JPS57212153A - Purification of naphthalenedisulfonic acid di-lower alkyl ester - Google Patents
Purification of naphthalenedisulfonic acid di-lower alkyl esterInfo
- Publication number
- JPS57212153A JPS57212153A JP9805481A JP9805481A JPS57212153A JP S57212153 A JPS57212153 A JP S57212153A JP 9805481 A JP9805481 A JP 9805481A JP 9805481 A JP9805481 A JP 9805481A JP S57212153 A JPS57212153 A JP S57212153A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- water
- reaction product
- compound shown
- alkyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: In the reaction between naphthalenedisulfonyl chloride and an aliphatic alcohol, to purify the titled compound useful as a drug in high purity, by treating the reaction product with an alkali metal alcoholate, followed by washing it with water.
CONSTITUTION: Naphthalenedisulfonyl chloride shown by the formulaI(the positions of the substituent groups are 1,5- or 2,6-) is reacted with an excess amount of an aliphatic alcohol shown by the formula ROH (R is methyl or ethyl) in the presence of an aqueous solution of an alkali, to give a naphthalenedisulfonic acid dilower alkyl ester shown by the formula II, the reaction product is treated with an alkali metal alcoholate shown by the formula ROM (M is Na or K), and washed with water, to purify the desired compound. A compound shown by the formulaIand a compound shown by the formula III contained in the reaction product as impurities are converted into the desired compound shown by the formula II, while water-soluble impurities are removed by the washing operation with water to give the extremely high-quality compound shown by the formula II.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9805481A JPS5851949B2 (en) | 1981-06-24 | 1981-06-24 | Purification method for naphthalene disulfonic acid di-lower alkyl ester |
US06/387,605 US4434104A (en) | 1981-06-17 | 1982-06-11 | Preparation of high purity di-lower alkyl naphthalenedisulfonates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9805481A JPS5851949B2 (en) | 1981-06-24 | 1981-06-24 | Purification method for naphthalene disulfonic acid di-lower alkyl ester |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57212153A true JPS57212153A (en) | 1982-12-27 |
JPS5851949B2 JPS5851949B2 (en) | 1983-11-19 |
Family
ID=14209537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9805481A Expired JPS5851949B2 (en) | 1981-06-17 | 1981-06-24 | Purification method for naphthalene disulfonic acid di-lower alkyl ester |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5851949B2 (en) |
-
1981
- 1981-06-24 JP JP9805481A patent/JPS5851949B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5851949B2 (en) | 1983-11-19 |
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