JPS56125333A - Phenylacetic acid derivative and its preparation - Google Patents
Phenylacetic acid derivative and its preparationInfo
- Publication number
- JPS56125333A JPS56125333A JP2940680A JP2940680A JPS56125333A JP S56125333 A JPS56125333 A JP S56125333A JP 2940680 A JP2940680 A JP 2940680A JP 2940680 A JP2940680 A JP 2940680A JP S56125333 A JPS56125333 A JP S56125333A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- phenylacetic acid
- derivative
- acid derivative
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
NEW MATERIAL:A phenylacetic acid derivative of formula I (R1 is halogen).
EXAMPLE: 4-Chloro-5-methoxy-2-biphenylylacetic acid.
USE: Drug having antiphlogistic and analgesic activities.
PROCESS: The starting material comprising an easily available, simple compound is converted to a cyclohexenone derivative having desired substituent group, which is reacted with an iodinating agent and then aromatized to obtain a phenylacetic acid ester derivative of formula II (R2 is lower alkyl). Reaction of the compound of formula II with a caustic alkali gives the asymmetric biphenyl derivative of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2940680A JPS56125333A (en) | 1980-03-07 | 1980-03-07 | Phenylacetic acid derivative and its preparation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2940680A JPS56125333A (en) | 1980-03-07 | 1980-03-07 | Phenylacetic acid derivative and its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS56125333A true JPS56125333A (en) | 1981-10-01 |
Family
ID=12275246
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2940680A Pending JPS56125333A (en) | 1980-03-07 | 1980-03-07 | Phenylacetic acid derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS56125333A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002504538A (en) * | 1998-02-27 | 2002-02-12 | バイエル・アクチエンゲゼルシヤフト | Arylphenyl-substituted cyclic keto-enols |
JP2002507599A (en) * | 1998-03-26 | 2002-03-12 | バイエル・アクチエンゲゼルシヤフト | Arylphenyl-substituted cyclic ketoenols |
WO2006058592A1 (en) | 2004-12-01 | 2006-06-08 | Merck Patent Gmbh | Novel specific caspase-10 inhibitors |
CN104892393A (en) * | 2015-04-29 | 2015-09-09 | 浙江普洛医药科技有限公司 | Preparation method of substituted phenylacetic acid derivative |
-
1980
- 1980-03-07 JP JP2940680A patent/JPS56125333A/en active Pending
Non-Patent Citations (1)
Title |
---|
JOURNAL OF MEDICINAL CHEMISTRY=1977 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002504538A (en) * | 1998-02-27 | 2002-02-12 | バイエル・アクチエンゲゼルシヤフト | Arylphenyl-substituted cyclic keto-enols |
JP2010174045A (en) * | 1998-02-27 | 2010-08-12 | Bayer Ag | Phenylacetic acid derivative |
JP2002507599A (en) * | 1998-03-26 | 2002-03-12 | バイエル・アクチエンゲゼルシヤフト | Arylphenyl-substituted cyclic ketoenols |
JP2010024237A (en) * | 1998-03-26 | 2010-02-04 | Bayer Ag | Substituted phenyl derivative |
WO2006058592A1 (en) | 2004-12-01 | 2006-06-08 | Merck Patent Gmbh | Novel specific caspase-10 inhibitors |
CN104892393A (en) * | 2015-04-29 | 2015-09-09 | 浙江普洛医药科技有限公司 | Preparation method of substituted phenylacetic acid derivative |
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