ES485489A0 - Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas - Google Patents

Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas

Info

Publication number: ES485489A0
Authority: ES; Spain
Prior art keywords: preparation; pirimido; isoquinolein; onas; derivatives
Prior art date: 1978-11-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES485489A

Other languages

English (en)

Other versions

ES8102125A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-11-03

Filing date

1979-10-29

Publication date

1980-12-16

1979-10-29 Application filed by Hoechst AG filed Critical Hoechst AG

1980-12-16 Publication of ES8102125A1 publication Critical patent/ES8102125A1/es

1980-12-16 Publication of ES485489A0 publication Critical patent/ES485489A0/es

Status Granted legal-status Critical Current

Links

239000000543 intermediate Substances 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Chemical group 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
CIVQDIGHVMGTPD-UHFFFAOYSA-N pyrimido[6,1-a]isoquinolin-4-one Chemical class C1=CC=C2C=CN3C(=O)N=CC=C3C2=C1 CIVQDIGHVMGTPD-UHFFFAOYSA-N 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

ES485489A 1978-11-03 1979-10-29 Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas Granted ES485489A0 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19782847693 DE2847693A1 (de)	1978-11-03	1978-11-03	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

Publications (2)

Publication Number	Publication Date
ES8102125A1 ES8102125A1 (es)	1980-12-16
ES485489A0 true ES485489A0 (es)	1980-12-16

Family

ID=6053766

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES485489A Granted ES485489A0 (es)	1978-11-03	1979-10-29	Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas
ES493011A Expired ES8103083A1 (es)	1978-11-03	1980-07-01	Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES493011A Expired ES8103083A1 (es)	1978-11-03	1980-07-01	Procedimiento para la preparacion de derivados de pirimi- do-(6,1-a)-isoquinolein-4-onas

Country Status (18)

Country	Link
US (1)	US4400506A (es)
EP (1)	EP0010759B1 (es)
JP (1)	JPS5564587A (es)
AT (1)	ATE21104T1 (es)
AU (1)	AU538039B2 (es)
CA (1)	CA1123434A (es)
DE (2)	DE2847693A1 (es)
DK (1)	DK465879A (es)
ES (2)	ES485489A0 (es)
FI (1)	FI66865C (es)
GR (1)	GR74082B (es)
HU (1)	HU181884B (es)
IL (1)	IL58609A0 (es)
NO (1)	NO793537L (es)
NZ (1)	NZ191994A (es)
PH (1)	PH15281A (es)
PT (1)	PT70401A (es)
ZA (1)	ZA795888B (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI64370C (fi) *	1977-05-05	1983-11-10	Hoechst Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de)	1978-11-03	1980-05-22	Hoechst Ag	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) *	1979-11-21	1981-05-29	Hoechst Ag	Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3126837A1 (de) *	1981-07-08	1983-01-27	Hoechst Ag, 6000 Frankfurt	Triazino-(2,1-a)isochinolinderivate
DE3135831A1 (de) *	1981-09-10	1983-04-28	Hoechst Ag, 6230 Frankfurt	9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4612376A (en) *	1983-03-25	1986-09-16	Fujisawa Pharmaceutical Co., Ltd.	Substituted-3,4-dihydro-4-(2,4,6-trimethoxyphenylimino)-2(1H)-pyrimidones useful as cardiotonic, antihypertensive, cerebrovascular vasodilator and anti-platelet agent
CA1237429A (en) *	1983-05-05	1988-05-31	Frank Kienzle	Pyrimidone derivatives
WO2001013953A2 (en) *	1999-08-21	2001-03-01	Byk Gulden Lomberg Chemische Fabrik Gmbh	Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist
BRPI0009446B8 (pt) *	1999-03-31	2021-05-25	Rhinopharma Ltd	composto derivado de pirimido [6,1-a] isoquinolin-4-ona, processo para preparar p mesmo, composição, e, uso de um composto
TWI347845B (en) *	2002-03-06	2011-09-01	Nycomed Gmbh	Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US8034782B2 (en)	2008-07-16	2011-10-11	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US7879802B2 (en)	2007-06-04	2011-02-01	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (ja)	2008-06-04	2011-08-04	シナジーファーマシューティカルズインコーポレイテッド	胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
EP2681236B1 (en)	2011-03-01	2018-01-03	Synergy Pharmaceuticals Inc.	Process of preparing guanylate cyclase c agonists
EP3718557A3 (en)	2013-02-25	2020-10-21	Bausch Health Ireland Limited	Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
WO2014151200A2 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
AU2014274812B2 (en)	2013-06-05	2018-09-27	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase C, method of making and using same
KR20220147691A (ko)	2013-08-09	2022-11-03	알데릭스, 인코포레이티드	인산염 수송을 억제하기 위한 화합물 및 방법
GB201613054D0 (en)	2016-07-28	2016-09-14	Verona Pharma Plc	New compound and process
EP3972599A1 (en)	2019-05-21	2022-03-30	Ardelyx, Inc.	Combination for lowering serum phosphate in a patient

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE590405A (es) *	1959-05-02
US3081306A (en) *	1959-11-04	1963-03-12	Pfizer & Co C	2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
GB1062357A (en) *	1965-03-23	1967-03-22	Pfizer & Co C	Quinazolone derivatives
US3476755A (en) *	1967-01-17	1969-11-04	Edward C Taylor	8,13-diazasteroids
US3594379A (en) *	1968-09-16	1971-07-20	Sandoz Ag	2,3-dihydroimidazo(1,2-c)quinazolines
US3876788A (en) *	1970-08-27	1975-04-08	Burroughs Wellcome Co	Heterocyclic compounds in the treatment of inflammatory of arthritic conditions
IN147624B (es)	1976-12-10	1980-05-03	Hoechst Pharma
DE2720085A1 (de)	1977-05-05	1978-11-16	Hoechst Ag	Pyrimido(6,1-a)isochinolin-2-on- derivate
FI64370C (fi) *	1977-05-05	1983-11-10	Hoechst Ag	Foerfarande foer framstaellning av terapeutiskt anvaendbara pyimido-(6,1-a)isokinolin-2-imino-4-onderivat
DE2847693A1 (de)	1978-11-03	1980-05-22	Hoechst Ag	Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen

1978
- 1978-11-03 DE DE19782847693 patent/DE2847693A1/de not_active Withdrawn
1979
- 1979-10-29 ES ES485489A patent/ES485489A0/es active Granted
- 1979-10-31 EP EP79104238A patent/EP0010759B1/de not_active Expired
- 1979-10-31 DE DE7979104238T patent/DE2967610D1/de not_active Expired
- 1979-10-31 AT AT79104238T patent/ATE21104T1/de not_active IP Right Cessation
- 1979-11-01 IL IL58609A patent/IL58609A0/xx unknown
- 1979-11-01 NZ NZ191994A patent/NZ191994A/xx unknown
- 1979-11-01 FI FI793430A patent/FI66865C/fi not_active IP Right Cessation
- 1979-11-01 GR GR60383A patent/GR74082B/el unknown
- 1979-11-01 JP JP14053279A patent/JPS5564587A/ja active Pending
- 1979-11-02 HU HU79HO2195A patent/HU181884B/hu unknown
- 1979-11-02 ZA ZA00795888A patent/ZA795888B/xx unknown
- 1979-11-02 NO NO793537A patent/NO793537L/no unknown
- 1979-11-02 PT PT70401A patent/PT70401A/pt unknown
- 1979-11-02 CA CA339,089A patent/CA1123434A/en not_active Expired
- 1979-11-02 AU AU52453/79A patent/AU538039B2/en not_active Ceased
- 1979-11-02 DK DK465879A patent/DK465879A/da not_active Application Discontinuation
- 1979-11-05 PH PH23245A patent/PH15281A/en unknown
1980
- 1980-07-01 ES ES493011A patent/ES8103083A1/es not_active Expired
1981
- 1981-10-26 US US06/314,994 patent/US4400506A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
FI66865C (fi)	1984-12-10
EP0010759A2 (de)	1980-05-14
FI793430A (fi)	1980-05-04
AU538039B2 (en)	1984-07-26
ZA795888B (en)	1980-10-29
EP0010759A3 (en)	1981-08-19
HU181884B (en)	1983-11-28
US4400506A (en)	1983-08-23
ES493011A0 (es)	1981-02-16
ES8102125A1 (es)	1980-12-16
DK465879A (da)	1980-05-04
IL58609A0 (en)	1980-02-29
PT70401A (de)	1979-12-01
DE2847693A1 (de)	1980-05-22
AU5245379A (en)	1980-05-08
JPS5564587A (en)	1980-05-15
EP0010759B1 (de)	1986-07-30
FI66865B (fi)	1984-08-31
NO793537L (no)	1980-05-06
ATE21104T1 (de)	1986-08-15
PH15281A (en)	1982-11-02
DE2967610D1 (en)	1986-09-04
CA1123434A (en)	1982-05-11
GR74082B (es)	1984-06-06
ES8103083A1 (es)	1981-02-16
NZ191994A (en)	1982-09-07

Publication	Publication Date	Title
ES485489A0 (es)	1980-12-16	Procedimiento para la preparacion de derivados de pirimido-(6,1-a)-isoquinolein-4-onas
ES486536A0 (es)	1980-12-16	Procedimiento para la preparacion de anilidas de acido-4- amino-2-ureido-(o-tioureido)-pirimidin-5-carboxilico
ES491916A0 (es)	1980-12-16	Procedimiento para la preparacion de 6b. 7b; 15.16-dimeti- len 1,4-androstadien-3-onas
ES526896A0 (es)	1984-08-01	Procedimiento para la preparacion de b-carbolinas
ES2062239T3 (es)	1994-12-16	Diamidas de acidos pirimidin-4,6-dicarboxilicos, procedimiento para su preparacion, utilizacion de las mismas, asi como medicamentos a base de estos compuestos.
ES521086A0 (es)	1984-01-01	Procedimiento para la preparacion de imidazolilfenil-tetrahidropiridazinas.
ES513391A0 (es)	1983-03-16	Procedimiento para la obtencion de 2-aril-3,4-diazabiciclo 4.n.0-alq-2-en-5-onas.
IL58299A (en)	1983-03-31	Fluorine-containing 1,4-dihydropyridine derivatives,their production and their medicinal use
AR221428A1 (es)	1981-01-30	Procedimiento para la preparacion de derivados de pirrolidinil-y de pirrolidinilmetil-benzamidas
AR223833A1 (es)	1981-09-30	Procedimiento para la preparacion de nuevos derivados antigenos
DK267979A (da)	1980-01-28	Fremgangsmaade til fremstilling af aryloxypropanolaminer
ES545155A0 (es)	1986-02-01	Procedimiento para la obtencion de (pirrol-1-il)-fenil-dihi-dropiridazinona
ES492537A0 (es)	1981-02-16	Procedimiento para la obtencion de pseudo-trisacaridos
MX6274E (es)	1985-03-05	Procedimiento para la preparacion de composiciones parmaceuticas que contienen alcohilantes citostaticos destoxificados
ES491116A0 (es)	1981-04-16	Procedimiento para la preparacion de derivados de bis (4-de-metoxidaunorubicin) dihidrazona
AR218060A1 (es)	1980-05-15	Procedimiento para la preparacion de derivados de acido 11-oxo-11h-pirido(2,1-b)quinazolina-2-carboxilico
ES487362A0 (es)	1980-12-01	Procedimiento para la preparacion de composiciones mixtas decetoperoxidos
MX152117A (es)	1985-05-30	Procedimiento para la preparacion de pigmentos de bis-n-dialquilcarbanoil-quinacridona
AR224366A1 (es)	1981-11-30	Procedimiento para preparar nuevos derivados de s-(carboxibencil)-l-cisteina y nuevos compuestos intermediarios para dicho procedimiento
ES487167A0 (es)	1980-12-16	Procedimiento para la obtencion de 2-fenilamino-imidazolinas-(2)sustituidos
MX6158E (es)	1984-11-29	Procedimiento para la preparacion de derivados piperazinilbenzoheterociclicos
ES2037116T3 (es)	1993-06-16	Procedimiento para la obtencion de bencilaminoarildihidropiridinlactonas.
AR220195A1 (es)	1980-10-15	Procedimiento para la preparacion de piperazin-1-carboxilatos 4 sustituidos de 2-metil-2-hidroxipropilo
ATE78466T1 (de)	1992-08-15	3-phenyl-2-styryl-pyrrolidine, ihre herstellung und verwendung.
MX154720A (es)	1987-12-07	Procedimiento para la preparacion de octahidro-1h-benzo 4,5-furo 3,2-e isoquinolinas