JPS5576884A - 2-alylthiomethylene-1-oxapenam derivative and its preparation - Google Patents
2-alylthiomethylene-1-oxapenam derivative and its preparationInfo
- Publication number
- JPS5576884A JPS5576884A JP15123378A JP15123378A JPS5576884A JP S5576884 A JPS5576884 A JP S5576884A JP 15123378 A JP15123378 A JP 15123378A JP 15123378 A JP15123378 A JP 15123378A JP S5576884 A JPS5576884 A JP S5576884A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound shown
- cooh
- compound
- oxapenam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:An oxapenam derivative shown by the formula I (R1 is H or lower alkyl; R2 is R1, lower alkoxycarbonyl, aralkyloxycarbonyl, or COOH; R3 is aryl; R4 is R2 except for COOH), its salt, and a diazoketone compound shown by the formula II.
EXAMPLE: 2-Phenylthiomethylene-1-oxapenam.
USE: An inhibitor of β-lactamase, antibacterial agent, and its synthetic intermediate. Syergistic effect can be obtained by using the title compound together with an antibiotic of a β-lactam compound.
PROCESS: For example, a compound shown by the formula II is obtained by several processes using a starting material, e.g., a compound shown by the formula III. The compound shown by the formula II is heated in the presence of copper or a cupric salt in a solvent to give a compound shown by a formula I (R2 is R5). An alkali salt of a compound shown by the formula I in the case of R2=H is reacted with CO2 to give a compound shown by the formula I in the case of R2=COOH.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15123378A JPS5576884A (en) | 1978-12-06 | 1978-12-06 | 2-alylthiomethylene-1-oxapenam derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15123378A JPS5576884A (en) | 1978-12-06 | 1978-12-06 | 2-alylthiomethylene-1-oxapenam derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5576884A true JPS5576884A (en) | 1980-06-10 |
Family
ID=15514149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP15123378A Pending JPS5576884A (en) | 1978-12-06 | 1978-12-06 | 2-alylthiomethylene-1-oxapenam derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5576884A (en) |
-
1978
- 1978-12-06 JP JP15123378A patent/JPS5576884A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1412130A (en) | 3-substituted-morphinan derivatives | |
JPS5576884A (en) | 2-alylthiomethylene-1-oxapenam derivative and its preparation | |
JPS54128591A (en) | Cephalosporin analog | |
JPS55139387A (en) | Novel synthetic method of 7-amino-3-heterocyclic thiomethyl-delta3-carboxylic acids | |
JPS57106663A (en) | 1,4-disubstituted piperazine derivative and its preparation | |
JPS5573656A (en) | 4-substituted azetidine-2-one compound and its preparation | |
JPS5553247A (en) | Novel benzylamine derivative | |
JPS54128599A (en) | Pyrrolobenzazepin derivative | |
JPS5759897A (en) | Thiazolineazatidinone | |
JPS5592363A (en) | New 2-azetidinone derivative | |
JPS5283393A (en) | Synthesis of novel penicillin derivatives | |
JPS54112867A (en) | 1,3-dithiethane compound and its preparation | |
JPS57116048A (en) | Novel quinoline derivative | |
JPS5547651A (en) | Production of sulfoxyimine | |
JPS5726660A (en) | Novel beta-lactam compound and its preparation | |
JPS5540631A (en) | Novel beta-lactam compound and its preparation | |
JPS55120591A (en) | Phosphinoethylmalonic acid derivative, and preparation thereof | |
JPS5287129A (en) | 4-trifluoromethyl phenoxy phenoxyankane carboxylic acid | |
JPS5687584A (en) | Preparation of 7-methoxycephem compound | |
JPS5726675A (en) | Novel guanidinothiazole derivative and its preparation | |
JPS52122391A (en) | Novel penicillins | |
JPS54119448A (en) | Preparaton of beta-lactam compound | |
JPS5630987A (en) | Preparation of 7alpha-methoxycephalosporin | |
JPS5663947A (en) | Bemzamide derivative | |
JPS5718686A (en) | Penicillin derivative and its salt |