IE42179L - Kanamycin derivatives - Google Patents

Kanamycin derivatives

Info

Publication number
IE42179L
IE42179L IE752502A IE250275A IE42179L IE 42179 L IE42179 L IE 42179L IE 752502 A IE752502 A IE 752502A IE 250275 A IE250275 A IE 250275A IE 42179 L IE42179 L IE 42179L
Authority
IE
Ireland
Prior art keywords
formula
acylating agent
meaning stated
kanamycin
compounds
Prior art date
Application number
IE752502A
Other versions
IE42179B1 (en
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of IE42179L publication Critical patent/IE42179L/en
Publication of IE42179B1 publication Critical patent/IE42179B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Semisynthetic derivatives of kanamycin A and B of the formula IV in which R3 and R have the meaning stated in Claim 1 are prepared. The process starts from corresponding compounds with R = hydrogen and comprises acylation with an acylating agent of the formula VII in which W and M have the meaning stated in Claim 1, and subsequent elimination of the amino protective group W. A preferred acylating agent of the formula VIIa is obtained in situ by mixing the appropriate N-protected carboxylic acid with equimolar amounts of N-hydroxy-5-norbornene-2,3-dicarboximide and dicyclohexylcarbodiimide as dehydrating agent. The said compounds have antibacterial activity and can therefore be used in medicines or as additives to animal feedstuffs. <IMAGE> [GB1535215A]
IE2502/75A 1974-12-09 1975-11-17 Kanamycin derivatives IE42179B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53078774A 1974-12-09 1974-12-09

Publications (2)

Publication Number Publication Date
IE42179L true IE42179L (en) 1976-06-09
IE42179B1 IE42179B1 (en) 1980-06-18

Family

ID=24114972

Family Applications (1)

Application Number Title Priority Date Filing Date
IE2502/75A IE42179B1 (en) 1974-12-09 1975-11-17 Kanamycin derivatives

Country Status (17)

Country Link
JP (1) JPS51105036A (en)
BE (1) BE836292A (en)
CA (1) CA1052780A (en)
CH (1) CH621558A5 (en)
CS (1) CS191168B2 (en)
DE (1) DE2555405A1 (en)
DK (1) DK149775B (en)
FR (1) FR2293941A1 (en)
GB (1) GB1535215A (en)
HU (1) HU175575B (en)
IE (1) IE42179B1 (en)
LU (1) LU73957A1 (en)
NL (1) NL7514322A (en)
SE (1) SE435513B (en)
SU (1) SU581873A3 (en)
YU (1) YU306475A (en)
ZA (1) ZA757652B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000473B1 (en) * 1977-06-24 1981-03-11 Scherico Ltd. Process for preparing aminoglycoside derivatives, novel derivatives obtained and pharmaceutical compositions containing such derivatives
CA2706369C (en) 2007-11-21 2014-03-25 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
CN103228282A (en) 2010-09-13 2013-07-31 苏黎世大学 Treatment of bacterial infectious diseases
US9981896B2 (en) 2016-07-01 2018-05-29 Res Usa, Llc Conversion of methane to dimethyl ether
US9938217B2 (en) 2016-07-01 2018-04-10 Res Usa, Llc Fluidized bed membrane reactor
WO2018004993A1 (en) 2016-07-01 2018-01-04 Res Usa, Llc Reduction of greenhouse gas emission

Also Published As

Publication number Publication date
SE7513804L (en) 1976-06-10
GB1535215A (en) 1978-12-13
FR2293941A1 (en) 1976-07-09
CS191168B2 (en) 1979-06-29
YU306475A (en) 1982-05-31
ZA757652B (en) 1976-11-24
SU581873A3 (en) 1977-11-25
LU73957A1 (en) 1976-11-11
NL7514322A (en) 1976-06-11
DK551075A (en) 1976-06-10
DE2555405A1 (en) 1976-06-10
CA1052780A (en) 1979-04-17
HU175575B (en) 1980-09-28
DK149775B (en) 1986-09-29
JPS51105036A (en) 1976-09-17
FR2293941B1 (en) 1978-11-10
SE435513B (en) 1984-10-01
BE836292A (en) 1976-06-04
AU8688275A (en) 1977-06-02
CH621558A5 (en) 1981-02-13
IE42179B1 (en) 1980-06-18

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