JPS5564587A - Pyrimidoo*6*11a**isoquinolinee44one compound and its manufacture - Google Patents
Pyrimidoo*6*11a**isoquinolinee44one compound and its manufactureInfo
- Publication number
- JPS5564587A JPS5564587A JP14053279A JP14053279A JPS5564587A JP S5564587 A JPS5564587 A JP S5564587A JP 14053279 A JP14053279 A JP 14053279A JP 14053279 A JP14053279 A JP 14053279A JP S5564587 A JPS5564587 A JP S5564587A
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidoo
- manufacture
- compound
- intermediates
- isoquinolin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- CIVQDIGHVMGTPD-UHFFFAOYSA-N pyrimido[6,1-a]isoquinolin-4-one Chemical class C1=CC=C2C=CN3C(=O)N=CC=C3C2=C1 CIVQDIGHVMGTPD-UHFFFAOYSA-N 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782847693 DE2847693A1 (de) | 1978-11-03 | 1978-11-03 | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5564587A true JPS5564587A (en) | 1980-05-15 |
Family
ID=6053766
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14053279A Pending JPS5564587A (en) | 1978-11-03 | 1979-11-01 | Pyrimidoo*6*11a**isoquinolinee44one compound and its manufacture |
Country Status (18)
Country | Link |
---|---|
US (1) | US4400506A (ja) |
EP (1) | EP0010759B1 (ja) |
JP (1) | JPS5564587A (ja) |
AT (1) | ATE21104T1 (ja) |
AU (1) | AU538039B2 (ja) |
CA (1) | CA1123434A (ja) |
DE (2) | DE2847693A1 (ja) |
DK (1) | DK465879A (ja) |
ES (2) | ES485489A0 (ja) |
FI (1) | FI66865C (ja) |
GR (1) | GR74082B (ja) |
HU (1) | HU181884B (ja) |
IL (1) | IL58609A0 (ja) |
NO (1) | NO793537L (ja) |
NZ (1) | NZ191994A (ja) |
PH (1) | PH15281A (ja) |
PT (1) | PT70401A (ja) |
ZA (1) | ZA795888B (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI64370C (fi) * | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
DE2847693A1 (de) | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
FR2470130A2 (fr) * | 1979-11-21 | 1981-05-29 | Hoechst Ag | Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique |
DE3126837A1 (de) * | 1981-07-08 | 1983-01-27 | Hoechst Ag, 6000 Frankfurt | Triazino-(2,1-a)isochinolinderivate |
DE3135831A1 (de) * | 1981-09-10 | 1983-04-28 | Hoechst Ag, 6230 Frankfurt | 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
US4612376A (en) * | 1983-03-25 | 1986-09-16 | Fujisawa Pharmaceutical Co., Ltd. | Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent |
CA1237429A (en) * | 1983-05-05 | 1988-05-31 | Frank Kienzle | Pyrimidone derivatives |
WO2001013953A2 (en) * | 1999-08-21 | 2001-03-01 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist |
BRPI0009446B8 (pt) * | 1999-03-31 | 2021-05-25 | Rhinopharma Ltd | composto derivado de pirimido [6,1-a] isoquinolin-4-ona, processo para preparar p mesmo, composição, e, uso de um composto |
TWI347845B (en) * | 2002-03-06 | 2011-09-01 | Nycomed Gmbh | Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US8034782B2 (en) | 2008-07-16 | 2011-10-11 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2681236B1 (en) | 2011-03-01 | 2018-01-03 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
EP3718557A3 (en) | 2013-02-25 | 2020-10-21 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
KR20220147691A (ko) | 2013-08-09 | 2022-11-03 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
GB201613054D0 (en) | 2016-07-28 | 2016-09-14 | Verona Pharma Plc | New compound and process |
EP3972599A1 (en) | 2019-05-21 | 2022-03-30 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE590405A (ja) * | 1959-05-02 | |||
US3081306A (en) * | 1959-11-04 | 1963-03-12 | Pfizer & Co C | 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines |
GB1062357A (en) * | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
US3476755A (en) * | 1967-01-17 | 1969-11-04 | Edward C Taylor | 8,13-diazasteroids |
US3594379A (en) * | 1968-09-16 | 1971-07-20 | Sandoz Ag | 2,3-dihydroimidazo(1,2-c)quinazolines |
US3876788A (en) * | 1970-08-27 | 1975-04-08 | Burroughs Wellcome Co | Heterocyclic compounds in the treatment of inflammatory of arthritic conditions |
IN147624B (ja) | 1976-12-10 | 1980-05-03 | Hoechst Pharma | |
DE2720085A1 (de) | 1977-05-05 | 1978-11-16 | Hoechst Ag | Pyrimido(6,1-a)isochinolin-2-on- derivate |
FI64370C (fi) * | 1977-05-05 | 1983-11-10 | Hoechst Ag | Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat |
DE2847693A1 (de) | 1978-11-03 | 1980-05-22 | Hoechst Ag | Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen |
-
1978
- 1978-11-03 DE DE19782847693 patent/DE2847693A1/de not_active Withdrawn
-
1979
- 1979-10-29 ES ES485489A patent/ES485489A0/es active Granted
- 1979-10-31 EP EP79104238A patent/EP0010759B1/de not_active Expired
- 1979-10-31 DE DE7979104238T patent/DE2967610D1/de not_active Expired
- 1979-10-31 AT AT79104238T patent/ATE21104T1/de not_active IP Right Cessation
- 1979-11-01 IL IL58609A patent/IL58609A0/xx unknown
- 1979-11-01 NZ NZ191994A patent/NZ191994A/xx unknown
- 1979-11-01 FI FI793430A patent/FI66865C/fi not_active IP Right Cessation
- 1979-11-01 GR GR60383A patent/GR74082B/el unknown
- 1979-11-01 JP JP14053279A patent/JPS5564587A/ja active Pending
- 1979-11-02 HU HU79HO2195A patent/HU181884B/hu unknown
- 1979-11-02 ZA ZA00795888A patent/ZA795888B/xx unknown
- 1979-11-02 NO NO793537A patent/NO793537L/no unknown
- 1979-11-02 PT PT70401A patent/PT70401A/pt unknown
- 1979-11-02 CA CA339,089A patent/CA1123434A/en not_active Expired
- 1979-11-02 AU AU52453/79A patent/AU538039B2/en not_active Ceased
- 1979-11-02 DK DK465879A patent/DK465879A/da not_active Application Discontinuation
- 1979-11-05 PH PH23245A patent/PH15281A/en unknown
-
1980
- 1980-07-01 ES ES493011A patent/ES8103083A1/es not_active Expired
-
1981
- 1981-10-26 US US06/314,994 patent/US4400506A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI66865C (fi) | 1984-12-10 |
EP0010759A2 (de) | 1980-05-14 |
FI793430A (fi) | 1980-05-04 |
AU538039B2 (en) | 1984-07-26 |
ZA795888B (en) | 1980-10-29 |
EP0010759A3 (en) | 1981-08-19 |
HU181884B (en) | 1983-11-28 |
US4400506A (en) | 1983-08-23 |
ES493011A0 (es) | 1981-02-16 |
ES8102125A1 (es) | 1980-12-16 |
DK465879A (da) | 1980-05-04 |
IL58609A0 (en) | 1980-02-29 |
PT70401A (de) | 1979-12-01 |
ES485489A0 (es) | 1980-12-16 |
DE2847693A1 (de) | 1980-05-22 |
AU5245379A (en) | 1980-05-08 |
EP0010759B1 (de) | 1986-07-30 |
FI66865B (fi) | 1984-08-31 |
NO793537L (no) | 1980-05-06 |
ATE21104T1 (de) | 1986-08-15 |
PH15281A (en) | 1982-11-02 |
DE2967610D1 (en) | 1986-09-04 |
CA1123434A (en) | 1982-05-11 |
GR74082B (ja) | 1984-06-06 |
ES8103083A1 (es) | 1981-02-16 |
NZ191994A (en) | 1982-09-07 |
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