JPS6116391B2 - - Google Patents

Info

Publication number: JPS6116391B2
Authority: JP; Japan
Prior art keywords: reaction; fluorouracil; solvent; fluoro; uracil
Prior art date: 1982-03-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP57033252A

Other languages

English (en)

Japanese (ja)

Other versions

JPS58150572A (ja

Inventor

Satoru Yoshizawa

Takaharu Nakano

Takeshi Inoi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

JNC Corp

Original Assignee

Chisso Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-03-03

Filing date

1982-03-03

Publication date

1986-04-30

1982-03-03 Application filed by Chisso Corp filed Critical Chisso Corp

1982-03-03 Priority to JP57033252A priority Critical patent/JPS58150572A/ja

1983-09-07 Publication of JPS58150572A publication Critical patent/JPS58150572A/ja

1986-04-30 Publication of JPS6116391B2 publication Critical patent/JPS6116391B2/ja

Status Granted legal-status Critical Current

Links

-1 5-fluoro-1-(2-trifluoromethylpropionyl)uracil Chemical compound 0.000 claims description 4
238000006243 chemical reaction Methods 0.000 description 9
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
239000002904 solvent Substances 0.000 description 6
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
229960002949 fluorouracil Drugs 0.000 description 4
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical class FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 3
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
239000013078 crystal Substances 0.000 description 3
238000000034 method Methods 0.000 description 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
239000000047 product Substances 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000000126 substance Substances 0.000 description 2
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
238000005160 1H NMR spectroscopy Methods 0.000 description 1
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 1
DQOGDQIDOONUSK-UHFFFAOYSA-N 3,3,3-trifluoro-2-methylpropanoic acid Chemical compound OC(=O)C(C)C(F)(F)F DQOGDQIDOONUSK-UHFFFAOYSA-N 0.000 description 1
NDLGCTJYADULQO-UHFFFAOYSA-N 3,3,3-trifluoro-2-methylpropanoyl chloride Chemical compound ClC(=O)C(C)C(F)(F)F NDLGCTJYADULQO-UHFFFAOYSA-N 0.000 description 1
WADSJYLPJPTMLN-UHFFFAOYSA-N 3-(cycloundecen-1-yl)-1,2-diazacycloundec-2-ene Chemical compound C1CCCCCCCCC=C1C1=NNCCCCCCCC1 WADSJYLPJPTMLN-UHFFFAOYSA-N 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
230000000259 anti-tumor effect Effects 0.000 description 1
239000002246 antineoplastic agent Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
239000007787 solid Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
229940035893 uracil Drugs 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP57033252A 1982-03-03 1982-03-03 ５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル Granted JPS58150572A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP57033252A JPS58150572A (ja)	1982-03-03	1982-03-03	５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP57033252A JPS58150572A (ja)	1982-03-03	1982-03-03	５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル

Publications (2)

Publication Number	Publication Date
JPS58150572A JPS58150572A (ja)	1983-09-07
JPS6116391B2 true JPS6116391B2 (zh)	1986-04-30

Family

ID=12381299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP57033252A Granted JPS58150572A (ja)	1982-03-03	1982-03-03	５−フルオロ−１−（２−トリフルオロメチルプロピオニル）ウラシル

Country Status (1)

Country	Link
JP (1)	JPS58150572A (zh)

1982
- 1982-03-03 JP JP57033252A patent/JPS58150572A/ja active Granted

Also Published As

Publication number	Publication date
JPS58150572A (ja)	1983-09-07

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