JPS60156379A - グルタチオン高含有酵母の製造方法 - Google Patents

グルタチオン高含有酵母の製造方法

Info

Publication number: JPS60156379A
Authority: JP; Japan
Prior art keywords: glutathione; yeast; gluthathione; strain; temperature
Prior art date: 1984-01-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP1200784A

Other languages

English (en)

Japanese (ja)

Other versions

JPH0318872B2 (de

Inventor

Tadayuki Hino

日野　忠行

Mokichi Harada

原田　茂吉

Hirokazu Maekawa

博和前川

Junichi Ito

伊東　順一

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kohjin Holdings Co Ltd

Kojin Co Ltd

Original Assignee

Kohjin Holdings Co Ltd

Kojin Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-01-27

Filing date

1984-01-27

Publication date

1985-08-16

1984-01-27 Application filed by Kohjin Holdings Co Ltd, Kojin Co Ltd filed Critical Kohjin Holdings Co Ltd

1984-01-27 Priority to JP1200784A priority Critical patent/JPS60156379A/ja

1985-08-16 Publication of JPS60156379A publication Critical patent/JPS60156379A/ja

1991-03-13 Publication of JPH0318872B2 publication Critical patent/JPH0318872B2/ja

Status Granted legal-status Critical Current

Links

240000004808 Saccharomyces cerevisiae Species 0.000 title claims abstract description 20
241000222120 Candida <Saccharomycetales> Species 0.000 claims abstract description 16
RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 84
108010024636 Glutathione Proteins 0.000 claims description 42
229960003180 glutathione Drugs 0.000 claims description 42
230000001580 bacterial effect Effects 0.000 claims description 13
238000012258 culturing Methods 0.000 claims description 8
238000004519 manufacturing process Methods 0.000 claims description 8
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 6
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 abstract description 6
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 abstract description 6
238000009825 accumulation Methods 0.000 abstract description 5
241000235646 Cyberlindnera jadinii Species 0.000 abstract description 4
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract description 4
239000008103 glucose Substances 0.000 abstract description 4
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract description 3
229910052943 magnesium sulfate Inorganic materials 0.000 abstract description 3
235000019341 magnesium sulphate Nutrition 0.000 abstract description 3
239000011591 potassium Substances 0.000 abstract description 3
229910052700 potassium Inorganic materials 0.000 abstract description 3
239000001103 potassium chloride Substances 0.000 abstract description 3
235000011164 potassium chloride Nutrition 0.000 abstract description 3
229910000147 aluminium phosphate Inorganic materials 0.000 abstract description 2
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 2
229910002651 NO3 Inorganic materials 0.000 abstract 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 abstract 1
229910000389 calcium phosphate Inorganic materials 0.000 abstract 1
229910017053 inorganic salt Inorganic materials 0.000 abstract 1
235000019691 monocalcium phosphate Nutrition 0.000 abstract 1
210000004027 cell Anatomy 0.000 description 19
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 4
238000000034 method Methods 0.000 description 4
230000000813 microbial effect Effects 0.000 description 4
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 description 3
229940041514 candida albicans extract Drugs 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
239000000284 extract Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000012138 yeast extract Substances 0.000 description 3
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
238000005273 aeration Methods 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
229910052921 ammonium sulfate Inorganic materials 0.000 description 2
235000011130 ammonium sulphate Nutrition 0.000 description 2
-1 and the like Substances 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
239000013078 crystal Substances 0.000 description 2
239000000203 mixture Substances 0.000 description 2
230000035772 mutation Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
229910000160 potassium phosphate Inorganic materials 0.000 description 2
235000011009 potassium phosphates Nutrition 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
210000005253 yeast cell Anatomy 0.000 description 2
229910052725 zinc Inorganic materials 0.000 description 2
239000011701 zinc Substances 0.000 description 2
MIQITCBUROTPKR-GEMLJDPKSA-N (2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;copper Chemical compound [Cu].OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O MIQITCBUROTPKR-GEMLJDPKSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
235000008733 Citrus aurantifolia Nutrition 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
229930189936 Glyoxalase Natural products 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
239000001888 Peptone Substances 0.000 description 1
108010080698 Peptones Proteins 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
235000011941 Tilia x europaea Nutrition 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 1
QLULGSLAHXLKSR-UHFFFAOYSA-N azane;phosphane Chemical compound N.P QLULGSLAHXLKSR-UHFFFAOYSA-N 0.000 description 1
YYRMJZQKEFZXMX-UHFFFAOYSA-N calcium;phosphoric acid Chemical compound [Ca+2].OP(O)(O)=O.OP(O)(O)=O YYRMJZQKEFZXMX-UHFFFAOYSA-N 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000003518 caustics Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
150000001879 copper Chemical class 0.000 description 1
229910000365 copper sulfate Inorganic materials 0.000 description 1
BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 description 1
ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
OMZSGWSJDCOLKM-UHFFFAOYSA-N copper(II) sulfide Chemical compound [S-2].[Cu+2] OMZSGWSJDCOLKM-UHFFFAOYSA-N 0.000 description 1
KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 description 1
229940112669 cuprous oxide Drugs 0.000 description 1
238000001784 detoxification Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
239000011790 ferrous sulphate Substances 0.000 description 1
235000003891 ferrous sulphate Nutrition 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
239000004571 lime Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000003908 liver function Effects 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
239000011572 manganese Substances 0.000 description 1
229940099596 manganese sulfate Drugs 0.000 description 1
239000011702 manganese sulphate Substances 0.000 description 1
235000007079 manganese sulphate Nutrition 0.000 description 1
SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
235000019319 peptone Nutrition 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000002426 superphosphate Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000002699 waste material Substances 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

JP1200784A 1984-01-27 1984-01-27 グルタチオン高含有酵母の製造方法 Granted JPS60156379A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP1200784A JPS60156379A (ja)	1984-01-27	1984-01-27	グルタチオン高含有酵母の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1200784A JPS60156379A (ja)	1984-01-27	1984-01-27	グルタチオン高含有酵母の製造方法

Publications (2)

Publication Number	Publication Date
JPS60156379A true JPS60156379A (ja)	1985-08-16
JPH0318872B2 JPH0318872B2 (de)	1991-03-13

Family

ID=11793527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1200784A Granted JPS60156379A (ja)	1984-01-27	1984-01-27	グルタチオン高含有酵母の製造方法

Country Status (1)

Country	Link
JP (1)	JPS60156379A (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6434279A (en) *	1987-07-29	1989-02-03	Ajinomoto Kk	Production of yeast with high glutathione content
JPH01141591A (ja) *	1987-11-26	1989-06-02	Ajinomoto Co Inc	高グルタチオン含有酵母の製造方法
WO2019181961A1 (ja)	2018-03-20	2019-09-26	三菱商事ライフサイエンス株式会社	β―ＮＭＮの製造方法およびその含有組成物

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY142328A (en)	2002-03-26	2010-11-15	Ajinomoto Kk	CANDIDA UTILIS CONTAINING y-GLUTAMYLCYSTEINE

1984
- 1984-01-27 JP JP1200784A patent/JPS60156379A/ja active Granted

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6434279A (en) *	1987-07-29	1989-02-03	Ajinomoto Kk	Production of yeast with high glutathione content
JPH01141591A (ja) *	1987-11-26	1989-06-02	Ajinomoto Co Inc	高グルタチオン含有酵母の製造方法
WO2019181961A1 (ja)	2018-03-20	2019-09-26	三菱商事ライフサイエンス株式会社	β―ＮＭＮの製造方法およびその含有組成物

Also Published As

Publication number	Publication date
JPH0318872B2 (de)	1991-03-13

Publication	Publication Date	Title
US4652527A (en)	1987-03-24	Process for culturing methylophilus methylotrophus
EP0079241B1 (de)	1988-03-09	Verfahren zur Herstellung von Glutathion
JPS60156379A (ja)	1985-08-16	グルタチオン高含有酵母の製造方法
JPS6358560B2 (de)	1988-11-16
US3964971A (en)	1976-06-22	Method for increasing the vitamin B12 production in fermentation processes carried out with methanobacteria
US3366550A (en)	1968-01-30	Method for the fermentative production of 5-fluorouracil ribotide
JPS61119194A (ja)	1986-06-06	発酵法によるｌ−オルニチンの製造法
JPS6131081A (ja)	1986-02-13	変異株
JP3100763B2 (ja)	2000-10-23	発酵法によるｌ−アルギニンの製造法
US3328261A (en)	1967-06-27	Method for the fermentative production of 5-amino-4-imidazole carboxamide ribotide
JPS63295A (ja)	1988-01-05	ニコチンアミドアデニンジヌクレオチドの製造法
US3369975A (en)	1968-02-20	Method for the fermentative synthesis of 5'-uridylic acid
JPS62236491A (ja)	1987-10-16	酢酸の製造方法
SU619506A1 (ru)	1978-08-15	Способ выращивани микроорганизмов
DE1642636C (de)	1973-04-05	Verfahren zur fermentativen Herstel lung des Enzyms L Methiomndecarboxylase
CA2029403A1 (en)	1991-05-09	Process for acidifying solutions of molasses
JPS61195694A (ja)	1986-08-29	α−位にスルフイド結合を有するスルホキシド類の製造方法
JPS635080B2 (de)	1988-02-02
JPH012592A (ja)	1989-01-06	ピロロキノリンキノンの製造法
JPH1014589A (ja)	1998-01-20	キャンディダ・リポリティカｈｎａ−１１０株及び２，６−ジヒドロキシ−３−ナフトエ酸の製造方法
JPH0424992B2 (de)	1992-04-28
JPS63112996A (ja)	1988-05-18	リボフラビンの製造方法
JPH0249598A (ja)	1990-02-19	微生物を用いるｄ−アラニンの製法
JPS5922515B2 (ja)	1984-05-26	微生物によるシアノ酢酸の製造法
EP0301107A1 (de)	1989-02-01	Verfahren zur herstellung von d-alanin

JPS60156379A - グルタチオン高含有酵母の製造方法 - Google Patents

Info

Links

Landscapes

Priority Applications (1)

Applications Claiming Priority (1)

Publications (2)

Family

ID=11793527

Family Applications (1)

Country Status (1)

Cited By (3)

Families Citing this family (1)

Cited By (3)

Also Published As

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