JPS5796261A - Preparation of immunoactive particle - Google Patents
Preparation of immunoactive particleInfo
- Publication number
- JPS5796261A JPS5796261A JP17256480A JP17256480A JPS5796261A JP S5796261 A JPS5796261 A JP S5796261A JP 17256480 A JP17256480 A JP 17256480A JP 17256480 A JP17256480 A JP 17256480A JP S5796261 A JPS5796261 A JP S5796261A
- Authority
- JP
- Japan
- Prior art keywords
- particle
- immunoactive
- polymer
- medium
- amino group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
PURPOSE:To obtain an immunoactive particle, by a method wherein an immunoactive substance with an amino group is reacted with a particle obtained by polymerizing glycidyl acrylate or glycidyl methacrylate in a medium which dissolves monomers but allows the produced polymer to precipitate. CONSTITUTION:A polymer in the form of particle with an average diameter of 0.03-10mum is obtained by polymerizing glycidyl acrylate or glycidyl methacrylate in a medium which dissolves monomers but separates out the polymer produced by the polymerization, such as ethyl acetate, n-propyl acetate, isopropyl acetate or the like. Then, a reagent is obtained by fixing an immunoactive substance on a carrier particle by means of a covalent bond between the free epoxy group on the particle-shaped polymer surface and the amino group of the immunoactive substance. According to the present invention, it is possible to produce free-epoxy group-containing carrier particles having a diameter suitable for an immunological inspection as well as having a narrow particle-diameter distribution only in a single stage.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17256480A JPS5796261A (en) | 1980-12-09 | 1980-12-09 | Preparation of immunoactive particle |
DE8181110260T DE3171273D1 (en) | 1980-12-09 | 1981-12-08 | Immunoparticles and process for preparing the same |
CA000391753A CA1177751A (en) | 1980-12-09 | 1981-12-08 | Immunoparticles and process for preparing same |
EP81110260A EP0054249B2 (en) | 1980-12-09 | 1981-12-08 | Immunoparticles and process for preparing the same |
US06/757,761 US4656144A (en) | 1980-12-09 | 1985-07-22 | Immunoparticles and process for preparing same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17256480A JPS5796261A (en) | 1980-12-09 | 1980-12-09 | Preparation of immunoactive particle |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5796261A true JPS5796261A (en) | 1982-06-15 |
JPS6315554B2 JPS6315554B2 (en) | 1988-04-05 |
Family
ID=15944176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17256480A Granted JPS5796261A (en) | 1980-12-09 | 1980-12-09 | Preparation of immunoactive particle |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5796261A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5919856A (en) * | 1982-07-27 | 1984-02-01 | Toray Ind Inc | Fine carrier particle for immobilizing amynologically active material |
JPS59204601A (en) * | 1983-05-09 | 1984-11-20 | Unitika Ltd | Manufacture of molded article having physiological activity |
JPH0684312B2 (en) * | 1987-08-14 | 1994-10-26 | 鐘淵化学工業株式会社 | Biospecific polymer |
JP2015114272A (en) * | 2013-12-13 | 2015-06-22 | 東ソー株式会社 | Polymerizable monomer and application thereof |
-
1980
- 1980-12-09 JP JP17256480A patent/JPS5796261A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5919856A (en) * | 1982-07-27 | 1984-02-01 | Toray Ind Inc | Fine carrier particle for immobilizing amynologically active material |
JPH0376426B2 (en) * | 1982-07-27 | 1991-12-05 | Toray Industries | |
JPS59204601A (en) * | 1983-05-09 | 1984-11-20 | Unitika Ltd | Manufacture of molded article having physiological activity |
JPH0684312B2 (en) * | 1987-08-14 | 1994-10-26 | 鐘淵化学工業株式会社 | Biospecific polymer |
JP2015114272A (en) * | 2013-12-13 | 2015-06-22 | 東ソー株式会社 | Polymerizable monomer and application thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS6315554B2 (en) | 1988-04-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES467190A1 (en) | Attachment of proteins to inert particles | |
AU566748B2 (en) | Aqueous coating compositions | |
JPS56141559A (en) | Reagent for immunological inspection | |
DE68916048D1 (en) | Process for the production of monodisperse polymer particles with increased particle size. | |
GB1294591A (en) | New copolymers suitable as carrier-binders for proteins and proteins bound to said copolymer carrier-binders | |
ES8307880A1 (en) | Multiple-surface systems for fixing substrates having nucleophilic groups. | |
ATE238376T1 (en) | METHOD FOR PRODUCING POLYMERIZED POWDERS THAT ARE REDISPERSIBLE IN AQUEOUS MEDIUM | |
JPS5796261A (en) | Preparation of immunoactive particle | |
GR3001259T3 (en) | Aqueous dispersion of an addition polymer, a coating composition based thereon and a process for coating a substrate with such coating composition | |
GB1412563A (en) | Method for preparation of insoluble biologically active compounds | |
JPS5796260A (en) | Immunoactive particle | |
JPS5322178A (en) | Blood purifying adsorbent | |
IL86323A (en) | Process for the preparation of polymer particles or of a latex made of polymer particles having on their surface amphiphilic molecules with ionogenic or reactive groups | |
JPS57132160A (en) | Manufacture of magnetic toner | |
JPS57143832A (en) | Manufacture of semiconductor device | |
JPS57163485A (en) | Immobilized enzyme | |
EP0346886A3 (en) | Water-dispersible resin composition, water-dispersible coating compositon and coating method using the coating composition | |
JPS51148791A (en) | A process for crosslinking of copolymers | |
JPS52110888A (en) | Immobilization of yeast or microbial cells | |
JPS6470504A (en) | Composition for treatment of fibrous substance | |
JPS5720923A (en) | Biaxially oriented polyester film for magnetic film | |
JPS54123185A (en) | Aqueous resin dispersion | |
WO1987006596A3 (en) | Process for affinity chromatographic separation of enzymes from aqueous solutions with the aid of solid carriers and specific ligands bound thereto | |
JPS57163483A (en) | Immobilized enzyme | |
JPS57150386A (en) | Immobilized enzyme |