JPS6338325B2 - - Google Patents

Info

Publication number: JPS6338325B2
Authority: JP; Japan
Prior art keywords: ganoderan; nakahiro; ganoderma; water; molecular weight
Prior art date: 1984-03-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP59040745A

Other languages

English (en)

Japanese (ja)

Other versions

JPS60184025A (ja

Inventor

Hiroshi Hikino

Teruaki Hayashi

Takeshi Takahashi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Toyo Yakushoku Kogyo Co Ltd

Original Assignee

Toyo Yakushoku Kogyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-02

Filing date

1984-03-02

Publication date

1988-07-29

1984-03-02 Application filed by Toyo Yakushoku Kogyo Co Ltd filed Critical Toyo Yakushoku Kogyo Co Ltd

1984-03-02 Priority to JP59040745A priority Critical patent/JPS60184025A/ja

1985-09-19 Publication of JPS60184025A publication Critical patent/JPS60184025A/ja

1988-07-29 Publication of JPS6338325B2 publication Critical patent/JPS6338325B2/ja

Status Granted legal-status Critical Current

Links

XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
240000008397 Ganoderma lucidum Species 0.000 claims description 17
238000000034 method Methods 0.000 claims description 17
BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 claims description 16
235000001637 Ganoderma lucidum Nutrition 0.000 claims description 16
238000010828 elution Methods 0.000 claims description 16
238000004587 chromatography analysis Methods 0.000 claims description 15
239000003960 organic solvent Substances 0.000 claims description 13
239000000284 extract Substances 0.000 claims description 12
150000004676 glycans Chemical class 0.000 claims description 12
229920001282 polysaccharide Polymers 0.000 claims description 12
239000005017 polysaccharide Substances 0.000 claims description 12
239000003365 glass fiber Substances 0.000 claims description 11
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 10
239000012141 concentrate Substances 0.000 claims description 10
239000008103 glucose Substances 0.000 claims description 10
239000000203 mixture Substances 0.000 claims description 10
238000000921 elemental analysis Methods 0.000 claims description 9
238000002523 gelfiltration Methods 0.000 claims description 9
241000222336 Ganoderma Species 0.000 claims description 8
238000000862 absorption spectrum Methods 0.000 claims description 8
230000002218 hypoglycaemic effect Effects 0.000 claims description 8
238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims description 8
239000000126 substance Substances 0.000 claims description 8
235000001674 Agaricus brunnescens Nutrition 0.000 claims description 7
238000005194 fractionation Methods 0.000 claims description 7
238000002955 isolation Methods 0.000 claims description 7
239000002244 precipitate Substances 0.000 claims description 6
239000003472 antidiabetic agent Substances 0.000 claims description 5
229940126904 hypoglycaemic agent Drugs 0.000 claims description 5
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 4
239000007864 aqueous solution Substances 0.000 claims description 4
230000003287 optical effect Effects 0.000 claims description 4
239000004480 active ingredient Substances 0.000 claims description 3
241001480597 Ganoderma tsugae Species 0.000 claims description 2
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
238000001914 filtration Methods 0.000 claims 1
239000003456 ion exchange resin Substances 0.000 claims 1
229920003303 ion-exchange polymer Polymers 0.000 claims 1
239000000243 solution Substances 0.000 description 19
238000000502 dialysis Methods 0.000 description 13
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
235000008504 concentrate Nutrition 0.000 description 8
239000007788 liquid Substances 0.000 description 8
239000000843 powder Substances 0.000 description 8
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 5
241000196324 Embryophyta Species 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
239000000872 buffer Substances 0.000 description 4
238000000605 extraction Methods 0.000 description 4
239000000546 pharmaceutical excipient Substances 0.000 description 4
238000000108 ultra-filtration Methods 0.000 description 4
229920002684 Sepharose Polymers 0.000 description 3
239000008280 blood Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000003814 drug Substances 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000002994 raw material Substances 0.000 description 3
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
241001460425 Ganoderma sessile Species 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
239000012506 Sephacryl® Substances 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
238000002835 absorbance Methods 0.000 description 2
239000002775 capsule Substances 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000008187 granular material Substances 0.000 description 2
235000013402 health food Nutrition 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000000463 material Substances 0.000 description 2
239000012528 membrane Substances 0.000 description 2
-1 methanol and ethanol Chemical class 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
239000007787 solid Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
229920000936 Agarose Polymers 0.000 description 1
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
206010006458 Bronchitis chronic Diseases 0.000 description 1
244000223760 Cinnamomum zeylanicum Species 0.000 description 1
206010052895 Coronary artery insufficiency Diseases 0.000 description 1
229920002307 Dextran Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
241001489089 Ganoderma neojaponicum Species 0.000 description 1
241001235534 Graphis <ascomycete fungus> Species 0.000 description 1
208000031226 Hyperlipidaemia Diseases 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
208000007443 Neurasthenia Diseases 0.000 description 1
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
244000269722 Thea sinensis Species 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
239000003957 anion exchange resin Substances 0.000 description 1
206010003549 asthenia Diseases 0.000 description 1
239000011324 bead Substances 0.000 description 1
238000009835 boiling Methods 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
208000007451 chronic bronchitis Diseases 0.000 description 1
235000017803 cinnamon Nutrition 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
238000012258 culturing Methods 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
238000004821 distillation Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
208000006454 hepatitis Diseases 0.000 description 1
231100000283 hepatitis Toxicity 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000004575 stone Substances 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000003826 tablet Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Plant Substances (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

JP59040745A 1984-03-02 1984-03-02 多糖類，その単離法及び用途 Granted JPS60184025A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP59040745A JPS60184025A (ja)	1984-03-02	1984-03-02	多糖類，その単離法及び用途

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP59040745A JPS60184025A (ja)	1984-03-02	1984-03-02	多糖類，その単離法及び用途

Publications (2)

Publication Number	Publication Date
JPS60184025A JPS60184025A (ja)	1985-09-19
JPS6338325B2 true JPS6338325B2 (pt)	1988-07-29

Family

ID=12589166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP59040745A Granted JPS60184025A (ja)	1984-03-02	1984-03-02	多糖類，その単離法及び用途

Country Status (1)

Country	Link
JP (1)	JPS60184025A (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000143526A (ja) *	1998-11-13	2000-05-23	Asuke Yakuhin Kk	田七人参、霊芝、アガリクス茸を主成分とする糖尿・高血圧・肝機能改善剤およびこれの製造方法
JP2001131083A (ja) *	1999-11-01	2001-05-15	Sakamoto Bio:Kk	鹿角霊芝抽出物活性物質及びそれを含む医薬、健康食品、化粧料
JP5101769B2 (ja) *	2000-09-27	2012-12-19	日本メナード化粧品株式会社	生体の酸化防止または予防剤
JP2005104938A (ja) *	2003-10-02	2005-04-21	Matsukawa Kagaku:Kk	皮膚用化粧料

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54138116A (en) *	1978-04-17	1979-10-26	Morinaga & Co	Medical constituent of mannentake
JPS5657801A (en) *	1979-10-16	1981-05-20	Morinaga & Co Ltd	Ganoderma lucidum karst component and its preparation
JPS57112331A (en) *	1980-12-29	1982-07-13	Toyo Yakushiyoku Kogyo Kk	Medical composition of ganoderma lucidum component

1984
- 1984-03-02 JP JP59040745A patent/JPS60184025A/ja active Granted

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54138116A (en) *	1978-04-17	1979-10-26	Morinaga & Co	Medical constituent of mannentake
JPS5657801A (en) *	1979-10-16	1981-05-20	Morinaga & Co Ltd	Ganoderma lucidum karst component and its preparation
JPS57112331A (en) *	1980-12-29	1982-07-13	Toyo Yakushiyoku Kogyo Kk	Medical composition of ganoderma lucidum component

Also Published As

Publication number	Publication date
JPS60184025A (ja)	1985-09-19

Publication	Publication Date	Title
AU2004200624B2 (en)	2006-02-16	Medicinal preparation containing phenylethanoid glycosides extracted from herbaceous plant, cistanche tubulosa (schenk.) wight, process of making the same, and uses of the same
US5854404A (en)	1998-12-29	Antitumor substance extracted from grifola
JPH045652B2 (pt)	1992-02-03
GB1571075A (en)	1980-07-09	Method of isolating nitrogen-containing polysaccharides
HU188599B (en)	1986-04-28	Process for preparing physiologically active substance designated as ch-1
US4801582A (en)	1989-01-31	Method and composition for treating hypoglycemia using aloe polysaccharides
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DK145424B (da)	1982-11-15	Fremgangsmaade til fremstilling af nitrogenholdige polysaccharider med antitumorigen virkning
NL8620077A (nl)	1987-02-02	Nieuwe tanninesamenstelling.
JPS6338325B2 (pt)	1988-07-29
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