with high humidity. The main causative organism is Candida albicans. Depending on the affected area (intraoral lining, face, space between fingers and toes, vulva, etc.), it can be classified into acne, stomatitis, vaginitis, etc. Antibiotics are mainly used to prevent or treat candidiasis, but the antibiotic component has the disadvantage that it can eliminate bacteria that normally inhabit the human body and can develop antibiotic-resistant bacteria, which can worsen the severity of the disease. In addition, human body cleansers (oral cleansers, feminine cleansers, chemicals (iodine, alcohol, etc.) that are applied directly to the skin) and synthetic fungicides have side effects that irritate or dry the skin.

이러한 화학 제제들이 나타내는 부작용을 보완할 수 있는 제제로 천연물을 활용한 항균제에 대한 연구가 활발히 진행되고 있다. 그러나 천연물질을 이용한 항균제의 효능은 단순히 병원성 미생물의 생장을 억제할 뿐 완전히 제거시키지 못한다. 억제된 미생물은 충분히 소생할 가능성이 매우 높아 감염질환의 재발을 불러일으킬 수 있으므로, 피부에 있는 병원성 미생물을 완전히 저감시키면서 동시에 민감한 피부에 자극이 되지 않도록 하는 인체 세정제 개발이 필요하다. Research on antimicrobial agents using natural products as agents that can compensate for the side effects exhibited by these chemical agents is being actively conducted. However, the efficacy of antimicrobial agents using natural substances simply inhibits the growth of pathogenic microorganisms and cannot completely eliminate them. Since the suppressed microorganisms have a very high possibility of sufficiently reviving, they can cause recurrence of infectious diseases, so it is necessary to develop a human body cleansing agent that completely reduces pathogenic microorganisms in the skin and does not irritate sensitive skin at the same time.

인체 세정제의 성분요소는 크게 보습제, 계면활성제, 항균제(또는 항균기능을 포함한 방부제)로 구성되어있고 이 밖에 점도 증진제, 피부컨디셔닝네 등이 있다. 보습제는 보통 물분자를 끌어들이는 강한 극성성질을 이용하여 보습효과를 지닌다. 그러나 강한 극성의 성질은 보통 항균제로부터 해리되는 수소이온까지 끌어들여 항균제의 항균효과를 감소시키기도 한다. 한편, 세정제에 많이 쓰이는 계면활성제에는 양쪽성 계면활성제가 있다. 이는 쯔비터 이온으로 보통 산성을 띠는 세정제 내에서 수소이온을 받아들여 항균제의 항균효과를 감소시키는 경향이 있다. 따라서 항균제는 기타 성분들에 의한 항균효능이 저감되는 현상을 막아 병원성 미생물을 충분히 제어하는 효과를 나타내야 하며 최소량이 첨가되어 피부자극이 일어나지 않도록 해야 한다. Ingredients of human body cleansers are largely composed of moisturizers, surfactants, antibacterial agents (or preservatives including antibacterial functions), and there are also viscosity enhancers and skin conditioning agents. Moisturizers usually have a moisturizing effect by using strong polar properties that attract water molecules. However, its strong polarity also attracts hydrogen ions that are usually dissociated from the antibacterial agent, reducing the antibacterial effect of the antibacterial agent. On the other hand, amphoteric surfactants are among the surfactants that are often used in detergents. This is a zwitter ion, which tends to reduce the antibacterial effect of the antimicrobial agent by accepting hydrogen ions in a detergent that is usually acidic. Therefore, the antibacterial agent should exhibit the effect of sufficiently controlling pathogenic microorganisms by preventing the phenomenon that the antimicrobial effect of other ingredients is reduced, and the minimum amount should be added to prevent skin irritation.

본 발명의 목적은 기존 인체 세정제 제품들의 문제점(계면활성제 및 항균물질의 무분별한 첨가, 낮은 항균력 등)을 해결하고자 함이다. 보습제로써 베타인 및 알란토인을 사용하였으며 계면활성제로 코코베타인을 첨가하였다. 극미량의 카프릴산, 카바크롤, 시트르산 조합물을 첨가하여 칸디다균을 단시간에 제어함으로써 피부 진균증 예방에 효과적인 인체 세정용 조성물을 제시하고자 하였다.It is an object of the present invention to solve the problems of existing human body cleaning products (indiscriminate addition of surfactants and antibacterial substances, low antibacterial activity, etc.). Betaine and allantoin were used as a moisturizing agent, and cocobetaine was added as a surfactant. It was intended to present a composition for cleansing the human body effective in preventing skin mycosis by controlling Candida bacteria in a short time by adding a combination of caprylic acid, carvacrol, and citric acid in a very small amount.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물은, 보습제, 계면활성제 및 항균제를 포함하고, 상기 항균제는 지방산, 에센셜 오일 및 유기산으로 이루어진 군에서 적어도 어느 하나를 포함한다. The composition for cleaning a human body according to various embodiments of the present invention includes a moisturizing agent, a surfactant, and an antibacterial agent, and the antimicrobial agent includes at least one of fatty acids, essential oils, and organic acids.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물에서, 상기 지방산은 카프릴산, 카프릭산 및 라우르산으로 이루어진 군에서 선택된 적어도 어느 하나인 것을 특징으로 한다.In the composition for cleaning the human body according to various embodiments of the present invention, the fatty acid is at least one selected from the group consisting of caprylic acid, capric acid, and lauric acid.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물에서, 상기 에센셜 오일은 카바크롤, 티몰 및 오레가노로 이루어진 군에서 선택된 적어도 어느 하나인 것을 특징으로 한다.In the composition for cleaning the human body according to various embodiments of the present invention, the essential oil is characterized in that at least one selected from the group consisting of carvacrol, thymol, and oregano.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물에서, 상기 유기산은 시트르산, 초산(아세트산), 말산, 락산(젖산), 포름산 및 옥살산으로 이루어진 군에서 선택된 적어도 어느 하나인 것을 특징으로 한다.In the composition for cleaning the human body according to various embodiments of the present invention, the organic acid is at least one selected from the group consisting of citric acid, acetic acid (acetic acid), malic acid, lactic acid (lactic acid), formic acid, and oxalic acid.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물에서, 상기 보습제는 베타인 및 알란토인으로 이루어진 군에서 선택된 적어도 어느 하나인 것을 특징으로 한다.In the composition for cleaning the human body according to various embodiments of the present invention, the moisturizing agent is characterized in that at least one selected from the group consisting of betaine and allantoin.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물에서, 상기 계면 활성제는 코코베타인인 것을 특징으로 한다.In the composition for cleaning the human body according to various embodiments of the present invention, the surfactant is characterized in that cocobetaine.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물에서, 상기 지방산은 카프릴산이고, 상기 에센셜 오일은 카바크롤이고, 상기 유기산은 시트르산인 것을 특징으로 한다.. In the composition for cleaning the human body according to various embodiments of the present invention, the fatty acid is caprylic acid, the essential oil is carvacrol, and the organic acid is citric acid.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물에서, 상기 카프릴산, 카바크롤, 시트르산의 농도가 0.03 % 내지 0.08% 인 것을 특징으로 한다. In the composition for cleaning the human body according to various embodiments of the present invention, the concentration of the caprylic acid, carvacrol, and citric acid is characterized in that 0.03% to 0.08%.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물은 Candida albicans의 제어를 위한 조성물이다. The composition for cleaning the human body according to various embodiments of the present invention is a composition for controlling Candida albicans.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물은 Candida albicans를 완전살균하는 것을 특징으로 한다.The composition for cleaning the human body according to various embodiments of the present invention is characterized in that Candida albicans is completely sterilized.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물은 Candida albicans의 초기균 및 상재균을 포함한 균을 모두 살균하여 완전 살균하는 것을 특징으로 한다.The composition for cleaning the human body according to various embodiments of the present invention is characterized in that it completely sterilizes all bacteria including the initial bacteria and the common bacteria of Candida albicans.

본 발명의 다양한 실시예에 따른 인체 세정용 조성물은, 천연물질만의 조합을 통해 칸디다 알비칸스를 1분 이내에 약 7 log CFU/ml 사멸시킬 수 있다. 이러한 저농도의 항균물질은 상피세포 손상, 인체 면역력 감소 등의 부작용을 줄일 수 있고 단독 성분들의 사용량 감소로 인한 비용 절감의 효과도 동시에 얻을 수 있다. The composition for cleaning the human body according to various embodiments of the present invention may kill about 7 log CFU/ml of Candida albicans within 1 minute through a combination of only natural substances. Such low-concentration antimicrobial substances can reduce side effects such as damage to epithelial cells and decrease in human immunity, and at the same time, the effect of cost reduction due to the reduction in the amount of use of single components can be obtained.

도 1은 조성물 내 천연물질 조성 조건을 달리한 비교예들 및 실시예들의 C. albicans 사멸에 대한 그래프이다.1 is a graph of C. albicans killing of Comparative Examples and Examples in which the composition conditions of natural substances in the composition were different.

다른 식으로 정의되지 않는 한, 본 명세서에서 사용된 모든 기술적 및 과학적 용어들은 본 발명이 속하는 기술분야에서 숙련된 전문가에 의해서 통상적으로 이해되는 것과 동일한 의미를 갖는다. 일반적으로 본 명세서에서 사용된 명명법은 본 기술분야에서 잘 알려져 있고 통상적으로 사용되는 것이다.Unless otherwise defined, all technical and scientific terms used in this specification have the same meaning as commonly understood by an expert skilled in the art to which the present invention belongs. In general, the nomenclature used in this specification is well known and commonly used in the art.

이하에서 본 발명을 첨부 도면을 참고하여 더욱 상세하게 설명한다. Hereinafter, the present invention will be described in more detail with reference to the accompanying drawings.

본 발명에 따른 인체 세정용 조성물은, 천연 유래 보습제 및 항균제로써, 천연물질만의 조합을 통해 단시간 내 인체 피부 감염 곰팡이를 제어할 수 있다. 본 발명은 피부 보호를 위해 최대량의 보습제와 최소량의 항균제를 적절히 조합하여 단시간 내에 병원성 진균을 저감시킬 수 있는 세정제를 제시하고자 한다. The composition for cleaning the human body according to the present invention is a naturally derived moisturizer and an antibacterial agent, and can control fungi in a short time through a combination of only natural substances. An object of the present invention is to provide a detergent capable of reducing pathogenic fungi within a short time by appropriately combining a maximum amount of a moisturizing agent and a minimum amount of an antimicrobial agent for skin protection.

구체적으로, 본 발명에 따른 인체 세정용 조성물은 보습제, 계면활성제 및 항균제를 포함하고, 이때 항균제는 지방산, 에센셜 오일 및 유기산으로 이루어진 군에서 적어도 어느 하나를 포함할 수 있다. Specifically, the composition for cleaning the human body according to the present invention includes a moisturizing agent, a surfactant, and an antibacterial agent, and the antibacterial agent may include at least one of fatty acids, essential oils, and organic acids.

보습제는 베타인 및 알란토인로 이루어진 군에서 선택된 적어도 어느 하나일 수 있다. 베타인은 사탕수수의 뿌리나 구기자에서 추출한 트리메틸글리신으로 극성의 물분자를 흡수하여 보습효과가 매우 우수하다. 피부자극완화제로 사용될 수 있는 알란토인(Allantoin)은 한해살이 풀인 컴프리, 밀의 싹에서 추출하는 물질로 세포의 활동을 활발하게 해서 피부 진정 및 완화 효과를 가지고 있어 연약하고 민감한 피부에 집중보습 관리를 위해 활용되는 물질이다. The moisturizing agent may be at least one selected from the group consisting of betaine and allantoin. Betaine is trimethylglycine extracted from sugar cane roots or goji berry. It absorbs polar water molecules and has excellent moisturizing effect. Allantoin, which can be used as a skin irritation reliever, is a substance extracted from the sprouts of comfrey and wheat, which is an annual herb, and has a skin soothing and relieving effect by activating cell activity. It is a substance.

본 발명에 따른 인체 세정용 조성물은 최대의 피부보습효과를 위해 알란토인 및 베타인을 최대 사용권장량으로 포함할 수 있다. 예를 들면, 알란토인은 최대 사용권장량인 0.5 %로 포함될 수 있고, 베타인은 최대 사용권장량인 5 %로 포함될 수 있다. The composition for cleaning the human body according to the present invention may contain allantoin and betaine in the maximum recommended amount for maximum skin moisturizing effect. For example, allantoin may be included at the maximum recommended use amount of 0.5%, and betaine may be included at the maximum recommended use amount of 5%.

계면활성제는 코코베타인일 수 있다. 코코베타인은 코코넛에 유래한 양쪽성 계면활성제이다. 최대 사용권장량은 20%이지만, 본 발명에서는 계면활성제에 의한 피부자극을 최소화하기 위하여 세정제 내 여러 물질들이 적절히 분산될 수 있도록 하는 최소량만을 첨가하였다. The surfactant may be cocobetaine. Cocobetaine is an amphoteric surfactant derived from coconut. The maximum recommended use amount is 20%, but in the present invention, in order to minimize skin irritation by the surfactant, only the minimum amount so that various substances in the detergent can be properly dispersed was added.

본 발명의 인체 세정용 조성물은 항균제로써 지방산, 에센셜 오일 및 유기산을 포함할 수 있다. 특히, 인체 세정용 조성물은 쯔비터이온(양쪽성 이온)의 성질을 가지는 물질과 함께 중쇄 지방산, 에센셜 오일 및 유기산을 포함할 수 있다. The composition for cleaning the human body of the present invention may contain fatty acids, essential oils, and organic acids as antibacterial agents. In particular, the composition for cleaning the human body may include a medium-chain fatty acid, an essential oil, and an organic acid along with a material having a zwitterion (amphipathic ion) property.

지방산은 카프릴산, 카프릭산 및 라우르산으로 이루어진 군에서 선택된 적어도 어느 하나일 수 있다. 바람직하게는 본 발명의 조성물에 포함되는 지방산은 카프릴산일 수 있다. 카프릴산은 코코넛 오일로부터 추출된 탄소수 8개를 지닌 지방산이다. 이는 미국 FDA로부터 GRAS (generally regarded as safe)로 선정된 물질이다. 카프릴산은 산성조건에서 비이온형으로 존재하여 중쇄지방산의 탄화수소부분이 미생물의 세포막과 상호작용하여 세포막을 손상시키는 기작을 지니고 있다. The fatty acid may be at least one selected from the group consisting of caprylic acid, capric acid, and lauric acid. Preferably, the fatty acid included in the composition of the present invention may be caprylic acid. Caprylic acid is a fatty acid with 8 carbon atoms extracted from coconut oil. It is a substance selected as GRAS (generally regarded as safe) by the US FDA. Caprylic acid exists in a nonionic form under acidic conditions, so the hydrocarbon portion of the medium chain fatty acid interacts with the cell membrane of microorganisms and has a mechanism to damage the cell membrane.

에센셜 오일은 카바크롤, 티몰 및 오레가노로 이루어진 군에서 선택된 적어도 어느 하나일 수 있다. 바람직하게는, 본 발명의 조성물에 포함되는 에센셜 오일은 카바크롤일 수 있다. 식물로부터 추출한 휘발성이 있는 방향 화합물인 에센셜 오일은 히드록시기를 지니고 있고 산성조건에서 대부분 비이온형으로 존재하여 세포막을 통과 후 세포질을 손상시키는 효능을 지니고 있다.The essential oil may be at least one selected from the group consisting of carvacrol, thymol, and oregano. Preferably, the essential oil included in the composition of the present invention may be carvacrol. Essential oil, a volatile aromatic compound extracted from plants, has a hydroxy group and is mostly nonionic in acidic conditions, so it has the effect of damaging the cytoplasm after passing through the cell membrane.

유기산은 시트르산, 초산(아세트산), 말산, 락산(젖산), 포름산 및 옥살산으로 이루어진 군에서 선택된 적어도 어느 하나일 수 있다. 바람직하게는, 본 발명의 조성물에 포함되는 유기산은 시트르산일 수 있다. 유기산은 카르복실산을 지니고 있으며 약산으로 분류되나 에센셜 오일보다 수소이온을 잘 해리시켜 용액의 pH를 감소시키는 효과를 지니고 있다. The organic acid may be at least one selected from the group consisting of citric acid, acetic acid (acetic acid), malic acid, lactic acid (lactic acid), formic acid, and oxalic acid. Preferably, the organic acid included in the composition of the present invention may be citric acid. Organic acids contain carboxylic acids and are classified as weak acids, but have the effect of reducing the pH of the solution by dissociating hydrogen ions better than essential oils.

본 발명의 바람직한 실시예에 따르면, 인체 세정용 조성물은 보습제로써 알란토인 및 베타인을 포함하고, 계면 활성제로써 코코베타인을 포함하며, 항균제로써, 카프릴산, 카바크롤 및 시트르산을 포함할 수 있다. 베타인 및 코코베타인과 같은 극성물질이 존재할 때, 카프릴산, 카바크롤, 시트르산의 농도가 0.03 % 내지 0.08% 일 수 있다. According to a preferred embodiment of the present invention, the composition for cleaning the human body includes allantoin and betaine as a moisturizing agent, cocobetaine as a surfactant, and caprylic acid, carvacrol, and citric acid as an antibacterial agent. When polar substances such as betaine and cocobetaine are present, the concentration of caprylic acid, carvacrol, and citric acid may be 0.03% to 0.08%.

본 발명의 인체 세정용 조성물은 Candida albicans를 제어할 수 있다. 본 발명은 Candida albicans를 완전살균할 수 있다. 즉, 본 발명의 인체 세정용 조성물은 Candida albicans의 초기균 및 상재균을 포함한 균을 모두 살균할 수 있다. 특히, 항균제로써 카프릴산, 카바크롤 및 시트르산을 포함하고, 카프릴산 및 카바크롤 중 적어도 어느 하나가 0.047 % 내지 0.049% 첨가된 조성물에서 칸디다가 1분 내에 완전히 사멸되는 효과(>6.85 log CFU/ml)가 있다. The composition for cleaning the human body of the present invention can control Candida albicans. The present invention can completely sterilize Candida albicans. In other words, the composition for cleaning the human body of the present invention can sterilize all bacteria including the initial bacteria and the common bacteria of Candida albicans. In particular, the effect of completely killing Candida within 1 minute in a composition containing caprylic acid, carvacrol, and citric acid as an antimicrobial agent, and in which at least one of caprylic acid and carvacrol is added 0.047% to 0.049% (>6.85 log CFU /ml).

한편, 본 발명에 따른 인체 세정용 조성물은 구강세정제, 외음부 세정제 및 세안제로 사용될 수 있고, 독성이 없어 피부패치, 여성용 패드로도 이용할 수 있다.On the other hand, the composition for cleaning the human body according to the present invention can be used as a mouthwash, a vulva cleaner, and a cleansing agent, and because it is not toxic, it can be used as a skin patch or a female pad.

이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것으로, 본 발명의 범위가 이들 실시예에 의해 제한되는 것으로 해석되지 않는 것은 당업계에서 통상의 지식을 가진 자에게 있어서 자명할 것이다.Hereinafter, the present invention will be described in more detail through examples. These examples are for illustrative purposes only, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not construed as being limited by these examples.

Candida albicans의 준비Preparation of Candida albicans

칸디다증의 주요 원인균인 Candida albicans (ATCC 10231, 18804, 11006)를 대상으로 실험을 수행하였다. 각 균주를 튜브에 담긴 30 ml 증균배지 Sabouraud Dextrose Broth (Difco, Becton Dickinson, Sparks, MD, USA)에 100 ul 씩 분주하여 30℃에서 24시간 배양하였으며 배양한 균을 3,000×g에서 15분간 원심분리하였다(Centra-CL2, Needham Heights, MA, USA). 상등액을 따라낸 후 0.85% 멸균 생리식염수를 이용하여 미생물 펠렛을 2회 세척하고, 다시 동량의 0.85% 멸균 생리식염수를 넣고 교반한 후 50 ml 플라스틱 튜브(Becton Diskinson, Franklin Lakes, NJ, USA)에 모두 혼합하여 균액을 준비하였다. An experiment was conducted on Candida albicans (ATCC 10231, 18804, 11006), the major causative agent of candidiasis. 100 ul of each strain was dispensed into a 30 ml thickening medium in a tube, Sabouraud Dextrose Broth (Difco, Becton Dickinson, Sparks, MD, USA), and cultured at 30°C for 24 hours, and the cultured bacteria were centrifuged at 3,000×g for 15 minutes. (Centra-CL2, Needham Heights, MA, USA). After decanting the supernatant, wash the microbial pellet twice with 0.85% sterile physiological saline, add the same amount of 0.85% sterilized physiological saline, stir, and place in a 50 ml plastic tube (Becton Diskinson, Franklin Lakes, NJ, USA). All were mixed to prepare a bacterial solution.

실시예-인체 세정용 조성물 제조 Example-Preparation of composition for cleaning the human body

멸균 증류수를 이용하여 5%의 Allantoin(Sigma Chemical co., St. Louis, MO, US)과 50%의 Betaine(Sigma Chemical co., St. Louis, MO, US)을 준비하여 멸균 튜브에 1 ml씩 첨가하였다. 그리고 30%의 cocobetiane(Dehytonⓡ AB 30, BASF, US)을 준비하여 각 튜브에 0.01 ml씩 첨가하였다. 98% 에탄올(ethanol, EtOH)을 이용하여 처리하고자 하는 농도의 100배 농도인 카프릴산(Sigma Chemical co., St. Louis, MO, USA), 카바크롤(Sigma Chemical co., St. Louis, MO)과 멸균한 증류수를 이용하여 처리하고자하는 농도의 100배 농도인 시트르산(Sigma Chemical co., St. Louis, MO, US)을 준비하여 멸균 튜브에 각 실험군에 해당하는 농도의 카프릴산, 카바크롤, 시트르산을 0.1 ml 씩 첨가하고 균질화하여 아래 표 1 내지 3과 같은 조성의 9.9 ml 세정제를 제조하였다.Using sterile distilled water, 5% of Allantoin (Sigma Chemical co., St. Louis, MO, US) and 50% of Betaine (Sigma Chemical co., St. Louis, MO, US) were prepared and 1 ml in a sterile tube. It was added gradually. And 30% of cocobetiane (Dehyton® AB 30, BASF, US) was prepared and added to each tube by 0.01 ml. Caprylic acid (Sigma Chemical co., St. Louis, MO, USA), which is 100 times the concentration to be treated with 98% ethanol (EtOH), and carvacrol (Sigma Chemical co., St. Louis, USA) MO) and sterilized distilled water are used to prepare citric acid (Sigma Chemical co., St. Louis, MO, US), which is 100 times the concentration to be treated, and caprylic acid at the concentration corresponding to each experimental group in a sterilized tube. 0.1 ml of carvacrol and citric acid were added and homogenized to prepare a 9.9 ml detergent having the composition shown in Tables 1 to 3 below.

성분명Ingredient name 비교예1Comparative Example 1 비교예2Comparative Example 2 비교예3Comparative Example 3 비교예4Comparative Example 4 비교예5Comparative Example 5 비교예6Comparative Example 6 알란토인Allantoin 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 코코베타인Coco betaine 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 베타인Betaine 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 카프릴산Caprylic acid 0.0320.032 0.0470.047 -- -- -- -- 카바크롤Carvacrol -- -- 0.0310.031 0.0470.047 -- -- 시트르산Citric acid -- -- -- -- 0.0390.039 0.0580.058

성분명Ingredient name 비교예7Comparative Example 7 비교예8Comparative Example 8 비교예9Comparative Example 9 비교예10Comparative Example 10 비교예
11Comparative example
11 비교예
12Comparative example
12 비교예
13Comparative example
13 비교예
14Comparative example
14 비교예
15Comparative example
15 비교예
16Comparative example
16 비교예
17Comparative example
17 비교예
18Comparative example
18 알란토인Allantoin 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 코코베타인Coco betaine 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 베타인Betaine 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 카프릴산Caprylic acid 0.0320.032 0.0320.032 0.0470.047 0.0470.047 -- -- -- -- 0.0320.032 0.0320.032 0.0470.047 0.0470.047 카바크롤Carvacrol 0.0310.031 0.0470.047 0.0310.031 0.0470.047 0.0310.031 0.0310.031 0.0470.047 0.0470.047 -- -- -- -- 시트르산Citric acid -- -- -- -- 0.0390.039 0.0580.058 0.0390.039 0.0580.058 0.0390.039 0.0580.058 0.0390.039 0.0580.058

성분명Ingredient name 비교예19Comparative Example 19 비교예20Comparative Example 20 실시예1Example 1 실시예2Example 2 실시예3Example 3 실시예4Example 4 실시예5Example 5 실시예6Example 6 알란토인Allantoin 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 0.5%0.5% 코코베타인Coco betaine 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 0.03%0.03% 베타인Betaine 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 5%5% 카프릴산Caprylic acid 0.0320.032 0.0320.032 0.0320.032 0.0320.032 0.0470.047 0.0470.047 0.0470.047 0.0470.047 카바크롤Carvacrol 0.0310.031 0.0310.031 0.0470.047 0.0470.047 0.0310.031 0.0310.031 0.0470.047 0.0470.047 시트르산Citric acid 0.0390.039 0.0580.058 0.0390.039 0.0580.058 0.0390.039 0.0580.058 0.0390.039 0.0580.058

실험예- Candida albicans에 대한 항진균 효과 확인(도1)Experimental Example-Confirmation of antifungal effect on Candida albicans (Fig. 1)

상기 표 1 내지 3에 제시된 각 조성물을 모두 22℃의 온도조건을 갖도록 한 후 항진균 효과를 확인하기 위해 약 9 log CFU/ml 수준의 Candida albicans 0.1 ml 균액을 접종(최종 농도: 약 7 log CFU/ml)한 다음 1분 처리 후의 용액을 Sabouraud Dextrose Agar (Difco, Becton Dickinson, Sparks, MD, USA)에 도말하였다(검출 한계: 1 CFU/ml). 초기균수를 측정하기 위해 멸균 0.85% 생리식염수 9.9 ml에 균액 0.1 ml을 접종하여 위와 같은 방법으로 수행하였다. 처리된 균을 도말한 배지는 37°C에서 48시간 배양 후 형성된 집락을 계수하여 균 농도를 log 값으로 나타냈다. 초기 균수(

Figure 112018062750362-pat00001
) 대비 각 실험군의 처리 후 균수(
Figure 112018062750362-pat00002
) 차이를 토대로 각 조건별 균의 저감화값(log(
Figure 112018062750362-pat00003
)-log(
Figure 112018062750362-pat00004
))을 산출하였다. After making each composition shown in Tables 1 to 3 have a temperature condition of 22°C, inoculate 0.1 ml of Candida albicans at a level of about 9 log CFU/ml to confirm the antifungal effect (final concentration: about 7 log CFU/ ml) and then the solution after 1 minute treatment was plated on Sabouraud Dextrose Agar (Difco, Becton Dickinson, Sparks, MD, USA) (limit of detection: 1 CFU/ml). In order to measure the initial number of bacteria, 0.1 ml of bacterial solution was inoculated into 9.9 ml of sterile 0.85% physiological saline, and the same was performed as above. The medium on which the treated bacteria were plated was cultured at 37°C for 48 hours, and colonies formed were counted, and the concentration of the bacteria was expressed as a log value. Initial bacterial count (
Figure 112018062750362-pat00001
) Compared to the number of bacteria after treatment in each experimental group (
Figure 112018062750362-pat00002
) Based on the difference, the reduction value of the bacteria for each condition (log(
Figure 112018062750362-pat00003
)-log(
Figure 112018062750362-pat00004
)) was calculated.

실험 결과, 알란토인, 베타인 및 코코베타인이 포함되어 있는 조성물에 각 항균제를 단독으로 첨가한 조성물에서의 저감효과는 최대 0. 5 log CFU/ml 밖에 보이지 않았다. 항균제를 두 가지의 조합(카프릴산+카바크롤, 카바크롤+시트르산, 카프릴산+시트르산)으로 첨가한 조성물에서는 4 log CFU/ml 이상의 칸디다균이 살아남았다. 4 log 정도의 칸디다균은 충분히 칸디다증을 일으킬 수 있고 좋은 환경에서 더 증식할 수 있다. 한편, 세 가지의 항균제를 모두 포함하는 조성물에서는, 카프릴산 및 카바크롤 중 적어도 어느 하나가 0.047-0.049% 첨가된 조성물에서 칸디다가 1분 내에 완전히 사멸되는 효과(>6.85 log CFU/ml)를 나타냈다. As a result of the experiment, the reduction effect in the composition in which each antimicrobial agent was added alone to the composition containing allantoin, betaine and cocobetaine was found to be only 0.5 log CFU/ml. In the composition in which the antimicrobial agent was added in combination of the two (caprylic acid + carbacrol, carbacrol + citric acid, caprylic acid + citric acid), 4 log CFU/ml or more of Candida bacteria survived. About 4 log of Candida bacteria can cause candidiasis enough and can grow further in good conditions. On the other hand, in a composition containing all three antimicrobial agents, the effect of completely killing Candida within 1 minute in a composition in which at least one of caprylic acid and carvacrol is added 0.047-0.049% (>6.85 log CFU/ml) Showed.

이상으로 본 발명 내용의 특정한 부분을 상세히 기술한 바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적 기술은 단지 바람직한 실시 양태일 뿐이며, 이에 의해 본 발명의 범위가 제한되는 것이 아닌 점은 명백할 것이다. 따라서 본 발명의 실질적인 범위는 첨부된 청구항들과 그것들의 등가물에 의하여 정의된다고 할 것이다.As described above, specific parts of the present invention have been described in detail, and it will be apparent to those of ordinary skill in the art that these specific techniques are only preferred embodiments, and the scope of the present invention is not limited thereby. will be. Therefore, it will be said that the practical scope of the present invention is defined by the appended claims and their equivalents.

Claims (11)

보습제, 계면활성제 및 항균제를 포함하고,
상기 항균제는 카프릴산, 카바크롤 및 시트르산을 포함하고,
상기 카프릴산의 농도는 0.03 v/v % 내지 0.08 v/v %이고,
상기 카바크롤의 농도는 0.03 v/v % 내지 0.08 v/v %이고,
상기 시트르산의 농도가 0.03 w/v % 내지 0.08 w/v % 인 것을 특징으로 하는 칸디다 알비칸스(Candida albicans)의 제어를 위한 인체 세정제 조성물.
Contains moisturizing agents, surfactants and antibacterial agents,
The antimicrobial agent includes caprylic acid, carvacrol and citric acid,
The concentration of the caprylic acid is 0.03 v/v% to 0.08 v/v %,
The concentration of carvacrol is 0.03 v/v% to 0.08 v/v %,
A human cleansing composition for controlling Candida albicans, characterized in that the concentration of the citric acid is 0.03 w/v% to 0.08 w/v %.
 삭제delete 삭제delete 삭제delete 제1항에 있어서,
상기 보습제는 베타인 및 알란토인으로 이루어진 군에서 선택된 적어도 어느 하나인 것을 특징으로 하는 인체 세정제 조성물.
The method of claim 1,
The human body cleaning composition, characterized in that the moisturizing agent is at least one selected from the group consisting of betaine and allantoin.
 제1항에 있어서,
상기 계면 활성제는 코코베타인인 것을 특징으로 하는 인체 세정제 조성물.
The method of claim 1,
The human body cleaning composition, characterized in that the surfactant is cocobetaine.
 삭제delete 삭제delete 삭제delete 제1항에 있어서,
상기 인체 세정용 조성물은 칸디다 알비칸스 (Candida albicans)를 완전살균하는 것을 특징으로 하는 인체 세정용 조성물.
The method of claim 1,
The composition for cleaning the human body is a composition for cleaning the human body, characterized in that the complete sterilization of Candida albicans (Candida albicans).
 제1항에 있어서,
상기 인체 세정용 조성물은 칸디다 알비칸스 (Candida albicans)의 초기균 및 상재균을 포함한 균을 모두 살균하는 것을 특징으로 하는 인체 세정용 조성물.The method of claim 1,
The composition for cleaning the human body is a composition for cleaning the human body, characterized in that it sterilizes all bacteria including the initial bacteria and the fungi of Candida albicans.
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