JPS559024A - Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent - Google Patents

Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent

Info

Publication number
JPS559024A
JPS559024A JP8128678A JP8128678A JPS559024A JP S559024 A JPS559024 A JP S559024A JP 8128678 A JP8128678 A JP 8128678A JP 8128678 A JP8128678 A JP 8128678A JP S559024 A JPS559024 A JP S559024A
Authority
JP
Japan
Prior art keywords
tetrahydro
formula
hyperlipemia
remedy
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8128678A
Other languages
Japanese (ja)
Other versions
JPS6026094B2 (en
Inventor
Akira Endo
Akira Terahara
Yoshio Tsujita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP8128678A priority Critical patent/JPS6026094B2/en
Publication of JPS559024A publication Critical patent/JPS559024A/en
Publication of JPS6026094B2 publication Critical patent/JPS6026094B2/en
Expired legal-status Critical Current

Links

Abstract

NEW MATERIAL:Tetrahydro ML-236B of formula I, a metal salt of the carboxylic acid of formula II: (M is metal element; n is the valence of the element), or an alkyl ester of formula III: (R is alkyl group).
USE: Remedies for hyperlipemia.
PROCESS: ML-236B is dissolved in tetrahydrofuran, and hydrogenated in the presence of a catalyst to give a tetrahydro ML-236B of formula I. An alkyl ester of ML-236B is dissolved in an alcohol and catalytically reduced in the presence of a catalyst to give an alkyl ester of ML-236B of formula III. The ester is converted into an alkali (earth) metal, or aluminum salt to give a metal salt of the tetrahydro ML-236B carboxylic acid of formula II.
COPYRIGHT: (C)1980,JPO&Japio
JP8128678A 1978-07-04 1978-07-04 Tetrahydro ML↓-236B and its derivatives, and a therapeutic agent for hyperlipidemia containing the same as an active ingredient Expired JPS6026094B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8128678A JPS6026094B2 (en) 1978-07-04 1978-07-04 Tetrahydro ML↓-236B and its derivatives, and a therapeutic agent for hyperlipidemia containing the same as an active ingredient

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8128678A JPS6026094B2 (en) 1978-07-04 1978-07-04 Tetrahydro ML↓-236B and its derivatives, and a therapeutic agent for hyperlipidemia containing the same as an active ingredient

Publications (2)

Publication Number Publication Date
JPS559024A true JPS559024A (en) 1980-01-22
JPS6026094B2 JPS6026094B2 (en) 1985-06-21

Family

ID=13742124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8128678A Expired JPS6026094B2 (en) 1978-07-04 1978-07-04 Tetrahydro ML↓-236B and its derivatives, and a therapeutic agent for hyperlipidemia containing the same as an active ingredient

Country Status (1)

Country Link
JP (1) JPS6026094B2 (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0033537A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. Hydrogenation products of mevinolin and dihydromevinolin, a process for preparing the same and an antihypercholesterolemic pharmaceutical composition containing the same
EP0033538A2 (en) 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same
JPS57149247A (en) * 1981-03-11 1982-09-14 Sankyo Co Ltd Trans tetrahydro ml-236b and its derivative
JPS58210043A (en) * 1982-05-31 1983-12-07 メルク　エンド　カムパニー　インコーポレーテツド 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)- 2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)- decahydronaphthyl-1(s))ethyl)- 4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS59122483A (en) * 1982-12-28 1984-07-14 Nippon Chemiphar Co Ltd Novel monacolin derivative, its preparation and remedy for hyperlipemia containing the same
JPS6037043U (en) * 1983-08-17 1985-03-14 松本　昌芳 key point tape

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0033537A2 (en) * 1980-02-04 1981-08-12 Merck & Co. Inc. Hydrogenation products of mevinolin and dihydromevinolin, a process for preparing the same and an antihypercholesterolemic pharmaceutical composition containing the same
EP0033538A2 (en) 1980-02-04 1981-08-12 Merck & Co. Inc. 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same
JPS56122374A (en) * 1980-02-04 1981-09-25 Merck & Co Inc Hypocholesterolemic hydrogenation product and its manufacture
JPH0136471B2 (en) * 1980-02-04 1989-07-31 Merck & Co Inc
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
JPS57149247A (en) * 1981-03-11 1982-09-14 Sankyo Co Ltd Trans tetrahydro ml-236b and its derivative
JPS58210043A (en) * 1982-05-31 1983-12-07 メルク　エンド　カムパニー　インコーポレーテツド 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)- 2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)- decahydronaphthyl-1(s))ethyl)- 4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one
JPS59122483A (en) * 1982-12-28 1984-07-14 Nippon Chemiphar Co Ltd Novel monacolin derivative, its preparation and remedy for hyperlipemia containing the same
JPH0468316B2 (en) * 1982-12-28 1992-11-02 Nippon Chemiphar Co
JPS6037043U (en) * 1983-08-17 1985-03-14 松本　昌芳 key point tape

Also Published As

Publication number Publication date
JPS6026094B2 (en) 1985-06-21

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