JPS5576884A - 2-alylthiomethylene-1-oxapenam derivative and its preparation - Google Patents

2-alylthiomethylene-1-oxapenam derivative and its preparation

Info

Publication number
JPS5576884A
JPS5576884A JP15123378A JP15123378A JPS5576884A JP S5576884 A JPS5576884 A JP S5576884A JP 15123378 A JP15123378 A JP 15123378A JP 15123378 A JP15123378 A JP 15123378A JP S5576884 A JPS5576884 A JP S5576884A
Authority
JP
Japan
Prior art keywords
formula
compound shown
cooh
compound
oxapenam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15123378A
Other languages
Japanese (ja)
Inventor
Eiji Oki
Sadao Oida
Akira Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP15123378A priority Critical patent/JPS5576884A/en
Publication of JPS5576884A publication Critical patent/JPS5576884A/en
Pending legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:An oxapenam derivative shown by the formula I (R1 is H or lower alkyl; R2 is R1, lower alkoxycarbonyl, aralkyloxycarbonyl, or COOH; R3 is aryl; R4 is R2 except for COOH), its salt, and a diazoketone compound shown by the formula II.
EXAMPLE: 2-Phenylthiomethylene-1-oxapenam.
USE: An inhibitor of β-lactamase, antibacterial agent, and its synthetic intermediate. Syergistic effect can be obtained by using the title compound together with an antibiotic of a β-lactam compound.
PROCESS: For example, a compound shown by the formula II is obtained by several processes using a starting material, e.g., a compound shown by the formula III. The compound shown by the formula II is heated in the presence of copper or a cupric salt in a solvent to give a compound shown by a formula I (R2 is R5). An alkali salt of a compound shown by the formula I in the case of R2=H is reacted with CO2 to give a compound shown by the formula I in the case of R2=COOH.
COPYRIGHT: (C)1980,JPO&Japio
JP15123378A 1978-12-06 1978-12-06 2-alylthiomethylene-1-oxapenam derivative and its preparation Pending JPS5576884A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15123378A JPS5576884A (en) 1978-12-06 1978-12-06 2-alylthiomethylene-1-oxapenam derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15123378A JPS5576884A (en) 1978-12-06 1978-12-06 2-alylthiomethylene-1-oxapenam derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5576884A true JPS5576884A (en) 1980-06-10

Family

ID=15514149

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15123378A Pending JPS5576884A (en) 1978-12-06 1978-12-06 2-alylthiomethylene-1-oxapenam derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5576884A (en)

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