JPS56142272A - Hydrazinopyridazine derivative - Google Patents

Hydrazinopyridazine derivative

Info

Publication number
JPS56142272A
JPS56142272A JP4574480A JP4574480A JPS56142272A JP S56142272 A JPS56142272 A JP S56142272A JP 4574480 A JP4574480 A JP 4574480A JP 4574480 A JP4574480 A JP 4574480A JP S56142272 A JPS56142272 A JP S56142272A
Authority
JP
Japan
Prior art keywords
compound
formula
reacted
lower alkyl
hydrazinopyridazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4574480A
Other languages
Japanese (ja)
Other versions
JPS6245865B2 (en
Inventor
Kikuo Yasuda
Takayuki Takezaki
Rikio Ouchi
Hiroshi Oyabu
Toshimi Seki
Takashi Yamaguchi
Akihiro Izumi
Tsutomu Ishimori
Norio Himori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to JP4574480A priority Critical patent/JPS56142272A/en
Publication of JPS56142272A publication Critical patent/JPS56142272A/en
Publication of JPS6245865B2 publication Critical patent/JPS6245865B2/ja
Granted legal-status Critical Current

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Abstract

NEW MATERIAL:A hydrazinopyridazine derivative expressed by formula I [R is 3C or 4C branched chain alkyl; Y is -NH2 or -N=CR1R2 (R1 and R2 are lower alkyl); z is S, SO2 or -N(R3)- (R3 is H, lower alkyl or hydroxy lower alkyl); n is an integer 1W4] and a salt thereof.
EXAMPLE: 1-[ 2-( 3-Hydrazino-6-pyridazinylthiomethyl )phenoxy ]-3-iso-propylamino-2-propanol.
USE: A hypotensive agent having improved β-blocking and vasodilator actions at the same time.
PROCESS: A compound of formula I (Z is S or SO2) is obtained as follows: A dihalopyridazine is reacted with 2-hydroxyphenylalkyl mercaptan to give a compound of formula II, which is then reacted with an epihalohydrin to afford a compound of formula III. The resultant compound is then reacted with an alkylamine to give a compound of formula IV, which is reacted with hydrazine, etc. to afford a compound of formula V. The compound of formula V thus obtained is finally reacted with a dialkyl ketone.
COPYRIGHT: (C)1981,JPO&Japio
JP4574480A 1980-04-09 1980-04-09 Hydrazinopyridazine derivative Granted JPS56142272A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4574480A JPS56142272A (en) 1980-04-09 1980-04-09 Hydrazinopyridazine derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4574480A JPS56142272A (en) 1980-04-09 1980-04-09 Hydrazinopyridazine derivative

Publications (2)

Publication Number Publication Date
JPS56142272A true JPS56142272A (en) 1981-11-06
JPS6245865B2 JPS6245865B2 (en) 1987-09-29

Family

ID=12727822

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4574480A Granted JPS56142272A (en) 1980-04-09 1980-04-09 Hydrazinopyridazine derivative

Country Status (1)

Country Link
JP (1) JPS56142272A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011226A1 (en) * 1993-10-20 1995-04-27 Ishihara Sangyo Kaisha Ltd. Substituted benzene derivatives, processes for their production and biocidal composition for control of harmful organisms containing them
WO2008130464A1 (en) * 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011226A1 (en) * 1993-10-20 1995-04-27 Ishihara Sangyo Kaisha Ltd. Substituted benzene derivatives, processes for their production and biocidal composition for control of harmful organisms containing them
WO2008130464A1 (en) * 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US9371297B2 (en) 2007-02-09 2016-06-21 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US9949949B2 (en) 2007-02-09 2018-04-24 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
US10258602B2 (en) 2007-02-09 2019-04-16 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same

Also Published As

Publication number Publication date
JPS6245865B2 (en) 1987-09-29

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