JPS5473767A - 2-oxo-phenylbutanoic acid derivative and its preparation - Google Patents
2-oxo-phenylbutanoic acid derivative and its preparationInfo
- Publication number
- JPS5473767A JPS5473767A JP13625477A JP13625477A JPS5473767A JP S5473767 A JPS5473767 A JP S5473767A JP 13625477 A JP13625477 A JP 13625477A JP 13625477 A JP13625477 A JP 13625477A JP S5473767 A JPS5473767 A JP S5473767A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- oxo
- compound
- acid derivative
- phenylbutanoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
NEW MATERIAL:An 2-oxo-phenylbutanoic acid derivative of formula I: (X is amino, OH, or lower alkoxy group)
EXAMPLE: 2-Oxo-3-[4-(1-oxo-2-isoindolynyl) phenyl] butanamide.
USE: Pharmaceuticals, e.g. anti-inflammatory and anaglgesic drugs, etc. having low toxicity and little side effect, e.g. damage to the stomach.
PROCESS: A compound of formula II is acetylated under the Friedel-Crafts reaction conditions to form a compound of formula III, which is reacted with a cyanoacetate in the presence of a catalyst to form a compound of formula IV: (R is lower alkyl group). The compound of formula IV thus obtained is oxidized and treated with an alkali to afford a compound of formula V: (M is alkali metal), which is decarboxylated in the presence of an acid, e.g. acetic acid under heating, and, if desired, hydrolyzed, then, if neccssary, esterified to give a 2-oxo-phenylbutanoic acid derivative of formula I.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES456182A ES456182A1 (en) | 1976-02-23 | 1977-02-23 | Improvements in telephone appliances. (Machine-translation by Google Translate, not legally binding) |
JP13625477A JPS5473767A (en) | 1977-11-15 | 1977-11-15 | 2-oxo-phenylbutanoic acid derivative and its preparation |
DE19772755345 DE2755345A1 (en) | 1977-04-05 | 1977-12-12 | 2-OXO-PHENYLBUTTERIC ACID DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS |
US05/862,206 US4166125A (en) | 1977-04-05 | 1977-12-19 | 2-oxo-phenylbutanoic acid derivatives |
GB52798/77A GB1554118A (en) | 1977-04-05 | 1977-12-19 | 2-oxo-3-phenylbutanoic acid derivatives |
CA293,440A CA1088077A (en) | 1977-04-05 | 1977-12-20 | 2-oxo-phenylbutanoic acid derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13625477A JPS5473767A (en) | 1977-11-15 | 1977-11-15 | 2-oxo-phenylbutanoic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5473767A true JPS5473767A (en) | 1979-06-13 |
Family
ID=15170874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13625477A Pending JPS5473767A (en) | 1976-02-23 | 1977-11-15 | 2-oxo-phenylbutanoic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5473767A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11584122B2 (en) | 2019-05-22 | 2023-02-21 | Canon Kabushiki Kaisha | Element substrate, liquid discharge head, and printing apparatus |
-
1977
- 1977-11-15 JP JP13625477A patent/JPS5473767A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11584122B2 (en) | 2019-05-22 | 2023-02-21 | Canon Kabushiki Kaisha | Element substrate, liquid discharge head, and printing apparatus |
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