JPS6314988B2 - - Google Patents
Info
- Publication number
- JPS6314988B2 JPS6314988B2 JP22928384A JP22928384A JPS6314988B2 JP S6314988 B2 JPS6314988 B2 JP S6314988B2 JP 22928384 A JP22928384 A JP 22928384A JP 22928384 A JP22928384 A JP 22928384A JP S6314988 B2 JPS6314988 B2 JP S6314988B2
- Authority
- JP
- Japan
- Prior art keywords
- apatite
- spinning
- flocculent
- hydroxyapatite
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229910052586 apatite Inorganic materials 0.000 claims description 50
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 50
- 239000001506 calcium phosphate Substances 0.000 claims description 14
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 14
- 235000011010 calcium phosphates Nutrition 0.000 claims description 12
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 11
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 11
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 11
- 239000011575 calcium Substances 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 2
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 2
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 2
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 2
- 238000009987 spinning Methods 0.000 description 23
- 239000000835 fiber Substances 0.000 description 13
- 210000000988 bone and bone Anatomy 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 7
- 239000002994 raw material Substances 0.000 description 6
- 238000004804 winding Methods 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 238000002074 melt spinning Methods 0.000 description 4
- 239000004745 nonwoven fabric Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 229920001218 Pullulan Polymers 0.000 description 3
- 239000004373 Pullulan Substances 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000010304 firing Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 235000019423 pullulan Nutrition 0.000 description 3
- 239000003232 water-soluble binding agent Substances 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000011882 ultra-fine particle Substances 0.000 description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 241001480003 Chaetothyriales Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000012784 inorganic fiber Substances 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
Description
【発明の詳細な説明】
産業上の利用分野
本発明は、生体との親和性が良好で、新生骨形
成能を有し、且つ複雑な形状をした骨欠損部位に
も極めて容易に適合させることのできるアパタイ
ト綿状体に関するものである。[Detailed Description of the Invention] Industrial Application Field The present invention has good compatibility with living organisms, has the ability to form new bone, and can be extremely easily adapted to bone defect sites with complex shapes. This is related to apatite flocculent bodies that can be produced.
従来の技術
周知のようにアパタイトはMm（RO4）nXなる
組成式で表示されるものであつて、代表的なもの
としてフツ素アパタイトCa5（PO4）3Fと水酸アパ
タイトCa5（PO4）3OHがある。水酸アパタイトは
歯や骨の主要無機成分としてよく知られており、
合成した水酸アパタイトの焼結体は歯や骨の組織
に対して優れた親和性を示し、骨組織や歯肉に直
接化学的に結合するため、新しい人工歯、人工骨
材料として注目を集めている。そして、アパタイ
ト焼結体による人工歯根及びアパタイト多孔体に
よる人工骨は実用化の段階に至つている。Prior Art As is well known, apatite is represented by the composition formula Mm(RO 4 )nX, and typical examples include fluoroapatite Ca 5 (PO 4 ) 3 F and hydroxyapatite Ca 5 ( There is PO 4 ) 3 OH. Hydroxyapatite is well known as the main inorganic component of teeth and bones.
The synthesized sintered hydroxyapatite exhibits excellent affinity for tooth and bone tissue, and because it chemically bonds directly to bone tissue and gums, it is attracting attention as a new artificial tooth and bone material. There is. Artificial tooth roots made of apatite sintered bodies and artificial bones made of apatite porous bodies have reached the stage of practical use.
しかしながら、アパタイト焼結体は圧縮には強
いが引つ張りに弱い脆性材料であるため、衝撃に
弱く、焼結体の表面に生じた微小なひび割れによ
つて引つ張り強度が大きく低下する（つまり、靭
性が低い）といつた欠点がある。このため、アパ
タイト焼結体の生体への適用範囲は非常に狭く、
過大な引つ張り応力が殆んどかからない、例えば
白歯部の人工歯根として使用されている程度であ
る。 However, since the apatite sintered body is a brittle material that is strong in compression but weak in tension, it is susceptible to impact, and its tensile strength is greatly reduced by minute cracks that occur on the surface of the sintered body ( In other words, it has the disadvantage of low toughness). For this reason, the scope of application of apatite sintered bodies to living organisms is extremely narrow.
Excessive tensile stress is hardly applied, and it is used, for example, as an artificial tooth root for white teeth.
上記アパタイト焼結体の欠点を除去するために
アパタイトを繊維状に形成し、骨欠損部あるいは
空隙部充填剤として使用できるようにした無機フ
アイバが、例えば特開昭57−117621号公報および
特開昭58−54023号公報に開示されている。 In order to eliminate the drawbacks of the above-mentioned apatite sintered bodies, inorganic fibers in which apatite is formed into fibers and can be used as fillers for bone defects or voids are disclosed in, for example, JP-A No. 57-117621 and JP-A No. It is disclosed in Publication No. 58-54023.
しかしながら、上記公報に示されたアパタイト
フアイバは高温度でアパタイトを溶融して紡糸す
るいわゆる溶融紡糸法によつて製造されている。
上記公報にも記載されているように、この溶融紡
糸法ではアパタイトを1500℃のような高温度で溶
融するためアパタイトのOH基が消失し、親和性
が欠如してしまうという重大な欠点がある。この
ため、形成されたアパタイト繊維状体に親和性を
もたせるための後処理が不可欠であつた。 However, the apatite fiber disclosed in the above publication is manufactured by a so-called melt spinning method in which apatite is melted at high temperature and spun.
As stated in the above publication, this melt-spinning method has a serious drawback in that apatite is melted at a high temperature of 1500°C, which causes the OH groups of apatite to disappear, resulting in a lack of affinity. . For this reason, post-treatment to impart affinity to the apatite fibrous bodies formed has been essential.
一方、溶融紡糸法以外の方法ではアパタイトの
繊維状体または綿状体（短繊維が互いに絡み合つ
た状態にあるものをいう。）を得ることは難かし
く、現在のところ実用化されていない。 On the other hand, it is difficult to obtain apatite fibrous bodies or flocculent bodies (meaning short fibers intertwined with each other) by methods other than melt spinning, and these methods have not been put to practical use at present.
発明が解決しようとする問題点
本発明者等は斯る従来のアパタイト繊維状体の
欠点を改良するべく、水酸アパタイトをバインダ
の水溶液に分散させて得られる分散液を紡糸孔か
ら連続的に押し出すと同時に、該紡糸孔に隣接し
て設置した気体吐出孔から気体を高速度で吐出さ
せ、前記紡糸孔から押し出される繊維の水分を蒸
発させ、該水分の除去された繊維流を捕集装置、
例えば捕集板に吹き付けてアパタイト綿状体を形
成するようにしたアパタイト綿状体の製造法を提
案した。Problems to be Solved by the Invention In order to improve the drawbacks of the conventional apatite fibrous material, the present inventors have developed a method in which a dispersion obtained by dispersing hydroxyapatite in an aqueous solution of a binder is continuously passed through a spinning hole. At the same time as the extrusion, gas is discharged at high speed from a gas discharge hole installed adjacent to the spinning hole to evaporate the moisture in the fibers extruded from the spinning hole, and the fiber stream from which the moisture has been removed is collected by a collection device. ,
For example, we proposed a method for producing apatite flocs by spraying onto a collection plate to form apatite flocs.
該方法に基ずくアパタイト綿状体は従来の繊維
状アパタイトの欠点を改良するものであつたが、
強度の点で未だ不十分であつた。 Although the apatite flocculent based on this method improved the drawbacks of conventional fibrous apatite,
The strength was still insufficient.
発明の目的
本発明はこのようなアパタイト綿状体の改良に
関するものである。OBJECTS OF THE INVENTION The present invention relates to improvements in such apatite flocs.
つまり、本発明の目的は、十分な強度をもつた
アパタイト綿状体を提供することである。 That is, an object of the present invention is to provide an apatite flocculent body having sufficient strength.
問題点を解決するための手段
上記目的は、本発明によつて完全に達成され
る。要約すると、本発明は、水酸アパタイト５〜
95重量％、好ましくは50重量％以上と、燐酸カル
シウム95〜５重量％、好ましくは50重量％以下の
混合物を含むことを特徴とするアパタイト綿状体
である。本発明に係るアパタイトは、好ましくは
特殊なバインダでアパタイト及び燐酸カルシウム
の微粒子を粘結し、紡糸後焼成するようにした溶
液紡糸法を使用するアパタイト綿状体の製造法に
よつて提供され、OH基を保有した、従つて親和
性が消失しない、しかも強度の大きなアパタイト
綿状体が後処理を必要とすることなく得られる。
更に詳しく言えば、本発明のアパタイト綿状体は
水酸アパタイト及び燐酸カルシウム粒子を含有す
る水溶液に水溶性バインダを添加して得た粘性体
を紡糸装置に設置した複数個の紡思孔から連続的
に紡糸すると同時に該紡糸孔に隣接して設置した
気体吐出孔から所定の気体を高速で吐出させ、前
記紡糸孔からの糸を延伸させて微細な繊維の流れ
にするとともに加熱して水分を除去し、該水分の
除去された繊維流を例えば捕集板の如き捕集装置
に吹き付けてアパタイト綿状体を得るようにした
アパタイト綿状体の製造法によつて提供される。Means for Solving the Problems The above objects are fully achieved by the present invention. In summary, the present invention provides hydroxyapatite 5-
An apatite flocculent body characterized in that it contains a mixture of 95% by weight, preferably 50% by weight or more, and 95-5% by weight, preferably 50% by weight or less of calcium phosphate. The apatite according to the present invention is preferably provided by a method for producing an apatite floc using a solution spinning method in which fine particles of apatite and calcium phosphate are bound together with a special binder, and then fired after spinning. An apatite flocculent that retains OH groups and therefore does not lose its affinity and has high strength can be obtained without the need for post-treatment.
More specifically, the apatite flocculent body of the present invention is produced by continuously spinning a viscous material obtained by adding a water-soluble binder to an aqueous solution containing hydroxyapatite and calcium phosphate particles through a plurality of spinning holes installed in a spinning device. At the same time as spinning, a predetermined gas is discharged at high speed from a gas discharge hole installed adjacent to the spinning hole, and the yarn from the spinning hole is drawn into a fine fiber flow and heated to remove moisture. and the dehydrated fiber stream is sprayed onto a collection device, such as a collection plate, to obtain an apatite floc.
本発明においてアパタイトは水酸アパタイト
（Ca5（PO4）3OH）であり、燐酸カルシウムは燐酸
水素カルシウム（CaHPO4）、燐酸三カルシウム
（Ca3（PO4）2）及び燐酸四カルシウム（Ca4O
（PO4）2）の群から選択される少なくとも一種で
ある。 In the present invention, apatite is hydroxyapatite (Ca 5 (PO 4 ) 3 OH), and calcium phosphate is calcium hydrogen phosphate (CaHPO 4 ), tricalcium phosphate (Ca 3 (PO 4 ) 2 ), and tetracalcium phosphate (Ca 4 O
( PO4 ) 2 ) At least one selected from the group of (PO4)2).
以下、添付図面を参照して本発明に係るアパタ
イト綿状体の好ましい一製造法について詳細に説
明する。 Hereinafter, a preferred method for producing an apatite flocculent according to the present invention will be described in detail with reference to the accompanying drawings.
第１図はアパタイト綿状体製造装置の一例を示
す。この製造装置１０は原料タンク１１、モータ
１２、ギアポンプ１３、紡糸ノズル１４、多段式
ブロアー１５、エアノズル１６、遠赤外線ヒータ
（インフラシユタイン）１７、捕集板となる巻取
装置（ネツト型ドラム）１８、およびリフター１
９より構成されている。 FIG. 1 shows an example of an apatite floc manufacturing apparatus. This manufacturing device 10 includes a raw material tank 11, a motor 12, a gear pump 13, a spinning nozzle 14, a multi-stage blower 15, an air nozzle 16, a far-infrared heater (infrared tine) 17, and a winding device (net-type drum) serving as a collection plate. 18, and lifter 1
It is composed of 9.
原料タンク１１には管路２０を通じてアパタイ
ト及び燐酸カルシウムの微粒物を含有する懸濁液
と特定の水溶性バインダとの混合液である粘性液
体が供給される。この粘性液体は管路２１を介し
て紡糸装置に供給され、紡糸孔である紡糸ノズル
１４よりモータ１２およびギアポンプ１３の作動
により紡糸される。従つて、原料タンク１１内の
粘性液体は添加するバインダにより紡糸に適した
粘度に調節する。バインダとしては医療用である
ため生体に無害であること（従つて天然物が良
い）、重金属を含まず、水溶性であり、かつ焼成
時に高温で溶融せず分解するものである必要があ
る。水溶性のバインダとしてはPVA、CMC、
HPC等があるが、本発明者の実験の結果、シヨ
糖やでん粉を黒酵母で醗酵させて作つた多糖類の
一種であるプルラン（C6H10O5）ｎ・H2Oが最適
であることが判明した。また、原料のアパタイト
及び燐酸カルシウムの水溶液は、粒径50Å〜1μm
の超微粒子状の水酸アパタイトCa10（PO4）6
（OH）2と、粒径50Å〜1μmの超微粒子状の上記い
ずれかの燐酸カルシウムとの混合水溶液が最適で
あることも判明した。この水溶液はカルシウムイ
オンを含むアルカリ性溶液（PH＝７〜11）に燐酸
水溶液を除々に滴下し、棒状の超微粒子の水性白
色懸濁液を合成したものである。 A viscous liquid, which is a mixed liquid of a suspension containing fine particles of apatite and calcium phosphate, and a specific water-soluble binder, is supplied to the raw material tank 11 through a pipe 20. This viscous liquid is supplied to the spinning device via a pipe line 21, and is spun through a spinning nozzle 14, which is a spinning hole, by the operation of a motor 12 and a gear pump 13. Therefore, the viscosity liquid in the raw material tank 11 is adjusted to have a viscosity suitable for spinning by the added binder. Since the binder is for medical use, it must be harmless to living organisms (natural products are therefore preferred), contain no heavy metals, be water-soluble, and decompose without melting at high temperatures during firing. Water-soluble binders include PVA, CMC,
There are HPC, etc., but as a result of the inventor's experiments, pullulan (C 6 H 10 O 5 ) nH 2 O, which is a type of polysaccharide made by fermenting sucrose and starch with black yeast, is the best. It turns out that there is something. In addition, the raw material apatite and calcium phosphate aqueous solution has a particle size of 50 Å to 1 μm.
Ultrafine particulate hydroxyapatite Ca 10 (PO 4 ) 6
It has also been found that a mixed aqueous solution of (OH) 2 and any of the above calcium phosphates in the form of ultrafine particles with a particle size of 50 Å to 1 μm is optimal. This aqueous solution was prepared by gradually dropping an aqueous phosphoric acid solution into an alkaline solution (PH=7 to 11) containing calcium ions to synthesize an aqueous white suspension of rod-shaped ultrafine particles.
上記粘性液体を紡糸すると同時に気体吐出孔で
あるエアノズル１６より多段式ブロアー１５の作
動を通じて空気を高速度で吐出させ、紡糸ノズル
１４からの糸を延伸させて微細な繊維状にし、捕
集装置、例えば巻取装置１８へ繊維流２２として
吹き付ける。紡糸ノズル１４から紡糸される糸に
はかなりの水分があり（全体の約70％が水分）、
従つて紡糸ノズル１４から巻取装置１８までの短
かい距離間で乾燥し、水分を蒸発させて糸にする
必要がある。従つて、本製造装置１０では遠赤外
線ヒータ１７よりなる電気炉において200℃〜500
℃で乾燥し、水分を蒸発させる。この時、及び引
きつずき行なわれる焼成時に乾燥及び焼成温度を
1500℃のように高くしたのでは上記したようにア
パタイトのOH基が消失してしまい、親和性がな
くなる。従つて、1300℃以下にすることが好まし
い。またあまり低くすると水分の蒸発が十分でな
くなり、良好な微細な繊維状にならなくなる。遠
赤外線ヒータ１７の代りにマイクロ波加熱を利用
しても、他の熱源を利用してもよい。なお、溶融
紡糸ではなくて室温紡糸であるので粘性液体の粘
度に対応したノズル形状とブローイング用ブロア
ー風量を設定する必要がある。 At the same time as the viscous liquid is spun, air is discharged at high speed from the air nozzle 16, which is a gas discharge hole, through the operation of the multi-stage blower 15, and the yarn from the spinning nozzle 14 is stretched into fine fibers, and a collection device, For example, it is sprayed as a fiber stream 22 onto the winding device 18 . The yarn spun from the spinning nozzle 14 contains a considerable amount of water (approximately 70% of the total water content).
Therefore, it is necessary to dry the yarn over a short distance from the spinning nozzle 14 to the winding device 18 to evaporate moisture and turn it into yarn. Therefore, in this manufacturing apparatus 10, the electric furnace consisting of the far-infrared heater 17 is heated at 200°C to 500°C.
Dry at °C and evaporate the moisture. Drying and firing temperatures should be adjusted at this time and during subsequent firing.
If the temperature is raised to a temperature as high as 1500°C, the OH groups of apatite will disappear as described above, resulting in a loss of affinity. Therefore, it is preferable to keep the temperature at 1300°C or lower. Furthermore, if the temperature is too low, moisture evaporation will not be sufficient and fine fibers will not form. Instead of the far-infrared heater 17, microwave heating or other heat sources may be used. Note that since it is not melt spinning but room temperature spinning, it is necessary to set the nozzle shape and blowing air volume corresponding to the viscosity of the viscous liquid.
水分の除去された繊維流は例えば捕集板（図示
せず）のような捕集装置に吹き付けられ、アパタ
イトの綿状体が形成されるが、本実施例では該ア
パタイト綿状体は、図示するような巻取装置１８
のネツト式ドラムコレクター２３によつて捕集さ
れ、次で巻取りドラム２４に巻取られ、布状とな
つたアパタイト綿状体、即ちアパタイト不織布と
される態様が例示されている。 The dehydrated fiber stream is blown onto a collection device, such as a collection plate (not shown), to form an apatite floc; in this example, the apatite floc is A winding device 18 that
An embodiment is illustrated in which the apatite is collected by a net-type drum collector 23 and then wound onto a winding drum 24 to form a cloth-like apatite floc, that is, an apatite nonwoven fabric.
実施例
一実施例においては原料タンク１１内の粘性液
体の成分は重量パーセントで水25％、水酸アパタ
イト35％、燐酸カルシウム30％、プルラン10％で
あり、この成分比が最適であつた。しかし、本発
明者の実験の結果、水５〜90％、アパタイト５〜
70％、燐酸カルシウム５〜70％、プルラン２〜30
％（いずれも重量パーセント）であると良好なア
パタイト綿状体が得られた。Example In one example, the components of the viscous liquid in the raw material tank 11 were 25% water, 35% hydroxyapatite, 30% calcium phosphate, and 10% pullulan in weight percent, and this component ratio was optimal. However, as a result of the inventor's experiments, 5 to 90% water and 5 to 90% apatite
70%, calcium phosphate 5-70%, pullulan 2-30
% (all percentages by weight), a good apatite flocculent body was obtained.
又、紡糸ノズルの口径は0.3mmで、紡糸温度は
室温25℃であり、ダイのエアー圧は300〜1000mm
H2Oであつた。 In addition, the diameter of the spinning nozzle is 0.3 mm, the spinning temperature is room temperature 25℃, and the air pressure of the die is 300 to 1000 mm.
It was H2O .
更に、遠赤外線ヒータ１７の長さは800〜1000
mm、４〜10Kwで乾燥温度は約400℃であり、ア
パタイト不織布の焼成は、温度1100℃、２時間、
昇温速度50℃/hrであつた。 Furthermore, the length of the far infrared heater 17 is 800 to 1000
mm, 4 to 10Kw and the drying temperature is about 400℃, and the apatite nonwoven fabric is fired at a temperature of 1100℃ for 2 hours.
The temperature increase rate was 50°C/hr.
上記実施例にて形成された焼成後の平均繊維径
は３〜15μであり、繊維の機械的強度、即ち引張
り強度及び耐衝撃性は大であつた。 The average diameter of the fired fibers formed in the above examples was 3 to 15 μm, and the mechanical strength, that is, the tensile strength and impact resistance of the fibers were high.
発明の効果
本発明に係るアパタイト綿状体（及び布状とさ
れた不織布）はOH基の消失が全くなく、従来の
アパタイト焼結体と全く変わらない生体親和性を
示し、しかも綿状体であるので耐衝撃性が大き
く、加工その他の作業性が良い。従つて、複雑な
形状をした骨欠損部位にも極めて容易に適合させ
ることができるから、人工歯のみならず、種々の
骨の再構築、人工間接にも適用でき、さらにバイ
オテクノロジーにおける三次元倍養池としての応
用も考えられる等その作用効果は顕著なものがあ
る。Effects of the Invention The apatite flocculent body (and cloth-shaped nonwoven fabric) according to the present invention has no loss of OH groups and exhibits biocompatibility that is no different from that of conventional apatite sintered bodies. Because of this, it has great impact resistance and is easy to process and work with. Therefore, it can be extremely easily adapted to bone defect sites with complex shapes, so it can be applied not only to artificial teeth but also to various bone reconstructions and artificial joints, and is also useful in three-dimensional multiplication in biotechnology. Its effects are remarkable, including the possibility of its application as a cultivation pond.
なお、上記実施例は本発明の単なる例示にすぎ
ず、本発明に係るアパタイト綿状体は不織布以外
にも必要に応じて種々の変形、変更がなし得るこ
とはいうまでもない。 It should be noted that the above-mentioned embodiments are merely illustrative of the present invention, and it goes without saying that the apatite floc-like body according to the present invention may be modified in various ways other than non-woven fabrics as necessary.
第１図は本発明に係るアパタイト綿状体の製造
装置の一例を示す概略構成図である。
１０：アパタイト綿状体製造装置、１１：原料
タンク、１４：紡糸ノズル、１６：エアノズル、
１７：遠赤外線ヒータ、１８：巻取装置。
FIG. 1 is a schematic diagram showing an example of an apatite floc manufacturing apparatus according to the present invention. 10: Apatite floc manufacturing device, 11: Raw material tank, 14: Spinning nozzle, 16: Air nozzle,
17: far infrared heater, 18: winding device.
Claims (1)
ム95〜５重量％の混合物を含むことを特徴とする
アパタイト綿状体。 ２ 燐酸カルシウムは燐酸水素カルシウム
（CaHPO4）、燐酸三カルシウム（Ca3（PO4）2）及
び燐酸四カルシウム（Ca4O（PO4）2）の群から選
択される少なくとも一種である特許請求の範囲第
１項記載のアパタイト綿状体。 ３ 水酸アパタイトは50重量％以上であり、燐酸
カルシウムは50重量％以下である特許請求の範囲
第１項記載のアパタイト綿状体。[Scope of Claims] 1. An apatite flocculent comprising a mixture of 5 to 95% by weight of hydroxyapatite and 95 to 5% by weight of calcium phosphate. 2. A patent claim in which the calcium phosphate is at least one selected from the group of calcium hydrogen phosphate (CaHPO 4 ), tricalcium phosphate (Ca 3 (PO 4 ) 2 ), and tetracalcium phosphate (Ca 4 O(PO 4 ) 2 ). The apatite flocculent body according to item 1. 3. The apatite flocculent according to claim 1, wherein the hydroxyapatite is 50% by weight or more and the calcium phosphate is 50% by weight or less.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59229283A JPS61106166A (en) | 1984-10-31 | 1984-10-31 | Apatite fluffy material |
| US06/773,482 US4659617A (en) | 1984-09-11 | 1985-09-06 | Fibrous apatite and method for producing the same |
| DE8585306409T DE3578624D1 (en) | 1984-09-11 | 1985-09-10 | APATITE FIBER MATERIAL AND METHOD FOR THE PRODUCTION THEREOF. |
| EP19850306409 EP0174827B1 (en) | 1984-09-11 | 1985-09-10 | Fibrous apatite material and method for producing the same |
| CA000493540A CA1261568A (en) | 1984-10-31 | 1985-10-22 | Fibrous apatite and method for producing the same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP59229283A JPS61106166A (en) | 1984-10-31 | 1984-10-31 | Apatite fluffy material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS61106166A JPS61106166A (en) | 1986-05-24 |
| JPS6314988B2 true JPS6314988B2 (en) | 1988-04-02 |
Family
ID=16889688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59229283A Granted JPS61106166A (en) | 1984-09-11 | 1984-10-31 | Apatite fluffy material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS61106166A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH021285A (en) * | 1988-01-11 | 1990-01-05 | Asahi Optical Co Ltd | Fixable dental and medical granular bone filler, fixing method thereof and bone prosthetic material |
| JPH0394761A (en) * | 1989-09-07 | 1991-04-19 | Ngk Spark Plug Co Ltd | Artificial supply and prosthesis material |
| JP3115642B2 (en) * | 1991-06-07 | 2000-12-11 | 日揮株式会社 | Artificial aggregate |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57117621A (en) * | 1981-01-10 | 1982-07-22 | Mitsubishi Mining & Cement Co Ltd | Inorganic fiber of calcium phosphate and an implant material utilizing its properties |
| JPS584821A (en) * | 1981-07-02 | 1983-01-12 | Mitsubishi Mining & Cement Co Ltd | Production of calcium phosphate fiber |
-
1984
- 1984-10-31 JP JP59229283A patent/JPS61106166A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57117621A (en) * | 1981-01-10 | 1982-07-22 | Mitsubishi Mining & Cement Co Ltd | Inorganic fiber of calcium phosphate and an implant material utilizing its properties |
| JPS584821A (en) * | 1981-07-02 | 1983-01-12 | Mitsubishi Mining & Cement Co Ltd | Production of calcium phosphate fiber |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61106166A (en) | 1986-05-24 |
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