JPS57134448A - Production of diaralkylamine - Google Patents
Production of diaralkylamineInfo
- Publication number
- JPS57134448A JPS57134448A JP2044781A JP2044781A JPS57134448A JP S57134448 A JPS57134448 A JP S57134448A JP 2044781 A JP2044781 A JP 2044781A JP 2044781 A JP2044781 A JP 2044781A JP S57134448 A JPS57134448 A JP S57134448A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- derivative
- diaralkylamine
- drugs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: The reaction of pyruvic acid derivative or benzaldehyde derivative with phenylalkylamine derivative is followed by reduction of the product to produce the titled compound used as a starting material for drugs in high yield.
CONSTITUTION: A compound of formula 2 (R is H, hydroxyl, halogen, 1W5C alkyl; n is 1W4) or formula 3 is made to react with a compound of formula 4 (R' is R; m is n) to give a compound of formula 5[X is CH, (CH2)n CH; Y is (CH2)m]. The reaction is conducted in an organic solvent such as DMSO at a temperature over 80°C, preferably at 130W160°C. Then, the compound of formula 5 is reduced, preferably with sodium cyanoborohydride to give the diaralkylamine of formula 1 (l, m is 1W4). The compound of formula 1, especially a diphenethylamine derivative is used as a starting material for drugs.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2044781A JPS57134448A (en) | 1981-02-14 | 1981-02-14 | Production of diaralkylamine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2044781A JPS57134448A (en) | 1981-02-14 | 1981-02-14 | Production of diaralkylamine |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57134448A true JPS57134448A (en) | 1982-08-19 |
JPS6126982B2 JPS6126982B2 (en) | 1986-06-23 |
Family
ID=12027305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2044781A Granted JPS57134448A (en) | 1981-02-14 | 1981-02-14 | Production of diaralkylamine |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57134448A (en) |
-
1981
- 1981-02-14 JP JP2044781A patent/JPS57134448A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6126982B2 (en) | 1986-06-23 |
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