JPS6148496B2 - - Google Patents

Info

Publication number: JPS6148496B2
Authority: JP; Japan
Prior art keywords: penicillamine; isopropylidenepenicillamine; acetone; crude; acid
Prior art date: 1978-02-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP1165678A

Other languages

English (en)

Japanese (ja)

Other versions

JPS54106488A (en

Inventor

Kaoru Soda

Kazuyuki Tomizawa

Jiro Sawada

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Taisho Pharmaceutical Co Ltd

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-02-04

Filing date

1978-02-04

Publication date

1986-10-24

1978-02-04 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

1978-02-04 Priority to JP1165678A priority Critical patent/JPS54106488A/ja

1979-08-21 Publication of JPS54106488A publication Critical patent/JPS54106488A/ja

1986-10-24 Publication of JPS6148496B2 publication Critical patent/JPS6148496B2/ja

Status Granted legal-status Critical Current

Links

229960001639 penicillamine Drugs 0.000 claims description 25
VVNCNSJFMMFHPL-VKHMYHEASA-N D-penicillamine Chemical compound CC(C)(S)[C@@H](N)C(O)=O VVNCNSJFMMFHPL-VKHMYHEASA-N 0.000 claims description 21
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 20
150000007524 organic acids Chemical class 0.000 claims description 7
238000000034 method Methods 0.000 claims description 6
230000003301 hydrolyzing effect Effects 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
POYPKGFSZHXASD-WDSKDSINSA-N D-penicillamine disulfide Chemical compound OC(=O)[C@H](N)C(C)(C)SSC(C)(C)[C@@H](N)C(O)=O POYPKGFSZHXASD-WDSKDSINSA-N 0.000 description 8
239000013078 crystal Substances 0.000 description 6
239000007788 liquid Substances 0.000 description 5
238000010992 reflux Methods 0.000 description 5
LJRDOKAZOAKLDU-UDXJMMFXSA-N (2s,3s,4r,5r,6r)-5-amino-2-(aminomethyl)-6-[(2r,3s,4r,5s)-5-[(1r,2r,3s,5r,6s)-3,5-diamino-2-[(2s,3r,4r,5s,6r)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol;sulfuric ac Chemical compound OS(O)(=O)=O.N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO LJRDOKAZOAKLDU-UDXJMMFXSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
239000012535 impurity Substances 0.000 description 4
238000001816 cooling Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
238000005406 washing Methods 0.000 description 2
CZDHUFYOXKHLME-DFWYDOINSA-N (2s)-2-amino-3-methyl-3-sulfanylbutanoic acid;hydrochloride Chemical compound Cl.CC(C)(S)[C@@H](N)C(O)=O CZDHUFYOXKHLME-DFWYDOINSA-N 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
238000011403 purification operation Methods 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1

Landscapes

Thiazole And Isothizaole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP1165678A 1978-02-04 1978-02-04 Purification for d-penicillamine Granted JPS54106488A (en)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP1165678A JPS54106488A (en)	1978-02-04	1978-02-04	Purification for d-penicillamine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1165678A JPS54106488A (en)	1978-02-04	1978-02-04	Purification for d-penicillamine

Publications (2)

Publication Number	Publication Date
JPS54106488A JPS54106488A (en)	1979-08-21
JPS6148496B2 true JPS6148496B2 (fr)	1986-10-24

Family

ID=11784001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1165678A Granted JPS54106488A (en)	1978-02-04	1978-02-04	Purification for d-penicillamine

Country Status (1)

Country	Link
JP (1)	JPS54106488A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002348282A (ja) *	2001-05-28	2002-12-04	Mitsubishi Gas Chem Co Inc	１，３−チアゾリジン−４−カルボン酸アミドの製造方法
JP4735263B2 (ja) *	2003-11-18	2011-07-27	三菱瓦斯化学株式会社	光学活性２−アルキルシステインの製造方法、並びにその誘導体及び製造方法
WO2008157151A1 (fr) *	2007-06-19	2008-12-24	Huntsman Petrochemical Corporation	Procédé de séparation d'amines et catalyseurs de type amines réactives pour mousse de polyuréthane
CN108164444B (zh) *	2018-01-04	2019-09-06	浙江东邦药业有限公司	一种d-青霉胺的精制方法

1978
- 1978-02-04 JP JP1165678A patent/JPS54106488A/ja active Granted

Also Published As

Publication number	Publication date
JPS54106488A (en)	1979-08-21

Publication	Publication Date	Title
JP3085776B2 (ja)	2000-09-11	アジピン酸を回収する方法
JPS6148496B2 (fr)	1986-10-24
JPS6013736A (ja)	1985-01-24	（±）−２−クロロプロピオン酸の光学分割法
EP0085513A1 (fr)	1983-08-10	Procédé de préparation de dérivés d'acides organogermanium propioniques
JPS6316374B2 (fr)	1988-04-08
JPH069683A (ja)	1994-01-18	製薬等級高純度イオデオキシコール酸の製造法
JPH0796537B2 (ja)	1995-10-18	３−（３，４−ジヒドロキシフェニル）セリンの精製方法
US2606921A (en)	1952-08-12	Glutamic acid synthesis
KR860000346B1 (ko)	1986-04-12	아미노산과 5베타-콜라닉 산의 개량된 축합방법
BE901069A (fr)	1985-03-15	Procede de synthese d'acide ursodesoxycholique conjugue avec la taurine et produit ainsi obtenu.
KR880000038B1 (ko)	1988-02-20	α-L-아스파틸-L-페닐알라닌 메틸 에스테르의 정제방법
JPH07267985A (ja)	1995-10-17	タウロウルソデオキシコール酸水和物の製法
US2738352A (en)	1956-03-13	Purification of pyridine compounds
JPS585194B2 (ja)	1983-01-29	Ｄｌ−システインまたはシスチンの製造方法
JPS60185752A (ja)	1985-09-21	α−アセトアミド桂皮酸類の製造法
Sauer et al.	1955	Nitramines. I. Methylenedinitramine1
JPS5993059A (ja)	1984-05-29	シトシン類の製法
JPS6337105B2 (fr)	1988-07-22
JPH0579660B2 (fr)	1993-11-04
EP0149297B1 (fr)	1987-11-25	Procédé pour préparation de 3H-phénothiazine-3-ones
JPS6327477A (ja)	1988-02-05	オキシラセタムの製造方法
JPS6213936B2 (fr)	1987-03-30
JP2003096039A (ja)	2003-04-03	高純度ｎ−長鎖アシルアミノ酸塩の製造法
JPS6252754B2 (fr)	1987-11-06
JPH06166655A (ja)	1994-06-14	テトラメトキシメチルベンズアルデヒドの製造方法