JPS6322510A - External preparation for skin - Google Patents
External preparation for skinInfo
- Publication number
- JPS6322510A JPS6322510A JP61165400A JP16540086A JPS6322510A JP S6322510 A JPS6322510 A JP S6322510A JP 61165400 A JP61165400 A JP 61165400A JP 16540086 A JP16540086 A JP 16540086A JP S6322510 A JPS6322510 A JP S6322510A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- peony
- pyridoxine
- external preparation
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 241000736199 Paeonia Species 0.000 claims abstract description 27
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 27
- 239000000284 extract Substances 0.000 claims abstract description 23
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 18
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 18
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 16
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 14
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 12
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 11
- 235000005282 vitamin D3 Nutrition 0.000 claims abstract description 11
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 11
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 11
- 229940021056 vitamin d3 Drugs 0.000 claims abstract description 11
- 229960002685 biotin Drugs 0.000 claims abstract description 9
- 235000020958 biotin Nutrition 0.000 claims abstract description 9
- 239000011616 biotin Substances 0.000 claims abstract description 9
- 235000008160 pyridoxine Nutrition 0.000 claims abstract description 9
- 239000011677 pyridoxine Substances 0.000 claims abstract description 9
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 9
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 8
- 235000001968 nicotinic acid Nutrition 0.000 claims abstract description 8
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 8
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 7
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims abstract description 7
- 235000019136 lipoic acid Nutrition 0.000 claims abstract description 7
- 229960002477 riboflavin Drugs 0.000 claims abstract description 7
- 235000019192 riboflavin Nutrition 0.000 claims abstract description 7
- 239000002151 riboflavin Substances 0.000 claims abstract description 7
- 229960002663 thioctic acid Drugs 0.000 claims abstract description 7
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 6
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 claims abstract description 6
- 229960003471 retinol Drugs 0.000 claims abstract description 6
- 235000020944 retinol Nutrition 0.000 claims abstract description 6
- 239000011607 retinol Substances 0.000 claims abstract description 6
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims abstract description 4
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 4
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims abstract description 4
- 239000011648 beta-carotene Substances 0.000 claims abstract description 4
- 229960002747 betacarotene Drugs 0.000 claims abstract description 4
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 4
- 229930002330 retinoic acid Natural products 0.000 claims description 5
- 229960001727 tretinoin Drugs 0.000 claims description 5
- 206010000496 acne Diseases 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 6
- 208000001840 Dandruff Diseases 0.000 abstract description 5
- 238000002156 mixing Methods 0.000 abstract description 4
- 210000004761 scalp Anatomy 0.000 abstract description 4
- 229940088594 vitamin Drugs 0.000 abstract description 4
- 229930003231 vitamin Natural products 0.000 abstract description 4
- 235000013343 vitamin Nutrition 0.000 abstract description 4
- 239000011782 vitamin Substances 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 2
- 230000003054 hormonal effect Effects 0.000 abstract description 2
- 230000007794 irritation Effects 0.000 abstract description 2
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 11
- 239000000203 mixture Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 8
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 8
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 8
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 8
- 208000002874 Acne Vulgaris Diseases 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 6
- 239000006071 cream Substances 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 239000002674 ointment Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- -1 ethanol Chemical compound 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
- 229940032094 squalane Drugs 0.000 description 3
- 230000001256 tonic effect Effects 0.000 description 3
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 150000001746 carotenes Chemical class 0.000 description 2
- 235000005473 carotenes Nutrition 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 210000004209 hair Anatomy 0.000 description 2
- 210000003780 hair follicle Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 210000002374 sebum Anatomy 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000001587 sorbitan monostearate Substances 0.000 description 2
- 235000011076 sorbitan monostearate Nutrition 0.000 description 2
- 229940035048 sorbitan monostearate Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 241001282290 Paeon Species 0.000 description 1
- 241001106477 Paeoniaceae Species 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 208000024330 bloating Diseases 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012456 homogeneous solution Substances 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/006—Antidandruff preparations
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野］
本発明は皮膚外用剤に関す
る。更に詳しくは、シャクヤク、ボタンピおよびそれら
の抽出物からなる群から選ばれた１種または２種以上と
、ピリドキシン、ビオチン、ニコチン酸、リポ酸、コレ
カルシフェロール、リボフラビン、レチノール、レチノ
イン酸、β−カロチン、コレカルシフェロール等および
それらの誘導体からなる群から選ばれた１種または２種
以上とを配合することを特徴とする皮膚外用剤に関する
もので、特にニキビの予防、治療、処置に有効に働き、
また、頭皮に使用してフケを有効に予防することができ
る。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external preparation for skin. More specifically, one or more selected from the group consisting of peony, botanpi and extracts thereof, and pyridoxine, biotin, nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid, β- This topical skin preparation is characterized by containing one or more selected from the group consisting of carotene, cholecalciferol, etc. and their derivatives, and is particularly effective for the prevention, treatment, and treatment of acne. work,
It can also be used on the scalp to effectively prevent dandruff.
［従来の技術］
ニキビは主として思春期に発現する皮膚疾患で病名を尋
常性線層といい、臨床的には゛°毛嚢脂腺系を中心に上
孔に起こる慢性の炎症性変化゛と定義されている。[Prior art] Acne is a skin disease that mainly occurs during adolescence, and is called stria vulgaris, and is clinically defined as ``chronic inflammatory changes that occur in the upper foramen, mainly in the pilosebaceous system.'' has been done.
ニキビの病因は現在まだ明らかではなく、種々の要因が
複雑にからみあっている皮膚疾患ではあるが一般には、
皮脂分泌過剰、毛嚢角化、毛嚢内細菌が重要な役割を果
たしていると考えられている。The etiology of acne is still unclear, and although it is a skin disease in which various factors are intricately intertwined, in general,
Excessive sebum secretion, hair follicle keratinization, and bacteria within the hair follicle are thought to play important roles.
従って、ニキビ治療の外用剤としては、各要因に対応し
て皮脂分泌抑制剤および抗菌剤を配合したクリーム、軟
膏が一般に多用されているほか各種ビタミン剤も症状に
応じて多用きれている。しかし、ビタミンは経皮で投与
した場合満足な治療効果は得られなかった。Therefore, as external preparations for treating acne, creams and ointments containing sebum secretion inhibitors and antibacterial agents are commonly used depending on the various factors, and various vitamin preparations are also used depending on the symptoms. However, when vitamins are administered transdermally, satisfactory therapeutic effects have not been obtained.
［発明が解決しようとする問題点］
本発明者らは、従来のいわゆるビタミン剤の効果を皮膚
上で増大きせるような化合物を研究していたところ、シ
ャクヤク、ボタンピまたはそれらの抽出物と、ピリドキ
シン、ビオチン、ニコチン酸、リポ酸、コレカルシフェ
ロール、リボフラビン、レチノール、レチノイン酸、β
−カロチン、コレカルシフェロール等またはそれらの誘
導体とを配合することを特徴とする皮膚外用剤が、この
目的を達成できることを見いだして、本発明を完成した
。[Problems to be Solved by the Invention] The present inventors were researching compounds that could enhance the effects of conventional so-called vitamins on the skin, and found that peony, botanpi or their extracts, and pyridoxine. , biotin, nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid, β
The present invention was completed based on the discovery that an external skin preparation characterized by containing carotene, cholecalciferol, etc. or derivatives thereof can achieve this objective.
［問題点を解決するための手段］
すなわち本発明は、シャクヤク、ボタンピおよびそれら
の抽出物からなる群から選ばれた１種又は２種以上と、
ピリドキシン、ビオチン、ニコチン酸、リポ酸、コレカ
ルシフェロール、リボフラビン、レチノール、レチノイ
ン酸、β−カロチン、コレカルシフェロールおよびそれ
らの誘導体からなる群から選ばれた１種又は２種以上と
を配合することを特徴とする皮膚外用剤である。かかる
皮膚外用剤は、特にニキビの予防、治療、処置に有効に
働き、また頭皮に使用してフケを有効に予防することが
できる。[Means for Solving the Problems] That is, the present invention provides one or more species selected from the group consisting of peonies, botanpi, and extracts thereof;
Blending one or more selected from the group consisting of pyridoxine, biotin, nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid, β-carotene, cholecalciferol, and derivatives thereof. It is a skin external preparation characterized by: Such external skin preparations are particularly effective in preventing, treating, and treating acne, and can also be used on the scalp to effectively prevent dandruff.
以下本発明の構成について詳述する。The configuration of the present invention will be explained in detail below.
本発明においては、シャクヤク、ボタンピおよびそれら
の抽出物からなる群から選ばれた任意の１種又は２種以
上を用いる。In the present invention, one or more selected from the group consisting of peonies, botanpis, and extracts thereof are used.
シャクヤクは、ボタン科（Ｐａｅｏｎ １ａｃｅａ’ｅ
）シャクヤクの根、またボタンピは同じくボタン科の
ボタンの根皮を乾燥したものである。シャクヤクまたは
ボタンピの抽出物は、上記のシャクヤクの根またはボタ
ンの根皮を水もしくは水性アルコール、たとえばエタノ
ールを用い、通常１５〜２５℃で抽出処理して得られる
。配合量は末、エキス（抽出溶媒を留去した残分）とも
に全組成中におおむね０．００５％（重量％）以上配合
する。配合量の上限は特に限定するものではないが着色
等の商品価値の観点から、乾燥残分として合計で約１０
％まで配合するのが好ましい。Peonies are members of the Paeonaceae family (Paeon 1acea'e).
) Peony root, also known as peony root, is the dried root bark of the peony, which also belongs to the peony family. The extract of Peony or Botanpi is obtained by extracting the root of the above-mentioned Peony or Botanpi using water or an aqueous alcohol, such as ethanol, usually at 15 to 25°C. The amount of the extract (residue after distilling off the extraction solvent) is approximately 0.005% (wt%) or more in the entire composition. The upper limit of the amount to be blended is not particularly limited, but from the viewpoint of commercial value such as coloring, the total amount of dry residue should be approximately 10
It is preferable to mix up to %.
本発明にはピリドキシン、ビオチン、ニコチン酸、リポ
酸、コレカルシフェロール、リボフラビン、レチノール
、レチノイン酸、β−カロチン、コレカルシフェロール
およびそれらの誘導体からなる群から選ばれた任意の１
種または２種以上を上記シャクヤク、ボタンピまたはそ
れらの抽出物に加えて用いる。The present invention includes any one selected from the group consisting of pyridoxine, biotin, nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid, β-carotene, cholecalciferol, and derivatives thereof.
Seeds or two or more seeds are used in addition to the above-mentioned peonies, botanpis, or extracts thereof.
配合量としては０．００１％以上５０％以下で、好まし
くは０．０１％以上２０以下である。The blending amount is 0.001% or more and 50% or less, preferably 0.01% or more and 20% or less.
本発明の皮膚外用剤には、シャクヤク、ボタンピおよび
それらの抽出物と、ピリドキシン、ビオチン、ニコチン
酸、リポ酸等およびそれらの誘導体のほかに、亜鉛およ
びその化合物、乳酸等の薬剤や角質剥離剤、抗の剤、抗
炎症剤および剤形によっても異なるが、油分、界面活性
剤、水、エタノール、保湿剤、増粘剤、香料、色素等を
本発明の効果を損なわない範囲で適宜配合することがで
きる。The skin external preparation of the present invention contains peony, botanpi, extracts thereof, pyridoxine, biotin, nicotinic acid, lipoic acid, etc., and derivatives thereof, as well as drugs such as zinc and its compounds, lactic acid, and exfoliating agents. , anti-inflammatory agent, anti-inflammatory agent, and dosage form, oils, surfactants, water, ethanol, humectants, thickeners, fragrances, pigments, etc. may be appropriately added within a range that does not impair the effects of the present invention. be able to.
本発明の皮膚外用剤の剤形は、クリーム、軟膏、ローシ
ョントニック等外皮に適用できる性状のものであればい
ずれでも良い。The external skin preparation of the present invention may be in any form as long as it can be applied to the skin, such as cream, ointment, lotion tonic, etc.
［発明の効果］
シャクヤク、ボタンピおよびそれらの抽出物の１種また
は２種以上とピリドキシン、ビオチン、ニコチン酸等お
よびそれらの誘導体を配合することを特徴とする皮膚外
用剤は非常に良く皮膚に浸透し、刺激やホルモン用副作
用を全く与えず、特にニキビの予防、治療、処置に有効
に働き、また、頭皮に使用してフケを有効に予防するこ
とができる。[Effect of the invention] A skin external preparation characterized by blending one or more of peony, botanpi, and their extracts with pyridoxine, biotin, nicotinic acid, etc. and their derivatives penetrates the skin very well. However, it does not cause any irritation or hormonal side effects, and is particularly effective in preventing, treating, and treating acne, and can be used on the scalp to effectively prevent dandruff.
［実施例］ 次に実施例を挙げて詳細に説明する。[Example] Next, a detailed explanation will be given with reference to examples.
実施例１ 化粧水
ソルビトール（７０％） ３．０ｇグリセ
リン ５．０ｇ塩酸ピリドキシン
０．２ｇ水
７０．０ｇこれらの成分を混合
溶解し、これに、
アラントイン ０．１ｇシャクヤ
クエキス ０．８ｇボタンピエキス
０・２ｇポリオキシエチレン硬化ヒ
マシ油誘導体０．７ｇ
エタノール ２０．０ｇ香ｊＥ＋
適量の混合溶液を攪拌
しながら加えて均一な溶液として化粧水を得る。Example 1 Lotion Sorbitol (70%) 3.0g Glycerin 5.0g Pyridoxine Hydrochloride 0.2g Water
70.0g Mix and dissolve these ingredients, add allantoin 0.1g peony extract 0.8g botanical extract
0.2g Polyoxyethylene hydrogenated castor oil derivative 0.7g Ethanol 20.0g Incense jE+
Add an appropriate amount of the mixed solution while stirring to obtain a lotion as a homogeneous solution.
実施例２ クリーム
ミツロウ １０．０ｇパラフィ
ンワックス ６．０ｇラノリン
３．０ｇイソプロピルミリステート
６．０ｇスクワラン
８．０ｇ流動パラフィン ２５．０
ｇシャクヤクエキス ０．５ｇビオチ
ン ２．０ｇポリオキシエチ
しンソルビタンモノステアレート
１ 、８ ｇソルビタンモノステアレート
４，２ｇ防腐剤 適量この成
分を混合し、約７５℃で加熱し溶解し、これに約７５℃
で、加熱した、
プロピレングリコール ２．Ｏｇホウ砂
０．５ｇ水
３１．０ｇの混合液を攪
拌しながら加え、冷却し、５５℃で香料を適量加え、４
５℃まで攪拌をつづけ、放置してクリームを得る。Example 2 Cream beeswax 10.0g paraffin wax 6.0g lanolin
3.0g isopropyl myristate 6.0g squalane
8.0g liquid paraffin 25.0
g Peony extract 0.5g biotin 2.0g polyoxyethin sorbitan monostearate
1,8 g sorbitan monostearate
4.2g preservative Mix appropriate amount of these ingredients, heat at about 75℃ to dissolve, and add to this at about 75℃
and heated propylene glycol 2. Og borax
0.5g water
Add 31.0g of the mixture while stirring, cool, add an appropriate amount of fragrance at 55°C,
Continue stirring until 5°C and leave to obtain cream.
実施例３ ヘアトニック
エタノール ５５．０ｇ塩酸リボ
フラビン ０．３ｇニッコールＨＣＯ
−６０ １．０ｇ香料
適量を室温下、溶解してアルコール相を得た。Example 3 Hair tonic ethanol 55.0g Riboflavin hydrochloride 0.3g Nikkor HCO
-60 1.0g fragrance
An appropriate amount was dissolved at room temperature to obtain an alcohol phase.
ボタンピエキス ０．７ｇ精製水
４２．０ｇグリセリン
１．０ｇ色素
適量の混合液を加熱下に溶解し冷却し水相を得た。Botanpi extract 0.7g purified water
42.0g glycerin
1.0g dye
An appropriate amount of the mixture was dissolved under heating and cooled to obtain an aqueous phase.
水相に前記アルコール相を加え可溶化してヘアトニック
を得た。The alcohol phase was added to the aqueous phase and solubilized to obtain a hair tonic.
実施例４ 軟膏
固体パラフィン １０．０ｇピースワ
ックス １０．０ｇスクワラン
１０．０ｇシャクヤクエキス
１．０ｇ塩酸ピリドキシン
０．５ｇイオウ ２．０
ｇ香料 適量ワセリン
６６．５ｇ上記成分を混合し、混
合物を８０℃に加熱溶解した後、攪拌冷却を行い、軟膏
を得た。Example 4 Ointment solid paraffin 10.0g peace wax 10.0g squalane
10.0g Peony extract
1.0g pyridoxine hydrochloride
0.5g sulfur 2.0
gFragrance Appropriate amount of Vaseline
66.5 g of the above components were mixed, the mixture was heated and dissolved at 80° C., and then cooled with stirring to obtain an ointment.
ざらに臨床例を挙げて本発明の効果を更に詳細に説明す
る。The effects of the present invention will be explained in more detail by briefly giving clinical examples.
（（５！用薬剤）
下記処方、製造法で得たローションタイプの皮膚外用剤
を使用した。((5! Drug) A lotion-type skin external preparation obtained by the following formulation and manufacturing method was used.
シャクヤクエキス １．０ｇＰ、Ｏ，
Ｅ、（６０モル）硬化ヒマシ油 ２．０ｇグリセリ
ン １０．０ｇジプロピレングリコ
ール １０．ｏｇｌ、３−ブチレングリコール
５．０ｇポリエチレングリコール１５００
５．０ｇ以上を６０’ Ｃで加熱溶解する。これに塩酸
ピリドキシン １．０ｇセチルイソオ
クタネート １０．○ｇスクワラン
５．０ｇメヂルパラベン
１．３ｇを同じく６０°Ｃに加熱溶解したものを
添加混合し、ホモミキサーで処理をしてゲルを作る。Peony extract 1.0gP, O,
E, (60 moles) hydrogenated castor oil 2.0 g glycerin 10.0 g dipropylene glycol 10. ogl, 3-butylene glycol 5.0g polyethylene glycol 1500
Heat and melt 5.0g or more at 60'C. Add to this pyridoxine hydrochloride 1.0g cetyl isooctane 10. ○g squalane
5.0g medylparaben
Add and mix 1.3 g of the same solution heated to 60°C, and process with a homomixer to form a gel.
次にこのゲルに
カルボキシビニルポリマー ０．３ｇへキサメ
タリン酸ソーダ ０．０８ｇを、
イオン交換水 １１．０ｇに溶解せ
しめたものを徐添加しホモミキサーで分散した後、
水酸化カリウム ０．１２ｇを
イオン交換水 ３８．２ｇに溶解した
ものを添加混合し、ホモミキサーで乳化してローション
タイプの皮膚外用剤を得た。Next, 0.3 g of carboxyvinyl polymer and 0.08 g of sodium hexametaphosphate dissolved in 11.0 g of ion-exchanged water were slowly added to this gel and dispersed with a homomixer, and then 0.12 g of potassium hydroxide was added to the ion-exchanged water. A solution dissolved in 38.2 g of exchanged water was added and mixed, and the mixture was emulsified using a homomixer to obtain a lotion-type skin preparation for external use.
なお対照薬剤としてシャクヤク抽出エキスのみまたは塩
酸ピリドキシンのみ合した外用剤を用いた。なお補正は
イオン交換水で行った。As control drugs, external preparations containing only peony extract or only pyridoxine hydrochloride were used. Note that correction was performed using ion-exchanged water.
症例Ｎｏ、 １〜１０ 塩酸ピリドキシンのみ配合。Case No. 1 to 10: Contains only pyridoxine hydrochloride.
症例Ｎｏ、１１〜２０ シャクヤク抽出エキスのみ配合
。Case No. 11-20 Contains only peony extract.
症例Ｎｏ、２１〜３０ 塩酸ピリドキシン＋シャクヤク
抽出エキス配合。Case No. 21-30 Contains pyridoxine hydrochloride + peony extract.
以上男女計３０名に約１カ月使用させな。A total of 30 men and women were allowed to use the product for about a month.
（使用方法）
化粧石鹸を用いて顔面をよ（洗浄した後、支庁の上にの
み、前記したローションタイプの皮膚外用剤を１日に１
〜３回塗布せしめた。(How to use) Wash your face with soap (after washing, apply the lotion type skin preparation mentioned above only on the branch area once a day)
It was applied ~3 times.
（観察項目および観察口）
面飽、丘疹、膿庖の３症状について観察し、その個々の
所見の程度をを総合して尋常性前症の重篤度を、重症、
中等症、軽症の３段階に分けた。経過観察は、治療前、
治療１週間後、２週間後、３週間後、４週間後の各回に
行った。(Observation items and observation ports) Observe the three symptoms of bloating, papules, and pus, and combine the severity of each individual finding to determine the severity of pre-vulgaris.
The symptoms were divided into three stages: moderate and mild. Follow-up is before treatment,
The test was conducted 1 week, 2 weeks, 3 weeks, and 4 weeks after the treatment.
（全般改善度）
使用前に比較して使用薬剤による症状の改善度、著しく
軽快（＋＋＋） 、かなり軽快（＋）、やや軽快（＋）
、不変（±）、増悪（−）の５段階に分けた。(Overall improvement level) Compared to before use, the degree of improvement in symptoms due to the drug used: markedly relieved (+++), considerably relieved (+), somewhat relieved (+)
It was divided into 5 stages: no change (±), and worsening (-).
（有用性）
全般改善度から、きわめて有用（＋＋＋）、かなり有用
（什）、やや有用（＋）、無効（±）と判定した。(Usefulness) Based on the overall degree of improvement, it was judged as extremely useful (+++), quite useful (slightly), somewhat useful (+), and ineffective (±).
（結果）
男４名、女２６名計３０名の臨床テスト結果は、塩酸ピ
リドキシンのみ配合外用剤使用１０名中＋（やや有用）
が６名（６０％）、±（無効）が４名（４０χ）、シャ
クヤク抽出物のみ配合外用剤使用１０名中＋（やや有用
）が３名（３０′Ｘ）、±（無効）が７名（７０χ）、
塩酸ピリドキシン＋シャクヤク抽出物配合外用剤使用１
０名中Ｈ＋（％わめて有用）が３名（３０χ）、什（か
なり有用）が５名（５０χ）、＋（やや有用）が２名（
２０％）であり、本発明のニキビ治療効果が立証された
。(Results) The clinical test results for a total of 30 people (4 men and 26 women) were + (slightly useful) out of 10 people using topical preparations containing only pyridoxine hydrochloride.
6 people (60%) answered ± (ineffective), 4 people (40χ), out of 10 people who used external preparations containing only peony extract, 3 people said + (slightly useful) (30'X), 7 people said ± (ineffective). name (70χ),
Use of external preparation containing pyridoxine hydrochloride + peony extract 1
Out of 0 people, 3 people (30χ) said H+ (% extremely useful), 5 people (50χ) said ``fairly useful'', and 2 people said + (somewhat useful) (
20%), demonstrating the effectiveness of the present invention in treating acne.
Claims (1)
から選ばれた１種又は２種以上と、ピリドキシン、ビオ
チン、ニコチン酸、リポ酸、コレカルシフェロール、リ
ボフラビン、レチノール、レチノイン酸、β−カロチン
、コレカルシフェロールおよびそれらの誘導体からなる
群から選ばれた１種又は２種以上とを配合することを特
徴とする皮膚外用剤。One or more selected from the group consisting of peonies, botanpi, and their extracts, and pyridoxine, biotin, nicotinic acid, lipoic acid, cholecalciferol, riboflavin, retinol, retinoic acid, β-carotene, and cholecalciferol. 1. A skin preparation for external use, characterized in that it contains one or more selected from the group consisting of ferols and their derivatives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61165400A JPS6322510A (en) | 1986-07-14 | 1986-07-14 | External preparation for skin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61165400A JPS6322510A (en) | 1986-07-14 | 1986-07-14 | External preparation for skin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS6322510A true JPS6322510A (en) | 1988-01-30 |
Family
ID=15811689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61165400A Pending JPS6322510A (en) | 1986-07-14 | 1986-07-14 | External preparation for skin |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6322510A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047116A1 (en) * | 1998-03-16 | 1999-09-23 | The Procter & Gamble Company | Skin care compositions |
| KR20010097012A (en) * | 2000-04-19 | 2001-11-08 | 손 경 식 | The Cosmetic Compositions for Controlling Sebum and Anti-Acne |
| JP2002535347A (en) * | 1999-01-28 | 2002-10-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Crude drug preparation containing biotin |
| EP1185257A4 (en) * | 1999-12-30 | 2003-04-23 | Nicholas V Perricone | Treatment of acne using lipoic acid |
| WO2005044214A1 (en) * | 2003-11-06 | 2005-05-19 | Unilever Plc | Improved cosmetic composition comprising vitamin b3, vitamin b6 and an organic acid |
| CN103816245A (en) * | 2012-06-12 | 2014-05-28 | 唐山职业技术学院 | Externally-used medicine for treating pimple |
| JP2014227374A (en) * | 2013-05-22 | 2014-12-08 | ピアス株式会社 | Composition, cosmetic preparation, and external skin preparation for improving pore |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS559007A (en) * | 1978-07-03 | 1980-01-22 | Aruso Lab Sa Esu Dei Dokutaa P | Composition for head skin treatment and hair loss prevention |
| JPS5823612A (en) * | 1981-08-04 | 1983-02-12 | Osaka Chem Lab | Cosmetic composition containing crude drug component |
| JPS5910506A (en) * | 1982-07-09 | 1984-01-20 | Lion Corp | Cosmetic composition |
| JPS5982371A (en) * | 1981-04-23 | 1984-05-12 | ダイオメツド・デベロプメンツ・リミテツド | Nitroimidazole compound, composition and manufacture |
| JPS60146829A (en) * | 1984-01-05 | 1985-08-02 | Rooto Seiyaku Kk | Testosterone 5alpha-reductase inhibitor |
| JPS6140210A (en) * | 1984-06-01 | 1986-02-26 | ロシデイ・イスマイル | Skin treating and protecting drug |
-
1986
- 1986-07-14 JP JP61165400A patent/JPS6322510A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS559007A (en) * | 1978-07-03 | 1980-01-22 | Aruso Lab Sa Esu Dei Dokutaa P | Composition for head skin treatment and hair loss prevention |
| JPS5982371A (en) * | 1981-04-23 | 1984-05-12 | ダイオメツド・デベロプメンツ・リミテツド | Nitroimidazole compound, composition and manufacture |
| JPS5823612A (en) * | 1981-08-04 | 1983-02-12 | Osaka Chem Lab | Cosmetic composition containing crude drug component |
| JPS5910506A (en) * | 1982-07-09 | 1984-01-20 | Lion Corp | Cosmetic composition |
| JPS60146829A (en) * | 1984-01-05 | 1985-08-02 | Rooto Seiyaku Kk | Testosterone 5alpha-reductase inhibitor |
| JPS6140210A (en) * | 1984-06-01 | 1986-02-26 | ロシデイ・イスマイル | Skin treating and protecting drug |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047116A1 (en) * | 1998-03-16 | 1999-09-23 | The Procter & Gamble Company | Skin care compositions |
| JP2002535347A (en) * | 1999-01-28 | 2002-10-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Crude drug preparation containing biotin |
| EP1185257A4 (en) * | 1999-12-30 | 2003-04-23 | Nicholas V Perricone | Treatment of acne using lipoic acid |
| JP2003519165A (en) * | 1999-12-30 | 2003-06-17 | ブイー ペリコン，ニコラス | Acne Treatment Using Lipoic Acid |
| KR20010097012A (en) * | 2000-04-19 | 2001-11-08 | 손 경 식 | The Cosmetic Compositions for Controlling Sebum and Anti-Acne |
| WO2005044214A1 (en) * | 2003-11-06 | 2005-05-19 | Unilever Plc | Improved cosmetic composition comprising vitamin b3, vitamin b6 and an organic acid |
| US7332152B2 (en) | 2003-11-06 | 2008-02-19 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Cosmetic composition |
| CN103816245A (en) * | 2012-06-12 | 2014-05-28 | 唐山职业技术学院 | Externally-used medicine for treating pimple |
| JP2014227374A (en) * | 2013-05-22 | 2014-12-08 | ピアス株式会社 | Composition, cosmetic preparation, and external skin preparation for improving pore |
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