JPS56135475A - Novel mandelic pyridine-n-oxide-2-yl-thiol ester and its preparative method - Google Patents
Novel mandelic pyridine-n-oxide-2-yl-thiol ester and its preparative methodInfo
- Publication number
- JPS56135475A JPS56135475A JP3750080A JP3750080A JPS56135475A JP S56135475 A JPS56135475 A JP S56135475A JP 3750080 A JP3750080 A JP 3750080A JP 3750080 A JP3750080 A JP 3750080A JP S56135475 A JPS56135475 A JP S56135475A
- Authority
- JP
- Japan
- Prior art keywords
- pyridine
- oxide
- thiol ester
- mandelic
- preparative method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyridine Compounds (AREA)
Abstract
NEW MATERIAL:Mandelic pyridine-N-oxide-2-yl thiol ester of formula I.
USE: It is very useful as an acylating agent for amines and hydrazines. For example, it is used as a reagent for synthesis of cephalosporin.
PREPARATION: The reaction between pyridine-N-oxide-2-thiol of formula II or its derivative and madelic acid or its derivative is conducted, in the presence of a condensation agent such as N,N'-dicyclohexylcarbodiimide, when free madelic acid is used, in a solvent of dioxane or ethyl acetate at -50°CW100°C, preferably at -20°CW50°C to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3750080A JPS56135475A (en) | 1980-03-26 | 1980-03-26 | Novel mandelic pyridine-n-oxide-2-yl-thiol ester and its preparative method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3750080A JPS56135475A (en) | 1980-03-26 | 1980-03-26 | Novel mandelic pyridine-n-oxide-2-yl-thiol ester and its preparative method |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56135475A true JPS56135475A (en) | 1981-10-22 |
Family
ID=12499238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3750080A Pending JPS56135475A (en) | 1980-03-26 | 1980-03-26 | Novel mandelic pyridine-n-oxide-2-yl-thiol ester and its preparative method |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56135475A (en) |
-
1980
- 1980-03-26 JP JP3750080A patent/JPS56135475A/en active Pending
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