JPS57106651A - 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient - Google Patents
1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredientInfo
- Publication number
- JPS57106651A JPS57106651A JP18140380A JP18140380A JPS57106651A JP S57106651 A JPS57106651 A JP S57106651A JP 18140380 A JP18140380 A JP 18140380A JP 18140380 A JP18140380 A JP 18140380A JP S57106651 A JPS57106651 A JP S57106651A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- leukotriene biosynthesis
- compound shown
- straight
- inhibitor against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A compound shown by the formulaI{X is single bond, or trans-vinylene; R1 is 6W10C straight-chain alkyl; R2 is group shown by the formula II[Y is -OR5(R5 is H, 1W5C straight-chain or branched-chain alkyl, etc.)]; R3 is H, 1W5C straight, branched-chain alkyl}.
EXAMPLE: 4-[4-(cis-1-Decenyl)benzamido]butanoic acid.
USE: An inhibitor against leukotriene biosynthesis. Having inhibiting action on 5- lipoxygenase, controlling leukotriene biosynthesis of mammals including human, useful for remedying and preventing allergic diseases of air tube and bronchus.
PROCESS: A compound shown by the formula III is treated with an alkocycarbonyl chloride and converted into an acid anhydride, which is reacted with a compound shown by the formula IV (m is 1W5), to give the titled compound shown by the formula V[R21 is group shown by the formula VI].
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18140380A JPS57106651A (en) | 1980-12-23 | 1980-12-23 | 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18140380A JPS57106651A (en) | 1980-12-23 | 1980-12-23 | 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57106651A true JPS57106651A (en) | 1982-07-02 |
Family
ID=16100138
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18140380A Pending JPS57106651A (en) | 1980-12-23 | 1980-12-23 | 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57106651A (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6097946A (en) * | 1983-11-01 | 1985-05-31 | Ono Pharmaceut Co Ltd | Carboxamide derivative, its production and remedy containing said derivative |
JPS60116657A (en) * | 1983-11-30 | 1985-06-24 | Ono Pharmaceut Co Ltd | Aniline derivative, its production, and remedy containing said derivative as active component |
JPS60142936A (en) * | 1983-12-28 | 1985-07-29 | Ono Pharmaceut Co Ltd | Substituted phenyl derivative, its preparation, and remedy containing it |
JPS6160609A (en) * | 1984-08-31 | 1986-03-28 | Green Cross Corp:The | Lipoxygenase inhibitor |
US4931469A (en) * | 1982-10-15 | 1990-06-05 | Burroughs Wellcome Co. | Novel pesticides, preparation and use |
EP1024134A1 (en) * | 1997-10-09 | 2000-08-02 | Ono Pharmaceutical Co., Ltd. | Aminobutanoic acid derivatives |
JP2007191280A (en) * | 2006-01-20 | 2007-08-02 | Duplo Corp | Binding processing device |
CN104105694A (en) * | 2012-02-10 | 2014-10-15 | 住友化学株式会社 | Amide compound and use thereof for pest control |
-
1980
- 1980-12-23 JP JP18140380A patent/JPS57106651A/en active Pending
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4931469A (en) * | 1982-10-15 | 1990-06-05 | Burroughs Wellcome Co. | Novel pesticides, preparation and use |
JPS6097946A (en) * | 1983-11-01 | 1985-05-31 | Ono Pharmaceut Co Ltd | Carboxamide derivative, its production and remedy containing said derivative |
JPH0379336B2 (en) * | 1983-11-01 | 1991-12-18 | Ono Pharmaceutical Co | |
JPS60116657A (en) * | 1983-11-30 | 1985-06-24 | Ono Pharmaceut Co Ltd | Aniline derivative, its production, and remedy containing said derivative as active component |
JPH0379337B2 (en) * | 1983-11-30 | 1991-12-18 | Ono Pharmaceutical Co | |
JPS60142936A (en) * | 1983-12-28 | 1985-07-29 | Ono Pharmaceut Co Ltd | Substituted phenyl derivative, its preparation, and remedy containing it |
JPH0419982B2 (en) * | 1983-12-28 | 1992-03-31 | Ono Pharmaceutical Co | |
JPS6160609A (en) * | 1984-08-31 | 1986-03-28 | Green Cross Corp:The | Lipoxygenase inhibitor |
EP1024134A1 (en) * | 1997-10-09 | 2000-08-02 | Ono Pharmaceutical Co., Ltd. | Aminobutanoic acid derivatives |
EP1024134A4 (en) * | 1997-10-09 | 2003-05-14 | Ono Pharmaceutical Co | Aminobutanoic acid derivatives |
JP2007191280A (en) * | 2006-01-20 | 2007-08-02 | Duplo Corp | Binding processing device |
CN104105694A (en) * | 2012-02-10 | 2014-10-15 | 住友化学株式会社 | Amide compound and use thereof for pest control |
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