JPS5461156A - Tropolone derivative - Google Patents
Tropolone derivativeInfo
- Publication number
- JPS5461156A JPS5461156A JP12517077A JP12517077A JPS5461156A JP S5461156 A JPS5461156 A JP S5461156A JP 12517077 A JP12517077 A JP 12517077A JP 12517077 A JP12517077 A JP 12517077A JP S5461156 A JPS5461156 A JP S5461156A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- mole
- moles
- hydroxyimino
- naoh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:A compound I (A is O, hydroxyimino).
EXAMPLE: 4-(3', 4'-Dichlorocinnamoyl)tropolone.
USE: Intermediate of carcinostatic agent.
PROCESS: The objective compound I wherein A is O, is prepared by reacting the compound II (1 mole) with 4-acetyltropolone III (1-3 moles) in an alcohol such as methanol, while adding alkali hydroxide such as NaOH (5-10 moles per 1 mole of the compound III; concentration of the NaOH is ≥ 20%) dropwise, at -10-+ 10°C. The compound can be converted to the compound I wherein A is hydroxyimino, by adding 1-20 moles of hydroxylamine hydrochloride to 1 mole of the compound (A is O), and refluxing by heating at a refluxing temperature of the alcohol used as solvent
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12517077A JPS5461156A (en) | 1977-10-20 | 1977-10-20 | Tropolone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12517077A JPS5461156A (en) | 1977-10-20 | 1977-10-20 | Tropolone derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5461156A true JPS5461156A (en) | 1979-05-17 |
Family
ID=14903609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12517077A Pending JPS5461156A (en) | 1977-10-20 | 1977-10-20 | Tropolone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5461156A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5208353A (en) * | 1989-06-14 | 1993-05-04 | Smithkline Beecham Corp. | Intermediates for preparing epoxy esters |
CN110357926A (en) * | 2019-07-26 | 2019-10-22 | 广西师范大学 | Tropolone and phenanthroline mixture manganese complex and its preparation method and application |
-
1977
- 1977-10-20 JP JP12517077A patent/JPS5461156A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5208353A (en) * | 1989-06-14 | 1993-05-04 | Smithkline Beecham Corp. | Intermediates for preparing epoxy esters |
CN110357926A (en) * | 2019-07-26 | 2019-10-22 | 广西师范大学 | Tropolone and phenanthroline mixture manganese complex and its preparation method and application |
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