JPH11255621A - Cosmetic for scalp and hair - Google Patents
Cosmetic for scalp and hairInfo
- Publication number
- JPH11255621A JPH11255621A JP7666298A JP7666298A JPH11255621A JP H11255621 A JPH11255621 A JP H11255621A JP 7666298 A JP7666298 A JP 7666298A JP 7666298 A JP7666298 A JP 7666298A JP H11255621 A JPH11255621 A JP H11255621A
- Authority
- JP
- Japan
- Prior art keywords
- hair
- effect
- cosmetic
- extract
- scalp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- Cosmetics (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、頭皮頭髪用化粧料
（以下，頭髪用化粧料という）に関する技術分野の発明
である。より詳細には、優れた養毛効果や脱毛防止効
果，頭皮のふけ，かゆみの防止効果を有し，かつ安全性
にも優れる頭髪用化粧料に関する発明であり、本発明頭
髪用化粧料は、特に医薬品，医薬部外品又は化粧品の分
野において用いられる。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a scalp hair cosmetic (hereinafter referred to as "hair cosmetic"). More specifically, the present invention relates to a hair cosmetic composition having an excellent hair-growing effect, an anti-hair loss effect, a scalp dandruff, and an anti-itch effect, and also having excellent safety. In particular, it is used in the fields of pharmaceuticals, quasi-drugs, and cosmetics.
【０００２】[0002]
【従来の技術】頭髪用化粧料には、様々な種類があり、
様々な頭皮頭髪状態に対応した製品が提供されている。
例えば、頭皮における血液循環を良好にして、頭皮にお
けるふけやかゆみを防止し、脱毛を防止し得る製品が開
発されている。頭皮における様々なトラブルは、高齢化
社会を迎えた今日では、社会的ストレスの増大も伴って
増加しつつあり、この頭皮におけるトラブルに対応した
頭髪用化粧料の需要は急増している。一般に、頭部の禿
や脱毛の原因としては、毛包上部の皮脂腺等の器官にお
ける男性ホルモンの活性化、毛乳頭や毛包への血流量の
低下による栄養物質の供給不足、上皮組織の角化異常等
によるふけの過剰発生、過剰な皮脂分泌、過酸化脂質の
生成、ストレス等が挙げられる。ふけ等が過剰になる
と、頭皮細菌などで分解され、分解物が頭皮を刺激し、
かゆみや炎症等を伴う脱毛を引き起こし得る。また、丈
夫で美しい毛髪を育てるうえで、毛乳頭や毛包への十分
な栄養補給が大切である。毛乳頭や毛包への血流量の低
下は、栄養不足や老廃物の***の機能の低下を招き、細
毛ややせ毛の原因となる。2. Description of the Related Art There are various types of hair cosmetics.
Products corresponding to various scalp hair conditions are provided.
For example, products have been developed that can improve blood circulation in the scalp, prevent dandruff and itch on the scalp, and prevent hair loss. Various troubles on the scalp are increasing with the increase of social stress in today's aging society, and the demand for hair cosmetics corresponding to the trouble on the scalp is rapidly increasing. In general, causes of baldness and hair loss on the head include activation of androgens in organs such as the sebaceous glands above the hair follicles, insufficient supply of nutrients due to a decrease in blood flow to the hair papilla and hair follicles, and corneal epithelium. Excessive dandruff, excessive sebum secretion, production of lipid peroxide, stress, and the like due to malformation and the like. When dandruff becomes excessive, it is decomposed by scalp bacteria, etc., and the decomposition products stimulate the scalp,
It can cause hair loss with itching and inflammation. In addition, in order to grow durable and beautiful hair, it is important to provide sufficient nutrition to the nipples and hair follicles. A decrease in blood flow to the dermal papilla or hair follicle causes nutritional deficiency and a decrease in the function of excreting waste products, and causes fine hair and thin hair.
【０００３】従来の頭髪用化粧料は、一般に、上述した
ような禿や脱毛等の原因と考えられる要素を取り除いた
り、軽減する作用を持つ物質を配合したものである。例
えば、頭皮における血流循環を良好にするために、セン
ブリエキス，ビタミンＥ及びその誘導体，アセチルコリ
ン誘導体，セファランチン等の血行促進剤が、過剰な皮
脂分泌等により起こる頭皮の炎症を抑制するために紫根
エキス等の消炎剤が、男性ホルモンを抑制するためにエ
ストラジオール等の女性ホルモン剤が、ふけやかゆみを
防止するためにサリチル酸等の抗菌剤が、また、毛包等
への栄養補給のためにセリン，メチオニン等のアミノ酸
類、ビタミン類等が配合され、禿や脱毛、毛髪の細りの
予防及び治療に用いられている。[0003] Conventional hair cosmetics generally contain a substance having an action of removing or reducing factors considered to be causes of baldness, hair loss and the like as described above. For example, in order to improve blood circulation in the scalp, blood circulation promoters such as assembly extract, vitamin E and its derivatives, acetylcholine derivatives, and cepharanthin are used to suppress scalp inflammation caused by excessive sebum secretion and the like. Anti-inflammatory agents such as extracts, female hormones such as estradiol to suppress male hormones, antibacterial agents such as salicylic acid to prevent dandruff and itching, and serine for nutritional supplementation to hair follicles Amino acids such as methionine and methionine, vitamins, etc. are blended and used for the prevention and treatment of baldness, hair loss and hair thinning.
【０００４】[0004]
【発明が解決しようとする課題】しかしながら、これら
の成分を少量のみ頭髪用化粧料中に配合しても十分な効
果を得ることは難しく、逆に、大量に配合すると使用部
分及びその周辺に不快な刺激感や発赤を伴う傾向が強ま
り、自ずとその配合量には限界があった。However, it is difficult to obtain a sufficient effect even if only a small amount of these components is incorporated into cosmetics for hair. There was a strong tendency to be accompanied by a tingling sensation and redness, and the blending amount was naturally limited.
【０００５】そこで本発明が解決すべき課題は、優れた
養毛効果や脱毛防止効果，頭皮のふけ，かゆみの防止効
果を有し、かつ安全性にも優れる頭髪用化粧料を提供す
ることである。The problem to be solved by the present invention is to provide a hair cosmetic which has an excellent hair-growth effect, an effect of preventing hair loss, an effect of preventing dandruff and itching of the scalp, and which is also excellent in safety. is there.
【０００６】[0006]
【課題を解決するための手段】本発明者は、この課題の
解決に向けて鋭意検討を行った。その結果、グリチルレ
チン酸類及び／又はグリチルリチン酸類と、特定のアミ
ンオキシドとを組み合わせて配合することにより、優れ
た養毛効果や脱毛防止効果，頭皮のふけ，かゆみの防止
効果を有し、かつ安全性にも優れる頭髪用化粧料が提供
されることを見出し、本発明を完成した。Means for Solving the Problems The present inventor has made intensive studies to solve this problem. As a result, by combining glycyrrhetinic acids and / or glycyrrhizic acids with a specific amine oxide, it has an excellent hair-growth effect, a hair loss-preventing effect, a scalp dandruff and itching-preventing effect, and safety. The present inventors have found that a hair cosmetic composition that is excellent in hair quality is provided, and completed the present invention.
【０００７】すなわち本発明は、１）グリチルレチン酸
類及び／又はグリチルリチン酸類、並びに、 ２）オレイルジメチルアミンオキシド及び／又はイソス
テアリルジメチルアミンオキシド を含有する頭髪用化粧料を提供する。That is, the present invention provides a hair cosmetic containing 1) glycyrrhetinic acids and / or glycyrrhizic acids, and 2) oleyldimethylamine oxide and / or isostearyldimethylamine oxide.
【０００８】また、この頭髪用化粧料が、グリチルレチ
ン酸類及び／又はグリチルリチン酸類を、頭髪用化粧料
全体に対して０．００１〜５．０重量％含有する場合
が、特に所期の効果を良好に発揮し得る。[0008] When the hair cosmetic contains glycyrrhetinic acids and / or glycyrrhizic acids in an amount of 0.001 to 5.0% by weight based on the total weight of the hair cosmetic, the desired effect is particularly good. Can be demonstrated.
【０００９】[0009]
【発明の実施の形態】以下、本発明の実施の形態につい
て説明する。本発明頭髪用化粧料は、グリチルレチン酸
類及び／又はグリチルリチン酸類とオレイルジメチルア
ミンオキシド及び／又はイソステアリルジメチルアミン
オキシドとを組み合わせて配合することにより、所期の
効果を発揮する頭髪用化粧料である。Embodiments of the present invention will be described below. The cosmetic for hair of the present invention is a cosmetic for hair that exerts an intended effect by blending glycyrrhetinic acids and / or glycyrrhizic acids with oleyldimethylamine oxide and / or isostearyldimethylamine oxide. .
【００１０】本発明頭髪用化粧料中に配合され得るグリ
チルレチン酸類及びグリチルリチン酸類は、甘草エキス
の主成分である、トリテルペノイドサポニンの一種であ
るグリチルリチン酸、そのアグルコンであるグリチルレ
チン酸、及びそれらの誘導体である。グリチルレチン酸
類及びグリチルリチン酸類は、抗炎症作用を有し、従来
から化粧料に消炎剤として配合されている。本発明頭髪
用化粧料中に配合され得るグリチルレチン酸類として
は、β−グリチルレチン酸；グリチルレチン酸グリセリ
ン，グリチルレチン酸ステアリル，グリチルレチン酸ピ
リドキシン，ステアリン酸グリチルレチニル等が挙げら
れる。また、本発明頭髪用化粧料中に配合され得るグリ
チルリチン酸類としては、グリチルリチン酸；グリチル
リチン酸ジカリウム，グリチルリチン酸三ナトリウム，
グリチルリチン酸モノアンモニウム，グリチルリチン酸
メチル、３−サクシニルオキシジグリチルリチン酸二ナ
トリウム等が挙げられる。Glycyrrhetinic acids and glycyrrhizic acids which can be incorporated into the hair cosmetic composition of the present invention are glycyrrhizic acid, a kind of triterpenoid saponin, glycyrrhetic acid, aglycone thereof, and derivatives thereof, which are main components of licorice extract. is there. Glycyrrhetinic acids and glycyrrhizic acids have an anti-inflammatory effect and have been conventionally blended into cosmetics as anti-inflammatory agents. Examples of glycyrrhetinic acids that can be incorporated in the hair cosmetic of the present invention include β-glycyrrhetinic acid; glyceryl glyceryl retinate, stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, and glycyrrhetinyl stearate. The glycyrrhizic acids that can be incorporated into the hair cosmetic of the present invention include glycyrrhizic acid; dipotassium glycyrrhizinate, trisodium glycyrrhizinate,
Monoammonium glycyrrhizinate, methyl glycyrrhizinate, disodium 3-succinyloxydiglycyrrhizinate and the like.
【００１１】これらのグリチルレチン酸類及びグリチル
リチン酸類は市販されており、また、従来公知の方法に
より、甘草根よりグリチルリチン酸を抽出し、抽出され
たグリチルリチン酸から製造することもできる。These glycyrrhizic acids and glycyrrhizic acids are commercially available, and glycyrrhizic acid can be extracted from licorice root by a conventionally known method, and can also be produced from the extracted glycyrrhizic acid.
【００１２】本発明頭髪用化粧料において、グリチルレ
チン酸類及びグリチルリチン酸類の１種又は２種以上
が、頭髪用化粧料全体に対して０．００１〜５．０重量
％の範囲で配合されるのが好ましい。グリチルレチン酸
類及び／又はグリチルリチン酸類の配合量が、頭髪用化
粧料全体に対して０．００１重量％未満であると、所望
する消炎効果を十分に発揮することが困難であり好まし
くない。また、頭髪用化粧料全体に対して５．０重量％
を超えると、製剤上不都合を生じる傾向が強まるだけで
なく、さらに頭皮に不快な刺激感を与える等、安全性の
側面からも問題が生じるおそれがあり好ましくない。In the hair cosmetic of the present invention, one or more of glycyrrhetinic acids and glycyrrhizic acids are blended in a range of 0.001 to 5.0% by weight based on the total weight of the hair cosmetic. preferable. If the blending amount of glycyrrhetinic acids and / or glycyrrhizic acids is less than 0.001% by weight based on the total amount of the cosmetic for hair, it is difficult to sufficiently exhibit a desired anti-inflammatory effect, which is not preferable. In addition, 5.0% by weight of the total hair cosmetics
If it exceeds, not only the tendency to cause inconvenience in the formulation increases, but also a problem may occur from the aspect of safety, such as giving an unpleasant irritant feeling to the scalp, which is not preferred.
【００１３】上記のグリチルレチン酸類及び／又はグリ
チルリチン酸類と共に本発明毛髪化粧料中に配合され
る、オレイルジメチルアミンオキシド及び／又はイソス
テアリルジメチルアミンオキシドは、次式で表される：The oleyl dimethylamine oxide and / or isostearyl dimethylamine oxide to be incorporated in the hair cosmetic composition of the present invention together with the above glycyrrhetinic acids and / or glycyrrhizic acids is represented by the following formula:
【化１】 これらのジメチルアミンオキシドは、従来公知のアミン
オキシドの製造方法に従って製造することができる。Embedded image These dimethylamine oxides can be produced according to a conventionally known method for producing an amine oxide.
【００１４】本発明頭髪用化粧料中におけるオレイルジ
メチルアミンオキシド及び／又はイソステアリルジメチ
ルアミンオキシドの配合量は、頭髪用化粧料全体に対し
て０．０００１重量％〜２０．０重量％が好ましく、同
０．０５重量％〜５．０重量％が特に好ましい。The amount of oleyldimethylamine oxide and / or isostearyldimethylamine oxide in the hair cosmetic of the present invention is preferably 0.0001% by weight to 20.0% by weight based on the total weight of the hair cosmetic. Particularly preferred is 0.05% by weight to 5.0% by weight.
【００１５】この配合量が頭髪用化粧料全体に対して
０．０００１重量％未満では、十分な消炎効果を発揮す
ることができず好ましくなく、同２０．０重量％を超え
て配合すると、製剤上不都合を生ずる傾向が強くなり、
さらに皮膚刺激性が生ずる等の点から好ましくない。If the amount is less than 0.0001% by weight based on the total weight of the cosmetic for hair, a sufficient anti-inflammatory effect cannot be exerted, which is not preferable. The tendency to cause inconvenience increases,
Further, it is not preferable in that it causes skin irritation.
【００１６】このようにして、グリチルレチン酸類及び
グリチルリチン酸類の１種又は２種以上と、オレイルジ
メチルアミンオキシド及びイソステアリルジメチルアミ
ンオキシドの１種又は２種とを組み合わせて配合するこ
とにより、優れた養毛効果や脱毛防止効果，頭皮のふ
け，かゆみの防止効果を有し、かつ安全性にも優れる本
発明頭髪用化粧料が提供される。As described above, by combining one or more of glycyrrhetinic acids and glycyrrhizic acids with one or two of oleyl dimethylamine oxide and isostearyl dimethylamine oxide, excellent nutrients can be obtained. The present invention provides a hair cosmetic composition having a hair effect, a hair loss preventing effect, a scalp dander and an itching preventing effect, and having excellent safety.
【００１７】なお、本発明頭髪用化粧料中には、通常頭
髪用化粧料中に配合される薬効成分を、その薬効成分が
有する一般的な効果を発揮させる目的のために、本発明
の所期の効果を損なわない限りにおいて配合することも
可能である。The cosmetic for hair of the present invention contains the medicinal component usually incorporated in the cosmetic for hair in order to exert the general effect of the medicinal component. It is also possible to mix as long as the effect of the period is not impaired.
【００１８】例えば、センブリエキス，ビタミンＥ若し
くはその誘導体，アセチルコリン誘導体，セファランチ
ン，塩化カルプロニウム等の血行促進剤；トウガラシチ
ンキ，カンタリスエキス，ノニル酸バニルアミド等の局
所刺激剤；ピリドキシン若しくはその誘導体，イオウ，
ビタミンＢ6 等の抗脂漏剤；塩化ベンザルコニウム，イ
ソプロピルメチルフェノール，レゾルシン，ジンクピリ
チオン，感光素１０１号，感光素１０２号，サリチル
酸，サリチル酸ナトリウム，オルトピロックス，ヒノキ
チオール等の抗菌剤；感光素３０１号，プラセンタエキ
ス，ビオチン等の代謝賦活剤；紫根エキス，メントール
等の消炎剤；エストラジオール，エストロン等の女性モ
ルモン；セリン，メチオニン，トリプトファン等のアミ
ノ酸類，ビタミンＡ，Ｂ2,Ｂ12, Ｄ，パントテン酸若し
くはその誘導体などのビタミン類等を本発明頭髪用化粧
料中に配合することができる。For example, blood circulation promoters such as assembly extract, vitamin E or derivatives thereof, acetylcholine derivatives, cepharanthin, carpronium chloride; local stimulants such as pepper tincture, cantharis extract, and nonylate vanilamide; pyridoxine or derivatives thereof, sulfur,
Anti-seborrhoeic agents such as vitamin B 6; benzalkonium chloride, isopropyl methyl phenol, resorcinol, zinc pyrithione, photosensitive No. 101-containing, photosensitizer No. 102, salicylic acid, sodium salicylate, Ol octopirox, antibacterial agents such as hinokitiol, photosensitizers No. 301, a metabolic activator such as placenta extract and biotin; an anti-inflammatory agent such as purple root extract and menthol; a female mormon such as estradiol and estrone; amino acids such as serine, methionine and tryptophan; vitamins A, B 2 , B 12 and D And vitamins such as pantothenic acid and derivatives thereof can be incorporated into the cosmetic for hair of the present invention.
【００１９】また、通常頭髪用化粧料中に配合される植
物抽出物、例えばアルテア抽出物，ヨクイニン抽出物，
ペパーミント抽出物，ヨウテイ抽出物，トウガラシ抽出
物，アロエ抽出物，クコ抽出物，ヨモギ抽出物，イネ抽
出物，マンケイシ抽出物，マンネンロウ抽出物，コッサ
イホ抽出物，エニシダ抽出物，リンドウ抽出物，タンジ
ン抽出物，ヘチマ抽出物，キキョウ抽出物，マツ抽出
物，クジン抽出物，トウキ抽出物，ベニバナ抽出物，メ
ギ抽出物，ビンロウジ抽出物，ユーカリ抽出物，カゴソ
ウ抽出物，モクソウ抽出物，ゴシツ抽出物，サイコ抽出
物，チャ抽出物，カンゾウ抽出物，ホップ抽出物，キク
抽出物，セネガ抽出物，ゴマ抽出物，センキュウ抽出
物，カシュウ抽出物，カッコン抽出物，マイカイカ抽出
物，サフラン抽出物，ローズマリー抽出物，ジオウ抽出
物，ゼニアオイ抽出物等を本発明頭髪用化粧料中に配合
することができる。Also, plant extracts, such as Altea extract, yoquinin extract, which are usually incorporated in hair cosmetics,
Peppermint extract, ginkgo biloba extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, rice extract, mankeishii extract, mannenwa extract, kossaiho extract, enishida extract, gentian extract, tanjin extract , Luffa extract, fennel extract, pine extract, kudin extract, touki extract, safflower extract, barberry extract, areca extract, eucalyptus extract, kagosou extract, mokusou extract, gossip extract, Psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, senkyu extract, cashew extract, cuckoo extract, Maikaika extract, saffron extract, rosemary An extract, a dirt extract, a mallow extract, and the like can be incorporated into the cosmetic for hair of the present invention.
【００２０】また、乳酸若しくはそのアルキルエステル
等；コハク酸，リンゴ酸，クエン酸等の有機酸類；トラ
ネキサム酸等のプロテアーゼ阻害剤；オリーブ油，スク
ワラン，流動パラフィン，イソプロピルミリステート，
高級脂肪酸，高級アルコール等の油分；グリセリン，プ
ロピレングリコール等の多価アルコール；その他ポリオ
キシエチレン硬化ヒマシ油等の界面活性剤，保湿剤，増
粘剤，酸化防止剤，紫外線吸収剤，清涼剤，香料，色
素，エタノール，水等を本発明の所期の効果を損なわな
い範囲で適宜配合することができる。Lactic acid or an alkyl ester thereof; organic acids such as succinic acid, malic acid and citric acid; protease inhibitors such as tranexamic acid; olive oil, squalane, liquid paraffin, isopropyl myristate,
Oils such as higher fatty acids and higher alcohols; polyhydric alcohols such as glycerin and propylene glycol; surfactants such as polyoxyethylene hydrogenated castor oil; humectants; thickeners; antioxidants; ultraviolet absorbers; Perfumes, pigments, ethanol, water, and the like can be appropriately blended within a range that does not impair the intended effects of the present invention.
【００２１】本発明頭髪用化粧料の形態は、液状，乳
液，軟膏，クリーム，ゲル，エアゾール等、外皮に適用
可能な性状のものであれば問われるものではなく、必要
に応じて適宜基剤成分等を配合して、所望する製品形態
の本発明頭髪用化粧料を調製することができる。また、
本発明頭髪用化粧料は、医薬品，医薬部外品又は化粧料
等の多様な分野において適用可能である。The form of the cosmetic for hair of the present invention is not limited as long as it can be applied to the outer skin, such as a liquid, an emulsion, an ointment, a cream, a gel, an aerosol, and the like. By blending the components and the like, it is possible to prepare the cosmetic for hair of the present invention in a desired product form. Also,
The cosmetic for hair of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.
【００２２】本発明頭髪用化粧料は、例えば脱毛やふ
け，かゆみ等の治療や予防に用いることが可能であり、
例えば男性性脱毛症の治療や予防、女性に多いびまん性
脱毛症の治療や予防、円形脱毛症の治療等に広く用いる
ことができる。ただし、ここに示した目的は例示であ
り、これらの目的に本発明頭髪用化粧料の適用可能な疾
患が限定されるものではない。The hair cosmetic composition of the present invention can be used for treating or preventing hair loss, dandruff, itch and the like, for example.
For example, it can be widely used for treatment and prevention of androgenetic alopecia, treatment and prevention of diffuse alopecia common to women, treatment of alopecia areata and the like. However, the objects shown here are examples, and the diseases applicable to the cosmetic for hair of the present invention are not limited to these objects.
【００２３】本発明頭髪用化粧料は、概ね皮膚に直接塗
布又は散布する等の経皮投与により投与される（なお、
本発明頭髪用化粧料においては，上記必須成分の組み合
わせ配合により、成分の経皮吸収が促進される）。そし
て、本発明頭髪用化粧料の投与量は、年齢，脱毛の程度
等の個人差やその製剤形態に応じて適宜決定されるべき
ものであるが、一般の大人に対する投与量は、体重１Kg
当り０．００１〜１００mg／日、好ましくは０．１〜１
０mg／日であり、これを１日２〜４回に分けて投与する
ことができる。The cosmetic for hair of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin (in addition,
In the hair cosmetic of the present invention, the percutaneous absorption of the components is promoted by the combination of the above essential components). The dosage of the cosmetic for hair of the present invention should be appropriately determined according to individual differences such as age and the degree of hair loss and the form of the preparation, but the dosage for general adults is 1 kg body weight.
0.001-100 mg / day, preferably 0.1-1
0 mg / day, which can be administered in 2 to 4 times a day.
【００２４】[0024]
【実施例】以下、実施例等により本発明をより具体的に
説明するが、これらの実施例等により本発明の技術的範
囲が限定されるべきものではない。まず、各実施例等の
開示に先立ち、これらの実施例等の養毛効果等を検討す
るための試験について説明する。EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to disclosure of each embodiment, a test for examining the hair growth effect and the like of each embodiment will be described.
【００２５】１．養毛効果試験 本発明頭髪用化粧料の養毛効果を検討するために、トリ
コグラム試験を行った。被験者は、男性で比較例及び実
施例各群１０名とした。試験塗布期間は４ヵ月間とし、
この試料を１日２回、１回につき２〜４mlを頭皮に塗布
した。塗布直前及び塗布３ヵ月後に、それぞれ被験者１
名につき頭頂部から毛髪を無作為に５０本抜去し、抜去
毛の毛根を顕微鏡下で観察し、毛根の状態から毛根休止
期率（％）を計算した。試料塗布前後における休止期率
の増減の割合を以下の基準で判定した。1. Hair- growth effect test In order to examine the hair-growth effect of the cosmetic for hair of the present invention, a tricogram test was performed. The test subjects were male and 10 persons in each group of Comparative Example and Example. The test application period is four months,
The sample was applied to the scalp twice to four times a day. Immediately before application and 3 months after application, subject 1
Fifty hairs were randomly removed from the crown for each name, the roots of the removed hairs were observed under a microscope, and the follicle resting period rate (%) was calculated from the state of the roots. The rate of increase or decrease in the telogen rate before and after the sample application was determined based on the following criteria.
【００２６】＜判定基準＞ 顕著な効果：毛根休止期率が３０％以上減少 効果あり ：毛根休止期率が２０％以上減少 弱い効果 ：毛根休止期率が１０％以上減少 効果なし ：毛根休止期率が１０％未満減少 養毛効果の評価としては、効果あり以上の被験者が５０
％を超えた場合を有効とし、その他は無効とした。<Judgment criteria> Remarkable effect: Hair root telogen rate reduced by 30% or more Effective: Hair root telogen rate reduced by 20% or more Weak effect: Hair root telogen rate reduced by 10% or more No effect: Hair root telogen Rate decreased by less than 10%.
% Is valid, and the others are invalid.
【００２７】２．脱毛防止効果試験 試料使用前後の洗髪脱毛本数の変化で脱毛防止効果を判
定した。被験者は男性で、男性で比較例及び実施例各群
１０名とした。試験期間は６ヵ月間とし、前半２ヵ月間
は試料を塗布しない期間，後半４ヵ月は試料を塗布する
期間とした。試料を塗布する期間には、試料を１日２
回、１回につき２〜４mlの試料を頭皮に塗布した。試験
期間中には、１日おきに洗髪して抜毛を回収し、１週間
分をまとめてその毛の本数を数えた。2. Hair loss prevention effect test The hair loss prevention effect was determined by the change in the number of hair washes before and after use of the sample. The test subjects were male, and the male and female subjects in the comparative example and the example were each 10 persons. The test period was six months, the first two months were a period during which no sample was applied, and the last four months were a period during which the sample was applied. During the sample application period, apply the sample 2 times a day.
Each time, 2 to 4 ml of the sample was applied to the scalp. During the test period, the hair was washed every other day to collect the extracted hairs, and the number of hairs was counted for one week.
【００２８】各期間の抜毛本数の表示は、試料を塗布し
ない２カ月間，計８回の抜毛本数のデータと、試料を塗
布する期間の後半２ヵ月間，計８回の抜毛本数のデータ
をそれぞれの期間ごとにまとめ、平均値±標準偏差の形
で１回当りの抜毛本数として表示した。The display of the number of hair removals in each period is based on the data of the number of hair removals eight times in total during the two months when the sample is not applied and the data of the number of hair removals eight times in the latter two months of the period in which the sample is applied. The results were summarized for each period and displayed as the number of hair removals per time in the form of average value ± standard deviation.
【００２９】効果の判定は、それぞれの期間の平均値の
差から次のように判定した。 ＜判定基準＞ ＋＋：抜毛本数が７０本以上減っており，著しい効果を
認めた ＋：抜毛本数が４０本以上減っており，かなりの効果を
認めた ±：抜毛本数が１０本以上減っており，やや効果が認め
られた −：抜毛本数の減少が１０本未満であり，無効であった 脱毛防止効果の評価としては、＋以上の被験者が５０％
を超えた場合を有効とし、その他は無効とした。The effect was judged as follows from the difference between the average values in each period. <Judgment criteria> ++: The number of removed hairs decreased by 70 or more, and a remarkable effect was recognized. +: The number of removed hairs decreased by 40 or more, and a considerable effect was recognized. ±: The number of removed hairs decreased by 10 or more. The effect was slightly recognized. −: The number of hair loss was less than 10 hairs, and the hair loss was ineffective.
Is valid when the value exceeds the limit, and invalid for the others.
【００３０】３．ふけ，かゆみの防止効果試験 ふけ，かゆみの防止効果については、試験期間終了後に
各被験者の頭皮のふけ，かゆみについて調査し、ふけの
程度とかゆみの程度によって比較した。被験者は、特に
ふけとかゆみを訴える男性とし、比較例及び実施例各群
10名とした。試料を塗布する期間は３ヵ月間とし、この
間薬剤無添加の同一シャンプーで１日１回洗髪し、試料
を１日２回、１回につき２〜４mlを頭皮に塗布した。試
験終了後に、各被験者の頭皮のふけ，かゆみの程度をそ
れぞれ以下のスコアで表した。3. Test of dandruff and itching prevention effect The dandruff and itch prevention effect were examined after each test period for each subject's scalp dandruff and itch, and the degree of dandruff and itching were compared. Subjects were males who complained of dandruff and itching, and each group of Comparative Examples and Examples
10 people. The sample was applied for a period of 3 months, during which time the hair was washed once a day with the same shampoo containing no drug, and the sample was applied to the scalp twice a day, twice a day. After the test, the degree of dandruff and itching of each subject was represented by the following scores.
【００３１】＜ふけのスコア＞ ３：ふけが著しく多い ２：ふけが多い １：ややふけが多い ０：ふけがほとんどない<Danmark score> 3: Significantly dandruff 2: Many dandruff 1: Slightly dandruff 0: Almost no dandruff
【００３２】＜かゆみのスコア＞ ３：強いかゆみがある ２：かゆみがある １：ややかゆみがある ０：かゆみがない<Itching score> 3: Strong itching 2: Itching 1: Slight itching 0: No itching
【００３３】〔実施例１〜９，比較例１〜６〕第１表
（実施例１〜９，比較例１〜６）に示した配合成分のロ
ーションを後述する製法に従って調製し、上記各試験を
行った。[Examples 1 to 9, Comparative Examples 1 to 6] Lotions of the components shown in Table 1 (Examples 1 to 9 and Comparative Examples 1 to 6) were prepared according to the production methods described below, and the above-mentioned tests were performed. Was done.
【００３４】[0034]
【表１】 [Table 1]
【００３５】＜製法＞９５％エタノールに、オレイルジ
メチルアミンオキシド及びイソステアリルジメチルアミ
ンオキシドをはじめとする各薬剤（グリチルリチン酸ジ
カリウム，β−グリチルレチン酸，グリチルリチン酸，
グリチルレチン酸ステアリル）、ジプロピレングリコー
ル、硬化ヒマシ油エチレンオキシド（５０モル）付加
物、リンゴ酸、香料を溶解させた（エタノール相）。次
いで精製水に色素を添加した後，溶解して、これを前記
エタノール相に添加した後，攪拌することにより、透明
液状のローションを得た。上記各試験の結果を、第２表
（養毛効果試験），第３表（脱毛防止効果試験）及び第
４表（ふけ，かゆみの防止効果試験）に示した。<Production method> Various drugs such as oleyldimethylamine oxide and isostearyldimethylamine oxide (dipotassium glycyrrhizinate, β-glycyrrhetinic acid, glycyrrhizic acid,
(Stearyl glycyrrhetinate), dipropylene glycol, hydrogenated castor oil ethylene oxide (50 mol) adduct, malic acid, and fragrance were dissolved (ethanol phase). Next, a dye was added to purified water, dissolved, and added to the ethanol phase, followed by stirring to obtain a clear liquid lotion. The results of the above tests are shown in Table 2 (hair growth effect test), Table 3 (hair loss prevention effect test), and Table 4 (dandruff and itching prevention effect test).
【００３６】[0036]
【表２】 [Table 2]
【００３７】[0037]
【表３】 [Table 3]
【００３８】[0038]
【表４】 [Table 4]
【００３９】これらの結果より明らかなように、グリチ
ルリチン酸ジカリウム，β−グリチルレチン酸，グリチ
ルリチン酸及びグリチルレチン酸ステアリルから選択さ
れる１種又は２種以上と、オレイルジメチルアミンオキ
シド及びイソステアリルジメチルアミンオキシドから選
択される１種又は２種とを配合した実施例のローション
には、養毛効果，脱毛防止効果及びふけ，かゆみの防止
効果が顕著に認められたが、グリチルリチン酸ジカリウ
ム，β−グリチルレチン酸，グリチルリチン酸，グリチ
ルレチン酸ステアリル，オレイルジメチルアミンオキシ
ド及びイソステアリルジメチルアミンオキシドのいずれ
か１種のみを配合した比較例のローションは、たとえこ
れらの成分を相当量配合しても、これらの効果は上記実
施例の結果と比べると著しく劣っていた。As is clear from these results, one or more selected from dipotassium glycyrrhizinate, β-glycyrrhetinic acid, glycyrrhizic acid and stearyl glycyrrhetinate, and oleyl dimethylamine oxide and isostearyl dimethylamine oxide In the lotion of the examples in which one or two kinds were selected, a hair growth effect, a hair loss preventing effect, and a dandruff and itching preventing effect were remarkably recognized, but dipotassium glycyrrhizinate, β-glycyrrhetinic acid, The lotion of Comparative Example containing only one of glycyrrhizic acid, stearyl glycyrrhetinate, oleyl dimethylamine oxide and isostearyl dimethylamine oxide has the above-mentioned effect even if a considerable amount of these components is blended. Compare with example results It was remarkably inferior.
【００４０】すなわち、グリチルレチン酸類及び／又は
グリチルリチン酸類とオレイルジメチルアミンオキシド
及び／又はイソステアリルジメチルアミンオキシドとを
組み合わせて配合した本発明頭髪用化粧料においては、
相乗的な養毛効果，脱毛防止効果及びふけ，かゆみの防
止効果が顕著に認められることが明らかになった。この
ことは、少量の有効成分であっても本発明頭髪用化粧料
においては所望する効果を得ることが可能であり、これ
らの成分を多量に配合することによって惹起される、塗
布部及びその周辺部の不快な刺激感や発赤を防ぐことが
可能になったことを示すものである。That is, in the hair cosmetic composition of the present invention in which glycyrrhetinic acids and / or glycyrrhizic acids are combined with oleyldimethylamine oxide and / or isostearyldimethylamine oxide,
It was clarified that a synergistic hair-raising effect, a hair loss-preventing effect and a dandruff-and-itch-preventing effect were remarkably observed. This is because the desired effect can be obtained in the hair cosmetic of the present invention even with a small amount of the active ingredient, and the application part and its surroundings caused by blending these components in a large amount can be obtained. This indicates that it has become possible to prevent unpleasant irritation and redness of the part.
【００４１】以下、さらに他の本発明頭髪用化粧料の処
方例を示す。 〔実施例１０〕 ローション （配合成分） 配合量（重量％） ９５％エタノール ５５．０ オレイルジメチルアミンオキシド ３．０ グリチルリチン酸モノアンモニウム ０．６ プロピレングリコール １．０ 硬化ヒマシ油エチレンオキシド（５０モル）付加物 ０．５ コハク酸 適 量 香料及び色素 適 量 精製水 残 部Hereinafter, still another formulation example of the hair cosmetic composition of the present invention will be described. [Example 10] Lotion (Blending ingredients) Blending amount (% by weight) 95% ethanol 55.0 Oleyldimethylamine oxide 3.0 Monoammonium glycyrrhizinate 0.6 Propylene glycol 1.0 Addition of hydrogenated castor oil ethylene oxide (50 mol) Substance 0.5 succinic acid qs perfume and dye qs purified water balance
【００４２】＜製法＞９５％エタノールにオレイルジメ
チルアミンオキシド、グリチルリチン酸モノアンモニウ
ム、プロピレングリコール、硬化ヒマシ油エチレンオキ
シド（５０モル）付加物、コハク酸及び香料を溶解させ
た（エタノール相）。次いで精製水に色素を溶解させた
後、これを前記エタノール相に添加し、攪拌溶解するこ
とによって、透明液状のローションを得た。<Preparation> Oleyldimethylamine oxide, monoammonium glycyrrhizinate, propylene glycol, adduct of hydrogenated castor oil ethylene oxide (50 mol), succinic acid and a fragrance were dissolved in 95% ethanol (ethanol phase). Next, after dissolving the dye in purified water, the dye was added to the ethanol phase and stirred and dissolved to obtain a clear liquid lotion.
【００４３】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.
【００４４】 〔実施例１１〕 ローション （配合成分） 配合量（重量％） ９５％エタノール ６５．０ イソステアリルジメチルアミンオキシド ３．０ β−グリチルレチン酸 １．０ グリチルリチン酸 ０．５ ジプロピレングリコール ２．０ 硬化ヒマシ油エチレンオキシド（６０モル）付加物 ０．５ 乳酸 適 量 乳酸ナトリウム 適 量 香料及び色素 適 量 精製水 残 部Example 11 Lotion (Blending Components) Blending Amount (% by Weight) 95% Ethanol 65.0 Isostearyldimethylamine Oxide 3.0 β-Glycyrrhetinic Acid 1.0 Glycyrrhizic Acid 0.5 Dipropylene Glycol 2. 0 Hardened castor oil ethylene oxide (60 mol) adduct 0.5 Sq. Lactate Sq. Lactate Sq. Perfume and pigment qs. Purified water balance
【００４５】＜製法＞９５％エタノールに、イソステア
リルジメチルアミンオキシド、β−グリチルレチン酸、
グリチルリチン酸、ジプロピレングリコール，硬化ヒマ
シ油エチレンオキシド（６０モル）付加物、乳酸、乳酸
ナトリウム及び香料を溶解させた（エタノール相）。次
いで精製水に色素を溶解させた後、これを前記エタノー
ル相に添加し、攪拌溶解することにより、透明液状のロ
ーションを得た。<Production method> Isostearyl dimethylamine oxide, β-glycyrrhetinic acid,
Glycyrrhizic acid, dipropylene glycol, hydrogenated castor oil ethylene oxide (60 mol) adduct, lactic acid, sodium lactate and fragrance were dissolved (ethanol phase). Next, after dissolving the dye in purified water, this was added to the ethanol phase and stirred and dissolved to obtain a transparent liquid lotion.
【００４６】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.
【００４７】 〔実施例１２〕 ローション （配合成分） 配合量（重量％） ９５％エタノール ７０．０ オレイルジメチルアミンオキシド １．０ イソステアリルジメチルアミンオキシド １．０ グリチルリチン酸ジカリウム ０．５ グリチルレチン酸ステアリル ０．５ １，３−ブチレングリコール ３．０ 硬化ヒマシ油エチレンオキシド（４０モル）付加物 ０．６ コハク酸 適 量 香料及び色素 適 量 精製水 残 部Example 12 Lotion (Blending Component) Blending Amount (% by Weight) 95% Ethanol 70.0 Oleyldimethylamine Oxide 1.0 Isostearyldimethylamine Oxide 1.0 Dipotassium Glycyrrhizinate 0.5 Stearyl Glycyrrhetinate 0 1.5 1,3-butylene glycol 3.0 Hardened castor oil ethylene oxide (40 mol) adduct 0.6 Succinic acid qs Perfume and pigment qs Purified water balance
【００４８】＜製法＞９５％エタノールに、オレイルジ
メチルアミンオキシド、イソステアリルジメチルアミン
オキシド、グリチルリチン酸ジカリウム、グリチルレチ
ン酸ステアリル、１，３−ブチレングリコール、硬化ヒ
マシ油エチレンオキシド（４０モル）付加物、コハク酸
及び香料を溶解させた（エタノール相）。次いで精製水
に色素を溶解させた後、これを前記エタノール相に添加
し、攪拌溶解することにより、透明液状のローションを
得た。<Production method> Oleyl dimethylamine oxide, isostearyl dimethylamine oxide, dipotassium glycyrrhizinate, stearyl glycyrrhetinate, 1,3-butylene glycol, hydrogenated castor oil ethylene oxide (40 mol) adduct, succinic acid in 95% ethanol And the fragrance were dissolved (ethanol phase). Next, after dissolving the dye in purified water, this was added to the ethanol phase and stirred and dissolved to obtain a transparent liquid lotion.
【００４９】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。When the above-mentioned test was carried out on the cosmetic for hair of the present invention, a hair-growth effect, an effect of preventing hair loss, and an effect of preventing dandruff and itching were remarkably recognized.
【００５０】 〔実施例１３〕 乳液 （配合成分） 配合量（重量％） （１）セタノール １．７ （２）ステアリン酸 １．１ （３）パルミチン酸 ０．５ （４）液状ラノリン １．５ （５）スクワラン １．０ （６）モノステアリン酸グリセリル ２．０ （７）ＰＯＥソルビタンモノステアレート ０．５ （８）イソステアリルジメチルアミンオキシド ２．０ （９）オレイルジメチルアミンオキシド １．０ （10）グリチルレチン酸ステアリル ０．５ （11）プロピレングリコール ３．０ （12）ポリエチレングリコール４００ ２．０ （13）トリエタノールアミン １．０ （14）精製水 残 部Example 13 Emulsion (Blending Components) Blending Amount (% by Weight) (1) Cetanol 1.7 (2) Stearic Acid 1.1 (3) Palmitic Acid 0.5 (4) Liquid Lanolin 1.5 (5) Squalane 1.0 (6) Glyceryl monostearate 2.0 (7) POE sorbitan monostearate 0.5 (8) Isostearyl dimethylamine oxide 2.0 (9) Oleyl dimethylamine oxide 1.0 ( 10) Stearyl glycyrrhetinate 0.5 (11) Propylene glycol 3.0 (12) Polyethylene glycol 400 2.0 (13) Triethanolamine 1.0 (14) Purified water balance
【００５１】＜製法＞（１）〜（10）の各成分を混合し
た混合物を調製した。これとは別に（11）〜（14）の成
分を混合した混合物を調製した。これらの混合物をそれ
ぞれ別々に７０℃に加熱して溶解後、両者を混合して、
これを乳化機により混合乳化した後、熱交換冷却を行っ
て、乳液を得た。<Production Method> A mixture was prepared by mixing the components (1) to (10). Separately, a mixture was prepared by mixing the components (11) to (14). These mixtures were separately heated to 70 ° C. and dissolved, and then both were mixed.
After this was mixed and emulsified by an emulsifier, heat exchange cooling was performed to obtain an emulsion.
【００５２】この本発明頭髪用化粧料に上記試験を行っ
たところ、養毛効果，脱毛防止効果及びふけ，かゆみの
防止効果が顕著に認められた。The above-mentioned test was carried out on the cosmetic for hair of the present invention. As a result, a hair-growth effect, a hair loss-preventing effect, and a dandruff and itching-preventing effect were remarkably recognized.
【００５３】[0053]
【発明の効果】本発明により、優れた養毛効果や脱毛防
止効果，頭皮のふけ, かゆみの防止効果を有し、かつ安
全性にも優れる頭髪用化粧料が提供される。Industrial Applicability According to the present invention, there is provided a hair cosmetic composition having an excellent hair-growth effect, an effect of preventing hair loss, an effect of preventing dandruff and itching of the scalp, and also having excellent safety.
Claims (2)
チルリチン酸類、並びに、 ２）オレイルジメチルアミンオキシド及び／又はイソス
テアリルジメチルアミンオキシド を含有する頭皮頭髪用化粧料。1. A cosmetic composition for scalp hair containing 1) glycyrrhetinic acids and / or glycyrrhizic acids, and 2) oleyldimethylamine oxide and / or isostearyldimethylamine oxide.
リチン酸類を、頭皮頭髪用化粧料全体に対して０．００
１〜５．０重量％含有する請求項１記載の頭皮頭髪用化
粧料。2. Glycyrrhetinic acids and / or glycyrrhizic acids are added in an amount of 0.00% to the total amount of the scalp hair cosmetic.
The scalp hair cosmetic according to claim 1, which is contained in an amount of 1 to 5.0% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7666298A JPH11255621A (en) | 1998-03-10 | 1998-03-10 | Cosmetic for scalp and hair |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7666298A JPH11255621A (en) | 1998-03-10 | 1998-03-10 | Cosmetic for scalp and hair |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11255621A true JPH11255621A (en) | 1999-09-21 |
Family
ID=13611633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP7666298A Withdrawn JPH11255621A (en) | 1998-03-10 | 1998-03-10 | Cosmetic for scalp and hair |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH11255621A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011184412A (en) * | 2010-03-11 | 2011-09-22 | Nippon Menaade Keshohin Kk | Emulsified composition, and skin care preparation for external use containing the same |
| EP2591824A3 (en) * | 2011-11-13 | 2013-07-10 | Compad Consulting GmbH | Sustainable cosmetic and dermatological formulations |
| US20130309282A1 (en) * | 2011-01-31 | 2013-11-21 | Kikuboshi Corporation | Hairstyling agent composition |
| JP2016088860A (en) * | 2014-10-31 | 2016-05-23 | 株式会社コーセー | Cosmetic or external preparation for skin |
| US11185557B2 (en) * | 2017-07-28 | 2021-11-30 | Isdin, S.A. | Use of rhamnose and derivatives thereof as antifungal agents |
-
1998
- 1998-03-10 JP JP7666298A patent/JPH11255621A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011184412A (en) * | 2010-03-11 | 2011-09-22 | Nippon Menaade Keshohin Kk | Emulsified composition, and skin care preparation for external use containing the same |
| US20130309282A1 (en) * | 2011-01-31 | 2013-11-21 | Kikuboshi Corporation | Hairstyling agent composition |
| EP2591824A3 (en) * | 2011-11-13 | 2013-07-10 | Compad Consulting GmbH | Sustainable cosmetic and dermatological formulations |
| JP2016088860A (en) * | 2014-10-31 | 2016-05-23 | 株式会社コーセー | Cosmetic or external preparation for skin |
| US11185557B2 (en) * | 2017-07-28 | 2021-11-30 | Isdin, S.A. | Use of rhamnose and derivatives thereof as antifungal agents |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A300 | Withdrawal of application because of no request for examination |
Free format text: JAPANESE INTERMEDIATE CODE: A300 Effective date: 20050510 |