JPS6360998B2 - - Google Patents
Info
- Publication number
- JPS6360998B2 JPS6360998B2 JP9812582A JP9812582A JPS6360998B2 JP S6360998 B2 JPS6360998 B2 JP S6360998B2 JP 9812582 A JP9812582 A JP 9812582A JP 9812582 A JP9812582 A JP 9812582A JP S6360998 B2 JPS6360998 B2 JP S6360998B2
- Authority
- JP
- Japan
- Prior art keywords
- trehalose
- enzyme
- maltose
- phosphorylase
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 32
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 31
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 31
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 16
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 16
- 108010074725 Alpha,alpha-trehalose phosphorylase Proteins 0.000 claims description 10
- 108010057899 Maltose phosphorylase Proteins 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102000004190 Enzymes Human genes 0.000 description 32
- 108090000790 Enzymes Proteins 0.000 description 32
- 229940088598 enzyme Drugs 0.000 description 32
- 239000000243 solution Substances 0.000 description 17
- 238000000034 method Methods 0.000 description 15
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 9
- 239000002244 precipitate Substances 0.000 description 9
- 239000006228 supernatant Substances 0.000 description 9
- 239000007979 citrate buffer Substances 0.000 description 8
- 239000013078 crystal Substances 0.000 description 8
- 235000011007 phosphoric acid Nutrition 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000012790 confirmation Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 108010093096 Immobilized Enzymes Proteins 0.000 description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 3
- JDIIGWSSTNUWGK-UHFFFAOYSA-N 1h-imidazol-3-ium;chloride Chemical compound [Cl-].[NH2+]1C=CN=C1 JDIIGWSSTNUWGK-UHFFFAOYSA-N 0.000 description 3
- 108010015776 Glucose oxidase Proteins 0.000 description 3
- 239000004366 Glucose oxidase Substances 0.000 description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 3
- 235000011130 ammonium sulphate Nutrition 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 3
- 239000004327 boric acid Substances 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- 229940116332 glucose oxidase Drugs 0.000 description 3
- 235000019420 glucose oxidase Nutrition 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 239000003456 ion exchange resin Substances 0.000 description 3
- 229920003303 ion-exchange polymer Polymers 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 description 3
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- 241000195620 Euglena Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 240000001929 Lactobacillus brevis Species 0.000 description 2
- 235000013957 Lactobacillus brevis Nutrition 0.000 description 2
- 102000007327 Protamines Human genes 0.000 description 2
- 108010007568 Protamines Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- FZQSLXQPHPOTHG-UHFFFAOYSA-N [K+].[K+].O1B([O-])OB2OB([O-])OB1O2 Chemical compound [K+].[K+].O1B([O-])OB2OB([O-])OB1O2 FZQSLXQPHPOTHG-UHFFFAOYSA-N 0.000 description 2
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 238000006911 enzymatic reaction Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 229940048914 protamine Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- DLYUQMMRRRQYAE-UHFFFAOYSA-N tetraphosphorus decaoxide Chemical compound O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- -1 yeast Natural products 0.000 description 2
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 description 1
- 241000186063 Arthrobacter Species 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 241000588650 Neisseria meningitidis Species 0.000 description 1
- 241000187654 Nocardia Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 102100029677 Trehalase Human genes 0.000 description 1
- 108010087472 Trehalase Proteins 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000004067 bulking agent Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 239000007981 phosphate-citrate buffer Substances 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 150000003625 trehaloses Chemical class 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9812582A JPS58216695A (ja) | 1982-06-07 | 1982-06-07 | トレハロ−スの製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9812582A JPS58216695A (ja) | 1982-06-07 | 1982-06-07 | トレハロ−スの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58216695A JPS58216695A (ja) | 1983-12-16 |
| JPS6360998B2 true JPS6360998B2 (da) | 1988-11-28 |
Family
ID=14211554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9812582A Granted JPS58216695A (ja) | 1982-06-07 | 1982-06-07 | トレハロ−スの製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58216695A (da) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63240758A (ja) * | 1987-03-30 | 1988-10-06 | Natl Food Res Inst | 新規食品素材 |
| GB8715238D0 (en) * | 1987-06-29 | 1987-08-05 | Quadrant Bioresources Ltd | Food process |
| CA2016363A1 (en) * | 1989-06-05 | 1990-12-05 | Kazuho Matsuura | Method of producing trehalose |
| JPH05211882A (ja) * | 1991-12-11 | 1993-08-24 | Ajinomoto Co Inc | トレハロースの製造法 |
| US5677442A (en) * | 1992-12-28 | 1997-10-14 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Method of crystallizing trehalose without using organic solvent |
| DK0691344T3 (da) * | 1992-12-28 | 2003-07-14 | Hayashibara Biochem Lab | Oprensning af trehalose |
| JP3633648B2 (ja) * | 1993-07-20 | 2005-03-30 | 株式会社林原生物化学研究所 | マルトース・トレハロース変換酵素とその製造方法並びに用途 |
| US5565341A (en) * | 1993-08-13 | 1996-10-15 | Kureha Chemical Industry Co., Ltd. | Process for producing trehalose |
| TW428027B (en) * | 1994-02-23 | 2001-04-01 | Hayashibara Biochem Lab | DNA encoding enzyme, recombinant DNA and enzyme, transformant, and theirpreparations and uses |
| KR100374449B1 (ko) * | 1994-03-07 | 2003-09-06 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | 효소를인코우드하는디엔에이(dna),재조합디엔에이(dna)와효소,형질전환체및이들의제조방법과용도 |
| JPH07327691A (ja) * | 1994-04-15 | 1995-12-19 | Kureha Chem Ind Co Ltd | トレハロースの製造方法 |
| JP3557277B2 (ja) | 1994-06-25 | 2004-08-25 | 株式会社林原生物化学研究所 | 耐熱性トレハロース遊離酵素とその製造方法並びに用途 |
| JP3793590B2 (ja) * | 1994-06-27 | 2006-07-05 | 株式会社林原生物化学研究所 | 非還元性糖質とその製造方法並びに用途 |
| US5908767A (en) * | 1994-06-02 | 1999-06-01 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Non-reducing saccharide and its production and use |
| EP0717047B1 (en) * | 1994-06-10 | 2001-05-16 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing disaccharides and novel saccharides |
| JP3650632B2 (ja) | 1994-06-16 | 2005-05-25 | 株式会社林原生物化学研究所 | マルトースをトレハロースに変換する組換え型酵素 |
| AU695080B2 (en) * | 1994-06-24 | 1998-08-06 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Thermostable non-reducing saccharide-forming enzyme, its production and uses |
| TW426737B (en) * | 1994-06-27 | 2001-03-21 | Hayashibara Biochem Lab | Saccharide composition with reduced reducibility, and preparation and uses thereof |
| EP0693558B1 (en) | 1994-07-19 | 2002-12-04 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Trehalose and its production and use |
| JP3557288B2 (ja) * | 1994-07-21 | 2004-08-25 | 株式会社林原生物化学研究所 | 還元性澱粉糖から末端にトレハロース構造を有する非還元性糖質を生成する組換え型耐熱性酵素 |
| JP3557289B2 (ja) | 1994-07-21 | 2004-08-25 | 株式会社林原生物化学研究所 | 非還元性糖質からトレハロースを遊離する組換え型耐熱性酵素 |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
| EP0707062B1 (en) * | 1994-09-16 | 2003-11-12 | Nihon Shokuhin Kako Co., Ltd. | Maltose phosphorylase, trehalose phosphorylase, plesiomonas strain and preparation process of trehalose |
| CZ88697A3 (en) | 1994-09-22 | 1997-09-17 | Quadrant Holdings Cambridge | Composition used for re-hydration and nourishment in the course of athletic outputs and processes for preparing thereof |
| JP3810457B2 (ja) * | 1994-10-01 | 2006-08-16 | 株式会社林原生物化学研究所 | マルトースをトレハロースに変換する組換え型耐熱性酵素 |
| US5892026A (en) * | 1995-04-12 | 1999-04-06 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | High Trehalose content syrup |
| US6964771B1 (en) | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
| US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
| US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
| US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
| US6468782B1 (en) | 1996-12-05 | 2002-10-22 | Quadrant Healthcare (Uk) Limited | Methods of preserving prokaryotic cells and compositions obtained thereby |
| JP4034846B2 (ja) * | 1996-12-10 | 2008-01-16 | 株式会社林原生物化学研究所 | 結晶性粉末糖質とその製造方法並びに用途 |
| EP0868916A3 (en) | 1997-03-04 | 2004-09-15 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Reduction inhibitory agent for active-oxygen eliminating activity |
| JP4034862B2 (ja) | 1997-06-02 | 2008-01-16 | 株式会社林原生物化学研究所 | スクロースの後味改善方法とその用途 |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| JPH11116588A (ja) | 1997-10-16 | 1999-04-27 | Hayashibara Biochem Lab Inc | トレハロース及び糖アルコールの製造方法 |
| JP3944323B2 (ja) | 1998-04-22 | 2007-07-11 | 株式会社林原生物化学研究所 | ノンフライ調理法とその用途 |
| JP4221078B2 (ja) | 1998-07-09 | 2009-02-12 | 株式会社林原生物化学研究所 | トレハロース２含水結晶とその製造方法並びに用途 |
| TWI283695B (en) | 1999-10-21 | 2007-07-11 | Hayashibara Biochem Lab | Thermoplastic shaped-body of trehalose, process and uses thereof |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| KR100877271B1 (ko) | 2001-04-26 | 2009-01-07 | 가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조 | 풀룰란 고함유 성형물과 그 제조방법 및 그 용도 |
| CN100469892C (zh) * | 2001-05-28 | 2009-03-18 | 江崎格力高株式会社 | 葡聚糖的生产方法和制备方法 |
| JP3759018B2 (ja) * | 2001-10-18 | 2006-03-22 | 株式会社林原生物化学研究所 | トレハロースを使用した梅肉シート |
| MXPA04005865A (es) | 2001-12-19 | 2004-09-13 | Nektar Therapeutics | Suministro de aminoglucosidos a los pulmones. |
-
1982
- 1982-06-07 JP JP9812582A patent/JPS58216695A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS58216695A (ja) | 1983-12-16 |
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