JPS5796260A - Immunoactive particle - Google Patents

Immunoactive particle

Info

Publication number
JPS5796260A
JPS5796260A JP17256380A JP17256380A JPS5796260A JP S5796260 A JPS5796260 A JP S5796260A JP 17256380 A JP17256380 A JP 17256380A JP 17256380 A JP17256380 A JP 17256380A JP S5796260 A JPS5796260 A JP S5796260A
Authority
JP
Japan
Prior art keywords
particle
glycidyl
substance
immunoactive
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17256380A
Other languages
Japanese (ja)
Other versions
JPS6315553B2 (en
Inventor
Shuntaro Hosaka
Yasuo Murao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Priority to JP17256380A priority Critical patent/JPS5796260A/en
Priority to DE8181110260T priority patent/DE3171273D1/en
Priority to CA000391753A priority patent/CA1177751A/en
Priority to EP81110260A priority patent/EP0054249B2/en
Publication of JPS5796260A publication Critical patent/JPS5796260A/en
Priority to US06/757,761 priority patent/US4656144A/en
Publication of JPS6315553B2 publication Critical patent/JPS6315553B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

PURPOSE:To obtain an inspection reagent by fixing an immunoactive substance with an amino group to a copolymer, having a diameter of 0.03-10mum, of glycidyl acrylate or glycidyl methacrylat and a water-soluble monomer with a carbon unsaturated double bond. CONSTITUTION:It is possible to vary within a range between 95:5 and 5:95 in mol ratio the ratio of the sum of glycidyl acrylate and glycidyl methacrylate in any ratio and the sum of water-soluble monomers such as 2-oxyethyl acrylate, 2-oxyethyl methacrylate or the like. An immunoactive substance is fixed on a carrier particle by means of the covalent bond produced through the reaction between the amino group of the substance and the free epoxy group on the particle surface. The immunoactive substance-fixed particle thus produced is stable to a specimen body fluid, so that a nonspecific agglutination hardly takes place and there is no nonspecific adhesion to cells.
JP17256380A 1980-12-09 1980-12-09 Immunoactive particle Granted JPS5796260A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP17256380A JPS5796260A (en) 1980-12-09 1980-12-09 Immunoactive particle
DE8181110260T DE3171273D1 (en) 1980-12-09 1981-12-08 Immunoparticles and process for preparing the same
CA000391753A CA1177751A (en) 1980-12-09 1981-12-08 Immunoparticles and process for preparing same
EP81110260A EP0054249B2 (en) 1980-12-09 1981-12-08 Immunoparticles and process for preparing the same
US06/757,761 US4656144A (en) 1980-12-09 1985-07-22 Immunoparticles and process for preparing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17256380A JPS5796260A (en) 1980-12-09 1980-12-09 Immunoactive particle

Publications (2)

Publication Number Publication Date
JPS5796260A true JPS5796260A (en) 1982-06-15
JPS6315553B2 JPS6315553B2 (en) 1988-04-05

Family

ID=15944161

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17256380A Granted JPS5796260A (en) 1980-12-09 1980-12-09 Immunoactive particle

Country Status (1)

Country Link
JP (1) JPS5796260A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919856A (en) * 1982-07-27 1984-02-01 Toray Ind Inc Fine carrier particle for immobilizing amynologically active material
JPS59204601A (en) * 1983-05-09 1984-11-20 Unitika Ltd Manufacture of molded article having physiological activity
JPH0684312B2 (en) * 1987-08-14 1994-10-26 鐘淵化学工業株式会社 Biospecific polymer
WO2004040305A1 (en) * 2002-10-31 2004-05-13 Reverse Proteomics Research Institute Co., Ltd. Method of immobilizing compound on solid phase support

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5919856A (en) * 1982-07-27 1984-02-01 Toray Ind Inc Fine carrier particle for immobilizing amynologically active material
JPH0376426B2 (en) * 1982-07-27 1991-12-05 Toray Industries
JPS59204601A (en) * 1983-05-09 1984-11-20 Unitika Ltd Manufacture of molded article having physiological activity
JPH0684312B2 (en) * 1987-08-14 1994-10-26 鐘淵化学工業株式会社 Biospecific polymer
WO2004040305A1 (en) * 2002-10-31 2004-05-13 Reverse Proteomics Research Institute Co., Ltd. Method of immobilizing compound on solid phase support
JPWO2004040305A1 (en) * 2002-10-31 2006-03-02 株式会社リバース・プロテオミクス研究所 Method for immobilizing a compound on a solid support
US7645614B2 (en) 2002-10-31 2010-01-12 Reverse Proteomics Research Institute Co., Ltd. Method of immobilizing compound on solid phase support

Also Published As

Publication number Publication date
JPS6315553B2 (en) 1988-04-05

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