JPS56125333A - Phenylacetic acid derivative and its preparation - Google Patents

Phenylacetic acid derivative and its preparation

Info

Publication number
JPS56125333A
JPS56125333A JP2940680A JP2940680A JPS56125333A JP S56125333 A JPS56125333 A JP S56125333A JP 2940680 A JP2940680 A JP 2940680A JP 2940680 A JP2940680 A JP 2940680A JP S56125333 A JPS56125333 A JP S56125333A
Authority
JP
Japan
Prior art keywords
formula
phenylacetic acid
derivative
acid derivative
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2940680A
Other languages
Japanese (ja)
Inventor
Yasumitsu Tamura
Masao Murayama
Shingo Matsumura
Yoshihiko Yoshimoto
Shinichi Tanda
Katsutoshi Kunimoto
Hiroshi Enomoto
Yoshihisa Shibata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Priority to JP2940680A priority Critical patent/JPS56125333A/en
Publication of JPS56125333A publication Critical patent/JPS56125333A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A phenylacetic acid derivative of formula I (R1 is halogen).
EXAMPLE: 4-Chloro-5-methoxy-2-biphenylylacetic acid.
USE: Drug having antiphlogistic and analgesic activities.
PROCESS: The starting material comprising an easily available, simple compound is converted to a cyclohexenone derivative having desired substituent group, which is reacted with an iodinating agent and then aromatized to obtain a phenylacetic acid ester derivative of formula II (R2 is lower alkyl). Reaction of the compound of formula II with a caustic alkali gives the asymmetric biphenyl derivative of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP2940680A 1980-03-07 1980-03-07 Phenylacetic acid derivative and its preparation Pending JPS56125333A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2940680A JPS56125333A (en) 1980-03-07 1980-03-07 Phenylacetic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2940680A JPS56125333A (en) 1980-03-07 1980-03-07 Phenylacetic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS56125333A true JPS56125333A (en) 1981-10-01

Family

ID=12275246

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2940680A Pending JPS56125333A (en) 1980-03-07 1980-03-07 Phenylacetic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56125333A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002504538A (en) * 1998-02-27 2002-02-12 バイエル・アクチエンゲゼルシヤフト Arylphenyl-substituted cyclic keto-enols
JP2002507599A (en) * 1998-03-26 2002-03-12 バイエル・アクチエンゲゼルシヤフト Arylphenyl-substituted cyclic ketoenols
WO2006058592A1 (en) 2004-12-01 2006-06-08 Merck Patent Gmbh Novel specific caspase-10 inhibitors
CN104892393A (en) * 2015-04-29 2015-09-09 浙江普洛医药科技有限公司 Preparation method of substituted phenylacetic acid derivative

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY=1977 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002504538A (en) * 1998-02-27 2002-02-12 バイエル・アクチエンゲゼルシヤフト Arylphenyl-substituted cyclic keto-enols
JP2010174045A (en) * 1998-02-27 2010-08-12 Bayer Ag Phenylacetic acid derivative
JP2002507599A (en) * 1998-03-26 2002-03-12 バイエル・アクチエンゲゼルシヤフト Arylphenyl-substituted cyclic ketoenols
JP2010024237A (en) * 1998-03-26 2010-02-04 Bayer Ag Substituted phenyl derivative
WO2006058592A1 (en) 2004-12-01 2006-06-08 Merck Patent Gmbh Novel specific caspase-10 inhibitors
CN104892393A (en) * 2015-04-29 2015-09-09 浙江普洛医药科技有限公司 Preparation method of substituted phenylacetic acid derivative

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