KR101202367B1 - Anti-acne composition containing a Nuruk ferment of Sophora flower extract - Google Patents
Anti-acne composition containing a Nuruk ferment of Sophora flower extract Download PDFInfo
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Abstract
본 발명은 여드름 피부용 화장료 조성물에 관한 것으로, 보다 상세하게는 회화나무꽃 추출물을 누룩 발효시켜 제조한 발효물을 함유하여 여드름 증상을 악화시키는 주 원인균인 프로피오니박테리움 아크네(Propionibacterium acnes)의 생육을 억제하는 우수한 여드름 치료 및 예방효과를 갖는 여드름 피부용 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition for acne skin, and more particularly, the growth of Propionibacterium acnes , which is a main cause of aggravating acne symptoms by containing a fermented product prepared by yeast fermentation of a flower extract It relates to a cosmetic composition for acne skin having an excellent acne treatment and prevention effect.
Description
본 발명은 여드름 피부용 조성물에 관한 것으로, 보다 상세하게는 회화나무꽃 추출물을 누룩 발효시켜 제조한 발효물을 함유하여 여드름 증상을 악화시키는 주 원인균인 프로피오니박테리움 아크네(Propionibacterium acnes)의 생육을 억제하는 우수한 여드름 치료 및 예방효과를 갖는 여드름 피부용 조성물에 관한 것이다.The present invention relates to a composition for acne skin, and more particularly, to inhibit the growth of propionibacterium acnes , which is a main cause of worsening acne symptoms by containing a fermented product prepared by yeast fermentation of the cedar flower extract. It relates to a composition for acne skin having an excellent acne treatment and prevention effect.
일반적으로 여드름은 피부의 모낭 피지선에서 발생하는 염증성 질환으로, 그 원인은 명확하게 규명되어 있지 않지만, 일반적으로 다음과 같은 기작이 제시되고 있다: 남성 호르몬인 테스토스테론에 의해 피지의 과다 분비가 되면 모낭관의 과각화가되고 그것은 모낭관에 의한 피지의 분비 출구를 막게 되는 결과를 초래하여 모낭에 피지가 쌓이게 한다. 과량의 피지가 쌓이게 되면 그 내부에서 여드름균 (예: Propionibacterium acnes)의 생육이 발생하게 되는데, 그 여드름균의 생장으로 인해 피지가 여드름균이 분비한 리파아제에 의해 유리 지방산으로 변화되고 그 유리 지방산은 피부에 자극을 유발하여 염증을 초래한다. 또한, 여드름균은 항원으로 인식되어 체내의 면역반응을 자극하여 염증 반응이 일어나게 된다. 이와 같은 기전에 의해, 구진과 염증성 여드름 병변이 발생하게 되고, 더욱 악화되면 모낭벽이 파괴되며, 조직이 손상되는 낭포, 농포 등의 병변으로 발전한다.Acne in general is an inflammatory disease of the hair follicle sebaceous gland of the skin, the cause of which is not clearly identified, but the following mechanisms are generally suggested: the secretion of sebaceous ducts when excessive secretion of sebum by the male hormone testosterone This causes the sebum to accumulate in the hair follicle, which results in blocking the secretory exit of the sebum by the hair follicle tube. Accumulation of excess sebum causes the growth of acne bacteria (for example, Propionibacterium acnes ) inside, which causes the sebum to be converted into free fatty acids by lipase secreted by acne bacteria. Causes skin irritation and causes inflammation. In addition, acne bacteria are recognized as antigens to stimulate the body's immune response to inflammatory reactions. By this mechanism, papules and inflammatory acne lesions are generated, and even worse, hair follicle walls are destroyed, and tissues are damaged, such as cysts and pustules.
따라서, 상기의 여드름을 치료하기 위해 피지 생성을 억제하는 항안드로겐제, 항염제로 사용하는 비스테로이드 소염제, 및 항균효과가 있는 레조시놀, 유황 및 벤조일 퍼옥사이드(benzoylperoxide)와 항생효과가 있는 테트라사이클린, 에리스로마이신, 매크로싸이클린 등에 의한 병산간균 등의 활성 억제 방법 등이 있다. 또한, 최근에는 레티노익산(retinoic acid) 등의 비타민 A 유도체에 의한 치료방법도 널리 사용되고 있다. Therefore, anti-androgens that inhibit sebum production, antisteroidal agents used as anti-inflammatory agents to treat acne, and antiseptic resorcinol, sulfur and benzoyl peroxide and tetracycline with antibiotic effect And methods for inhibiting activity such as bacillus bacillus by erythromycin, macrocycline and the like. In recent years, a treatment method with vitamin A derivatives such as retinoic acid has also been widely used.
그러나, 상기의 방법들은 여드름 치료와 예방에 있어 어느 정도 효과를 가지고 있으나 피부안전성 측면에 있어서 부작용을 가지는 문제점이 있다. 즉, 호르몬제의 사용은 표피의 성장억제 등의 역효과를 유발할 수 있으며, 레티노익산과 벤조일 퍼옥사이드 등은 피부 자극성과 접촉성 피부염의 우려가 있고 테트라사이클린과 같은 항생물질은 내균성과 광과민 작용의 문제점이 있음이 알려져 있다. However, the above methods have some effects in the treatment and prevention of acne, but have problems in terms of skin safety. In other words, the use of hormonal agents may cause adverse effects such as growth inhibition of the epidermis. Retinoic acid and benzoyl peroxide may cause skin irritation and contact dermatitis, while antibiotics such as tetracycline may be resistant to bacteria and photosensitization. It is known that there is a problem.
본 발명자들은 상기한 문제점을 해결하기 위하여 여드름의 주 원인균인 프로피오니박테리움 아크네에 대해 특이적인 항균작용을 갖고 있으면서도 장기간 사용해도 부작용이 없는 천연물을 발굴하기 위해 연구를 거듭한 결과, 종래 피부 항염증 효과가 큰 것으로 알려져 있는 회화나무꽃이 누룩 발효과정을 통해 우수한 여드름 치료 효과를 갖는 것을 발견하고, 본 발명을 완성하게 되었다.In order to solve the above problems, the present inventors have repeatedly studied to find natural products having a specific antibacterial activity against propionibacterium acne, which is a main cause of acne, and having no side effects even after long-term use. Painting tree flower is known to have a great effect through the yeast fermentation process has found an excellent acne treatment effect, to complete the present invention.
따라서 본 발명의 목적은 회화나무꽃 추출물을 누룩 발효시켜 제조한 발효물을 함유하는 것을 특징으로 하는 여드름 피부 개선용 화장료 조성물 및 약학적 조성물을 제공하는 것이다. Accordingly, an object of the present invention is to provide a cosmetic composition and pharmaceutical composition for improving acne skin, which comprises a fermented product prepared by yeast fermentation of the cedar flower extract.
상기와 같은 목적을 달성하기 위하여, 본 발명에 따른 여드름 예방 및 치료용 조성물(화장료 조성물 및 약학적 조성물 포함)는 회화나무꽃 추출물의 누룩 발효물을 유효성분으로 함유하는 것을 특징으로 한다.In order to achieve the above object, the composition for preventing and treating acne (including the cosmetic composition and the pharmaceutical composition) according to the present invention is characterized in that it contains the yeast fermented product of the cedar flower extract as an active ingredient.
본 발명에 따른 여드름 피부용 화장료 조성물에 있어서, 상기 회화나무꽃 추출물의 누룩 발효물의 함량은 전체 조성물 함량을 기준으로 0.01~10.0 중량%인 것이 바람직하다. In the cosmetic composition for acne skin according to the present invention, the content of yeast fermentation of the painting flower extract is preferably 0.01 to 10.0% by weight based on the total composition content.
본 발명에 따른 여드름 피부용 조성물은 회화나무꽃 추출물의 누룩 발효물을 유효성분으로 함유함으로써 여드름 원인균인 프로피오니박테리움 아크네(Propionibacterium acnes)의 생육을 효과적으로 억제하며, 여드름의 개선 효과가 뛰어나 여드름의 치료에 유용하게 사용될 수 있다.The composition for acne skin according to the present invention effectively inhibits the growth of propionibacterium acnes , which is a cause of acne, by containing the yeast fermented product of the cedar flower extract as an active ingredient, and has an excellent effect of improving acne to treat acne. It can be usefully used.
도 1은 살리실산, 회화나무꽃 추출물과 회화나무꽃 추출물의 누룩 발효물의 프로피오니박테리움 아크네에 대한 생장억제환을 나타낸 도이다.1 is a diagram showing the growth inhibitory ring for the propionibacterium acne of salicylic acid, yeast fermentation of the cedar flower extract and the cedar flower extract.
상기 목적을 달성하기 위해 본 발명은 회화나무꽃 추출물의 누룩 발효물을 여드름 피부에 적용하는 것을 특징으로 하는 여드름 피부용 조성물을 제공한다.In order to achieve the above object, the present invention provides a composition for acne skin, characterized in that to apply the yeast fermented product of the cedar flower extract to acne skin.
본 발명에서 회화나무꽃 추출액 중 유효성분을 생전환시키기 위한 방법은 회화나무꽃 추출액에 누룩 곰팡이를 직접 배양하거나 누룩 곰팡이를 배양하여 회수한 효소액을 처리하거나 β-글루코시다제와 아피오시다제 활성이 있는 효소를 처리하는 방법이 있을 수 있으며, 바람직한 방법은 누룩 곰팡이를 회화나무꽃 추출액과 혼합하여 직접 배양하는 것이다. In the present invention, the method for the bioconversion of the active ingredient in the extract of the flowering tree flower is treated with the enzyme solution recovered by incubating the yeast fungus or the culture of the yeast fungus directly on the painting flower extract or β-glucosidase and apiosidase activity There may be a method of treating an enzyme present, and a preferable method is to mix the yeast fungus with a painting flower extract and incubate it directly.
회화나무꽃 추출액에 누룩 곰팡이를 배양하는 방법으로는 누룩 곰팡이, 바람직하게는 Aspergillus nigar, Aspergillus oryzae 또는 이들의 혼합균주를 넣고 20~50℃에서 1 내지 10일 동안 배양기에서 배양하는 것이 바람직하다.As a method of culturing yeast fungus in the extract of the flowering tree flower, it is preferable to add yeast fungus, preferably Aspergillus nigar , Aspergillus oryzae or a mixed strain thereof, and incubate in the incubator at 20-50 ° C. for 1 to 10 days.
누룩 곰팡이 중에서 Aspergillus nigar, Aspergillus oryzae 또는 이들의 혼합균주를 사용하는 것은 글루코시다제 활성이 있는 효소를 생산하여 루틴(rutin)을 퀘세르틴(quercetin)으로 생전환시키기에 가장 적합할 뿐만 아니라 배양 중에 생성된 코직산(kojic acid)과의 시너지 작용을 통해 더욱 우수한 항여드름 효과가 있는 조성물을 제조할 수 있기 때문이다.The use of Aspergillus nigar , Aspergillus oryzae or a combination of these among yeast fungi is most suitable for the production of enzymes with glucosidase activity, which is most suitable for the bioconversion of rutin to quercetin, as well as during culture. This is because a synergistic effect with the resulting kojic acid can produce a composition having a better anti-acne effect.
본 발명에 따른 화장료에 있어서, 회화나무꽃 추출물의 누룩 발효물의 함량은 화장료 총 중량을 기준으로 0.01 내지 10중량%인 것이 바람직하며, 0.5 내지 10중량%인 것이 더욱 바람직하다. 0.01 중량% 미만일 경우에는 그 효과가 미미하고, 10.0 중량%를 초과하여 투입할 경우에는 용해도로 인한 석출의 문제가 발생할 수 있다. In the cosmetics according to the present invention, the content of the yeast fermented product of the flower extract is preferably 0.01 to 10% by weight, more preferably 0.5 to 10% by weight based on the total weight of the cosmetic. If the amount is less than 0.01% by weight, the effect is insignificant. If it is added in excess of 10.0% by weight, problems of precipitation due to solubility may occur.
본 발명에 따른 화장료에는 살리실산, 레티노익산, 레티노익산 유도체, 벤조일 퍼옥사이드, 아하(AHA) 성분과 같이 과각화 억제 물질을 더 함유할 수 있으며, 이러한 화장료는 스킨, 로션, 크림, 파운데이션, 에센스, 젤, 팩, 폼 클렌징, 비누와 같은 다양한 제형으로 제조할 수 있다. The cosmetics according to the present invention may further contain a hyperkeratosis suppressant such as salicylic acid, retinoic acid, retinoic acid derivatives, benzoyl peroxide, AHA, and such cosmetics may be skins, lotions, creams, foundations, essences, gels. It can be prepared in various formulations such as, packs, foam cleansing, soaps.
본 발명의 회화나무꽃 추출물의 누룩 발효물은 여드름 피부용 화장료 조성물 이외에도 약학적 조성물로서 여드름 피부용 외용제로도 이용될 수 있다. The yeast fermented product of the painting tree flower extract of the present invention can be used as an external preparation for acne skin as a pharmaceutical composition in addition to the cosmetic composition for acne skin.
이하, 보다 구체적인 실시예를 들어 본 발명에 대해 상세히 설명하지만, 본 발명이 이하 실시예로만 한정된는 것은 아니다. Hereinafter, the present invention will be described in detail with reference to more specific examples, but the present invention is not limited to the following examples.
<실시예 1> 회화나무꽃 추출물의 제조Example 1 Preparation of Painting Tree Flower Extract
회화나무꽃은 시중에 판매되는 건조 상태의 전초를 구입하여 분쇄기를 이용하여 분말로 만들어 준비하였다. 준비된 회화나무꽃 1 ㎏에 에탄올 10ℓ를 넣고, 실온에서 3시간 동안 300 rpm으로 교반하면서 추출하였다. 그 다음 여과지를 이용하여 추출용액을 여과하여 회수한 후, 회수된 용액을 냉각콘덴서가 달린 증류장치를 이용하여 47℃에서 감압농축하여 회화나무꽃 추출물을 제조하였다. Painting tree flowers were prepared by purchasing commercially available dried outposts into powder using a grinder. 10 kg of ethanol was added to 1 kg of the prepared flower, and extracted with stirring at 300 rpm for 3 hours at room temperature. Then, the extraction solution was collected by filtration using a filter paper, and the recovered solution was concentrated under reduced pressure at 47 ° C. using a distillation apparatus equipped with a cooling capacitor to prepare a extract of the flower of the painting.
<실시예 2> 회화나무꽃 추출물로부터 누룩 발효물의 제조Example 2 Preparation of Nuruk Fermented Product from Painting Tree Flower Extract
상기 용매를 완전히 제거한 상태의 회화나무꽃 추출물을 증류수에 현탁시킨 후, 누룩을 밀기울과 글루코즈 용액을 혼합한 배지에 첨가하여 배양하였으며 30℃에서 5일간 배양하고, 이 배양체에 100 mM 인산나트륨완충액(pH 7.0) 50 ㎖를 넣고, 4℃에서 8시간 방치 후 miracloth로 1차 여과하고 여과액을 12,000 rpm에서 20분간 원심분리한 다음 얻은 상등액을 회화나무꽃 추출물의 누룩 발효물로 사용하였다. After removing the solvent of the cedar flower extract with the solvent completely removed, the yeast was incubated by adding the bran and the glucose solution to the mixed medium and incubated at 30 ° C. for 5 days, and 100 mM sodium phosphate buffer solution ( 50 ml of pH 7.0) was added thereto, and the mixture was left to stand at 4 ° C. for 8 hours, filtered first with miracloth, and the filtrate was centrifuged at 12,000 rpm for 20 minutes.
<시험예> <Test Example>
1. 사용균주, 배지 및 배양조건1. Use strain, medium and culture conditions
본 발명에 사용된 균주는 여드름의 원인균인 프로피오니박테리움 아크네 KCTC3314이고, 이들 균주는 한국유전자은행에서 분양받아 사용하였다. 여드름균의 배양 배지는 Reinforced clostridial (RC) 배지(Merck, Germany)를 사용하였고, 프로피오니박테리움 아크네는 4℃에서 보관하면서 실험 3일 전에 활성화했다. 균을 배양 배지에 접종한 후 anaerobic jar에서 Gaspack system(Merck AnaerocultGaspack system, Germany)을 이용하여 밀봉한 다음, 37℃의 인큐베이터에서 3일 동안 혐기성 배양하였다. The strain used in the present invention is propionibacterium acne KCTC3314, the causative agent of acne, and these strains were used by the Korea Gene Bank. Reinforced clostridial (RC) medium (Merck, Germany) was used as a culture medium for acne bacteria, and propionibacterium acne was activated 3 days before the experiment while stored at 4 ° C. The bacteria were inoculated in the culture medium and sealed in an anaerobic jar using a Gaspack system (Merck AnaerocultGaspack system, Germany), followed by anaerobic culture for 3 days in an incubator at 37 ℃.
2. 여드름균에 대한 항균 활성 측정2. Determination of antimicrobial activity against acne
항균 활성 측정은 디스크 확산법(paper disk diffusion method)과 최소억제농도(Minimum inhibitoryconcentration : MIC)를 사용하여 평가하였다. Antimicrobial activity was measured using paper disk diffusion method and minimum inhibitory concentration (MIC).
(1) 디스크 확산법(paper disk diffusion method) (1) paper disk diffusion method
균주를 Reinforced clostridial(RC) 액체배지에서 3일간 배양한 다음, 균 현탁액을 일정한 농도(optical density 620 nm에서 흡광값 0.5)로 조절한 것을 멸균된 면봉을 이용하여 RC 한천플레이트(agar plate)에 균일하게 도말하였다. 플레이트를 건조시킨 후, paper disk(Φ 6 mm, Adventec. USA)를 균주를 접종한 플레이트 표면 위에 올려놓고 회화나무꽃 추출물 또는 회화나무꽃 추출물의 누룩 발효물을 DMSO에 희석하여 5 ㎍/10㎕/disk씩 흡수시켰다. 시료가 처리된 플레이트를 anaerobic jar에서 Gaspack system을 이용하여 3일간 배양한 후 디스크 주위의 생육 억제환(inhibition zone)의 크기로 항균 활성을 측정하였다. The strain was incubated in a Reinforced clostridial (RC) liquid medium for 3 days, and then the bacterial suspension was adjusted to a constant concentration (absorption value at 0.5 at an optical density of 620 nm) to agar plate using a sterile swab. She said. After the plate was dried, a paper disk (Φ 6 mm, Adventec. USA) was placed on the surface of the plate inoculated with the strain, and 5 μg / 10 μl of the yeast fermentation of the cedar flower extract or the cedar flower extract was diluted in DMSO. Absorbed by / disk. The plate treated with the sample was incubated in an anaerobic jar using a Gaspack system for 3 days, and then the antimicrobial activity was measured by the size of the inhibition zone around the disc.
이때 대조군으로는 화장료 조성물의 항균제로 많이 사용되고 있는 살리실산(salicylic acid)을 사용하였다.
At this time, the control group was used salicylic acid (salicylic acid) which is widely used as an antibacterial agent of the cosmetic composition.
상기 표 1의 결과로부터 회화나무꽃 추출물은 항여드름균 활성이 낮지만, 회화나무꽃 추출물의 누룩 발효물은 강력한 항여드름균 활성을 나타내어 누룩 발효가 회화나무꽃 추출물의 항여드름균 활성에 중대한 영향을 미친다는 사실을 알 수 있었다. 또한, 회화나무꽃 추출물의 누룩 발효물의 항여드름균 활성은 대조군으로 사용한 살리실산의 활성보다 높게 나타났다. From the results of Table 1, the painting tree flower extract has a low anti-acne bacterium activity, but the yeast fermentation of the painting tree flower extract shows a strong anti-acne bacterium activity, so that yeast fermentation has a significant effect on the anti-acne bacterium activity of the painting tree flower extract. I knew it was crazy. In addition, the anti acne activity of the yeast fermentation of the cedar flower extract was higher than that of the salicylic acid used as a control.
(2) 최소억제농도(Minimum inhibitory concentration, MIC) (2) Minimum inhibitory concentration (MIC)
MIC 평가는 96-well plate를 이용한 broth-dilution법을 일부 변형하여 수행하였다(K. Yasunaka et al., Antibacterial activity of crude extracts from mexican medicinal plants and purified coumarins and xanthones, J. Ethnopharmacol., 97, 293 (2005)). 72시간 배양한 여드름균을 McFarland standard 0.5의 값으로 조절하여 1.5x108 cells/ml로 희석된 균주를 배지 160 ㎕가 들어 있는 각 well에 20 ㎕씩 접종해 주었다. 회화나무꽃 추출물 또는 회화나무꽃 추출물의 누룩 발효물을 DMSO에 용해시켜 RC 액체 배지를 이용하여 균주와 배지가 들어있는 96-well plate에 20 ㎕씩 넣어 주고 잘 섞어 주었다. 대조군으로는 10% DMSO를 사용하였다. 균 희석액 및 시료를 접종한 96-well plate를 anaerocult Gaspack system을 이용하여 3일간 배양한 후 균의 생육이 나타나지 않는 최소 농도를 MIC로 결정하였다. 이때 대조군으로 살리실산을 사용하였다.
MIC evaluation was performed with some modifications of the broth-dilution method using 96-well plates (K. Yasunaka et al., Antibacterial activity of crude extracts from mexican medicinal plants and purified coumarins and xanthones, J. Ethnopharmacol., 97, 293 (2005)). The acne bacteria cultured for 72 hours were adjusted to the value of McFarland standard 0.5, and 20 µl of each strain containing 160 µl of the medium diluted to 1.5x10 8 cells / ml was inoculated. Yeast fermentation of the cedar flower extract or cedar flower extract was dissolved in DMSO and 20 μl each was added to a 96-well plate containing strain and medium using RC liquid medium and mixed well. 10% DMSO was used as a control. After incubating 96-well plates inoculated with bacterial dilutions and samples using an anaerocult gaspack system for 3 days, the minimum concentration at which bacterial growth was not determined was determined by MIC. Salicylic acid was used as a control.
이상의 결과에서 보는 바와 같이 회화나무꽃 추출물의 누룩 발효물은 대조군인 살리실산 보다 최소억제농도가 67배 더 낮게 나타나, 본 발명의 회화나무꽃 추출물의 누룩 발효물 및 이를 함유하는 화장료 조성물은 여드름 예방 및/또는 치료와, 프로피오니박테리움 아크네의 생육을 억제하는 효과가 매우 우수함을 알 수 있다. As shown in the above results, the yeast fermented product of the cedar flower extract showed a minimum inhibitory concentration of 67 times lower than the salicylic acid as a control, and the yeast fermented product of the cedar flower extract of the present invention and the cosmetic composition containing the same were used to prevent acne. It can be seen that the treatment and the effect of inhibiting the growth of propionibacterium acne are very excellent.
본 발명의 회화나무꽃 추출물의 누룩 발효물로부터 유래하는 여드름 예방 및/또는 치료용 유효 성분물질을 포함하는 것을 특징으로 하는 화장료 조성물은 회화나무꽃 추출물의 누룩 발효물을 0.01~10중량%으로 할 수 있다. 이때 회화나무 추출물의 누룩 발효물의 함량을 0.5~10중량%로 할 경우 더욱 바람직하다. The cosmetic composition comprising an active ingredient for preventing and / or treating acne derived from the yeast fermentation product of the cedar flower extract of the present invention is 0.01 to 10% by weight of the yeast fermentation product of the cedar flower extract. Can be. At this time, the content of yeast fermented product of the sakura extract is more preferably 0.5 to 10% by weight.
본 발명의 회화나무꽃 추출물의 누룩 발효물을 함유하는 화장료 조성물은 여드름 피부를 위한 화장품 및 세안제 등에 다양하게 이용될 수 있으며, 제형은 임의로 선택할 수 있다. 본 조성물을 첨가할 수 있는 제품으로는 각종 피부에 바르는 외용제인 크림, 밀크로션, 파운데이션, 스킨 등과 같은 화장품류와 클린징, 세안제, 비누, 트리트먼트, 미용액 등을 포함한다. The cosmetic composition containing the yeast fermentation product of the cedar flower extract of the present invention can be variously used in cosmetics and face washes for acne skin, and the formulation can be arbitrarily selected. Products to which the present composition may be added include cosmetics such as creams, milk lotions, foundations, skins, and the like, which are applied to various skins, and cleansing, face washes, soaps, treatments, and essences.
이하는 본 발명의 회화나무꽃 추출물의 누룩 발효물을 함유하는 화장료 조성물의 구체적인 제형예를 나타낸 것으로, 본 발명의 화장료 조성물을 포함하는 제형은 이에 한정되는 것이 아니다.
The following shows an example of the specific formulation of the cosmetic composition containing the yeast fermentation of the cedar flower extract of the present invention, the formulation comprising the cosmetic composition of the present invention is not limited thereto.
<제형예 1> 유연 화장수(skin toner)Formulation Example 1 Skin Toner
<제형예 2> 수렴 화장수(astringent)<Formulation Example 2> Converging Lotion (astringent)
<제형예 3> 로션(에멀젼)Formulation Example 3 Lotion (Emulsion)
<제형예 4> 크림(cream)<Formulation Example 4> Cream
<제형예 5> 유액상 화운데이션(liquid foundation)Formulation Example 5 Latex Liquid Foundation
<제형예 6> 비누(soap)<Formulation Example 6> Soap
Claims (4)
Cosmetic composition for improving acne, characterized in that it contains the yeast fermentation product of the cedar flower extract having the effect of inhibiting the growth of propionibacterium acnes , which is a main cause of worsening acne symptoms.
The cosmetic composition for improving acne according to claim 1, wherein the yeast fermented product of the extract of the flower of Fig. Is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition.
The cosmetic composition for improving acne according to claim 1, wherein the yeast is any one of Aspergillus niger , Aspergillus oryzae, and a mixed strain thereof.
A pharmaceutical agent for preventing and treating acne, comprising as a active ingredient the yeast fermentation product of the cedar flower extract, which has the effect of inhibiting the growth of propionibacterium acnes , which is a main cause of worsening acne symptoms. Composition.
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| KR20190006303A (en) * | 2017-07-10 | 2019-01-18 | 정문석 | Cosmetic composition for treating acne containing mixed herbal extracts fermented with Nuruk |
| KR20190009164A (en) * | 2017-07-18 | 2019-01-28 | 코스맥스 주식회사 | A composition for skin smoothing comprising an extract of fermented ponciri fructus |
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| KR101868050B1 (en) * | 2011-10-25 | 2018-06-18 | (주)아모레퍼시픽 | Fermentation method using medicinal flower and skin external composition containing fermented extract by the method |
| CN104982919B (en) * | 2015-04-30 | 2018-02-02 | 新昌县大成生物科技有限公司 | A kind of preparation method for sophora flower powder of fermenting |
| CN104940089A (en) * | 2015-07-15 | 2015-09-30 | 韩诚 | Chinese herb mouth wash |
| KR101905005B1 (en) * | 2017-01-09 | 2018-10-08 | 주식회사 아미코스메틱 | Cosmetic composition for acne improvement comprising myrciaria dubia, malpighia emarginata and sophora japonica extract |
| CN114246208B (en) * | 2021-12-29 | 2024-04-19 | 烟台固特丽生物科技股份有限公司 | Method for preparing fruit and vegetable preservative through pagodatree flower bud fermentation and extraction |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190006303A (en) * | 2017-07-10 | 2019-01-18 | 정문석 | Cosmetic composition for treating acne containing mixed herbal extracts fermented with Nuruk |
| KR101985660B1 (en) * | 2017-07-10 | 2019-06-04 | 정문석 | Cosmetic composition for treating acne containing mixed herbal extracts fermented with Nuruk |
| KR20190009164A (en) * | 2017-07-18 | 2019-01-28 | 코스맥스 주식회사 | A composition for skin smoothing comprising an extract of fermented ponciri fructus |
| KR101994618B1 (en) * | 2017-07-18 | 2019-07-02 | 코스맥스 주식회사 | A composition for skin smoothing comprising an extract of fermented ponciri fructus |
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