JPS5780380A - Alpha-oxyalkanothienone acetal - Google Patents
Alpha-oxyalkanothienone acetalInfo
- Publication number
- JPS5780380A JPS5780380A JP15518580A JP15518580A JPS5780380A JP S5780380 A JPS5780380 A JP S5780380A JP 15518580 A JP15518580 A JP 15518580A JP 15518580 A JP15518580 A JP 15518580A JP S5780380 A JPS5780380 A JP S5780380A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- acetal
- thienyl
- oxyalkanothienone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An α-oxyalkanothienone acetal of formula I[R1, R2 and R3 are lower alkyl; Y is H or formula II (R is aromatic group or substituted or unsubstituted alkyl) or R1 and R2 together form a cyclic acetal].
EXAMPLE: 1-(2-Thienyl)-2-hydroxyl-1-propanone dimethyl acetal.
USE: A raw material for a compound useful as a synthetic intermediate for medicines, particularly capable of easily giving an α-(5-benzoly-2-thienyl)propionic acid having anti-inflammatory and analgesic actions by reacting an α-(2-thienyl) propionic acid which is an intermediate therefor with benzoyl chloride in the presence of a Lewis acid.
PROCESS: An α-haloketone of formula III (X is halogen) is reacted with a compound of the formula R1OM (M is alkaline metallic atom) in the presence of an alcohol to give the compound of formula IV which is the compound of formula I (Y is H).
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15518580A JPS5780380A (en) | 1980-11-06 | 1980-11-06 | Alpha-oxyalkanothienone acetal |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15518580A JPS5780380A (en) | 1980-11-06 | 1980-11-06 | Alpha-oxyalkanothienone acetal |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5780380A true JPS5780380A (en) | 1982-05-19 |
Family
ID=15600334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15518580A Pending JPS5780380A (en) | 1980-11-06 | 1980-11-06 | Alpha-oxyalkanothienone acetal |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5780380A (en) |
-
1980
- 1980-11-06 JP JP15518580A patent/JPS5780380A/en active Pending
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