JPS5793972A - Preparation of piperazine derivative - Google Patents

Preparation of piperazine derivative

Info

Publication number
JPS5793972A
JPS5793972A JP56116541A JP11654181A JPS5793972A JP S5793972 A JPS5793972 A JP S5793972A JP 56116541 A JP56116541 A JP 56116541A JP 11654181 A JP11654181 A JP 11654181A JP S5793972 A JPS5793972 A JP S5793972A
Authority
JP
Japan
Prior art keywords
isopropenyl
trialkoxybenzylpiperazine
preparation
piperazine derivative
coronary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP56116541A
Other languages
Japanese (ja)
Inventor
Hiroshi Murai
Yoshiaki Aoyanagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP56116541A priority Critical patent/JPS5793972A/en
Publication of JPS5793972A publication Critical patent/JPS5793972A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The N-substituted trialkoxybenzylpiperazine derivtive of formulaI(R is CH3 or C2H5; Z is isopropenyl).
EXAMPLE: N-Isopropenyl-N'-2,3,4-trimethoxybenzylpiperazine.
USE: Remedy for iscemic cardiopathy. It has various pharmacological activities to coronary circulatory system such as coronary vessel dilating action, cardiac motion suppressing action, etc.
PROCESS: The compound of formulaIcan be prepared in high yield, by reacting the N-trialkoxybenzylpiperazine of formula II with an isopropenyl halide in an inert solvent such as DMF, etc. at room temp. W100°C for 0.5W6hr, if necessary in the presence of a proper acid acceptor.
COPYRIGHT: (C)1982,JPO&Japio
JP56116541A 1981-07-24 1981-07-24 Preparation of piperazine derivative Pending JPS5793972A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP56116541A JPS5793972A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56116541A JPS5793972A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2744277A Division JPS53112886A (en) 1976-04-09 1977-03-12 Production of n-substituted trialkoxybenzylpiperazine derivative

Publications (1)

Publication Number Publication Date
JPS5793972A true JPS5793972A (en) 1982-06-11

Family

ID=14689666

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56116541A Pending JPS5793972A (en) 1981-07-24 1981-07-24 Preparation of piperazine derivative

Country Status (1)

Country Link
JP (1) JPS5793972A (en)

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