JPS5473767A - 2-oxo-phenylbutanoic acid derivative and its preparation - Google Patents

2-oxo-phenylbutanoic acid derivative and its preparation

Info

Publication number
JPS5473767A
JPS5473767A JP13625477A JP13625477A JPS5473767A JP S5473767 A JPS5473767 A JP S5473767A JP 13625477 A JP13625477 A JP 13625477A JP 13625477 A JP13625477 A JP 13625477A JP S5473767 A JPS5473767 A JP S5473767A
Authority
JP
Japan
Prior art keywords
formula
oxo
compound
acid derivative
phenylbutanoic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13625477A
Other languages
Japanese (ja)
Inventor
Kazuo Kikazawa
Mineji Hiiragi
Haruhide Ishimaru
Seiji Haga
Keiko Shiroyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Grelan Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES456182A priority Critical patent/ES456182A1/en
Application filed by Grelan Pharmaceutical Co Ltd filed Critical Grelan Pharmaceutical Co Ltd
Priority to JP13625477A priority patent/JPS5473767A/en
Priority to DE19772755345 priority patent/DE2755345A1/en
Priority to US05/862,206 priority patent/US4166125A/en
Priority to GB52798/77A priority patent/GB1554118A/en
Priority to CA293,440A priority patent/CA1088077A/en
Publication of JPS5473767A publication Critical patent/JPS5473767A/en
Pending legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

NEW MATERIAL:An 2-oxo-phenylbutanoic acid derivative of formula I: (X is amino, OH, or lower alkoxy group)
EXAMPLE: 2-Oxo-3-[4-(1-oxo-2-isoindolynyl) phenyl] butanamide.
USE: Pharmaceuticals, e.g. anti-inflammatory and anaglgesic drugs, etc. having low toxicity and little side effect, e.g. damage to the stomach.
PROCESS: A compound of formula II is acetylated under the Friedel-Crafts reaction conditions to form a compound of formula III, which is reacted with a cyanoacetate in the presence of a catalyst to form a compound of formula IV: (R is lower alkyl group). The compound of formula IV thus obtained is oxidized and treated with an alkali to afford a compound of formula V: (M is alkali metal), which is decarboxylated in the presence of an acid, e.g. acetic acid under heating, and, if desired, hydrolyzed, then, if neccssary, esterified to give a 2-oxo-phenylbutanoic acid derivative of formula I.
COPYRIGHT: (C)1979,JPO&Japio
JP13625477A 1976-02-23 1977-11-15 2-oxo-phenylbutanoic acid derivative and its preparation Pending JPS5473767A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES456182A ES456182A1 (en) 1976-02-23 1977-02-23 Improvements in telephone appliances. (Machine-translation by Google Translate, not legally binding)
JP13625477A JPS5473767A (en) 1977-11-15 1977-11-15 2-oxo-phenylbutanoic acid derivative and its preparation
DE19772755345 DE2755345A1 (en) 1977-04-05 1977-12-12 2-OXO-PHENYLBUTTERIC ACID DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PREPARATIONS CONTAINING THESE COMPOUNDS
US05/862,206 US4166125A (en) 1977-04-05 1977-12-19 2-oxo-phenylbutanoic acid derivatives
GB52798/77A GB1554118A (en) 1977-04-05 1977-12-19 2-oxo-3-phenylbutanoic acid derivatives
CA293,440A CA1088077A (en) 1977-04-05 1977-12-20 2-oxo-phenylbutanoic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13625477A JPS5473767A (en) 1977-11-15 1977-11-15 2-oxo-phenylbutanoic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5473767A true JPS5473767A (en) 1979-06-13

Family

ID=15170874

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13625477A Pending JPS5473767A (en) 1976-02-23 1977-11-15 2-oxo-phenylbutanoic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5473767A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584122B2 (en) 2019-05-22 2023-02-21 Canon Kabushiki Kaisha Element substrate, liquid discharge head, and printing apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584122B2 (en) 2019-05-22 2023-02-21 Canon Kabushiki Kaisha Element substrate, liquid discharge head, and printing apparatus

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