JPH0318872B2 - - Google Patents

Info

Publication number: JPH0318872B2
Authority: JP; Japan
Prior art keywords: glutathione; strain; temperature; culture; candeida
Prior art date: 1984-01-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP1200784A

Other languages

English (en)

Japanese (ja)

Other versions

JPS60156379A (ja

Inventor

Tadayuki Hino

Mokichi Harada

Hirokazu Maekawa

Junichi Ito

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kojin Co Ltd

Original Assignee

Kojin Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-01-27

Filing date

1984-01-27

Publication date

1991-03-13

1984-01-27 Application filed by Kojin Co Ltd filed Critical Kojin Co Ltd

1984-01-27 Priority to JP1200784A priority Critical patent/JPS60156379A/ja

1985-08-16 Publication of JPS60156379A publication Critical patent/JPS60156379A/ja

1991-03-13 Publication of JPH0318872B2 publication Critical patent/JPH0318872B2/ja

Status Granted legal-status Critical Current

Links

RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims description 78
108010024636 Glutathione Proteins 0.000 claims description 39
229960003180 glutathione Drugs 0.000 claims description 39
230000001580 bacterial effect Effects 0.000 claims description 12
240000004808 Saccharomyces cerevisiae Species 0.000 claims description 11
238000012258 culturing Methods 0.000 claims description 8
LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 claims description 7
GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 5
210000004027 cell Anatomy 0.000 description 16
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
238000009825 accumulation Methods 0.000 description 4
239000007788 liquid Substances 0.000 description 4
238000000034 method Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
241000894006 Bacteria Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
239000000284 extract Substances 0.000 description 3
239000008103 glucose Substances 0.000 description 3
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 3
239000004254 Ammonium phosphate Substances 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
239000001888 Peptone Substances 0.000 description 2
108010080698 Peptones Proteins 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
229910000148 ammonium phosphate Inorganic materials 0.000 description 2
235000019289 ammonium phosphates Nutrition 0.000 description 2
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
229910052921 ammonium sulfate Inorganic materials 0.000 description 2
235000011130 ammonium sulphate Nutrition 0.000 description 2
229940041514 candida albicans extract Drugs 0.000 description 2
239000013078 crystal Substances 0.000 description 2
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 2
229910052943 magnesium sulfate Inorganic materials 0.000 description 2
235000019341 magnesium sulphate Nutrition 0.000 description 2
230000035772 mutation Effects 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
235000019319 peptone Nutrition 0.000 description 2
239000011591 potassium Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
239000001103 potassium chloride Substances 0.000 description 2
235000011164 potassium chloride Nutrition 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000002699 waste material Substances 0.000 description 2
210000005253 yeast cell Anatomy 0.000 description 2
239000012138 yeast extract Substances 0.000 description 2
MIQITCBUROTPKR-GEMLJDPKSA-N (2s)-2-amino-5-[[(2r)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid;copper Chemical compound [Cu].OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O MIQITCBUROTPKR-GEMLJDPKSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
235000008733 Citrus aurantifolia Nutrition 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
229930189936 Glyoxalase Natural products 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
235000011941 Tilia x europaea Nutrition 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
238000005273 aeration Methods 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
YYRMJZQKEFZXMX-UHFFFAOYSA-N calcium;phosphoric acid Chemical compound [Ca+2].OP(O)(O)=O.OP(O)(O)=O YYRMJZQKEFZXMX-UHFFFAOYSA-N 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000003518 caustics Substances 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
150000001879 copper Chemical class 0.000 description 1
229910000365 copper sulfate Inorganic materials 0.000 description 1
BERDEBHAJNAUOM-UHFFFAOYSA-N copper(I) oxide Inorganic materials [Cu]O[Cu] BERDEBHAJNAUOM-UHFFFAOYSA-N 0.000 description 1
ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 1
OMZSGWSJDCOLKM-UHFFFAOYSA-N copper(II) sulfide Chemical compound [S-2].[Cu+2] OMZSGWSJDCOLKM-UHFFFAOYSA-N 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
229940099112 cornstarch Drugs 0.000 description 1
KRFJLUBVMFXRPN-UHFFFAOYSA-N cuprous oxide Chemical compound [O-2].[Cu+].[Cu+] KRFJLUBVMFXRPN-UHFFFAOYSA-N 0.000 description 1
229940112669 cuprous oxide Drugs 0.000 description 1
238000010586 diagram Methods 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000000605 extraction Methods 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
239000011790 ferrous sulphate Substances 0.000 description 1
235000003891 ferrous sulphate Nutrition 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000011630 iodine Substances 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
-1 iron ions Chemical class 0.000 description 1
BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
239000004571 lime Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
229910052748 manganese Inorganic materials 0.000 description 1
239000011572 manganese Substances 0.000 description 1
229940099596 manganese sulfate Drugs 0.000 description 1
239000011702 manganese sulphate Substances 0.000 description 1
235000007079 manganese sulphate Nutrition 0.000 description 1
SQQMAOCOWKFBNP-UHFFFAOYSA-L manganese(II) sulfate Chemical compound [Mn+2].[O-]S([O-])(=O)=O SQQMAOCOWKFBNP-UHFFFAOYSA-L 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
239000000203 mixture Substances 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
238000011002 quantification Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000002426 superphosphate Substances 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
239000011701 zinc Substances 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

JP1200784A 1984-01-27 1984-01-27 グルタチオン高含有酵母の製造方法 Granted JPS60156379A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP1200784A JPS60156379A (ja)	1984-01-27	1984-01-27	グルタチオン高含有酵母の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1200784A JPS60156379A (ja)	1984-01-27	1984-01-27	グルタチオン高含有酵母の製造方法

Publications (2)

Publication Number	Publication Date
JPS60156379A JPS60156379A (ja)	1985-08-16
JPH0318872B2 true JPH0318872B2 (de)	1991-03-13

Family

ID=11793527

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1200784A Granted JPS60156379A (ja)	1984-01-27	1984-01-27	グルタチオン高含有酵母の製造方法

Country Status (1)

Country	Link
JP (1)	JPS60156379A (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003080832A1 (fr)	2002-03-26	2003-10-02	Ajinomoto Co.,Inc.	Candida utilis contenant de la $g(g)-glutamylcysteine

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6434279A (en) *	1987-07-29	1989-02-03	Ajinomoto Kk	Production of yeast with high glutathione content
JPH01141591A (ja) *	1987-11-26	1989-06-02	Ajinomoto Co Inc	高グルタチオン含有酵母の製造方法
US20210108242A1 (en)	2018-03-20	2021-04-15	Mitsubishi Corporation Life Sciences Limited	Method for producing beta-nmn and composition containing the same

1984
- 1984-01-27 JP JP1200784A patent/JPS60156379A/ja active Granted

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003080832A1 (fr)	2002-03-26	2003-10-02	Ajinomoto Co.,Inc.	Candida utilis contenant de la $g(g)-glutamylcysteine
EP2213734A1 (de)	2002-03-26	2010-08-04	Ajinomoto Co., Inc.	Candida utilis mit Gamma-Glutamylcystein

Also Published As

Publication number	Publication date
JPS60156379A (ja)	1985-08-16

Publication	Publication Date	Title
JPS5937951B2 (ja)	1984-09-12	アミドの生物学的製造法
US3998697A (en)	1976-12-21	Process for preparing 2-keto-L-gulonic acid
US7479381B1 (en)	2009-01-20	Production of itaconic acid by Pseudozyma antarctica
US3959076A (en)	1976-05-25	Process for producing 2-keto-L-gulonic acid
US3963574A (en)	1976-06-15	Process for producing 2-keto-L-gulonic acid
US4652527A (en)	1987-03-24	Process for culturing methylophilus methylotrophus
EP0079241B1 (de)	1988-03-09	Verfahren zur Herstellung von Glutathion
JPH0318872B2 (de)	1991-03-13
JPS6358560B2 (de)	1988-11-16
US3964971A (en)	1976-06-22	Method for increasing the vitamin B12 production in fermentation processes carried out with methanobacteria
JP2885643B2 (ja)	1999-04-26	フェノール性化合物の分解処理方法
US4371440A (en)	1983-02-01	Method of treating a waste water rich in protein
JPH01168292A (ja)	1989-07-03	Ｄ−グリセリン酸の製造法
JPS6151874B2 (de)	1986-11-11
KR950005925B1 (ko)	1995-06-07	D-(-)-타르타르산의 제조법
CN86102773A (zh)	1986-11-12	生产l-山梨糖的方法
US3310475A (en)	1967-03-21	Method for producing l-aspartic acid
US5422255A (en)	1995-06-06	Method for producing D-alanine
JP2505466B2 (ja)	1996-06-12	Ｄ−セリンの製造法
US3366550A (en)	1968-01-30	Method for the fermentative production of 5-fluorouracil ribotide
JPH0565160B2 (de)	1993-09-17
US4795708A (en)	1989-01-03	Novel backteria and single cell protein production therewith
JPS592693A (ja)	1984-01-09	アミドの生物学的製造法
JPH0249598A (ja)	1990-02-19	微生物を用いるｄ−アラニンの製法
JP2715260B2 (ja)	1998-02-18	新規緑藻類、新規酵母および該緑藻類又は該酵母を用いた２，６−ナフタレンジカルボン酸の製造法