JPS5466652A - O-(2,6-dichloroanilino)-alpha-hydroxyphenylacetic acid - Google Patents
O-(2,6-dichloroanilino)-alpha-hydroxyphenylacetic acidInfo
- Publication number
- JPS5466652A JPS5466652A JP13086477A JP13086477A JPS5466652A JP S5466652 A JPS5466652 A JP S5466652A JP 13086477 A JP13086477 A JP 13086477A JP 13086477 A JP13086477 A JP 13086477A JP S5466652 A JPS5466652 A JP S5466652A
- Authority
- JP
- Japan
- Prior art keywords
- moles
- solvent
- compound
- dichloroanilino
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:The title compound of formula I.
USE: Antiphlogistic, analogesic agent. An intermediate of diclofenac which a non- steroid-type antiphlogistic, analgesic agent.
PROCESS: The objective compound I is prepared either (1) by hydrolyzing 1 mole of the compound II (novel compound) with 1-10 moles (pref. 1-5 moles) of NaOH, KOH, etc., in a solvent comprising water, alcohols or their mixture, at the refluxing temperature of the solvent for 5 min-48 hours, or (2) by reducing 1 mole of the compound III with 1/3-5 moles (pref. 1-3 moles) of aluminum isopropoxide, etc., in a solvent such as isopropyl alcohol, etc. at the refluxing temprature of the solvent for 15 min-48 hours.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13086477A JPS5466652A (en) | 1977-11-02 | 1977-11-02 | O-(2,6-dichloroanilino)-alpha-hydroxyphenylacetic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13086477A JPS5466652A (en) | 1977-11-02 | 1977-11-02 | O-(2,6-dichloroanilino)-alpha-hydroxyphenylacetic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5466652A true JPS5466652A (en) | 1979-05-29 |
Family
ID=15044478
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13086477A Pending JPS5466652A (en) | 1977-11-02 | 1977-11-02 | O-(2,6-dichloroanilino)-alpha-hydroxyphenylacetic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5466652A (en) |
-
1977
- 1977-11-02 JP JP13086477A patent/JPS5466652A/en active Pending
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS5731615A (en) | Remedy for skin disease with keratinization | |
JPS5466652A (en) | O-(2,6-dichloroanilino)-alpha-hydroxyphenylacetic acid | |
JPS559025A (en) | Preparation of polyfluoroalcohol | |
JPS5368741A (en) | Preparation of substd. diphenylamine derivative | |
JPS56125333A (en) | Phenylacetic acid derivative and its preparation | |
JPS54148757A (en) | (2-fluoro-4-biphenylyl) ketene mercaptal s-oxide | |
JPS559028A (en) | Novel 3'-(alpha-hydroxybenzyl)-propiophenone and its preparation | |
JPS5572151A (en) | Threo-(2rs)-3-amino-2-hydroxy-4-oxo-4-phenylbutyric acid, its ester, and their preparation | |
JPS572270A (en) | Preparation of 1-methyl-5- p-toluoyl pyrrole-2-acetic acid | |
JPS54144347A (en) | 3-(2-fluoro-4-biphenylyl)-2-butanone | |
JPS5334743A (en) | Preparation of 2-(4-alkylphenyl)propionic acids | |
JPS568345A (en) | Production of propionic acid derivative and its ester | |
JPS5334742A (en) | Preparation of 2-(4-alkylphenyl)propionic acids | |
JPS5562050A (en) | Preparation of substituted phenylacetohydroxamic acid | |
JPS56113736A (en) | Preparation of 2-arylalkanoic acid | |
JPS55153777A (en) | Improved method of preparation of 3-methyl-3-(substituted phenyl)-glycidic ester | |
JPS55149223A (en) | Preparation process of 4-allyl or methallyloxyphenyl- acetic acids | |
JPS5721339A (en) | Esterification of organic carboxylic acid | |
JPS57209256A (en) | Novel salt of aminobutyric acid derivative | |
JPS5461156A (en) | Tropolone derivative | |
JPS55108845A (en) | Preparation of substituted phenylacetic acid derivative | |
JPS54154732A (en) | Production of haloganeated hydroxymandelic acid | |
JPS549214A (en) | Preparation of carboxylic acid ester of secondary or tertiary alcohol | |
JPS54112842A (en) | Preparation of alpha-biphenylyl-propionic acid derivative | |
JPS55104233A (en) | Preparation of beta-orcylcarboxylic acid methyl ester |