JPS57106651A - 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient - Google Patents

1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient

Info

Publication number
JPS57106651A
JPS57106651A JP18140380A JP18140380A JPS57106651A JP S57106651 A JPS57106651 A JP S57106651A JP 18140380 A JP18140380 A JP 18140380A JP 18140380 A JP18140380 A JP 18140380A JP S57106651 A JPS57106651 A JP S57106651A
Authority
JP
Japan
Prior art keywords
formula
leukotriene biosynthesis
compound shown
straight
inhibitor against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP18140380A
Other languages
Japanese (ja)
Inventor
Yoshinobu Arai
Yoshitaka Konishi
Akira Doi
Tsumoru Miyamoto
Masaki Hayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Priority to JP18140380A priority Critical patent/JPS57106651A/en
Publication of JPS57106651A publication Critical patent/JPS57106651A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formulaI{X is single bond, or trans-vinylene; R1 is 6W10C straight-chain alkyl; R2 is group shown by the formula II[Y is -OR5(R5 is H, 1W5C straight-chain or branched-chain alkyl, etc.)]; R3 is H, 1W5C straight, branched-chain alkyl}.
EXAMPLE: 4-[4-(cis-1-Decenyl)benzamido]butanoic acid.
USE: An inhibitor against leukotriene biosynthesis. Having inhibiting action on 5- lipoxygenase, controlling leukotriene biosynthesis of mammals including human, useful for remedying and preventing allergic diseases of air tube and bronchus.
PROCESS: A compound shown by the formula III is treated with an alkocycarbonyl chloride and converted into an acid anhydride, which is reacted with a compound shown by the formula IV (m is 1W5), to give the titled compound shown by the formula V[R21 is group shown by the formula VI].
COPYRIGHT: (C)1982,JPO&Japio
JP18140380A 1980-12-23 1980-12-23 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient Pending JPS57106651A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18140380A JPS57106651A (en) 1980-12-23 1980-12-23 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18140380A JPS57106651A (en) 1980-12-23 1980-12-23 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient

Publications (1)

Publication Number Publication Date
JPS57106651A true JPS57106651A (en) 1982-07-02

Family

ID=16100138

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18140380A Pending JPS57106651A (en) 1980-12-23 1980-12-23 1,4-disubstituted benzene compound, its preparation, and inhibitor against leukotriene biosynthesis comprising it as active ingredient

Country Status (1)

Country Link
JP (1) JPS57106651A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6097946A (en) * 1983-11-01 1985-05-31 Ono Pharmaceut Co Ltd Carboxamide derivative, its production and remedy containing said derivative
JPS60116657A (en) * 1983-11-30 1985-06-24 Ono Pharmaceut Co Ltd Aniline derivative, its production, and remedy containing said derivative as active component
JPS60142936A (en) * 1983-12-28 1985-07-29 Ono Pharmaceut Co Ltd Substituted phenyl derivative, its preparation, and remedy containing it
JPS6160609A (en) * 1984-08-31 1986-03-28 Green Cross Corp:The Lipoxygenase inhibitor
US4931469A (en) * 1982-10-15 1990-06-05 Burroughs Wellcome Co. Novel pesticides, preparation and use
EP1024134A1 (en) * 1997-10-09 2000-08-02 Ono Pharmaceutical Co., Ltd. Aminobutanoic acid derivatives
JP2007191280A (en) * 2006-01-20 2007-08-02 Duplo Corp Binding processing device
CN104105694A (en) * 2012-02-10 2014-10-15 住友化学株式会社 Amide compound and use thereof for pest control

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4931469A (en) * 1982-10-15 1990-06-05 Burroughs Wellcome Co. Novel pesticides, preparation and use
JPS6097946A (en) * 1983-11-01 1985-05-31 Ono Pharmaceut Co Ltd Carboxamide derivative, its production and remedy containing said derivative
JPH0379336B2 (en) * 1983-11-01 1991-12-18 Ono Pharmaceutical Co
JPS60116657A (en) * 1983-11-30 1985-06-24 Ono Pharmaceut Co Ltd Aniline derivative, its production, and remedy containing said derivative as active component
JPH0379337B2 (en) * 1983-11-30 1991-12-18 Ono Pharmaceutical Co
JPS60142936A (en) * 1983-12-28 1985-07-29 Ono Pharmaceut Co Ltd Substituted phenyl derivative, its preparation, and remedy containing it
JPH0419982B2 (en) * 1983-12-28 1992-03-31 Ono Pharmaceutical Co
JPS6160609A (en) * 1984-08-31 1986-03-28 Green Cross Corp:The Lipoxygenase inhibitor
EP1024134A1 (en) * 1997-10-09 2000-08-02 Ono Pharmaceutical Co., Ltd. Aminobutanoic acid derivatives
EP1024134A4 (en) * 1997-10-09 2003-05-14 Ono Pharmaceutical Co Aminobutanoic acid derivatives
JP2007191280A (en) * 2006-01-20 2007-08-02 Duplo Corp Binding processing device
CN104105694A (en) * 2012-02-10 2014-10-15 住友化学株式会社 Amide compound and use thereof for pest control

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