ES8601099A1 - Derivatives of n-(methoxyphenacyl)amine, their therapeutical use and process for their preparation - Google Patents

Derivatives of n-(methoxyphenacyl)amine, their therapeutical use and process for their preparation

Info

Publication number
ES8601099A1
ES8601099A1 ES538230A ES538230A ES8601099A1 ES 8601099 A1 ES8601099 A1 ES 8601099A1 ES 538230 A ES538230 A ES 538230A ES 538230 A ES538230 A ES 538230A ES 8601099 A1 ES8601099 A1 ES 8601099A1
Authority
ES
Spain
Prior art keywords
methoxyphenacyl
preparation
derivatives
amine
therapeutical use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES538230A
Other languages
Spanish (es)
Other versions
ES538230A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Laboratoire L Lafon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoire L Lafon SA filed Critical Laboratoire L Lafon SA
Publication of ES8601099A1 publication Critical patent/ES8601099A1/en
Publication of ES538230A0 publication Critical patent/ES538230A0/en
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Abstract

This invention relates to new N-(methoxyphenacyl)-amine derivatives selected from the group consisting of (i) the N-(methoxyphenacyl)-alkylamines of the general formula < IMAGE > (I) wherein A is OCH3, and R is C3-C8-alkyl or C3-C8-hydroxyalkyl and, (ii) addition salts thereof. These new derivatives are useful as pharmaceuticals, in particular as peripheral vasodilating agents. Their method of preparation is based upon the following reaction scheme < IMAGE > +TR
ES538230A 1983-11-25 1984-11-23 PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF N- (METOXIFENACIL) -AMINE Granted ES538230A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8318868A FR2555576B1 (en) 1983-11-25 1983-11-25 N- (METHOXYPHENACYL) -AMINE DERIVATIVES, USE IN PARTICULAR IN THERAPEUTICS AND METHOD OF PREPARATION

Publications (2)

Publication Number Publication Date
ES8601099A1 true ES8601099A1 (en) 1985-11-01
ES538230A0 ES538230A0 (en) 1985-11-01

Family

ID=9294554

Family Applications (1)

Application Number Title Priority Date Filing Date
ES538230A Granted ES538230A0 (en) 1983-11-25 1984-11-23 PROCEDURE FOR THE PREPARATION OF NEW DERIVATIVES OF N- (METOXIFENACIL) -AMINE

Country Status (9)

Country Link
US (1) US4603019A (en)
EP (1) EP0143711B1 (en)
JP (1) JPH075526B2 (en)
AT (1) ATE28858T1 (en)
CA (1) CA1220224A (en)
DE (1) DE3465297D1 (en)
ES (1) ES538230A0 (en)
FR (1) FR2555576B1 (en)
ZA (1) ZA849159B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3663955D1 (en) * 1985-11-12 1989-07-20 Inst Francais Du Petrole Process and apparatus for the catalytic cracking of a hydrocarbon feedstock submitted to a pretreatment with solid particles having a poor activity
JPH0798782B2 (en) * 1987-02-06 1995-10-25 三井石油化学工業株式会社 Method for producing aminoketones
JPH07103076B2 (en) * 1987-02-06 1995-11-08 三井石油化学工業株式会社 Production of aminoketones
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
GB0604822D0 (en) * 2006-03-09 2006-04-19 Arakis Ltd The treatment of inflammatory disorders and pain
GB0624757D0 (en) * 2006-12-12 2007-01-17 Sosei R & D Ltd Novel compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE518636C (en) * 1926-03-22 1931-02-20 Helmut Legerlotz Dr Process for the preparation of N-alkylated and arylated monoxy-ªÏ-aminoacetophenones
US2606208A (en) * 1948-04-17 1952-08-05 Searle & Co Aminoalkyl hydroxynaphthyl ketones and salts thereof
BE495065A (en) * 1949-04-13
US3317604A (en) * 1962-06-28 1967-05-02 Burroughs Wellcome Co 2, 5-dialkoxy-alpha-tertiary amino propiophenones and salts thereof
US3225096A (en) * 1964-03-02 1965-12-21 Lilly Co Eli N-cyclopropylamine aralkanone and aralkanol amine derivatives
DE1242241B (en) * 1964-04-08 1967-06-15 Boehringer Sohn Ingelheim Process for the preparation of substituted phenyl-alpha-aminoketones and their acid addition salts or their optical antipodes
DE1543361A1 (en) * 1966-07-27 1970-07-02 Boehringer Sohn Ingelheim Process for the preparation of new substituted phenyl-alpha-aminoketones
DE1593890C3 (en) * 1967-05-09 1974-03-14 Goedecke Ag, 7800 Freiburg Substituted alpha- (beta-phenylisopropyl) -amino-acetophenones, their optical antipodes and racemates, as well as their acid addition salts and processes for their preparation
FR2092133B1 (en) * 1970-05-06 1974-03-22 Orsymonde
US3873539A (en) * 1973-10-03 1975-03-25 Sandoz Ag Substituted-4-aminoacetyl alkanoylphenones
FR2460668A1 (en) * 1979-07-13 1981-01-30 Lafon Labor 2-Amino-1-phenyl-1-ethanol cpds. - use as medicaments, i.e. as CNS and/or cardiovascular agents
ATE8987T1 (en) * 1981-03-23 1984-09-15 Laboratoire L. Lafon Societe Anonyme Dite: FLUORPHENACYL-AMINE DERIVATIVES AND THEIR THERAPEUTIC USE.
FR2503143A1 (en) * 1981-03-31 1982-10-08 Lafon Labor Tri:methoxy phenacyl alkylamine(s) - having sedative, anti:depressant, and anti:aggressive activity

Also Published As

Publication number Publication date
JPS60132937A (en) 1985-07-16
EP0143711A3 (en) 1985-08-07
ATE28858T1 (en) 1987-08-15
JPH075526B2 (en) 1995-01-25
FR2555576B1 (en) 1986-06-13
CA1220224A (en) 1987-04-07
DE3465297D1 (en) 1987-09-17
ZA849159B (en) 1985-07-31
EP0143711A2 (en) 1985-06-05
ES538230A0 (en) 1985-11-01
FR2555576A1 (en) 1985-05-31
EP0143711B1 (en) 1987-08-12
US4603019A (en) 1986-07-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040503