JPS5716852A - Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same - Google Patents
Nitrile derivative, its preparation, and fibrosis suppressing agent containing the sameInfo
- Publication number
- JPS5716852A JPS5716852A JP9092480A JP9092480A JPS5716852A JP S5716852 A JPS5716852 A JP S5716852A JP 9092480 A JP9092480 A JP 9092480A JP 9092480 A JP9092480 A JP 9092480A JP S5716852 A JPS5716852 A JP S5716852A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- preparation
- fibrosis
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:The compound of formula I (R is H or lower alkyl; l is 1W4; m is 0W4; n is 1W2).
EXAMPLE: N-(2-Cyanoethyl)-3,5-dihydroxy-3-methylpentanamide.
USE: Agent for suppressing fibrosis of animal tissue. Effective for the remedy and prevention of fibrosis of organs, hepatocirrhosis, arterioscrelosis, chronic arthritis, etc. Low toxic.
PROCESS: The compound of formula I is prepared by reacting (A) the compound of formula II (X is OH or halogen), the compound of formula III or the compound of formula IV with (B) cyanomethylamine or 2-cyanoethylamine of formula V, pref. in a solvent such as heptane, dioxane, ethanol, etc., at 50W75°C.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9092480A JPS5716852A (en) | 1980-07-02 | 1980-07-02 | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9092480A JPS5716852A (en) | 1980-07-02 | 1980-07-02 | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5716852A true JPS5716852A (en) | 1982-01-28 |
JPS6320426B2 JPS6320426B2 (en) | 1988-04-27 |
Family
ID=14011972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9092480A Granted JPS5716852A (en) | 1980-07-02 | 1980-07-02 | Nitrile derivative, its preparation, and fibrosis suppressing agent containing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5716852A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61249587A (en) * | 1985-04-27 | 1986-11-06 | Maeda Kensetsu Kogyo Kk | Treatment of harmful substance-contaminated soil at home position |
US5338115A (en) * | 1992-12-11 | 1994-08-16 | The United States Of America As Represented By The United States Department Of Energy | Mixing device for materials with large density differences |
US5401880A (en) * | 1987-06-04 | 1995-03-28 | Oculon Corporation | Chemical prevention or reversal of cataract by phase separation inhibitors |
JP2017538403A (en) * | 2014-11-26 | 2017-12-28 | ビゾリス インコーポレイテッド | Biologically induced mevalonic acid conversion method |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022014599A1 (en) | 2020-07-15 | 2022-01-20 | デンカ株式会社 | Composition and cured body |
-
1980
- 1980-07-02 JP JP9092480A patent/JPS5716852A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61249587A (en) * | 1985-04-27 | 1986-11-06 | Maeda Kensetsu Kogyo Kk | Treatment of harmful substance-contaminated soil at home position |
JPH058078B2 (en) * | 1985-04-27 | 1993-02-01 | Maeda Kensetsu Kogyo Kk | |
US5401880A (en) * | 1987-06-04 | 1995-03-28 | Oculon Corporation | Chemical prevention or reversal of cataract by phase separation inhibitors |
US5338115A (en) * | 1992-12-11 | 1994-08-16 | The United States Of America As Represented By The United States Department Of Energy | Mixing device for materials with large density differences |
JP2017538403A (en) * | 2014-11-26 | 2017-12-28 | ビゾリス インコーポレイテッド | Biologically induced mevalonic acid conversion method |
Also Published As
Publication number | Publication date |
---|---|
JPS6320426B2 (en) | 1988-04-27 |
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