JPS56104816A - Preventive and remedy for caridac infarction - Google Patents
Preventive and remedy for caridac infarctionInfo
- Publication number
- JPS56104816A JPS56104816A JP690780A JP690780A JPS56104816A JP S56104816 A JPS56104816 A JP S56104816A JP 690780 A JP690780 A JP 690780A JP 690780 A JP690780 A JP 690780A JP S56104816 A JPS56104816 A JP S56104816A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- carboxyl
- trans
- ethyl ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PURPOSE: To prepare the high safety titled agent containing specific L-leucine derivative.
CONSTITUTION: An agent containing N-(dl-3-trans-carboxyl-2-carbonyl)-L-leucine ethyl ester of formula or its salt. The experimentally induced cardiac infarction of rabbit can be suppressed to 70% of the contrast group by the administration with 25mg/kg of the compound of formula. The acute toxicity test of mouse by injecting 1,000mg/kg of the compound gives no significant changes. It is administered orally or parenterally. The compound of formula can be prepared by protecting one of the carboxyl groups of trans-epoxysuccinic acid, reacting with L-leucine ethyl ester, and eliminating the carboxyl-protecting group.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP690780A JPS56104816A (en) | 1980-01-25 | 1980-01-25 | Preventive and remedy for caridac infarction |
ES498734A ES8201567A1 (en) | 1980-01-25 | 1981-01-22 | Epoxysuccinic Acid Derivatives |
BR8100350A BR8100350A (en) | 1980-01-25 | 1981-01-23 | PROCESS FOR OBTAINING EPOXISUCCINIC ACID DERIVATIVES |
FR8101330A FR2474497A1 (en) | 1980-01-25 | 1981-01-23 | EPOXYSUCCINIC ACID DERIVATIVE, PROCESS FOR PREPARING THE SAME AND THERAPEUTIC APPLICATION THEREOF |
DE19813102486 DE3102486A1 (en) | 1980-01-25 | 1981-01-26 | EPOXYBERSTEINSEUR DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THEM |
IT19331/81A IT1141956B (en) | 1980-01-25 | 1981-01-26 | EPOXY-SUCCINIC ACID DERIVATIVE, PROCEDURE FOR ITS PREPARATION AND AGENT AGAINST MYOCARDIC INFARCTION CONTAINING THIS DERIVATIVE |
GB8102291A GB2067999A (en) | 1980-01-25 | 1981-01-26 | Epoxysuccinic Acid Derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP690780A JPS56104816A (en) | 1980-01-25 | 1980-01-25 | Preventive and remedy for caridac infarction |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS56104816A true JPS56104816A (en) | 1981-08-20 |
JPS6365644B2 JPS6365644B2 (en) | 1988-12-16 |
Family
ID=11651300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP690780A Granted JPS56104816A (en) | 1980-01-25 | 1980-01-25 | Preventive and remedy for caridac infarction |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS56104816A (en) |
BR (1) | BR8100350A (en) |
DE (1) | DE3102486A1 (en) |
ES (1) | ES8201567A1 (en) |
FR (1) | FR2474497A1 (en) |
GB (1) | GB2067999A (en) |
IT (1) | IT1141956B (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1595168A (en) * | 1977-03-03 | 1981-08-12 | Taisho Pharmaceutical Co Ltd | Expoxysuccinic acid derivatives |
-
1980
- 1980-01-25 JP JP690780A patent/JPS56104816A/en active Granted
-
1981
- 1981-01-22 ES ES498734A patent/ES8201567A1/en not_active Expired
- 1981-01-23 FR FR8101330A patent/FR2474497A1/en active Pending
- 1981-01-23 BR BR8100350A patent/BR8100350A/en unknown
- 1981-01-26 GB GB8102291A patent/GB2067999A/en not_active Withdrawn
- 1981-01-26 IT IT19331/81A patent/IT1141956B/en active
- 1981-01-26 DE DE19813102486 patent/DE3102486A1/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE3102486A1 (en) | 1981-11-19 |
ES498734A0 (en) | 1982-01-01 |
BR8100350A (en) | 1981-08-11 |
ES8201567A1 (en) | 1982-01-01 |
FR2474497A1 (en) | 1981-07-31 |
GB2067999A (en) | 1981-08-05 |
IT1141956B (en) | 1986-10-08 |
IT8119331A0 (en) | 1981-01-26 |
JPS6365644B2 (en) | 1988-12-16 |
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