JPS5492915A - Preparation of beta-hydroxyamino acid - Google Patents

Preparation of beta-hydroxyamino acid

Info

Publication number
JPS5492915A
JPS5492915A JP15836077A JP15836077A JPS5492915A JP S5492915 A JPS5492915 A JP S5492915A JP 15836077 A JP15836077 A JP 15836077A JP 15836077 A JP15836077 A JP 15836077A JP S5492915 A JPS5492915 A JP S5492915A
Authority
JP
Japan
Prior art keywords
acid
alkyl
formula
isocyanoacetic
hydroxyamino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15836077A
Other languages
Japanese (ja)
Inventor
Soji Miyoshi
Kazuo Matsumoto
Yasuhiko Ozaki
Naoto Yoneda
Mamoru Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Priority to JP15836077A priority Critical patent/JPS5492915A/en
Publication of JPS5492915A publication Critical patent/JPS5492915A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PURPOSE: To obtain β-hydroxyamino acid in high yield, without side reactions, and high steric selectivity, by the reaction of a moderately reactive α-isocyanoacetic acid dialkylamide with an aldehyde or a ketone, followed by hydrolysis.
CONSTITUTION: α-Isocyanoacetic acid dialklamide of formula I (R3, R4=alkyl) obtained by the reaction of α-isocyanoacetic acid ester with dialkylamine, e.g. α-isocyanoacetic acid dimethylamide, is made to react with an aldehyde or a ketone of formula II (R1=H, COOH, alkyl, etc,; R2=H, alkyl) in the presence of a base, e.g. NaOH, to prepare 5-substituted or unsubstituted-2-oxazoline-4-carboxylic acid dialkylamide. The compound obtained is hydrolyzed to prepare β-hydroxyamino acid of formula IV.
COPYRIGHT: (C)1979,JPO&Japio
JP15836077A 1977-12-28 1977-12-28 Preparation of beta-hydroxyamino acid Pending JPS5492915A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15836077A JPS5492915A (en) 1977-12-28 1977-12-28 Preparation of beta-hydroxyamino acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15836077A JPS5492915A (en) 1977-12-28 1977-12-28 Preparation of beta-hydroxyamino acid

Publications (1)

Publication Number Publication Date
JPS5492915A true JPS5492915A (en) 1979-07-23

Family

ID=15669962

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15836077A Pending JPS5492915A (en) 1977-12-28 1977-12-28 Preparation of beta-hydroxyamino acid

Country Status (1)

Country Link
JP (1) JPS5492915A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0253781A (en) * 1988-08-17 1990-02-22 Ajinomoto Co Inc Oxazolinecarboxamide derivative and production thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0253781A (en) * 1988-08-17 1990-02-22 Ajinomoto Co Inc Oxazolinecarboxamide derivative and production thereof

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