JPS5668610A - Antitumorigenic agent containing napthalenesulfonamide as effective component - Google Patents
Antitumorigenic agent containing napthalenesulfonamide as effective componentInfo
- Publication number
- JPS5668610A JPS5668610A JP14382279A JP14382279A JPS5668610A JP S5668610 A JPS5668610 A JP S5668610A JP 14382279 A JP14382279 A JP 14382279A JP 14382279 A JP14382279 A JP 14382279A JP S5668610 A JPS5668610 A JP S5668610A
- Authority
- JP
- Japan
- Prior art keywords
- effective component
- formula
- antitumorigenic
- napthalenesulfonamide
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: An antitumorigenic agent that contains a napthalenesulfonamide derivative as an effective component, thus showing low toxicity and high antitumorigenic activity and being used orally or parenterally.
CONSTITUTION: An antitumorigenic agent that contains a naphthalenesulfoneamide derivative of formula I [X is H, halogen; So2NHR connects to the 1 or 2 position in the naphthalene ring; R is H, amino, -(CH2)mNH2, formula II; m is 1W10; n is 4W6] such as N-(5-aminobutyl)-5-chloro-1-naphthalenesulfonamide (A-5) as an effective component. The dose is usually 10W100mg a day. The compound of formula I is obtained by reaction of a naphthalenesulfonic acid derivative of formula III (X1 is halogen) with an amine of R-NH2 or its acylated product and, when necessary, subsequent deacylation of the amino-protecting group.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14382279A JPS5668610A (en) | 1979-11-08 | 1979-11-08 | Antitumorigenic agent containing napthalenesulfonamide as effective component |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14382279A JPS5668610A (en) | 1979-11-08 | 1979-11-08 | Antitumorigenic agent containing napthalenesulfonamide as effective component |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5668610A true JPS5668610A (en) | 1981-06-09 |
Family
ID=15347756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14382279A Pending JPS5668610A (en) | 1979-11-08 | 1979-11-08 | Antitumorigenic agent containing napthalenesulfonamide as effective component |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5668610A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4681899A (en) * | 1985-03-29 | 1987-07-21 | Ohnishi S Tsuyoshi | Method of preventing the growth of malaria parasites in erythrocytes |
US5707985A (en) * | 1995-06-07 | 1998-01-13 | Tanabe Seiyaku Co. Ltd. | Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators |
-
1979
- 1979-11-08 JP JP14382279A patent/JPS5668610A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4681899A (en) * | 1985-03-29 | 1987-07-21 | Ohnishi S Tsuyoshi | Method of preventing the growth of malaria parasites in erythrocytes |
US5707985A (en) * | 1995-06-07 | 1998-01-13 | Tanabe Seiyaku Co. Ltd. | Naphthyl-, quinolyl- and isoquinolyl- sulfonamide derivatives as cell adhesion modulators |
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