JPS57131777A - Preparation of piperazine derivative - Google Patents

Preparation of piperazine derivative

Info

Publication number
JPS57131777A
JPS57131777A JP56116544A JP11654481A JPS57131777A JP S57131777 A JPS57131777 A JP S57131777A JP 56116544 A JP56116544 A JP 56116544A JP 11654481 A JP11654481 A JP 11654481A JP S57131777 A JPS57131777 A JP S57131777A
Authority
JP
Japan
Prior art keywords
compound
formula
formulai
preparation
actions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56116544A
Other languages
Japanese (ja)
Inventor
Hiroshi Murai
Yoshiaki Aoyanagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP56116544A priority Critical patent/JPS57131777A/en
Publication of JPS57131777A publication Critical patent/JPS57131777A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An N-substituted trialkoxybenzylpiperazine derivative of formulaI[R is methyl or ethyl; Z is a group of formula II (A is H, lower alkyl, oxymethyl, etc.)].
EXAMPLE: C16H26N2O4.2HCl
USE: Useful as a remedy for ischemic heart deseases, etc. having actions on circulatory systems, e.g. coronary arterial vasodilator or cardioinetic inhibitory actions.
PROCESS: A compound of formula III is reacted with a compound of formula IV by the reductive N-alkylation reaction, e.g. the Leukart-Wallach reaction or catalytic reduction, to give the compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
JP56116544A 1981-07-24 1981-07-24 Preparation of piperazine derivative Pending JPS57131777A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56116544A JPS57131777A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56116544A JPS57131777A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2744377A Division JPS53112887A (en) 1976-04-09 1977-03-12 Production of n-substituted trialkoxybenzylpiperazine derivative

Publications (1)

Publication Number Publication Date
JPS57131777A true JPS57131777A (en) 1982-08-14

Family

ID=14689738

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56116544A Pending JPS57131777A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Country Status (1)

Country Link
JP (1) JPS57131777A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190216936A1 (en) * 2017-06-20 2019-07-18 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190216936A1 (en) * 2017-06-20 2019-07-18 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US10918728B2 (en) 2017-06-20 2021-02-16 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US10953102B2 (en) 2017-06-20 2021-03-23 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US11376330B2 (en) 2017-06-20 2022-07-05 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US11844840B2 (en) 2017-06-20 2023-12-19 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11746090B2 (en) 2020-06-30 2023-09-05 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4- trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

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