JPS56142272A - Hydrazinopyridazine derivative - Google Patents
Hydrazinopyridazine derivativeInfo
- Publication number
- JPS56142272A JPS56142272A JP4574480A JP4574480A JPS56142272A JP S56142272 A JPS56142272 A JP S56142272A JP 4574480 A JP4574480 A JP 4574480A JP 4574480 A JP4574480 A JP 4574480A JP S56142272 A JPS56142272 A JP S56142272A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- reacted
- lower alkyl
- hydrazinopyridazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A hydrazinopyridazine derivative expressed by formula I [R is 3C or 4C branched chain alkyl; Y is -NH2 or -N=CR1R2 (R1 and R2 are lower alkyl); z is S, SO2 or -N(R3)- (R3 is H, lower alkyl or hydroxy lower alkyl); n is an integer 1W4] and a salt thereof.
EXAMPLE: 1-[ 2-( 3-Hydrazino-6-pyridazinylthiomethyl )phenoxy ]-3-iso-propylamino-2-propanol.
USE: A hypotensive agent having improved β-blocking and vasodilator actions at the same time.
PROCESS: A compound of formula I (Z is S or SO2) is obtained as follows: A dihalopyridazine is reacted with 2-hydroxyphenylalkyl mercaptan to give a compound of formula II, which is then reacted with an epihalohydrin to afford a compound of formula III. The resultant compound is then reacted with an alkylamine to give a compound of formula IV, which is reacted with hydrazine, etc. to afford a compound of formula V. The compound of formula V thus obtained is finally reacted with a dialkyl ketone.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4574480A JPS56142272A (en) | 1980-04-09 | 1980-04-09 | Hydrazinopyridazine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4574480A JPS56142272A (en) | 1980-04-09 | 1980-04-09 | Hydrazinopyridazine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56142272A true JPS56142272A (en) | 1981-11-06 |
JPS6245865B2 JPS6245865B2 (en) | 1987-09-29 |
Family
ID=12727822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4574480A Granted JPS56142272A (en) | 1980-04-09 | 1980-04-09 | Hydrazinopyridazine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56142272A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995011226A1 (en) * | 1993-10-20 | 1995-04-27 | Ishihara Sangyo Kaisha Ltd. | Substituted benzene derivatives, processes for their production and biocidal composition for control of harmful organisms containing them |
WO2008130464A1 (en) * | 2007-02-09 | 2008-10-30 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
-
1980
- 1980-04-09 JP JP4574480A patent/JPS56142272A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995011226A1 (en) * | 1993-10-20 | 1995-04-27 | Ishihara Sangyo Kaisha Ltd. | Substituted benzene derivatives, processes for their production and biocidal composition for control of harmful organisms containing them |
WO2008130464A1 (en) * | 2007-02-09 | 2008-10-30 | Tranzyme Pharma, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
US9371297B2 (en) | 2007-02-09 | 2016-06-21 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
US9949949B2 (en) | 2007-02-09 | 2018-04-24 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
US10258602B2 (en) | 2007-02-09 | 2019-04-16 | Ocera Therapeutics, Inc. | Macrocyclic ghrelin receptor modulators and methods of using the same |
Also Published As
Publication number | Publication date |
---|---|
JPS6245865B2 (en) | 1987-09-29 |
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