JPS55111470A - Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient - Google Patents
Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredientInfo
- Publication number
- JPS55111470A JPS55111470A JP1721979A JP1721979A JPS55111470A JP S55111470 A JPS55111470 A JP S55111470A JP 1721979 A JP1721979 A JP 1721979A JP 1721979 A JP1721979 A JP 1721979A JP S55111470 A JPS55111470 A JP S55111470A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- geldanamycin
- preparation
- active ingredient
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Other In-Based Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A geldamycin derivative shown by formula I (R1 is methoxy or di lower alkyl amino; R2 is di lower alkyl amino).
EXAMPLE: 17-Dimethoxy-17,19-bisdimethylamino-geldanamycin.
USE: A synthetic intermediate for an antitumor agent, a drug for a veterinarian, or other derivative. a daily dose for an adult is 0.5W80mg/kg in the case of nonoral administration and 1W100mg/kg in the case of oral administration.
PROCESS: A geldanamycin shown by the formula II is reacted with a di lower alkylamine, e.g., dimethylamine, preferably in an organic solvent, e.g., a mixed solvent of chloroform and methanol at room temperature to give the desired compound shown by the formula I. The di lower alkylamine can also be used in the form of an aqueous solution.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1721979A JPS55111470A (en) | 1979-02-19 | 1979-02-19 | Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient |
US06/109,314 US4261989A (en) | 1979-02-19 | 1980-01-03 | Geldanamycin derivatives and antitumor drug |
AU54430/80A AU532333B2 (en) | 1979-02-19 | 1980-01-08 | Geldanamycin derivatives |
GB8001321A GB2042523B (en) | 1979-02-19 | 1980-01-15 | Geldanamycin derivatives and anti-tumor drug |
FR8002589A FR2449084A1 (en) | 1979-02-19 | 1980-02-06 | NOVEL GELDANAMYCIN DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION |
NL8000857A NL8000857A (en) | 1979-02-19 | 1980-02-12 | MONEY ANAMYCIN DERIVATIVES, METHOD FOR PREPARING THE SAME AND USE AS A MEDICINAL PRODUCT. |
CA345,489A CA1113935A (en) | 1979-02-19 | 1980-02-13 | Geldanamycin derivatives and antitumor drug |
IT20017/80A IT1147315B (en) | 1979-02-19 | 1980-02-19 | GELDANAMYCIN DERIVATIVES AND ANTI-CANCER DRUGS |
DE19803006097 DE3006097A1 (en) | 1979-02-19 | 1980-02-19 | MONEY AMININE DERIVATIVES AND ANTITUARY MEDICINES WITH THE SAME |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1721979A JPS55111470A (en) | 1979-02-19 | 1979-02-19 | Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55111470A true JPS55111470A (en) | 1980-08-28 |
JPS6312065B2 JPS6312065B2 (en) | 1988-03-17 |
Family
ID=11937822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1721979A Granted JPS55111470A (en) | 1979-02-19 | 1979-02-19 | Geldanamycin derivative, its preparation, antitumor drug comprising it as active ingredient |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55111470A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US6890917B2 (en) | 2001-03-30 | 2005-05-10 | The United States Of America As Represented By The Department Of Health And Human Services | Geldanamycin derivative and method of treating cancer using same |
US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0457021U (en) * | 1990-09-10 | 1992-05-15 |
-
1979
- 1979-02-19 JP JP1721979A patent/JPS55111470A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6890917B2 (en) | 2001-03-30 | 2005-05-10 | The United States Of America As Represented By The Department Of Health And Human Services | Geldanamycin derivative and method of treating cancer using same |
US6872715B2 (en) | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US7405208B2 (en) | 2001-08-06 | 2008-07-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
US7378407B2 (en) | 2004-05-20 | 2008-05-27 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
Also Published As
Publication number | Publication date |
---|---|
JPS6312065B2 (en) | 1988-03-17 |
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