JPH11263714A - Cosmetic for scalp and hair of head - Google Patents
Cosmetic for scalp and hair of headInfo
- Publication number
- JPH11263714A JPH11263714A JP10084986A JP8498698A JPH11263714A JP H11263714 A JPH11263714 A JP H11263714A JP 10084986 A JP10084986 A JP 10084986A JP 8498698 A JP8498698 A JP 8498698A JP H11263714 A JPH11263714 A JP H11263714A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- cosmetic
- tincture
- extract
- scalp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、頭皮頭髪用化粧料
（以下，頭髪用化粧料という）に関する技術分野の発明
である。より詳細には、優れた養毛効果や脱毛防止効
果，頭皮のふけ，かゆみの防止効果を有し，かつ安全性
にも優れる頭髪用化粧料に関し、本発明頭髪用化粧料
は、特に医薬品，医薬部外品又は化粧品の分野において
用いられる。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scalp hair cosmetic (hereinafter referred to as "hair cosmetic"). More specifically, the present invention relates to a hair cosmetic which has an excellent hair-growing effect and an effect of preventing hair loss, an effect of preventing dandruff and itchiness of the scalp, and which is also excellent in safety. Used in the field of quasi-drugs or cosmetics.
【０００２】[0002]
【従来の技術】頭髪用化粧料には、様々な種類があり、
様々な頭皮頭髪状態に対応した製品が存在している。例
えば、頭皮における血液循環を良好にして、頭皮におけ
るふけやかゆみを防止し、脱毛を防止し得る製品が開発
されている。頭皮における様々なトラブルは、高齢化社
会を迎えた今日では、社会的ストレスの増大も伴って増
加しつつあり、この頭皮におけるトラブルに対応した頭
髪用化粧料の需要は急増している。一般に、頭部の禿や
脱毛の原因としては、毛包上部の皮脂腺等の器官におけ
る男性ホルモンの活性化、毛乳頭や毛包への血流量の低
下による栄養物質の供給不足、上皮組織の角化異常等に
よるふけの過剰発生、過剰な皮脂分泌、過酸化脂質の生
成、ストレス等が挙げられる。ふけ等が過剰になると、
頭皮細菌などで分解され、分解物が頭皮を刺激し、かゆ
みや炎症等を伴う脱毛を引き起こし得る。また、丈夫で
美しい毛髪を育てるうえで、毛乳頭や毛包への十分な栄
養補給が大切である。毛乳頭や毛包への血流量の低下
は、栄養不足や老廃物の***の機能の低下を招き、細毛
ややせ毛の原因となる。2. Description of the Related Art There are various types of hair cosmetics.
There are products for various scalp hair conditions. For example, products have been developed that can improve blood circulation in the scalp, prevent dandruff and itch on the scalp, and prevent hair loss. Various troubles on the scalp are increasing with the increase of social stress in today's aging society, and the demand for hair cosmetics corresponding to the trouble on the scalp is rapidly increasing. In general, causes of baldness and hair loss on the head include activation of androgens in organs such as the sebaceous glands above the hair follicles, insufficient supply of nutrients due to a decrease in blood flow to the hair papilla and hair follicles, and corneal epithelium. Excessive dandruff, excessive sebum secretion, production of lipid peroxide, stress, and the like due to malformation and the like. When dandruff becomes excessive,
It is decomposed by scalp bacteria and the like, and the decomposed substance stimulates the scalp and may cause hair loss accompanied by itching and inflammation. In addition, in order to grow durable and beautiful hair, it is important to provide sufficient nutrition to the nipples and hair follicles. A decrease in blood flow to the dermal papilla or hair follicle causes nutritional deficiency and a decrease in the function of excreting waste products, and causes fine hair and thin hair.
【０００３】従来の頭髪用化粧料は、一般に、上述した
ような禿や脱毛等の原因と考えられる要素を取り除いた
り、軽減する作用を持つ物質を配合したものである。例
えば、頭皮における血流循環を良好にするために、セン
ブリエキス，ビタミンＥ及びその誘導体，アセチルコリ
ン誘導体，セファランチン等の血行促進剤，トウガラシ
チンキ等の局所刺激剤が、過剰な皮脂分泌等により起こ
る頭皮の炎症を抑制するために紫根エキス等の消炎剤
が、男性ホルモンを抑制するためにエストラジオール等
の女性ホルモン剤が、ふけやかゆみを防止するためにサ
リチル酸等の抗菌剤が、また、毛包等への栄養補給のた
めにセリン，メチオニン等のアミノ酸類、ビタミン類等
が配合され、禿や脱毛、ふけやかゆみ等の予防及び治療
に用いられている。[0003] Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be causes of baldness, hair loss and the like as described above. For example, in order to improve blood circulation in the scalp, a blood circulation enhancer such as assembly extract, vitamin E and its derivatives, an acetylcholine derivative, cepharanthin and the like, and a local stimulant such as chili tincture are caused by excessive sebum secretion and the like. Antiinflammatory agents such as purple root extract to suppress inflammation of the skin, female hormones such as estradiol to suppress androgen, antibacterial agents such as salicylic acid to prevent dandruff and itching, and hair follicles Amino acids such as serine and methionine, vitamins, and the like are blended for nutritional supplementation, and are used for prevention and treatment of baldness, hair loss, dandruff and itching.
【０００４】[0004]
【発明が解決しようとする課題】しかしながら、これら
の成分を少量のみ頭髪用化粧料中に配合しても十分な効
果を得ることは難しく、逆に、大量に配合すると使用部
分及びその周辺に不快な刺激感や発赤を伴う傾向が強ま
り、自ずとその配合量には限界があった。However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into cosmetics for hair. There was a strong tendency to be accompanied by a tingling sensation and redness, and the blending amount was naturally limited.
【０００５】そこで本発明が解決すべき課題は、優れた
養毛効果や脱毛防止効果，頭皮のふけ，かゆみの防止効
果を有し、かつ安全性にも優れる頭髪用化粧料を提供す
ることである。The problem to be solved by the present invention is to provide a hair cosmetic which has an excellent hair-growth effect, an effect of preventing hair loss, an effect of preventing dandruff and itching of the scalp, and which is also excellent in safety. is there.
【０００６】[0006]
【課題を解決するための手段】本発明者は、この課題の
解決に向けて鋭意検討を行った。その結果、局所刺激剤
と、特定のアミンオキシドとを組み合わせて配合するこ
とにより、優れた養毛効果や脱毛防止効果，頭皮のふ
け，かゆみの防止効果を有し、かつ安全性にも優れる頭
髪用化粧料が提供されることを見出し、本発明を完成し
た。Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by combining a topical stimulant with a specific amine oxide, the hair has an excellent hair nourishing effect, a hair loss preventing effect, a scalp dandruff and itching preventing effect, and is also excellent in safety. The present inventors have found that cosmetics for cosmetics are provided and completed the present invention.
【０００７】すなわち本発明は、１）局所刺激剤、並び
に、２）オレイルジメチルアミンオキシド及び／又はイ
ソステアリルジメチルアミンオキシドを含有する頭髪用
化粧料を提供する発明である。That is, the present invention is an invention which provides a hair cosmetic containing 1) a topical stimulant and 2) oleyldimethylamine oxide and / or isostearyldimethylamine oxide.
【０００８】また、この局所刺激剤が、トウガラシチン
キ，カンタリスチンキ，カンフル及びノニル酸ワニリル
アミドからなる群の局所刺激剤から選ばれる１種又は２
種以上の局所刺激剤である場合が、特に所定の効果を有
効に発揮し得る。また、この頭髪用化粧料が、局所刺激
剤を、頭髪用化粧料全体に対して０．００１〜２．０重
量％含有する場合が、特に所期の効果を良好に発揮し得
る。The local stimulant may be one or two selected from the group consisting of pepper tincture, tincture tincture, camphor and vanillyl amide nonylate.
In particular, a certain effect can be effectively exerted when the local stimulant is more than one kind. In addition, when the cosmetic for hair contains a topical stimulant in an amount of 0.001 to 2.0% by weight based on the total weight of the cosmetic for hair, the intended effect can be particularly favorably exhibited.
【０００９】[0009]
【発明の実施の形態】以下、本発明の実施の形態につい
て説明する。本発明頭髪用化粧料は、局所刺激剤とオレ
イルジメチルアミンオキシド及び／又はイソステアリル
ジメチルアミンオキシドとを組み合わせて配合すること
により、所期の効果を発揮する頭髪用化粧料である。Embodiments of the present invention will be described below. The cosmetic for hair of the present invention is a cosmetic for hair that exerts an intended effect by combining a topical stimulant with oleyldimethylamine oxide and / or isostearyldimethylamine oxide.
【００１０】本発明頭髪用化粧料中に配合可能な局所刺
激剤は、それを皮膚上に塗布することにより，人体のそ
の部分を刺激することが可能であり、かつ外用剤の配合
成分として安全性上問題がない限り、特に限定されるも
のではなく、その作用機序も問われるべきものではな
い。[0010] The topical irritant that can be incorporated into the cosmetic for hair of the present invention can irritate that part of the human body by applying it on the skin, and is safe as a component of an external preparation. There is no particular limitation as long as there is no sexual problem, and the mechanism of action is not to be questioned.
【００１１】具体的には、トウガラシチンキ，カンタリ
スチンキ，カンフル，ノニル酸ワニリルアミド，ショウ
キョウチンキ，ニコチン酸ベンジルエステル等の従来か
ら頭髪用化粧料に局所刺激剤として配合されているもの
を適宜選択することができる。これらの局所刺激剤のう
ちでも特に、トウガラシチンキ，カンタリスチンキ，カ
ンフル又はノニル酸ワニリルアミドを選択して本発明頭
髪用化粧料中に配合することが好ましい。[0011] Specifically, those conventionally compounded as a local stimulant in cosmetics for hair, such as pepper tincture, tincture tincture, camphor, vanillyl amide nonylate, tincture tincture, and benzyl nicotinate, are appropriately selected. can do. Among these local stimulants, it is particularly preferable to select tincture tincture, tincture tincture, camphor or nonylate wanillylamide and blend it in the cosmetic for hair of the present invention.
【００１２】トウガラシチンキは、トウガラシ又はその
変種の果実をエタノールで抽出して得たチンキであり、
皮膚刺激作用，毛根刺激作用，頭皮刺激作用等があるこ
とが知られている。トウガラシチンキは市販されており
（例えば、アルプス薬品工業，香栄興業，小城製薬
等）、本発明頭髪用化粧料においては、トウガラシ等の
果実をエタノールで抽出して得たチンキも、市販されて
いるトウガラシチンキも配合することができる。[0012] Pepper tincture is a tincture obtained by extracting the fruit of a pepper or a variety thereof with ethanol,
It is known that it has a skin stimulating action, a hair root stimulating action, a scalp stimulating action, and the like. Pepper tincture is commercially available (for example, Alps Pharmaceutical Industries, Koei Kogyo, Koshiro Pharmaceutical, etc.), and in the cosmetic for hair of the present invention, tincture obtained by extracting fruits such as peppers with ethanol is also commercially available. Pepper tincture can also be added.
【００１３】カンタリスチンキは、マメハンミョウを乾
燥したものをエタノールで抽出して得たチンキ剤であ
る。カンタリスチンキも、皮膚刺激作用，毛根刺激作
用，頭皮刺激作用等があることが知られており、すでに
市販されている（例えば、小城製薬，司生堂製薬等）。
本発明頭髪用化粧料においては、マメハンミョウを乾燥
したものをエタノールで抽出して得たチンキも、市販さ
れているカンタリスチンキも配合することができる。[0013] Cantaris tincture is a tincture obtained by extracting dried bean halibut with ethanol. Cantaris tincture is also known to have a skin stimulating action, a hair root stimulating action, a scalp stimulating action, and the like, and is already commercially available (eg, Ogi Pharmaceutical, Shiseido Pharmaceutical, etc.).
In the cosmetic for hair of the present invention, a tincture obtained by extracting a dried bean halibut with ethanol and a commercially available tincture tincture can be blended.
【００１４】カンフルは、二環性モノテルペンケトンの
一つであり、局所刺激作用，中枢刺激作用，防腐作用等
があることが知られている。カンフルにはｄ−カンフ
ル，ｌ−カンフル及びｄｌ−カンフルがあるが、ｄ−カ
ンフル及びｄｌ−カンフルが一般に使用される。ｄ−カ
ンフルはクスノキ等中に含まれ材片を水蒸気蒸留して得
られ、また，ｄｌ−カンフルは、公知の方法、例えばピ
ネンよりの合成で得られる。これらのカンフルはすでに
市販されており（例えば、日本精化，小城製薬，日本テ
ルペン化学等）、本発明頭髪用化粧料においては、クス
ノキ等の材片から得たｄ−カンフル及び公知の方法で合
成したｄｌ−カンフルも、市販のｄ−カンフル及びｄｌ
−カンフルも配合することができる。[0014] Camphor is one of the bicyclic monoterpene ketones, and is known to have a local stimulating action, a central stimulating action, an antiseptic action and the like. The camphor includes d-camphor, 1-camphor and dl-camphor, but d-camphor and dl-camphor are generally used. d-Camphor is obtained by steam distillation of a piece contained in camphor and the like, and dl-camphor is obtained by a known method, for example, synthesis from pinene. These camphors are already commercially available (for example, Nippon Seika, Koshiro Pharmaceutical, Nippon Terpene Chemical, etc.), and in the cosmetic for hair of the present invention, d-camphor obtained from a piece of camphor tree or the like and a known method. Synthesized dl-camphor is also commercially available d-camphor and dl
-Camphor can also be included.
【００１５】ノニル酸ワニリルアミドは、下記に示した
構造を有する化合物で、性状としては白色〜類白色の結
晶性粉末で、わずかに特異臭がある。皮膚刺激作用、末
梢血管拡張作用があり、筋肉痛、神経炎、座骨神経痛な
どに外用剤としての使用が知られている。ノニル酸ワニ
リルアミドの製法は公知ではないが、市販されており
（例えば、マツモト交商）、本発明頭髪用化粧料におい
ては、市販されているノニル酸ワニリルアミドを配合す
る。Nonylic acid vanillylamide is a compound having the structure shown below, and is a white to almost white crystalline powder having a slightly peculiar odor. It has a skin stimulating action and a peripheral vasodilating action, and is known to be used as an external preparation for muscle pain, neuritis, sciatica and the like. Although the method for producing nonylate varnish is not known, it is commercially available (for example, Matsumoto Trading), and the cosmetic for hair of the present invention contains commercially available nonylate varnishylamide.
【化１】 Embedded image
【００１６】本発明頭髪用化粧料において、局所刺激剤
は、１種類のみを配合することも、２種類以上の局所刺
激剤を組み合わせて配合することもでき、特に、トウガ
ラシチンキ，カンタリスチンキ，カンフル及びノニル酸
ワニリルアミドからなる群の局所刺激剤から選ばれる１
種の局所刺激剤を配合するか、又は２種以上の局所刺激
剤を組み合わせて配合するのが好ましい。In the cosmetic for hair of the present invention, the topical stimulant may be used alone or in combination of two or more kinds of local stimulants. In particular, pepper tincture, canthalis tincture, 1 selected from a group of topical stimulants consisting of camphor and nonylate vanillylamide
It is preferred to formulate two or more local stimulants or to combine two or more local stimulants.
【００１７】本発明頭髪用化粧料においては、局所刺激
剤は、頭髪用化粧料全体に対して０．００１〜２．０重
量％の範囲で配合されるのが好ましい。局所刺激剤の配
合量が頭髪用化粧料全体に対して０．００１重量％未満
であると十分な局所刺激効果が得られず好ましくない。
また、頭髪用化粧料全体に対して２．０重量％を超える
と、製剤上不都合を生じる傾向が強まるだけでなく、さ
らに頭皮に不快な刺激感を与える等、安全性の側面から
も問題が生じる恐れがあり好ましくない。In the hair cosmetic of the present invention, the topical stimulant is preferably contained in the range of 0.001 to 2.0% by weight based on the total weight of the hair cosmetic. If the amount of the local stimulant is less than 0.001% by weight based on the total weight of the cosmetic for hair, a sufficient local stimulating effect cannot be obtained, which is not preferable.
On the other hand, if the content exceeds 2.0% by weight based on the total weight of the cosmetic for hair, not only the tendency to cause inconvenience in the formulation increases, but also a scalp gives an unpleasant irritating sensation. It is not preferable because it may occur.
【００１８】上記の局所刺激剤と共に本発明毛髪化粧料
中に配合される、オレイルジメチルアミンオキシド及び
／又はイソステアリルジメチルアミンオキシドは、次式
で表される：The oleyl dimethylamine oxide and / or isostearyl dimethylamine oxide to be incorporated into the hair cosmetic composition of the present invention together with the above-mentioned topical stimulant is represented by the following formula:
【化２】 これらのジメチルアミンオキシドは、従来公知のアミン
オキシドの製造方法に従って製造することができる。Embedded image These dimethylamine oxides can be produced according to a conventionally known method for producing an amine oxide.
【００１９】本発明頭髪用化粧料中におけるオレイルジ
メチルアミンオキシド及び／又はイソステアリルジメチ
ルアミンオキシドの配合量は、頭髪用化粧料全体に対し
て０．０００１重量％〜２０．０重量％が好ましく、同
０．０５重量％〜５．０重量％が特に好ましい。The content of oleyldimethylamine oxide and / or isostearyldimethylamine oxide in the hair cosmetic composition of the present invention is preferably 0.0001% by weight to 20.0% by weight based on the total weight of the hair cosmetic composition. Particularly preferred is 0.05% by weight to 5.0% by weight.
【００２０】この配合量が頭髪用化粧料全体に対して
０．０００１重量％未満では、十分な消炎効果を発揮す
ることができず好ましくなく、同２０．０重量％を超え
て配合すると、製剤上不都合を生ずる傾向が強くなり，
また皮膚刺激性が生ずる等の点から好ましくない。If the amount is less than 0.0001% by weight based on the total weight of the cosmetic for hair, a sufficient anti-inflammatory effect cannot be exerted, which is not preferable. The tendency to cause inconvenience becomes stronger,
Further, it is not preferable from the point that skin irritation occurs.
【００２１】このようにして、局所刺激剤と、オレイル
ジメチルアミンオキシド及びイソステアリルジメチルア
ミンオキシドの１種又は２種とを組み合わせて配合する
ことにより、優れた養毛効果や脱毛防止効果，頭皮のふ
け，かゆみの防止効果を有し、かつ安全性にも優れる本
発明頭髪用化粧料が提供される。In this way, by combining the topical stimulant with one or two of oleyldimethylamine oxide and isostearyldimethylamine oxide, an excellent hair-growth effect, an anti-hair loss effect, and a scalp The present invention provides a hair cosmetic composition having an effect of preventing dandruff and itching and having excellent safety.
【００２２】なお、本発明頭髪用化粧料中には、通常頭
髪用化粧料中に配合される薬効成分を、その薬効成分が
有する一般的な効果を発揮させる目的のために、本発明
の所期の効果を損なわない限りにおいて配合することも
可能である。In the hair cosmetic composition of the present invention, the medicinal component usually incorporated in the hair cosmetic composition is used in order to exert the general effect of the medicinal component. It is also possible to mix as long as the effect of the period is not impaired.
【００２３】例えば、センブリエキス，ビタミンＥ若し
くはその誘導体，アセチルコリン誘導体，セファランチ
ン，塩化カルプロニウム等の血行促進剤；ピリドキシン
若しくはその誘導体，イオウ，ビタミンＢ6 等の抗脂漏
剤；塩化ベンザルコニウム，イソプロピルメチルフェノ
ール，レゾルシン，ジンクピリチオン，感光素１０１
号，感光素１０２号，サリチル酸，サリチル酸ナトリウ
ム，オルトピロックス，ヒノキチオール等の抗菌剤；感
光素３０１号，プラセンタエキス，ビオチン等の代謝賦
活剤；グリチルリチン酸，グリチルレチン酸，若しくは
それらの誘導体，紫根エキス，メントール等の消炎剤；
エストラジオール，エストロン等の女性ホルモン；セリ
ン，メチオニン，トリプトファン等のアミノ酸類，ビタ
ミンＡ，Ｂ2,Ｂ12, Ｄ，パントテン酸若しくはその誘導
体などのビタミン類等を本発明頭髪用化粧料中に配合す
ることもできる。[0023] For example, assembly extract, vitamin E or its derivatives, acetylcholine derivatives, cepharanthin, blood circulation promoters, such as carpronium chloride; pyridoxine or derivatives thereof, sulfur, anti-seborrhoeic agents such as vitamin B 6; benzalkonium chloride, isopropyl Methylphenol, resorcin, zinc pyrithione, photosensitizer 101
No. 102, photosensitizer 102, antibacterial agents such as salicylic acid, sodium salicylate, orthopyrox, hinokitiol, etc .; metabolic activators such as photosensitizer 301, placenta extract, biotin, etc .; , Menthol and other anti-inflammatory agents;
Female hormones such as estradiol and estrone; amino acids such as serine, methionine and tryptophan; vitamins such as vitamins A, B 2 , B 12 , D, pantothenic acid and derivatives thereof are incorporated into the cosmetic for hair of the present invention. You can also.
【００２４】また、通常頭髪用化粧料中に配合される植
物抽出物、例えばアルテア抽出物，ヨクイニン抽出物，
ペパーミント抽出物，ヨウテイ抽出物，トウガラシ抽出
物，アロエ抽出物，クコ抽出物，ヨモギ抽出物，イネ抽
出物，マンケイシ抽出物，マンネンロウ抽出物，コッサ
イホ抽出物，エニシダ抽出物，リンドウ抽出物，タンジ
ン抽出物，ヘチマ抽出物，キキョウ抽出物，マツ抽出
物，クジン抽出物，トウキ抽出物，ベニバナ抽出物，メ
ギ抽出物，ビンロウジ抽出物，ユーカリ抽出物，カゴソ
ウ抽出物，モクソウ抽出物，ゴシツ抽出物，サイコ抽出
物，チャ抽出物，カンゾウ抽出物，ホップ抽出物，キク
抽出物，セネガ抽出物，ゴマ抽出物，センキュウ抽出
物，カシュウ抽出物，カッコン抽出物，マイカイカ抽出
物，サフラン抽出物，ローズマリー抽出物，ジオウ抽出
物，ゼニアオイ抽出物等を本発明頭髪用化粧料中に配合
することができる。In addition, plant extracts, such as Altea extract, yoquinin extract, and the like, which are usually incorporated in hair cosmetics,
Peppermint extract, ginkgo biloba extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishii extract, mannenwa extract, kossaiho extract, enishida extract, gentian extract, tanjin extract , Luffa extract, fennel extract, pine extract, kudin extract, touki extract, safflower extract, barberry extract, areca extract, eucalyptus extract, kagosou extract, mokusou extract, gossip extract, Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, cashew extract, cuckoo extract, Maikaika extract, saffron extract, rosemary An extract, a dirt extract, a mallow extract, and the like can be incorporated into the cosmetic for hair of the present invention.
【００２５】また、乳酸若しくはそのアルキルエステル
等；コハク酸，リンゴ酸，クエン酸等の有機酸類；トラ
ネキサム酸等のプロテアーゼ阻害剤；オリーブ油，スク
ワラン，流動パラフィン，イソプロピルミリステート，
高級脂肪酸，高級アルコール等の油分；グリセリン，プ
ロピレングリコール等の多価アルコール；その他ポリオ
キシエチレン硬化ヒマシ油等の界面活性剤，保湿剤，増
粘剤，酸化防止剤，紫外線吸収剤，清涼剤，香料，色
素，エタノール，水等を本発明の所期の効果を損なわな
い範囲で適宜配合することができる。Lactic acid or an alkyl ester thereof; organic acids such as succinic acid, malic acid and citric acid; protease inhibitors such as tranexamic acid; olive oil, squalane, liquid paraffin, isopropyl myristate,
Oils such as higher fatty acids and higher alcohols; polyhydric alcohols such as glycerin and propylene glycol; surfactants such as polyoxyethylene hydrogenated castor oil; humectants; thickeners; antioxidants; ultraviolet absorbers; Perfumes, pigments, ethanol, water, and the like can be appropriately blended within a range that does not impair the intended effects of the present invention.
【００２６】本発明頭髪用化粧料の形態は、液状，乳
液，軟膏，クリーム，ゲル，エアゾール等、外皮に適用
可能な性状のものであれば問われるものではなく、必要
に応じて適宜基剤成分等を配合して、所望する製品形態
の本発明頭髪用化粧料を調製することができる。また、
本発明頭髪用化粧料は、医薬品，医薬部外品又は化粧料
等の多様な分野において適用可能である。The form of the cosmetic for hair of the present invention is not limited as long as it has a property applicable to the outer skin, such as a liquid, an emulsion, an ointment, a cream, a gel, an aerosol, and the like. By blending the components and the like, it is possible to prepare the cosmetic for hair of the present invention in a desired product form. Also,
The cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.
【００２７】本発明頭髪用化粧料は、例えば脱毛やふ
け，かゆみ等の治療や予防に用いることが可能であり、
例えば男性性脱毛症の治療や予防、女性に多いびまん性
脱毛症の治療や予防、円形脱毛症の治療等に広く用いる
ことができる。ただし、ここに示した目的は例示であ
り、これらの目的に本発明頭髪用化粧料の適用可能な疾
患が限定されるものではない。The hair cosmetic of the present invention can be used for treating or preventing hair loss, dandruff, itch and the like, for example.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. However, the objects shown here are examples, and the diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.
【００２８】本発明頭髪用化粧料は、概ね皮膚に直接塗
布又は散布する等の経皮投与により投与される（なお、
本発明頭髪用化粧料においては，上記必須成分の組み合
わせ配合により、成分の経皮吸収が促進される）。そし
て、本発明頭髪用化粧料の投与量は、年齢，脱毛の程度
等の個人差やその製剤形態に応じて適宜決定されるべき
ものであるが、一般の大人に対する投与量は、体重１Kg
当り０．００１〜１００mg／日、好ましくは０．１〜１
０mg／日であり、これを１日２〜４回に分けて投与する
ことができる。The hair cosmetic composition of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin (in addition,
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.
【００２９】[0029]
【実施例】以下、実施例等により本発明をより具体的に
説明するが、これらの実施例等により本発明の技術的範
囲が限定されるべきものではない。まず、各実施例等の
開示に先立ち、これらの実施例等の養毛効果等を検討す
るための試験について説明する。EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to disclosure of each embodiment, a test for examining the hair growth effect and the like of each embodiment will be described.
【００３０】１．養毛効果試験 本発明頭髪用化粧料の養毛効果を検討するために、トリ
コグラム試験を行った。被験者は、男性で比較例及び実
施例各群１０名とした。試験塗布期間は４ヵ月間とし、
この試料を１日２回、１回につき２〜４mLを頭皮に塗布
した。塗布直前及び塗布３ヵ月後に、それぞれ被験者１
名につき頭頂部から毛髪を無作為に５０本抜去し、抜去
毛の毛根を顕微鏡下で観察し、毛根の状態から毛根休止
期率（％）を計算した。試料塗布前後における休止期率
の増減の割合を以下の基準で判定した。1. Hair- growth effect test In order to examine the hair-growth effect of the cosmetic for hair of the present invention, a tricogram test was performed. The test subjects were male and 10 persons in each group of Comparative Example and Example. The test application period is four months,
The sample was applied to the scalp twice a day, 2 to 4 mL each time. Immediately before application and 3 months after application, subject 1
Fifty hairs were randomly removed from the crown for each name, the roots of the removed hairs were observed under a microscope, and the follicle resting period rate (%) was calculated from the state of the roots. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria.
【００３１】＜判定基準＞ 顕著な効果：毛根休止期率が３０％以上減少 効果あり ：毛根休止期率が２０％以上減少 弱い効果 ：毛根休止期率が１０％以上減少 効果なし ：毛根休止期率が１０％未満減少 養毛効果の評価としては、効果あり以上の被験者が５０
％を超えた場合を有効とし、その他は無効とした。<Judgment criteria> Remarkable effect: Hair root telogen rate reduced by 30% or more Effective: Hair root telogen rate reduced by 20% or more Weak effect: Hair root telogen rate reduced by 10% or more No effect: Hair root telogen Rate decreased by less than 10%.
% Is valid, and the others are invalid.
【００３２】２．脱毛防止効果試験 試料使用前後の洗髪脱毛本数の変化で脱毛防止効果を判
定した。被験者は男性で、男性で比較例及び実施例各群
１０名とした。試験期間は６ヵ月間とし、前半２ヵ月間
は試料を塗布しない期間，後半４ヵ月は試料を塗布する
期間とした。試料を塗布する期間には、試料を１日２
回、１回につき２〜４mLの試料を頭皮に塗布した。試験
期間中には、１日おきに洗髪して抜毛を回収し、１週間
分をまとめてその毛の本数を数えた。2. Hair loss prevention effect test The hair loss prevention effect was determined by the change in the number of hair washes before and after use of the sample. The test subjects were male, and the male and female subjects in the comparative example and the example were each 10 persons. The test period was six months, the first two months were a period during which no sample was applied, and the last four months were a period during which the sample was applied. During the sample application period, apply the sample 2 times a day.
Each time, 2 to 4 mL of the sample was applied to the scalp. During the test period, the hair was washed every other day to collect the extracted hairs, and the number of hairs was counted for one week.
【００３３】各期間の抜毛本数の表示は、試料を塗布し
ない２カ月間，計８回の抜毛本数のデータと、試料を塗
布する期間の後半２ヵ月間，計８回の抜毛本数のデータ
をそれぞれの期間ごとにまとめ、平均値±標準偏差の形
で１回当りの抜毛本数として表示した。The display of the number of hair removals in each period is expressed by data on the number of hair removals eight times in total during the two months when the sample is not applied, and data on the number of hair removals eight times in the latter two months of the period in which the sample is applied. The results were summarized for each period and displayed as the number of hair removals per time in the form of average value ± standard deviation.
【００３４】効果の判定は、それぞれの期間の平均値の
差から次のように判定した。 ＜判定基準＞ ＋＋：抜毛本数が７０本以上減っており，著しい効果を
認めた ＋：抜毛本数が４０本以上減っており，かなりの効果を
認めた ±：抜毛本数が１０本以上減っており，やや効果が認め
られた −：抜毛本数の減少が１０本未満であり，無効であった 脱毛防止効果の評価としては、＋以上の被験者が５０％
を超えた場合を有効とし、その他は無効とした。The effect was determined as follows from the difference between the average values in each period. <Judgment criteria> ++: The number of removed hairs decreased by 70 or more, and a remarkable effect was recognized. +: The number of removed hairs decreased by 40 or more, and a considerable effect was recognized. ±: The number of removed hairs decreased by 10 or more. The effect was slightly recognized. −: The number of hair loss was less than 10 hairs, and the hair loss was ineffective.
Is valid when the value exceeds the limit, and invalid for the others.
【００３５】３．ふけ，かゆみの防止効果試験 ふけ，かゆみの防止効果については、試験期間終了後に
各被験者の頭皮のふけ，かゆみについて調査し、ふけの
程度とかゆみの程度によって比較した。被験者は、特に
ふけとかゆみを訴える男性とし、比較例及び実施例各群
10名とした。試料を塗布する期間は３ヵ月間とし、この
間薬剤無添加の同一シャンプーで１日１回洗髪し、試料
を１日２回、１回につき２〜４mLを頭皮に塗布した。試
験終了後に、各被験者の頭皮のふけ，かゆみの程度をそ
れぞれ以下のスコアで表した。3. Test of dandruff and itching prevention effect The dandruff and itch prevention effect were examined after each test period for each subject's scalp dandruff and itch, and the degree of dandruff and itching were compared. Subjects were males who complained of dandruff and itching, and each group of Comparative Examples and Examples
10 people. The sample was applied for a period of three months, during which time the hair was washed once a day with the same shampoo containing no drug, and the sample was applied twice a day to the scalp twice a day. After the test, the degree of dandruff and itching of each subject was represented by the following scores.
【００３６】＜ふけのスコア＞ ３：ふけが著しく多い ２：ふけが多い １：ややふけが多い ０：ふけがほとんどない<Drunk score> 3: Significantly dandruff 2: Many dandruff 1: Slightly dandruff 0: Little dandruff
【００３７】＜かゆみのスコア＞ ３：強いかゆみがある ２：かゆみがある １：ややかゆみがある ０：かゆみがない<Itchy score> 3: Strong itching 2: Itching 1: Slight itching 0: No itching
【００３８】〔実施例１〜９，比較例１〜６〕第１表
（実施例１〜９，比較例１〜６）に示した配合成分のロ
ーションを後述する製法に従って調製し、上記各試験を
行った。[Examples 1 to 9, Comparative Examples 1 to 6] Lotions of the components shown in Table 1 (Examples 1 to 9 and Comparative Examples 1 to 6) were prepared according to the production methods described below, and the above-mentioned tests were performed. Was done.
【００３９】[0039]
【表１】 [Table 1]
【００４０】＜製法＞９５％エタノールに、オレイルジ
メチルアミンオキシド及びイソステアリルジメチルアミ
ンオキシドをはじめとする各薬剤（トウガラシチンキ，
カンタリスチンキ，カンフル及びノニル酸ワニリルアミ
ド）、プロピレングリコール、硬化ヒマシ油エチレンオ
キシド（４０モル）付加物、リンゴ酸、香料を溶解させ
た（エタノール相）。次いで精製水に色素を添加した
後，溶解して、これを前記エタノール相に添加した後，
攪拌することにより、透明液状のローションを得た。上
記各試験の結果を、第２表（養毛効果試験），第３表
（脱毛防止効果試験）及び第４表（ふけ，かゆみの防止
効果試験）に示した。<Production method> Each of the drugs including oleyl dimethylamine oxide and isostearyl dimethylamine oxide (capsicum tincture,
Cantalis tincture, camphor and nonylate vanillylamide), propylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct, malic acid, and flavor were dissolved (ethanol phase). Next, the dye was added to purified water, dissolved, and added to the ethanol phase.
By stirring, a transparent liquid lotion was obtained. The results of the above tests are shown in Table 2 (hair growth effect test), Table 3 (hair loss prevention effect test), and Table 4 (dandruff and itching prevention effect test).
【００４１】[0041]
【表２】 [Table 2]
【００４２】[0042]
【表３】 [Table 3]
【００４３】[0043]
【表４】 [Table 4]
【００４４】これらの結果より明らかなように、トウガ
ラシチンキ，カンタリスチンキ，カンフル及びノニル酸
ワニリルアミドから選択される１種又は２種以上の局所
刺激剤と、オレイルジメチルアミンオキシド及びイソス
テアリルジメチルアミンオキシドから選択される１種又
は２種とを配合した実施例のローションには、養毛効
果，脱毛防止効果及びふけ，かゆみの防止効果が顕著に
認められたが、局所刺激剤と上記ジメチルアミンオキシ
ドのいずれ一方のみを配合した比較例のローションは、
たとえこれらの成分を相当量配合しても、これらの効果
は上記実施例の結果と比べると著しく劣っていた。As is apparent from these results, one or more local stimulants selected from tincture tincture, tincture tincture, camphor and nonylyl vanillylamide, oleyldimethylamine oxide and isostearyldimethylamine oxide In the lotion of the examples in which one or two selected from the group consisting of dimethylamine oxide and a stimulant, the local stimulant and the dimethylamine oxide were effective. The lotion of Comparative Example containing only one of
Even if these components were added in a considerable amount, these effects were remarkably inferior to the results of the above examples.
【００４５】すなわち、局所刺激剤とオレイルジメチル
アミンオキシド及び／又はイソステアリルジメチルアミ
ンオキシドとを組み合わせて配合した本発明頭髪用化粧
料においては、相乗的な養毛効果，脱毛防止効果及びふ
け，かゆみの防止効果が顕著に認められることが明らか
になった。このことは、少量の有効成分であっても本発
明頭髪用化粧料においては所望する効果を得ることが可
能であり、これらの成分を多量に配合することによって
惹起される、塗布部及びその周辺部の不快な刺激感や発
赤を防ぐことが可能になったことを示すものである。That is, in the hair cosmetic composition of the present invention in which a topical stimulant is combined with oleyl dimethylamine oxide and / or isostearyl dimethylamine oxide, a synergistic hair-growth effect, a hair loss-preventing effect and a dandruff, itch It was clarified that the effect of preventing odor was remarkably recognized. This is because the desired effect can be obtained in the hair cosmetic of the present invention even with a small amount of the active ingredient, and the application part and its surroundings caused by blending these components in a large amount can be obtained. This indicates that it has become possible to prevent unpleasant irritation and redness of the part.
【００４６】以下、さらに他の本発明頭髪用化粧料の処
方例を示す。 〔実施例１０〕 ローション （配合成分） 配合量（重量％） ９５％エタノール ６５．０ オレイルジメチルアミンオキシド ３．０ トウガラシアチンキ ０．６ グリセリン ２．０ 硬化ヒマシ油エチレンオキシド（５０モル）付加物 ０．５ コハク酸 適 量 香料及び色素 適 量 精製水 残 部Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 10] Lotion (Blending component) Blending amount (% by weight) 95% ethanol 65.0 Oleyldimethylamine oxide 3.0 Pepper tincture 0.6 Glycerin 2.0 Hardened castor oil ethylene oxide (50 mol) adduct 0 .5 Succinic acid qs Perfume and pigment qs Purified water balance
【００４７】＜製法＞９５％エタノールに、オレイルジ
メチルアミンオキシド、トウガラシチンキ、グリセリ
ン、硬化ヒマシ油エチレンオキシド（５０モル）付加
物、コハク酸及び香料を溶解させた（エタノール相）。
次いで精製水に色素を溶解させた後、これを前記エタノ
ール相に添加し、攪拌溶解することによって、透明液状
のローションを得た。<Production Method> Oleyldimethylamine oxide, pepper tincture, glycerin, hydrogenated castor oil ethylene oxide (50 mol) adduct, succinic acid, and a fragrance were dissolved in 95% ethanol (ethanol phase).
Next, after dissolving the dye in purified water, the dye was added to the ethanol phase and stirred and dissolved to obtain a clear liquid lotion.
【００４８】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.
【００４９】 〔実施例１１〕 ローション （配合成分） 配合量（重量％） ９５％エタノール ５５．０ イソステアリルジメチルアミンオキシド １．０ カンタリスチンキ ０．１ カンフル ０．５ ノニル酸ワニリルアミド ０．０１ ジプロピレングリコール １．０ 硬化ヒマシ油エチレンオキシド（６０モル）付加物 ０．５ リンゴ酸 適 量 香料及び色素 適 量 精製水 残 部Example 11 Lotion (Blending Components) Blending Amount (% by Weight) 95% Ethanol 55.0 Isostearyl Dimethylamine Oxide 1.0 Cantaristinctin 0.1 Camphor 0.5 Nonylate Vanillylamide 0.01 di Propylene glycol 1.0 Hardened castor oil Ethylene oxide (60 mol) adduct 0.5 Malic acid Appropriate amount Flavor and dye Appropriate amount Purified water balance
【００５０】＜製法＞９５％エタノールに、イソステア
リルジメチルアミンオキシド、カンタリスチンキ、カン
フル、ノニル酸ワニリルアミド、ジプロピレングリコー
ル，硬化ヒマシ油エチレンオキシド（６０モル）付加
物、リンゴ酸及び香料を溶解させた（エタノール相）。
次いで精製水に色素を溶解させた後、これを前記エタノ
ール相に添加し、攪拌溶解することにより、透明液状の
ローションを得た。<Production method> Isostearyl dimethylamine oxide, tincture tincture, camphor, vanillyl amide nonylate, dipropylene glycol, adduct of hydrogenated castor oil ethylene oxide (60 mol), malic acid and flavor were dissolved in 95% ethanol. (Ethanol phase).
Next, after dissolving the dye in purified water, this was added to the ethanol phase and stirred and dissolved to obtain a transparent liquid lotion.
【００５１】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.
【００５２】 〔実施例１２〕 ローション （配合成分） 配合量（重量％） ９５％エタノール ５５．０ オレイルジメチルアミンオキシド ２．０ イソステアリルジメチルアミンオキシド ２．０ トウガラシチンキ ０．５ カンタリスチンキ ０．３ カンフル ０．５ １，３−ブチレングリコール ２．０ 硬化ヒマシ油エチレンオキシド（４０モル）付加物 ０．７ リンゴ酸 適 量 香料及び色素 適 量 精製水 残 部Example 12 Lotion (Blending Component) Blending Amount (% by Weight) 95% Ethanol 55.0 Oleyldimethylamine Oxide 2.0 Isostearyldimethylamine Oxide 2.0 Pepper Tint 0.5 Canthari tincture 3 camphor 0.5 1,3-butylene glycol 2.0 hydrogenated castor oil ethylene oxide (40 mol) adduct 0.7 malic acid qs perfume and pigment qs purified water balance
【００５３】＜製法＞９５％エタノールに、オレイルジ
メチルアミンオキシド、イソステアリルジメチルアミン
オキシド、トウガラシチンキ、カンタリスチンキ、カン
フル、１，３−ブチレングリコール、硬化ヒマシ油エチ
レンオキシド（４０モル）付加物、リンゴ酸及び香料を
溶解させた（エタノール相）。次いで精製水に色素を溶
解させた後、これを前記エタノール相に添加し、攪拌溶
解することにより、透明液状のローションを得た。<Production method> Oleyl dimethylamine oxide, isostearyl dimethylamine oxide, pepper tincture, cantaris tincture, camphor, 1,3-butylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct, 95% ethanol, apple The acid and fragrance were dissolved (ethanol phase). Next, after dissolving the dye in purified water, this was added to the ethanol phase and stirred and dissolved to obtain a transparent liquid lotion.
【００５４】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。When the above-described test was carried out on the cosmetic for hair of the present invention, a hair-growing effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.
【００５５】 〔実施例１３〕 乳液 （配合成分） 配合量（重量％） （１）セタノール １．７ （２）ステアリン酸 １．０ （３）パルミチン酸 ０．６ （４）液状ラノリン ２．０ （５）スクワラン １．０ （６）モノステアリン酸グリセリル １．８ （７）ＰＯＥソルビタンモノステアレート ０．３ （８）イソステアリルジメチルアミンオキシド ２．０ （９）オレイルジメチルアミンオキシド １．０ （10）カンフル ０．８２ （11）ノニル酸ワニリルアミド ０．０３ （12）ポリエチレングリコール ５．０ （13）トリエタノールアミン １．０ （14）精製水 残 部Example 13 Emulsion (Blending Components) Blending Amount (% by Weight) (1) Cetanol 1.7 (2) Stearic Acid 1.0 (3) Palmitic Acid 0.6 (4) Liquid Lanolin 2.0 (5) Squalane 1.0 (6) Glyceryl monostearate 1.8 (7) POE sorbitan monostearate 0.3 (8) Isostearyl dimethylamine oxide 2.0 (9) Oleyl dimethylamine oxide 1.0 ( 10) Camphor 0.82 (11) Vanillyl amide nonylate 0.03 (12) Polyethylene glycol 5.0 (13) Triethanolamine 1.0 (14) Purified water balance
【００５６】＜製法＞（１）〜（11）の各成分を混合し
た混合物を調製した。これとは別に（12）〜（14）の成
分を混合した混合物を調製した。これらの混合物をそれ
ぞれ別々に７０℃に加熱して溶解後、両者を混合して、
これを乳化機により混合乳化した後、熱交換冷却を行っ
て、乳液を得た。<Production Method> A mixture was prepared by mixing the components (1) to (11). Separately, a mixture was prepared by mixing the components (12) to (14). These mixtures were separately heated to 70 ° C. and dissolved, and then both were mixed.
After this was mixed and emulsified by an emulsifier, heat exchange cooling was performed to obtain an emulsion.
【００５７】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect and a dandruff and itching-preventing effect were remarkably recognized.
【００５８】[0058]
【発明の効果】本発明により、優れた養毛効果や脱毛防
止効果，頭皮のふけ, かゆみの防止効果を有し、かつ安
全性にも優れる頭髪用化粧料が提供される。Industrial Applicability According to the present invention, there is provided a hair cosmetic composition having an excellent hair-growth effect, an effect of preventing hair loss, an effect of preventing dandruff and itching of the scalp, and also having excellent safety.
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.6 識別記号 ＦＩ Ａ６１Ｋ 35/78 Ａ６１Ｋ 35/78 Ｒ ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 6 Identification code FI A61K 35/78 A61K 35/78 R
Claims (3)
テアリルジメチルアミンオキシド を含有する頭皮頭髪用化粧料。1. A scalp / hair cosmetic containing 1) a local stimulant and 2) oleyldimethylamine oxide and / or isostearyldimethylamine oxide.
タリスチンキ，カンフル及びノニル酸ワニリルアミドか
らなる群の局所刺激剤から選ばれる１種又は２種以上の
局所刺激剤である請求項１記載の頭皮頭髪用化粧料。2. The scalp according to claim 1, wherein the local stimulant is at least one local stimulant selected from the group consisting of pepper tincture, tincture tincture, camphor, and vanillyl amide nonylate. Hair cosmetics.
対して０．００１〜２．０重量％含有する請求項１又は
２記載の頭皮頭髪用化粧料。3. The scalp hair cosmetic according to claim 1, wherein the topical stimulant is contained in an amount of 0.001 to 2.0% by weight based on the entire scalp hair cosmetic.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10084986A JPH11263714A (en) | 1998-03-16 | 1998-03-16 | Cosmetic for scalp and hair of head |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10084986A JPH11263714A (en) | 1998-03-16 | 1998-03-16 | Cosmetic for scalp and hair of head |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11263714A true JPH11263714A (en) | 1999-09-28 |
Family
ID=13845955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10084986A Withdrawn JPH11263714A (en) | 1998-03-16 | 1998-03-16 | Cosmetic for scalp and hair of head |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH11263714A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528482A (en) * | 2005-01-20 | 2008-07-31 | クワン・ドン・ファーマシューティカル・カンパニー・リミテッド | Composition for improving hair growth comprising a non-polar solvent soluble extract of Cantalis as an active ingredient |
| JP2011148792A (en) * | 2009-12-25 | 2011-08-04 | Nippon Supplement Kk | Hair-growing agent |
| EP2591824A3 (en) * | 2011-11-13 | 2013-07-10 | Compad Consulting GmbH | Sustainable cosmetic and dermatological formulations |
| FR2993455A1 (en) * | 2012-07-17 | 2014-01-24 | Oreal | Essential oil of Achillea used in cosmetic composition in form of shampoo, gel or lotion for providing antidandruff and deodorant effects, comprises Artemisia ketone and chrysanthenone |
-
1998
- 1998-03-16 JP JP10084986A patent/JPH11263714A/en not_active Withdrawn
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008528482A (en) * | 2005-01-20 | 2008-07-31 | クワン・ドン・ファーマシューティカル・カンパニー・リミテッド | Composition for improving hair growth comprising a non-polar solvent soluble extract of Cantalis as an active ingredient |
| JP2011148792A (en) * | 2009-12-25 | 2011-08-04 | Nippon Supplement Kk | Hair-growing agent |
| EP2591824A3 (en) * | 2011-11-13 | 2013-07-10 | Compad Consulting GmbH | Sustainable cosmetic and dermatological formulations |
| FR2993455A1 (en) * | 2012-07-17 | 2014-01-24 | Oreal | Essential oil of Achillea used in cosmetic composition in form of shampoo, gel or lotion for providing antidandruff and deodorant effects, comprises Artemisia ketone and chrysanthenone |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A300 | Withdrawal of application because of no request for examination |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20050607 |