JPS5772974A - Novel 1-methyl-tetrazol-5-yl-thiol ester and its preparation - Google Patents
Novel 1-methyl-tetrazol-5-yl-thiol ester and its preparationInfo
- Publication number
- JPS5772974A JPS5772974A JP14817880A JP14817880A JPS5772974A JP S5772974 A JPS5772974 A JP S5772974A JP 14817880 A JP14817880 A JP 14817880A JP 14817880 A JP14817880 A JP 14817880A JP S5772974 A JPS5772974 A JP S5772974A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- compound
- methyl
- tetrazol
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Plural Heterocyclic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formulaI(R is 2-trifluoromethylthioacetic acid, 2-cyano-methylthioacetic acid, 2-chloroacetic acid, 2-thienylacetic acid, 2-thienyl-2- (N-methyl-N-benzoxyaminocarbamoyl)acetic acid, 3-hydroxy-4-amino-1,2-thiazol- 5-yl-thioacetic acid, or protected compound thereof).
USE: An acylating agent for amines or hydrazines. Useful esp. as an active ester for the synthesis of cephalosporin compound for pharmaceutical use.
PROCESS: The compound of formulaIis prepared by reacting a compound of formula II or its derivative with 2-trifluoromethylthioacetic acid or its derivative, etc. in a solvent such as dioxane, acetone, chloroform, etc. at -W+50°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14817880A JPS5772974A (en) | 1980-10-24 | 1980-10-24 | Novel 1-methyl-tetrazol-5-yl-thiol ester and its preparation |
| EP81106833A EP0047014B1 (en) | 1980-09-02 | 1981-09-01 | Novel thioesters and process for the preparation of the same |
| AT84109690T ATE31416T1 (en) | 1980-09-02 | 1981-09-01 | PROCESS FOR THE PRODUCTION OF CEPHALOSPORIN DERIVATIVES USING NEW THIOESTERS. |
| EP84109690A EP0137227B1 (en) | 1980-09-02 | 1981-09-01 | Process for the preparation of cephalosporin derivatives using novel thioesters |
| DE8181106833T DE3173499D1 (en) | 1980-09-02 | 1981-09-01 | Novel thioesters and process for the preparation of the same |
| DE8484109690T DE3176575D1 (en) | 1980-09-02 | 1981-09-01 | Process for the preparation of cephalosporin derivatives using novel thioesters |
| US06/298,884 US4463179A (en) | 1980-09-02 | 1981-09-02 | 1H-1,2,3-triazol-5-ylthio ester of N-carbobenzyloxy-p-hydroxyphenylglycine |
| US06/414,946 US4456754A (en) | 1980-09-02 | 1982-09-03 | Process for the preparation of cephalosporin derivatives using thioesters |
| US06/545,202 US4454323A (en) | 1980-09-02 | 1983-10-25 | 1-Methyltetrazol-5-ylthio ester of cyanomethylthioacetic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14817880A JPS5772974A (en) | 1980-10-24 | 1980-10-24 | Novel 1-methyl-tetrazol-5-yl-thiol ester and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5772974A true JPS5772974A (en) | 1982-05-07 |
Family
ID=15446989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14817880A Pending JPS5772974A (en) | 1980-09-02 | 1980-10-24 | Novel 1-methyl-tetrazol-5-yl-thiol ester and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5772974A (en) |
-
1980
- 1980-10-24 JP JP14817880A patent/JPS5772974A/en active Pending
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