JPS595188A - １０−ヒドロキシカンプトテシンの製造法 - Google Patents
１０−ヒドロキシカンプトテシンの製造法Info
- Publication number
- JPS595188A JPS595188A JP11159082A JP11159082A JPS595188A JP S595188 A JPS595188 A JP S595188A JP 11159082 A JP11159082 A JP 11159082A JP 11159082 A JP11159082 A JP 11159082A JP S595188 A JPS595188 A JP S595188A
- Authority
- JP
- Japan
- Prior art keywords
- hydroxycamptothecin
- tetrahydrocamptothecin
- camptothecin
- salt
- oxidizing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11159082A JPS595188A (ja) | 1982-06-30 | 1982-06-30 | １０−ヒドロキシカンプトテシンの製造法 |
| BR1100882-2A BR1100882A (pt) | 1982-06-30 | 1997-05-14 | Processo para a preparação de 10-hidroxicamptotecina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11159082A JPS595188A (ja) | 1982-06-30 | 1982-06-30 | １０−ヒドロキシカンプトテシンの製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS595188A true JPS595188A (ja) | 1984-01-12 |
| JPS6232749B2 JPS6232749B2 (de) | 1987-07-16 |
Family
ID=14565217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11159082A Granted JPS595188A (ja) | 1982-06-30 | 1982-06-30 | １０−ヒドロキシカンプトテシンの製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS595188A (de) |
Cited By (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62195384A (ja) * | 1986-02-24 | 1987-08-28 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5049668A (en) * | 1989-09-15 | 1991-09-17 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin analogs |
| US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| WO1992005785A1 (en) * | 1990-09-28 | 1992-04-16 | Smithkline Beecham Corporation | Water soluble camptothecin analogues, processes and methods |
| US5106742A (en) * | 1987-03-31 | 1992-04-21 | Wall Monroe E | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5122606A (en) * | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
| US5122526A (en) * | 1987-03-31 | 1992-06-16 | Research Triangle Institute | Camptothecin and analogs thereof and pharmaceutical compositions and method using them |
| US5180722A (en) * | 1987-04-14 | 1993-01-19 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
| US5225404A (en) * | 1989-11-06 | 1993-07-06 | New York University | Methods of treating colon tumors with tumor-inhibiting camptothecin compounds |
| US5227380A (en) * | 1987-03-31 | 1993-07-13 | Research Triangle Institute | Pharmaceutical compositions and methods employing camptothecins |
| US5340817A (en) * | 1987-04-14 | 1994-08-23 | Research Triangle Institute | Method of treating tumors with anti-tumor effective camptothecin compounds |
| US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
| US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
| US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
| US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| US5883255A (en) * | 1990-10-31 | 1999-03-16 | Smithkline Beecham Corporation | Substituted indolizino 1,2-b!quinolinones |
| US5932588A (en) * | 1995-11-22 | 1999-08-03 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties |
| US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| US6562834B2 (en) | 2000-10-27 | 2003-05-13 | Aventis Pharma S. A. | Combination comprising camptothecin and a stilbene derivative for the treatment of cancer |
| US6664242B2 (en) | 2000-02-28 | 2003-12-16 | Aventis Pharma S.A. | Composition and method comprising CPT-11 and a pyrimidine derivative for the treatment of cancer |
| WO2004100897A2 (en) | 2003-05-12 | 2004-11-25 | Scinopharm Taiwan, Ltd. | Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin |
| US6872829B2 (en) * | 2002-12-16 | 2005-03-29 | Council Of Scientific And Industrial Research | Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of camptothecins or mappicene ketones |
| US6960596B2 (en) | 2000-03-17 | 2005-11-01 | Aventis Pharma S.A. | Composition comprising camptothecin or a comptothecin derivative and a platin derivative for the treatment of cancer |
| WO2005117881A1 (en) * | 2004-06-04 | 2005-12-15 | Chatham Biotec Ltd. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
| JP2007517778A (ja) * | 2003-12-16 | 2007-07-05 | プリヴァ−ラケマ，エー．エス． | ７−エチル−１０−ヒドロキシカンプトテシンの製造方法 |
| CZ298934B6 (cs) * | 2003-08-26 | 2008-03-12 | Pliva- Lachema A.S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| KR20110010767A (ko) | 2008-05-29 | 2011-02-07 | 메루샹가부시키가이샤 | 캠토테신 유도체의 제조 방법 |
-
1982
- 1982-06-30 JP JP11159082A patent/JPS595188A/ja active Granted
Cited By (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62195384A (ja) * | 1986-02-24 | 1987-08-28 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| US5122526A (en) * | 1987-03-31 | 1992-06-16 | Research Triangle Institute | Camptothecin and analogs thereof and pharmaceutical compositions and method using them |
| US4981968A (en) * | 1987-03-31 | 1991-01-01 | Research Triangle Institute | Synthesis of camptothecin and analogs thereof |
| US5364858A (en) * | 1987-03-31 | 1994-11-15 | Research Triangle Institute | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5227380A (en) * | 1987-03-31 | 1993-07-13 | Research Triangle Institute | Pharmaceutical compositions and methods employing camptothecins |
| US5106742A (en) * | 1987-03-31 | 1992-04-21 | Wall Monroe E | Camptothecin analogs as potent inhibitors of topoisomerase I |
| US5180722A (en) * | 1987-04-14 | 1993-01-19 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs |
| US5122606A (en) * | 1987-04-14 | 1992-06-16 | Research Triangle Institute | 10,11-methylenedioxy camptothecins |
| US5340817A (en) * | 1987-04-14 | 1994-08-23 | Research Triangle Institute | Method of treating tumors with anti-tumor effective camptothecin compounds |
| US5053512A (en) * | 1987-04-14 | 1991-10-01 | Research Triangle Institute | Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives |
| US5049668A (en) * | 1989-09-15 | 1991-09-17 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin analogs |
| US5652244A (en) * | 1989-11-06 | 1997-07-29 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5225404A (en) * | 1989-11-06 | 1993-07-06 | New York University | Methods of treating colon tumors with tumor-inhibiting camptothecin compounds |
| US6624170B2 (en) | 1989-11-06 | 2003-09-23 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble S-Camptothecin of the closed lactone ring form and derivatives thereof |
| US6342506B1 (en) | 1989-11-06 | 2002-01-29 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US6166029A (en) * | 1989-11-06 | 2000-12-26 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5552154A (en) * | 1989-11-06 | 1996-09-03 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof |
| US5889017A (en) * | 1989-11-06 | 1999-03-30 | The Stehlin Foundation For Cancer Research | Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5734056A (en) * | 1990-09-28 | 1998-03-31 | Smithkline Beecham Corporation | Process for the preparation of certain 9-substituted camptothecins |
| WO1992005785A1 (en) * | 1990-09-28 | 1992-04-16 | Smithkline Beecham Corporation | Water soluble camptothecin analogues, processes and methods |
| US5883255A (en) * | 1990-10-31 | 1999-03-16 | Smithkline Beecham Corporation | Substituted indolizino 1,2-b!quinolinones |
| US6080751A (en) * | 1992-01-14 | 2000-06-27 | The Stehlin Foundation For Cancer Research | Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof |
| US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
| US5633260A (en) * | 1994-04-19 | 1997-05-27 | Bionumerik Pharmaceuticals, Inc. | 11,7 Substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
| US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
| US6040313A (en) * | 1994-07-20 | 2000-03-21 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| US5916896A (en) * | 1994-07-20 | 1999-06-29 | Research Triange Institute | Water-soluble esters of camptothecin compounds |
| US5646159A (en) * | 1994-07-20 | 1997-07-08 | Research Triangle Institute | Water-soluble esters of camptothecin compounds |
| US5614529A (en) * | 1994-09-22 | 1997-03-25 | Research Triangle Institute | Inhibition of plasmodia parasites by camptothecin compounds |
| US5932588A (en) * | 1995-11-22 | 1999-08-03 | Research Triangle Institute | Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties |
| US6664242B2 (en) | 2000-02-28 | 2003-12-16 | Aventis Pharma S.A. | Composition and method comprising CPT-11 and a pyrimidine derivative for the treatment of cancer |
| US6960596B2 (en) | 2000-03-17 | 2005-11-01 | Aventis Pharma S.A. | Composition comprising camptothecin or a comptothecin derivative and a platin derivative for the treatment of cancer |
| US6486320B2 (en) | 2000-09-15 | 2002-11-26 | Aventis Pharma S.A. | Preparation of camptothecin and of its derivatives |
| US6562834B2 (en) | 2000-10-27 | 2003-05-13 | Aventis Pharma S. A. | Combination comprising camptothecin and a stilbene derivative for the treatment of cancer |
| US6872829B2 (en) * | 2002-12-16 | 2005-03-29 | Council Of Scientific And Industrial Research | Process for the direct preparation of 5-alkoxy and 5-acyloxy analogues of camptothecins or mappicene ketones |
| WO2004100897A2 (en) | 2003-05-12 | 2004-11-25 | Scinopharm Taiwan, Ltd. | Process for the preparation of 7-alkyl-10-hydroxy-20(s)-camptothecin |
| CZ298934B6 (cs) * | 2003-08-26 | 2008-03-12 | Pliva- Lachema A.S. | Zpusob výroby 7-ethyl-10-hydroxykamptothecinu |
| JP2007517778A (ja) * | 2003-12-16 | 2007-07-05 | プリヴァ−ラケマ，エー．エス． | ７−エチル−１０−ヒドロキシカンプトテシンの製造方法 |
| WO2005117881A1 (en) * | 2004-06-04 | 2005-12-15 | Chatham Biotec Ltd. | Process to prepare camptothecin derivatives and novel intermediate and compounds thereof |
| KR20110010767A (ko) | 2008-05-29 | 2011-02-07 | 메루샹가부시키가이샤 | 캠토테신 유도체의 제조 방법 |
| US8299251B2 (en) | 2008-05-29 | 2012-10-30 | Sichuan Xieli Pharmaceutical Co., Ltd. | Method for producing camptothecin derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6232749B2 (de) | 1987-07-16 |
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