JPS56128786A - Novel oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamidocephalosporanic acid, their manufacture, their use as drug, drug containing them and novel intermediate - Google Patents
Novel oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamidocephalosporanic acid, their manufacture, their use as drug, drug containing them and novel intermediateInfo
- Publication number
- JPS56128786A JPS56128786A JP2160081A JP2160081A JPS56128786A JP S56128786 A JPS56128786 A JP S56128786A JP 2160081 A JP2160081 A JP 2160081A JP 2160081 A JP2160081 A JP 2160081A JP S56128786 A JPS56128786 A JP S56128786A
- Authority
- JP
- Japan
- Prior art keywords
- radical
- formula
- atom
- product
- possibly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8003479A FR2476087A1 (fr) | 1980-02-18 | 1980-02-18 | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR8214575A FR2532313A2 (fr) | 1980-02-18 | 1982-08-25 | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkylthio-methyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56128786A true JPS56128786A (en) | 1981-10-08 |
JPH0143757B2 JPH0143757B2 (ja) | 1989-09-22 |
Family
ID=26221608
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2160081A Granted JPS56128786A (en) | 1980-02-18 | 1981-02-18 | Novel oxime derivatives of 3-alkyloxy or 3-alkylthiomethyl-7-aminothiazolylacetamidocephalosporanic acid, their manufacture, their use as drug, drug containing them and novel intermediate |
JP58019848A Expired - Lifetime JPH0794462B2 (ja) | 1980-02-18 | 1983-02-10 | 3−アルキルオキシ又は3−アルキルチオメチル−7−アミノチアゾリルアセトアミドセファロスポラン酸の新規なオキシム誘導体、それらの製造法及びそれらを含む薬剤 |
JP63051810A Expired - Lifetime JPH0639476B2 (ja) | 1980-02-18 | 1988-03-07 | 3‐アルキルオキシ又は3‐アルキルチオメチル‐7‐アミノチアゾリルアセトアミドセフアロスポラン酸の新規なオキシム誘導体 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP58019848A Expired - Lifetime JPH0794462B2 (ja) | 1980-02-18 | 1983-02-10 | 3−アルキルオキシ又は3−アルキルチオメチル−7−アミノチアゾリルアセトアミドセファロスポラン酸の新規なオキシム誘導体、それらの製造法及びそれらを含む薬剤 |
JP63051810A Expired - Lifetime JPH0639476B2 (ja) | 1980-02-18 | 1988-03-07 | 3‐アルキルオキシ又は3‐アルキルチオメチル‐7‐アミノチアゾリルアセトアミドセフアロスポラン酸の新規なオキシム誘導体 |
Country Status (14)
Country | Link |
---|---|
US (1) | US4992431A (ja) |
EP (1) | EP0034536B1 (ja) |
JP (3) | JPS56128786A (ja) |
AT (1) | ATE10941T1 (ja) |
AU (1) | AU542325B2 (ja) |
CA (1) | CA1181740A (ja) |
DE (3) | DE3177186D1 (ja) |
ES (2) | ES8206520A1 (ja) |
FR (2) | FR2476087A1 (ja) |
GR (1) | GR73815B (ja) |
HU (1) | HU185628B (ja) |
PT (1) | PT72512B (ja) |
SU (1) | SU1194279A3 (ja) |
ZA (1) | ZA81800B (ja) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5965094A (ja) * | 1982-10-06 | 1984-04-13 | Sumitomo Chem Co Ltd | セフアロスポリン化合物の製造法 |
JPS59130293A (ja) * | 1983-01-04 | 1984-07-26 | Fujisawa Pharmaceut Co Ltd | 新規セフエム化合物およびその製造方法 |
WO1984004747A1 (en) * | 1983-03-02 | 1984-12-06 | Kyoto Pharma Ind | Cephem compounds |
JPS6034976A (ja) * | 1984-02-17 | 1985-02-22 | Sankyo Co Ltd | 経口用セフアロスポリン化合物 |
JPS60109590A (ja) * | 1983-10-31 | 1985-06-15 | Fujisawa Pharmaceut Co Ltd | 新規セフエム化合物およびその製造方法 |
JPS6140291A (ja) * | 1984-07-31 | 1986-02-26 | Shionogi & Co Ltd | ヒドロキシアルキルチオセフアロスポリン |
JPS61178994A (ja) * | 1984-06-08 | 1986-08-11 | Takeda Chem Ind Ltd | セフエム化合物 |
JP2008074803A (ja) * | 2006-09-25 | 2008-04-03 | Meiji Seika Kaisha Ltd | 経口投与用カルバペネム |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
US5243043A (en) * | 1980-02-18 | 1993-09-07 | Roussel Uclaf | Cephalosporins |
FR2482587A1 (fr) * | 1980-05-14 | 1981-11-20 | Poudres & Explosifs Ste Nale | Procede de synthese de chloroformiates a-chlores et nouveaux chloroformiates a-chlores |
US4486425A (en) * | 1980-09-30 | 1984-12-04 | Sankyo Company Limited | 7-[2-(2-Aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methoxymethyl-3-cephem-4-carboxylates |
JPS5759894A (en) * | 1980-09-30 | 1982-04-10 | Sankyo Co Ltd | Cephalosporin for oral administration |
FR2499995A1 (fr) * | 1981-02-13 | 1982-08-20 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkylthiomethyl 7-amino thiazolylacetamido cephalosporanique, leur preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus. |
JPS5896091A (ja) * | 1981-12-01 | 1983-06-07 | Sankyo Co Ltd | 3−アルコキシメチルセフアロスポリン類の製造法 |
JPS5984889A (ja) * | 1982-11-05 | 1984-05-16 | Sumitomo Chem Co Ltd | セフアロスポリン誘導体およびその製造方法 |
FR2551058B1 (fr) * | 1983-08-26 | 1986-09-26 | Poudres & Explosifs Ste Nale | Procede de preparation de chloroformiates a-chlores |
GB8400024D0 (en) * | 1984-01-03 | 1984-02-08 | Glaxo Group Ltd | Cephalosporin antibiotics |
JPS63269027A (ja) * | 1987-04-25 | 1988-11-07 | Sukegawa Denki Kogyo Kk | シース型測温ケーブルの接続端子 |
DK637888A (da) * | 1987-11-24 | 1989-05-25 | Hoffmann La Roche | Carboxylsyreestere |
DE3804841A1 (de) * | 1988-02-17 | 1989-08-31 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
IT1224252B (it) * | 1988-04-08 | 1990-09-26 | Sclavo Spa | Metodo di protezione del gruppo carbossilico nella chimica dei composti beta lattamici |
DK492289A (da) * | 1988-10-07 | 1990-04-08 | Sankyo Co | 3-aryloxymethyl-cephalosporinderivater og fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende derivaterne |
DE3901405A1 (de) * | 1989-01-19 | 1990-07-26 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
DE3910093A1 (de) * | 1989-03-29 | 1990-10-04 | Hoechst Ag | Cephalosporinderivate und verfahren zu ihrer herstellung |
DE3919259A1 (de) * | 1989-06-13 | 1990-12-20 | Hoechst Ag | Kristalline cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
YU48484B (sh) * | 1991-05-24 | 1998-09-18 | Hoechst Aktiengesellschaft | Kristalne kiselinske adicione soli diastereomerno čistih 1-(2,2-dimetilpropioniloksi)-etilestara 3-cefem-4-karbonske kiseline |
DE59209994D1 (de) * | 1991-09-07 | 2004-04-29 | Aventis Pharma Gmbh | Diastereomer des 3-Cephem-4-carbonsäure-1-(-isopropoxycarbonyloxy)ethylesters und Verfahren zu dessen Herstellung |
TW212181B (ja) * | 1992-02-14 | 1993-09-01 | Hoechst Ag | |
ES2117066T3 (es) * | 1992-05-21 | 1998-08-01 | Hoechst Ag | Procedimiento para la disociacion de esteres profarmacos de cefalosporina para dar acido 7-amino-3-metoximetil-cef-3-em-4-carboxilico. |
FR2716110B1 (fr) | 1994-02-16 | 1996-04-05 | Roussel Uclaf | Compositions cosmétiques ou pharmaceutiques comprenant des liposomes. |
AU7224300A (en) * | 1999-05-07 | 2000-11-21 | Ranbaxy Laboratories Limited | Process for the preparation of cefpodoxime acid |
IL147976A0 (en) * | 1999-08-06 | 2002-09-12 | Janssen Pharmaceutica Nv | Interleukin-5 inhibiting 6-azauracil derivatives |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
EP1404324B2 (en) * | 2001-06-11 | 2011-04-06 | XenoPort, Inc. | Prodrugs of gaba analogs, compositions and uses thereof |
US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
KR20070026295A (ko) * | 2003-08-25 | 2007-03-08 | 레박스 파마슈티칼즈, 엘엘씨 | 경구 신경치료 세파졸린 조성물 |
EP1621536A1 (en) | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
FR2896504B1 (fr) | 2006-01-23 | 2012-07-13 | Aventis Pharma Sa | Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases |
FR2907453B1 (fr) | 2006-10-24 | 2008-12-26 | Sanofi Aventis Sa | Nouveaux derives du fluorene,compositions les contenant et utilisation |
AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
CN102417451B (zh) * | 2011-12-20 | 2013-12-04 | 浙江国邦药业有限公司 | 一种合成(r,s)1-溴代乙基乙酸酯的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5686188A (en) * | 1979-11-19 | 1981-07-13 | Fujisawa Pharmaceut Co Ltd | 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS502518B1 (ja) * | 1970-12-24 | 1975-01-27 | ||
GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
DE2760484C2 (ja) * | 1976-04-14 | 1992-12-03 | Takeda Chemical Industries, Ltd., Osaka, Jp | |
JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
GB1565941A (en) * | 1977-02-08 | 1980-04-23 | Toyama Chemical Co Ltd | Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids |
JPS53103493A (en) * | 1977-02-18 | 1978-09-08 | Takeda Chem Ind Ltd | Cephalosporin derivatives and process for their preparation |
PH17188A (en) * | 1977-03-14 | 1984-06-14 | Fujisawa Pharmaceutical Co | New cephem and cepham compounds and their pharmaceutical compositions and method of use |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
DE2716677C2 (de) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
FR2410655A1 (fr) * | 1977-12-05 | 1979-06-29 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
JPS5759894A (en) * | 1980-09-30 | 1982-04-10 | Sankyo Co Ltd | Cephalosporin for oral administration |
-
1980
- 1980-02-18 FR FR8003479A patent/FR2476087A1/fr active Granted
-
1981
- 1981-02-06 ZA ZA00810800A patent/ZA81800B/xx unknown
- 1981-02-13 AT AT81400224T patent/ATE10941T1/de not_active IP Right Cessation
- 1981-02-13 DE DE8383200381T patent/DE3177186D1/de not_active Expired - Fee Related
- 1981-02-13 DE DE8282201058T patent/DE3177185D1/de not_active Expired - Fee Related
- 1981-02-13 EP EP81400224A patent/EP0034536B1/fr not_active Expired
- 1981-02-13 DE DE8181400224T patent/DE3167891D1/de not_active Expired
- 1981-02-16 GR GR64158A patent/GR73815B/el unknown
- 1981-02-17 HU HU81379A patent/HU185628B/hu not_active IP Right Cessation
- 1981-02-17 ES ES499487A patent/ES8206520A1/es not_active Expired
- 1981-02-17 SU SU813248459A patent/SU1194279A3/ru active
- 1981-02-17 AU AU67381/81A patent/AU542325B2/en not_active Ceased
- 1981-02-17 PT PT72512A patent/PT72512B/pt unknown
- 1981-02-18 JP JP2160081A patent/JPS56128786A/ja active Granted
- 1981-02-18 CA CA000371163A patent/CA1181740A/fr not_active Expired
-
1982
- 1982-01-28 ES ES509128A patent/ES509128A0/es active Granted
- 1982-06-30 US US06/393,761 patent/US4992431A/en not_active Expired - Lifetime
- 1982-08-25 FR FR8214575A patent/FR2532313A2/fr active Granted
-
1983
- 1983-02-10 JP JP58019848A patent/JPH0794462B2/ja not_active Expired - Lifetime
-
1988
- 1988-03-07 JP JP63051810A patent/JPH0639476B2/ja not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5686188A (en) * | 1979-11-19 | 1981-07-13 | Fujisawa Pharmaceut Co Ltd | 7-acylamino-3-substituted cephalosporanic acid derivative and its preparation |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5965094A (ja) * | 1982-10-06 | 1984-04-13 | Sumitomo Chem Co Ltd | セフアロスポリン化合物の製造法 |
JPH0239519B2 (ja) * | 1982-10-06 | 1990-09-05 | Sumitomo Pharma | |
JPS59130293A (ja) * | 1983-01-04 | 1984-07-26 | Fujisawa Pharmaceut Co Ltd | 新規セフエム化合物およびその製造方法 |
WO1984004747A1 (en) * | 1983-03-02 | 1984-12-06 | Kyoto Pharma Ind | Cephem compounds |
JPS60109590A (ja) * | 1983-10-31 | 1985-06-15 | Fujisawa Pharmaceut Co Ltd | 新規セフエム化合物およびその製造方法 |
JPS6034976A (ja) * | 1984-02-17 | 1985-02-22 | Sankyo Co Ltd | 経口用セフアロスポリン化合物 |
JPS61178994A (ja) * | 1984-06-08 | 1986-08-11 | Takeda Chem Ind Ltd | セフエム化合物 |
JPS6140291A (ja) * | 1984-07-31 | 1986-02-26 | Shionogi & Co Ltd | ヒドロキシアルキルチオセフアロスポリン |
JP2008074803A (ja) * | 2006-09-25 | 2008-04-03 | Meiji Seika Kaisha Ltd | 経口投与用カルバペネム |
Also Published As
Publication number | Publication date |
---|---|
FR2476087A1 (fr) | 1981-08-21 |
ES499487A0 (es) | 1982-08-16 |
ZA81800B (en) | 1982-02-24 |
JPS58170789A (ja) | 1983-10-07 |
JPH0143757B2 (ja) | 1989-09-22 |
ES8206520A1 (es) | 1982-08-16 |
EP0034536A2 (fr) | 1981-08-26 |
EP0034536A3 (en) | 1981-11-04 |
GR73815B (ja) | 1984-04-18 |
DE3177185D1 (de) | 1990-06-28 |
FR2532313A2 (fr) | 1984-03-02 |
EP0034536B1 (fr) | 1984-12-27 |
AU6738181A (en) | 1981-08-27 |
JPH0639476B2 (ja) | 1994-05-25 |
HU185628B (en) | 1985-03-28 |
PT72512A (fr) | 1981-03-01 |
SU1194279A3 (ru) | 1985-11-23 |
AU542325B2 (en) | 1985-02-21 |
PT72512B (fr) | 1982-10-21 |
ES8302003A1 (es) | 1983-01-01 |
ES509128A0 (es) | 1983-01-01 |
JPH0794462B2 (ja) | 1995-10-11 |
DE3167891D1 (en) | 1985-02-07 |
ATE10941T1 (de) | 1985-01-15 |
JPS6452784A (en) | 1989-02-28 |
DE3177186D1 (de) | 1990-06-28 |
CA1181740A (fr) | 1985-01-29 |
US4992431A (en) | 1991-02-12 |
FR2476087B1 (ja) | 1983-07-18 |
FR2532313B2 (ja) | 1985-03-22 |
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